Mutagenetix > Incidental Mutation

Incidental Mutation 'R4125:Slco6b1'

315340

Institutional Source

Beutler Lab

Gene Symbol

Slco6b1

Ensembl Gene

ENSMUSG00000045463

Gene Name

solute carrier organic anion transporter family, member 6b1

Synonyms

1700022M03Rik

MMRRC Submission

041633-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.070) question?

Stock #

R4125 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

96849643-96924962 bp(-) (GRCm39)

Type of Mutation

exon

DNA Base Change (assembly)

T to A at 96915622 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Gene Model

predicted gene model for transcript(s):

AlphaFold

no structure available at present

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000167383

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000178359

SMART Domains

Protein: ENSMUSP00000136663
Gene: ENSMUSG00000045463

Domain	Start	End	E-Value	Type
Pfam:MFS_1	103	481	1.6e-12	PFAM
Pfam:OATP	108	668	9.7e-128	PFAM
Pfam:Kazal_2	511	552	5.1e-8	PFAM
transmembrane domain	670	692	N/A	INTRINSIC

Meta Mutation Damage Score

0.0869

Coding Region Coverage

1x: 99.5%
3x: 98.7%
10x: 97.3%
20x: 95.1%

Validation Efficiency

98% (52/53)

Allele List at MGI

Other mutations in this stock

Total: 49 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adam30	T	A	3: 98,068,679 (GRCm39)	C43S	probably damaging	Het
Adamts6	A	T	13: 104,449,412 (GRCm39)	Y274F	probably damaging	Het
Ap2b1	A	G	11: 83,256,471 (GRCm39)		probably null	Het
Atm	A	C	9: 53,361,921 (GRCm39)	L2732R	probably damaging	Het
Bbox1	A	G	2: 110,100,525 (GRCm39)	V224A	probably benign	Het
Bmpr1a	T	C	14: 34,156,690 (GRCm39)	D112G	probably benign	Het
Cdk19	A	G	10: 40,270,391 (GRCm39)	I67V	probably benign	Het
Cds2	A	G	2: 132,139,191 (GRCm39)	T145A	probably benign	Het
Chd9	A	G	8: 91,777,912 (GRCm39)	D2641G	probably damaging	Het
Chn2	G	T	6: 54,249,963 (GRCm39)	R24M	probably damaging	Het
Chuk	T	C	19: 44,088,613 (GRCm39)	I121V	probably null	Het
Ctsr	A	T	13: 61,309,659 (GRCm39)	D183E	probably benign	Het
Elp3	T	C	14: 65,797,630 (GRCm39)	E347G	possibly damaging	Het
Fhip1a	A	G	3: 85,572,690 (GRCm39)	S988P	possibly damaging	Het
Gnas	A	G	2: 174,141,958 (GRCm39)	N709S	possibly damaging	Het
Gramd2b	T	C	18: 56,618,296 (GRCm39)	S199P	probably damaging	Het
Gtf3c1	A	T	7: 125,246,622 (GRCm39)	C1562*	probably null	Het
Ifit1bl1	T	A	19: 34,572,188 (GRCm39)	I90F	probably damaging	Het
Igf2r	A	T	17: 12,921,141 (GRCm39)	H1313Q	possibly damaging	Het
Ighj4	T	C	12: 113,392,176 (GRCm39)		probably benign	Het
Kansl2	G	T	15: 98,429,636 (GRCm39)	P132Q	possibly damaging	Het
Lman1	T	C	18: 66,120,932 (GRCm39)	H430R	possibly damaging	Het
Lrrk2	T	C	15: 91,699,686 (GRCm39)	I2511T	probably benign	Het
Lvrn	C	A	18: 47,010,036 (GRCm39)	P395T	possibly damaging	Het
Myrip	C	A	9: 120,293,764 (GRCm39)	S753*	probably null	Het
Nectin4	A	G	1: 171,213,301 (GRCm39)	S408G	probably benign	Het
Or14j8	A	G	17: 38,263,681 (GRCm39)	I78T	probably benign	Het
Or52ae9	T	C	7: 103,390,207 (GRCm39)	K80R	probably benign	Het
Pcdhb13	T	C	18: 37,576,873 (GRCm39)	I417T	probably damaging	Het
Per2	T	C	1: 91,357,172 (GRCm39)	T664A	possibly damaging	Het
Plec	A	T	15: 76,056,962 (GRCm39)	L4347Q	probably damaging	Het
Poln	A	G	5: 34,261,295 (GRCm39)	S561P	probably benign	Het
Polr1a	T	C	6: 71,942,690 (GRCm39)	F1177L	probably benign	Het
Pramel24	C	T	4: 143,452,850 (GRCm39)	R94*	probably null	Het
Ptprb	A	T	10: 116,189,754 (GRCm39)	R1804S	probably benign	Het
Rhof	C	T	5: 123,257,588 (GRCm39)	V181M	probably damaging	Het
Rufy4	T	C	1: 74,186,822 (GRCm39)	C537R	probably damaging	Het
Slc22a12	T	C	19: 6,588,818 (GRCm39)	E281G	probably damaging	Het
Stac	C	A	9: 111,433,126 (GRCm39)		probably null	Het
Tcof1	C	A	18: 60,952,673 (GRCm39)	A898S	unknown	Het
Tep1	C	T	14: 51,081,191 (GRCm39)	R1349Q	possibly damaging	Het
Thoc6	A	T	17: 23,888,319 (GRCm39)		probably benign	Het
Tmem179	A	T	12: 112,477,461 (GRCm39)	F8I	possibly damaging	Het
Tnpo3	A	G	6: 29,560,091 (GRCm39)	L684P	probably damaging	Het
Ubash3a	T	C	17: 31,456,249 (GRCm39)	Y506H	probably damaging	Het
Umps	G	A	16: 33,777,288 (GRCm39)	Q431*	probably null	Het
Unc13c	A	G	9: 73,481,289 (GRCm39)		probably null	Het
Vmn1r210	A	T	13: 23,011,779 (GRCm39)	M169K	probably benign	Het
Zfp946	C	T	17: 22,673,548 (GRCm39)	Q101*	probably null	Het

Other mutations in Slco6b1

Allele	Source	Chr	Coord	Type	Predicted Effect
IGL00434:Slco6b1	APN	1	96,916,375 (GRCm39)	exon	noncoding transcript
IGL02110:Slco6b1	APN	1	96,915,607 (GRCm39)	exon	noncoding transcript
IGL02416:Slco6b1	APN	1	96,852,058 (GRCm39)	exon	noncoding transcript
IGL03406:Slco6b1	APN	1	96,875,310 (GRCm39)	exon	noncoding transcript
R0147:Slco6b1	UTSW	1	96,915,562 (GRCm39)	exon	noncoding transcript
R0277:Slco6b1	UTSW	1	96,916,398 (GRCm39)	exon	noncoding transcript
R0513:Slco6b1	UTSW	1	96,924,909 (GRCm39)	unclassified	noncoding transcript
R1401:Slco6b1	UTSW	1	96,857,610 (GRCm39)	splice site	noncoding transcript
R1823:Slco6b1	UTSW	1	96,888,901 (GRCm39)	exon	noncoding transcript
R1888:Slco6b1	UTSW	1	96,849,786 (GRCm39)	splice site	noncoding transcript
R4281:Slco6b1	UTSW	1	96,925,115 (GRCm39)	unclassified	noncoding transcript
R4282:Slco6b1	UTSW	1	96,925,115 (GRCm39)	unclassified	noncoding transcript
R4576:Slco6b1	UTSW	1	96,916,422 (GRCm39)	exon	noncoding transcript
R4850:Slco6b1	UTSW	1	96,839,558 (GRCm39)	unclassified	noncoding transcript
R5222:Slco6b1	UTSW	1	96,925,216 (GRCm39)	unclassified	noncoding transcript
R5389:Slco6b1	UTSW	1	96,916,309 (GRCm39)	exon	noncoding transcript
R5801:Slco6b1	UTSW	1	96,875,356 (GRCm39)	exon	noncoding transcript

Predicted Primers

PCR Primer
(F):5'- ATGTGCACATCACCAGAAGTTG -3'
(R):5'- CTGCCCTACTAATTTGGGATTTGTTAG -3'

Sequencing Primer
(F):5'- GCACTATTTGTGAGTTACTC -3'
(R):5'- TGGGATTTGTTAGAATCAATTCCAG -3'

Posted On

2015-05-14