Incidental Mutation 'R4127:Or5d36'
ID 315423
Institutional Source Beutler Lab
Gene Symbol Or5d36
Ensembl Gene ENSMUSG00000075137
Gene Name olfactory receptor family 5 subfamily D member 36
Synonyms Olfr1163, MOR174-8, GA_x6K02T2Q125-49563265-49562315
MMRRC Submission 040860-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.073) question?
Stock # R4127 (G1)
Quality Score 225
Status Not validated
Chromosome 2
Chromosomal Location 87900709-87901751 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 87901579 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 49 (V49A)
Ref Sequence ENSEMBL: ENSMUSP00000149399 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099835] [ENSMUST00000215268]
AlphaFold Q8VFR4
Predicted Effect probably benign
Transcript: ENSMUST00000099835
AA Change: V49A

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
SMART Domains Protein: ENSMUSP00000097423
Gene: ENSMUSG00000075137
AA Change: V49A

DomainStartEndE-ValueType
Pfam:7tm_4 33 310 1.2e-44 PFAM
Pfam:7tm_1 43 292 2.3e-13 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000215268
AA Change: V49A

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.6%
  • 10x: 97.1%
  • 20x: 94.5%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca13 A G 11: 9,141,973 (GRCm39) H3R probably benign Het
Actg2 A T 6: 83,499,866 (GRCm39) F128Y possibly damaging Het
Ankrd6 G A 4: 32,822,241 (GRCm39) T176M probably damaging Het
Atp6ap1l T C 13: 91,046,826 (GRCm39) D117G probably damaging Het
Cd209b A G 8: 3,968,714 (GRCm39) I284T probably damaging Het
Cfl2 C T 12: 54,908,143 (GRCm39) A123T probably benign Het
Cgnl1 T C 9: 71,631,822 (GRCm39) T510A probably benign Het
Chn2 G T 6: 54,249,963 (GRCm39) R24M probably damaging Het
Cyfip2 T C 11: 46,161,474 (GRCm39) I339V probably benign Het
Etl4 C T 2: 20,748,886 (GRCm39) P539L possibly damaging Het
Fras1 A G 5: 96,918,512 (GRCm39) D3516G probably benign Het
Frem2 T C 3: 53,433,317 (GRCm39) Y2669C probably damaging Het
Gga2 G T 7: 121,601,943 (GRCm39) H205N probably damaging Het
Gm5592 G A 7: 40,938,491 (GRCm39) G591D probably benign Het
Gtf3c1 A T 7: 125,246,622 (GRCm39) C1562* probably null Het
Heatr3 T A 8: 88,864,939 (GRCm39) C59S probably damaging Het
Heatr5b A G 17: 79,060,603 (GRCm39) M2024T possibly damaging Het
Jarid2 T C 13: 45,055,732 (GRCm39) S313P probably damaging Het
Lzts3 A G 2: 130,477,285 (GRCm39) S502P probably damaging Het
Pcdhb2 A T 18: 37,428,594 (GRCm39) D189V probably damaging Het
Pias3 G T 3: 96,606,982 (GRCm39) G82C probably damaging Het
Polg T C 7: 79,105,285 (GRCm39) E753G probably damaging Het
Pus10 T C 11: 23,668,654 (GRCm39) probably null Het
Pxn A G 5: 115,684,966 (GRCm39) R264G probably damaging Het
Rag1 A G 2: 101,472,416 (GRCm39) Y909H probably damaging Het
Rell2 A G 18: 38,091,267 (GRCm39) H144R probably benign Het
Rufy4 T C 1: 74,186,822 (GRCm39) C537R probably damaging Het
Ryr2 C T 13: 11,602,323 (GRCm39) V4520I possibly damaging Het
Scp2 A G 4: 107,921,181 (GRCm39) F10L probably benign Het
Slc9b2 T C 3: 135,035,598 (GRCm39) Y356H probably benign Het
Sorcs1 T C 19: 50,210,597 (GRCm39) D756G probably benign Het
Stra6 T A 9: 58,058,501 (GRCm39) V454E probably damaging Het
Tbc1d8 T C 1: 39,411,512 (GRCm39) N1108S probably benign Het
Tep1 C T 14: 51,081,191 (GRCm39) R1349Q possibly damaging Het
Tmem132d T C 5: 128,345,884 (GRCm39) R213G probably benign Het
Ubash3a T C 17: 31,456,249 (GRCm39) Y506H probably damaging Het
Xcr1 A C 9: 123,685,561 (GRCm39) V67G probably damaging Het
Zranb2 C A 3: 157,243,227 (GRCm39) C74* probably null Het
Other mutations in Or5d36
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01447:Or5d36 APN 2 87,901,468 (GRCm39) missense possibly damaging 0.56
IGL01472:Or5d36 APN 2 87,901,322 (GRCm39) missense possibly damaging 0.56
IGL02111:Or5d36 APN 2 87,901,571 (GRCm39) missense probably benign 0.22
R1274:Or5d36 UTSW 2 87,900,939 (GRCm39) missense probably damaging 1.00
R1938:Or5d36 UTSW 2 87,901,300 (GRCm39) missense probably damaging 1.00
R2012:Or5d36 UTSW 2 87,901,063 (GRCm39) missense probably benign 0.03
R3056:Or5d36 UTSW 2 87,901,583 (GRCm39) missense probably benign
R4748:Or5d36 UTSW 2 87,900,956 (GRCm39) missense probably benign 0.44
R4749:Or5d36 UTSW 2 87,900,956 (GRCm39) missense probably benign 0.44
R4769:Or5d36 UTSW 2 87,901,073 (GRCm39) missense probably benign 0.25
R6647:Or5d36 UTSW 2 87,901,053 (GRCm39) missense probably benign 0.03
R7111:Or5d36 UTSW 2 87,901,000 (GRCm39) missense probably damaging 1.00
R7168:Or5d36 UTSW 2 87,900,921 (GRCm39) missense probably benign 0.37
R8222:Or5d36 UTSW 2 87,901,381 (GRCm39) missense probably benign 0.00
R8869:Or5d36 UTSW 2 87,901,753 (GRCm39) critical splice acceptor site probably null
R9043:Or5d36 UTSW 2 87,900,983 (GRCm39) missense possibly damaging 0.94
R9205:Or5d36 UTSW 2 87,900,778 (GRCm39) missense probably benign 0.16
Predicted Primers PCR Primer
(F):5'- AGCGATCATAAGCCATAACTGC -3'
(R):5'- GCAAGTCTTCTGTCTCAGCTG -3'

Sequencing Primer
(F):5'- GCCATAACTGCTAGTAAGTAGGACTC -3'
(R):5'- TGTCCACTATGGTGCCACTGG -3'
Posted On 2015-05-14