Incidental Mutation 'R4117:Zfp607b'
ID 315131
Institutional Source Beutler Lab
Gene Symbol Zfp607b
Ensembl Gene ENSMUSG00000057093
Gene Name zinc finger protein 607B
Synonyms C030039L03Rik
MMRRC Submission 040991-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.081) question?
Stock # R4117 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 27388765-27405909 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 27398107 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Valine at position 64 (I64V)
Ref Sequence ENSEMBL: ENSMUSP00000112494 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000076421] [ENSMUST00000120004]
AlphaFold G3X9H3
Predicted Effect probably damaging
Transcript: ENSMUST00000076421
AA Change: I64V

PolyPhen 2 Score 0.972 (Sensitivity: 0.77; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000075755
Gene: ENSMUSG00000057093
AA Change: I64V

DomainStartEndE-ValueType
KRAB 14 75 1.29e-35 SMART
ZnF_C2H2 172 194 1.08e-1 SMART
ZnF_C2H2 200 222 4.24e-4 SMART
ZnF_C2H2 228 250 2.2e-2 SMART
ZnF_C2H2 256 278 1.69e-3 SMART
ZnF_C2H2 284 306 4.94e-5 SMART
ZnF_C2H2 312 334 2.36e-2 SMART
ZnF_C2H2 339 361 1.18e-2 SMART
ZnF_C2H2 367 389 1.67e-2 SMART
ZnF_C2H2 395 417 1.38e-3 SMART
ZnF_C2H2 423 445 1.06e-4 SMART
ZnF_C2H2 451 473 1.67e-2 SMART
ZnF_C2H2 479 501 6.67e-2 SMART
ZnF_C2H2 507 529 3.52e-1 SMART
ZnF_C2H2 535 557 3.49e-5 SMART
ZnF_C2H2 563 585 1.56e-2 SMART
ZnF_C2H2 591 613 3.89e-3 SMART
ZnF_C2H2 619 641 9.73e-4 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000120004
AA Change: I64V

PolyPhen 2 Score 0.972 (Sensitivity: 0.77; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000112494
Gene: ENSMUSG00000057093
AA Change: I64V

DomainStartEndE-ValueType
KRAB 14 75 1.29e-35 SMART
ZnF_C2H2 172 194 1.08e-1 SMART
ZnF_C2H2 200 222 4.24e-4 SMART
ZnF_C2H2 228 250 2.2e-2 SMART
ZnF_C2H2 256 278 1.69e-3 SMART
ZnF_C2H2 284 306 4.94e-5 SMART
ZnF_C2H2 312 334 2.36e-2 SMART
ZnF_C2H2 339 361 1.18e-2 SMART
ZnF_C2H2 367 389 1.67e-2 SMART
ZnF_C2H2 395 417 1.38e-3 SMART
ZnF_C2H2 423 445 1.06e-4 SMART
ZnF_C2H2 451 473 1.67e-2 SMART
ZnF_C2H2 479 501 6.67e-2 SMART
ZnF_C2H2 507 529 3.52e-1 SMART
ZnF_C2H2 535 557 3.49e-5 SMART
ZnF_C2H2 563 585 1.56e-2 SMART
ZnF_C2H2 591 613 3.89e-3 SMART
ZnF_C2H2 619 641 9.73e-4 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000124397
Predicted Effect noncoding transcript
Transcript: ENSMUST00000127200
Meta Mutation Damage Score 0.3674 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.9%
Validation Efficiency 97% (31/32)
Allele List at MGI
Other mutations in this stock
Total: 31 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acss2 T C 2: 155,398,313 (GRCm39) F358L probably damaging Het
Adamts16 A G 13: 70,916,111 (GRCm39) Y775H probably benign Het
Bard1 A T 1: 71,085,922 (GRCm39) H594Q probably damaging Het
Cd109 CATTTATTTATTTATTTATTTATTTATTTATTTAT CATTTATTTATTTATTTATTTATTTATTTATTTATTTAT 9: 78,619,782 (GRCm39) probably benign Het
Cenpt G A 8: 106,576,332 (GRCm39) S73L probably benign Het
Ctdnep1 C A 11: 69,879,497 (GRCm39) A7D probably damaging Het
Fam210b T C 2: 172,193,486 (GRCm39) S100P probably benign Het
Fyb1 A C 15: 6,659,597 (GRCm39) D434A probably damaging Het
H2-T15 T C 17: 36,368,496 (GRCm39) D144G probably damaging Het
Heph T C X: 95,544,221 (GRCm39) V615A probably benign Het
Icam5 T A 9: 20,948,886 (GRCm39) V746E probably damaging Het
Maml2 A G 9: 13,617,230 (GRCm39) Q192R probably damaging Het
Npas4 T C 19: 5,037,391 (GRCm39) Y301C probably damaging Het
Nup205 C T 6: 35,217,947 (GRCm39) Q1767* probably null Het
Or51f5 T A 7: 102,423,684 (GRCm39) probably null Het
Pigg A G 5: 108,495,908 (GRCm39) R982G probably benign Het
Plekhg2 A T 7: 28,060,313 (GRCm39) H1005Q probably benign Het
Rdh12 C T 12: 79,260,419 (GRCm39) R172C probably damaging Het
Rufy4 T C 1: 74,186,822 (GRCm39) C537R probably damaging Het
Semp2l2b T A 10: 21,943,615 (GRCm39) N122Y probably benign Het
Septin4 T C 11: 87,459,108 (GRCm39) F494S probably damaging Het
Serpinb9 T A 13: 33,199,579 (GRCm39) D291E probably benign Het
She A T 3: 89,759,679 (GRCm39) Y394F probably damaging Het
Sipa1l2 T C 8: 126,195,249 (GRCm39) S830G probably damaging Het
Stmn4 T C 14: 66,598,581 (GRCm39) *217Q probably null Het
Stx17 A G 4: 48,180,689 (GRCm39) D178G probably damaging Het
Tbc1d9 T G 8: 83,992,776 (GRCm39) I960S possibly damaging Het
Ubxn10 G T 4: 138,448,276 (GRCm39) D133E probably benign Het
Vmn2r42 T C 7: 8,197,839 (GRCm39) Y260C probably damaging Het
Vmn2r7 A C 3: 64,623,138 (GRCm39) probably benign Het
Zfp143 C T 7: 109,691,120 (GRCm39) T557I probably damaging Het
Other mutations in Zfp607b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02090:Zfp607b APN 7 27,398,140 (GRCm39) missense possibly damaging 0.75
IGL02114:Zfp607b APN 7 27,403,150 (GRCm39) missense probably benign 0.19
IGL03171:Zfp607b APN 7 27,393,020 (GRCm39) missense possibly damaging 0.70
IGL03329:Zfp607b APN 7 27,403,295 (GRCm39) missense probably damaging 1.00
R0988:Zfp607b UTSW 7 27,402,401 (GRCm39) missense probably benign 0.34
R1518:Zfp607b UTSW 7 27,398,087 (GRCm39) missense possibly damaging 0.95
R1672:Zfp607b UTSW 7 27,391,948 (GRCm39) missense possibly damaging 0.86
R1733:Zfp607b UTSW 7 27,391,949 (GRCm39) missense possibly damaging 0.66
R1992:Zfp607b UTSW 7 27,401,949 (GRCm39) missense possibly damaging 0.87
R2849:Zfp607b UTSW 7 27,401,819 (GRCm39) missense probably benign 0.00
R3879:Zfp607b UTSW 7 27,403,476 (GRCm39) missense possibly damaging 0.91
R4439:Zfp607b UTSW 7 27,402,149 (GRCm39) missense probably damaging 1.00
R4610:Zfp607b UTSW 7 27,403,120 (GRCm39) missense probably damaging 1.00
R4755:Zfp607b UTSW 7 27,402,930 (GRCm39) missense probably damaging 1.00
R4909:Zfp607b UTSW 7 27,403,221 (GRCm39) missense probably benign
R5095:Zfp607b UTSW 7 27,393,061 (GRCm39) intron probably benign
R5301:Zfp607b UTSW 7 27,403,172 (GRCm39) missense probably benign
R5422:Zfp607b UTSW 7 27,401,813 (GRCm39) missense probably benign 0.00
R5538:Zfp607b UTSW 7 27,402,294 (GRCm39) missense probably damaging 1.00
R5546:Zfp607b UTSW 7 27,402,032 (GRCm39) missense probably benign 0.19
R5644:Zfp607b UTSW 7 27,403,194 (GRCm39) missense probably damaging 1.00
R5649:Zfp607b UTSW 7 27,403,406 (GRCm39) missense probably damaging 1.00
R5692:Zfp607b UTSW 7 27,402,889 (GRCm39) missense probably benign 0.17
R5945:Zfp607b UTSW 7 27,401,841 (GRCm39) missense probably benign 0.06
R6695:Zfp607b UTSW 7 27,403,464 (GRCm39) missense probably benign 0.04
R7402:Zfp607b UTSW 7 27,392,919 (GRCm39) missense probably damaging 1.00
R7515:Zfp607b UTSW 7 27,402,921 (GRCm39) missense probably benign 0.03
R8402:Zfp607b UTSW 7 27,402,127 (GRCm39) missense probably damaging 1.00
R8954:Zfp607b UTSW 7 27,403,387 (GRCm39) missense probably benign 0.00
R9494:Zfp607b UTSW 7 27,403,092 (GRCm39) missense probably damaging 1.00
R9554:Zfp607b UTSW 7 27,402,464 (GRCm39) missense probably damaging 0.99
R9727:Zfp607b UTSW 7 27,403,125 (GRCm39) missense probably benign
Z1177:Zfp607b UTSW 7 27,401,819 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- GGGGTCATGGTCAAGTACAC -3'
(R):5'- GTCACTTCTGCTGAAACCGTC -3'

Sequencing Primer
(F):5'- ATTAAAGTGGACTGCTACCTGGC -3'
(R):5'- GTCAAGAACTCTGAGAGCTCTGC -3'
Posted On 2015-05-14