Incidental Mutation 'R4128:Lyplal1'
ID 315462
Institutional Source Beutler Lab
Gene Symbol Lyplal1
Ensembl Gene ENSMUSG00000039246
Gene Name lysophospholipase-like 1
Synonyms Q96AVO
MMRRC Submission 041635-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R4128 (G1)
Quality Score 225
Status Not validated
Chromosome 1
Chromosomal Location 185819929-185849507 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 185821736 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Arginine at position 129 (C129R)
Ref Sequence ENSEMBL: ENSMUSP00000048229 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000045388]
AlphaFold no structure available at present
Predicted Effect possibly damaging
Transcript: ENSMUST00000045388
AA Change: C129R

PolyPhen 2 Score 0.937 (Sensitivity: 0.80; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000048229
Gene: ENSMUSG00000039246
AA Change: C129R

DomainStartEndE-ValueType
Pfam:Esterase 3 213 3.6e-8 PFAM
Pfam:Abhydrolase_2 11 230 1.5e-44 PFAM
Pfam:Abhydrolase_5 24 213 1.5e-13 PFAM
Pfam:Abhydrolase_3 89 167 1.5e-6 PFAM
Pfam:DLH 89 224 2.3e-6 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000195481
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.6%
  • 10x: 97.1%
  • 20x: 94.5%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamtsl4 C T 3: 95,588,982 (GRCm39) R483Q probably benign Het
Bbox1 A G 2: 110,100,525 (GRCm39) V224A probably benign Het
Cavin2 A G 1: 51,340,581 (GRCm39) *419W probably null Het
Cdk19 A G 10: 40,270,391 (GRCm39) I67V probably benign Het
Cds2 A G 2: 132,139,191 (GRCm39) T145A probably benign Het
Chn2 G T 6: 54,249,963 (GRCm39) R24M probably damaging Het
Csl T C 10: 99,594,462 (GRCm39) D201G probably benign Het
Erap1 T C 13: 74,814,315 (GRCm39) I33T probably damaging Het
Ermap T C 4: 119,044,308 (GRCm39) T163A possibly damaging Het
Gnas A G 2: 174,141,958 (GRCm39) N709S possibly damaging Het
Hsd17b14 G A 7: 45,212,432 (GRCm39) V155M probably damaging Het
Igf2bp2 C T 16: 21,897,371 (GRCm39) V281I probably benign Het
Ighj4 T C 12: 113,392,176 (GRCm39) probably benign Het
Ireb2 T A 9: 54,788,716 (GRCm39) D63E probably benign Het
Jarid2 T C 13: 45,055,732 (GRCm39) S313P probably damaging Het
Kcnj11 A G 7: 45,749,143 (GRCm39) F60S probably damaging Het
Mertk C T 2: 128,619,358 (GRCm39) Q539* probably null Het
Myrip C A 9: 120,293,764 (GRCm39) S753* probably null Het
Narf G A 11: 121,141,261 (GRCm39) probably null Het
Neb C A 2: 52,182,712 (GRCm39) L1051F probably damaging Het
Nid1 T C 13: 13,650,957 (GRCm39) V498A probably damaging Het
Or10ab5 T C 7: 108,245,633 (GRCm39) N50S probably benign Het
Or14j8 A G 17: 38,263,681 (GRCm39) I78T probably benign Het
Pam A G 1: 97,762,193 (GRCm39) Y691H probably damaging Het
Poln A G 5: 34,261,295 (GRCm39) S561P probably benign Het
Rab39 T A 9: 53,597,804 (GRCm39) I154L probably benign Het
Rnf187 A T 11: 58,824,883 (GRCm39) S220T probably benign Het
Stac C A 9: 111,433,126 (GRCm39) probably null Het
Stxbp3 T C 3: 108,702,147 (GRCm39) Q553R probably benign Het
Tmem179 A T 12: 112,477,461 (GRCm39) F8I possibly damaging Het
Trip11 G A 12: 101,861,957 (GRCm39) Q203* probably null Het
Ubash3a T C 17: 31,456,249 (GRCm39) Y506H probably damaging Het
Unc13c C A 9: 73,641,819 (GRCm39) A1225S probably damaging Het
Zranb1 C A 7: 132,568,281 (GRCm39) S313* probably null Het
Other mutations in Lyplal1
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0056:Lyplal1 UTSW 1 185,820,763 (GRCm39) missense probably benign 0.36
R0166:Lyplal1 UTSW 1 185,820,943 (GRCm39) missense probably benign 0.00
R1169:Lyplal1 UTSW 1 185,846,531 (GRCm39) missense probably benign 0.08
R1840:Lyplal1 UTSW 1 185,832,414 (GRCm39) missense probably damaging 1.00
R3498:Lyplal1 UTSW 1 185,820,857 (GRCm39) missense possibly damaging 0.95
R3499:Lyplal1 UTSW 1 185,820,857 (GRCm39) missense possibly damaging 0.95
R4613:Lyplal1 UTSW 1 185,820,949 (GRCm39) missense probably benign
R6447:Lyplal1 UTSW 1 185,821,639 (GRCm39) critical splice donor site probably null
R7102:Lyplal1 UTSW 1 185,832,524 (GRCm39) missense probably damaging 1.00
R9639:Lyplal1 UTSW 1 185,849,409 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- AATCTGTATCAAGTAGGCACCAC -3'
(R):5'- CCTAAGATGGCAACTGACGTTC -3'

Sequencing Primer
(F):5'- CAAGTAGGCACCACATTTTATTGC -3'
(R):5'- AGATGGCAACTGACGTTCTTTTTAG -3'
Posted On 2015-05-14