Incidental Mutation 'R4156:Vmn2r50'
ID 315537
Institutional Source Beutler Lab
Gene Symbol Vmn2r50
Ensembl Gene ENSMUSG00000094606
Gene Name vomeronasal 2, receptor 50
Synonyms EG434117
MMRRC Submission 040862-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.117) question?
Stock # R4156 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 9771162-9787105 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 9774309 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Arginine at position 529 (K529R)
Ref Sequence ENSEMBL: ENSMUSP00000074476 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000074943] [ENSMUST00000086298]
AlphaFold E9PW61
Predicted Effect probably benign
Transcript: ENSMUST00000074943
AA Change: K529R

PolyPhen 2 Score 0.117 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000074476
Gene: ENSMUSG00000094606
AA Change: K529R

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
Pfam:ANF_receptor 73 469 1.4e-32 PFAM
Pfam:NCD3G 512 565 2.9e-20 PFAM
Pfam:7tm_3 597 833 1.3e-55 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000086298
AA Change: K513R

PolyPhen 2 Score 0.066 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000083478
Gene: ENSMUSG00000094606
AA Change: K513R

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
Pfam:ANF_receptor 73 452 7e-31 PFAM
Pfam:NCD3G 496 549 5.3e-19 PFAM
Pfam:7tm_3 579 818 3.9e-78 PFAM
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.4%
  • 20x: 95.6%
Validation Efficiency 96% (44/46)
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2410004B18Rik T A 3: 145,644,018 (GRCm39) F69I possibly damaging Het
Acot12 C T 13: 91,932,882 (GRCm39) L552F probably benign Het
Aff4 T A 11: 53,301,726 (GRCm39) probably benign Het
Aldh18a1 A G 19: 40,539,725 (GRCm39) V750A probably damaging Het
Anapc1 A G 2: 128,469,149 (GRCm39) probably benign Het
Arl6ip1 AAAATAAATAAATAAATAAATAAATA AAAATAAATAAATAAATAAATAAATAAATA 7: 117,721,122 (GRCm39) probably benign Het
Bcl11b A T 12: 107,883,684 (GRCm39) probably null Het
Ccpg1 C A 9: 72,919,449 (GRCm39) Q355K probably benign Het
Cdc42bpb G A 12: 111,260,573 (GRCm39) P1702S probably benign Het
Ddx20 G T 3: 105,586,249 (GRCm39) Q699K probably benign Het
Ecd A G 14: 20,374,632 (GRCm39) S503P probably damaging Het
Etaa1 C T 11: 17,890,281 (GRCm39) R860Q probably damaging Het
Ffar2 T A 7: 30,519,093 (GRCm39) Y149F probably damaging Het
Gamt T A 10: 80,096,558 (GRCm39) R60* probably null Het
Gm6871 T C 7: 41,195,510 (GRCm39) N302S probably damaging Het
Hps3 A G 3: 20,083,393 (GRCm39) S135P probably damaging Het
Ifi203 T A 1: 173,764,106 (GRCm39) N122I probably damaging Het
Leng9 T C 7: 4,152,433 (GRCm39) D81G possibly damaging Het
Lrrc23 T A 6: 124,747,804 (GRCm39) K262* probably null Het
Morc2b T A 17: 33,357,401 (GRCm39) T124S probably benign Het
Mroh1 G A 15: 76,286,326 (GRCm39) probably null Het
Naxe T C 3: 87,964,011 (GRCm39) K240R probably benign Het
Ncan C A 8: 70,562,727 (GRCm39) E510D possibly damaging Het
Ndufs4 A T 13: 114,444,390 (GRCm39) S129R probably benign Het
Oog2 A G 4: 143,920,523 (GRCm39) probably benign Het
Or5h18 A T 16: 58,847,931 (GRCm39) F113Y probably damaging Het
Or8h8 T C 2: 86,753,222 (GRCm39) Y218C probably damaging Het
Or8j3c C A 2: 86,253,544 (GRCm39) V159L possibly damaging Het
Papola G A 12: 105,767,010 (GRCm39) probably null Het
Pasd1 T C X: 70,983,161 (GRCm39) C378R possibly damaging Het
Plec A G 15: 76,056,453 (GRCm39) S4517P probably damaging Het
Rpap1 C T 2: 119,604,660 (GRCm39) R416H probably damaging Het
Rpl31-ps17 C T 12: 54,748,397 (GRCm39) noncoding transcript Het
Rxfp2 G A 5: 149,975,020 (GRCm39) V210I probably benign Het
Ryr3 T C 2: 112,484,020 (GRCm39) D3909G probably damaging Het
Spata31d1a T A 13: 59,852,861 (GRCm39) K76N possibly damaging Het
Srgn A G 10: 62,333,613 (GRCm39) F55L possibly damaging Het
Tmem54 G A 4: 129,004,504 (GRCm39) R151Q probably damaging Het
Tns1 T A 1: 73,953,790 (GRCm39) N1848Y probably damaging Het
Trim33 G T 3: 103,217,630 (GRCm39) V192L possibly damaging Het
Trpm5 G T 7: 142,642,792 (GRCm39) L52I probably benign Het
Uaca A G 9: 60,779,035 (GRCm39) S1141G probably benign Het
Vmn1r63 T C 7: 5,806,531 (GRCm39) T34A possibly damaging Het
Vmn2r9 T C 5: 108,995,743 (GRCm39) T302A possibly damaging Het
Ylpm1 T C 12: 85,104,177 (GRCm39) probably benign Het
Zfp410 G A 12: 84,374,206 (GRCm39) R181H probably damaging Het
Other mutations in Vmn2r50
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01536:Vmn2r50 APN 7 9,771,610 (GRCm39) missense probably damaging 1.00
IGL01739:Vmn2r50 APN 7 9,771,364 (GRCm39) missense probably damaging 1.00
IGL02351:Vmn2r50 APN 7 9,787,002 (GRCm39) missense probably benign 0.01
IGL02358:Vmn2r50 APN 7 9,787,002 (GRCm39) missense probably benign 0.01
IGL02871:Vmn2r50 APN 7 9,781,714 (GRCm39) missense possibly damaging 0.91
IGL02962:Vmn2r50 APN 7 9,784,252 (GRCm39) missense probably damaging 1.00
IGL03187:Vmn2r50 APN 7 9,771,368 (GRCm39) missense probably damaging 1.00
IGL03346:Vmn2r50 APN 7 9,779,929 (GRCm39) missense probably damaging 0.99
PIT4651001:Vmn2r50 UTSW 7 9,771,659 (GRCm39) missense probably benign 0.30
R0530:Vmn2r50 UTSW 7 9,781,644 (GRCm39) missense possibly damaging 0.82
R1291:Vmn2r50 UTSW 7 9,771,404 (GRCm39) missense probably damaging 0.98
R1438:Vmn2r50 UTSW 7 9,784,062 (GRCm39) nonsense probably null
R1713:Vmn2r50 UTSW 7 9,771,731 (GRCm39) missense probably damaging 1.00
R1747:Vmn2r50 UTSW 7 9,781,605 (GRCm39) missense probably benign 0.20
R1750:Vmn2r50 UTSW 7 9,786,915 (GRCm39) missense possibly damaging 0.69
R1918:Vmn2r50 UTSW 7 9,781,610 (GRCm39) missense probably benign 0.03
R2435:Vmn2r50 UTSW 7 9,787,026 (GRCm39) missense probably benign 0.27
R2511:Vmn2r50 UTSW 7 9,781,640 (GRCm39) missense possibly damaging 0.81
R3795:Vmn2r50 UTSW 7 9,771,851 (GRCm39) missense probably benign 0.18
R4332:Vmn2r50 UTSW 7 9,786,922 (GRCm39) missense probably benign 0.32
R4399:Vmn2r50 UTSW 7 9,781,834 (GRCm39) missense possibly damaging 0.81
R4411:Vmn2r50 UTSW 7 9,784,235 (GRCm39) missense probably damaging 0.99
R4412:Vmn2r50 UTSW 7 9,784,235 (GRCm39) missense probably damaging 0.99
R4413:Vmn2r50 UTSW 7 9,784,235 (GRCm39) missense probably damaging 0.99
R4645:Vmn2r50 UTSW 7 9,771,162 (GRCm39) makesense probably null
R5151:Vmn2r50 UTSW 7 9,786,970 (GRCm39) missense probably benign 0.00
R5175:Vmn2r50 UTSW 7 9,771,644 (GRCm39) missense probably damaging 1.00
R5291:Vmn2r50 UTSW 7 9,781,752 (GRCm39) missense probably damaging 1.00
R5457:Vmn2r50 UTSW 7 9,781,873 (GRCm39) missense probably damaging 0.98
R5559:Vmn2r50 UTSW 7 9,771,253 (GRCm39) missense probably damaging 1.00
R5579:Vmn2r50 UTSW 7 9,784,016 (GRCm39) missense probably benign 0.00
R5711:Vmn2r50 UTSW 7 9,774,299 (GRCm39) missense possibly damaging 0.81
R5759:Vmn2r50 UTSW 7 9,781,905 (GRCm39) missense probably damaging 1.00
R6004:Vmn2r50 UTSW 7 9,783,986 (GRCm39) missense probably benign 0.00
R6394:Vmn2r50 UTSW 7 9,774,253 (GRCm39) missense probably damaging 1.00
R6488:Vmn2r50 UTSW 7 9,771,644 (GRCm39) missense probably damaging 1.00
R6762:Vmn2r50 UTSW 7 9,787,010 (GRCm39) missense probably benign 0.04
R6995:Vmn2r50 UTSW 7 9,779,964 (GRCm39) nonsense probably null
R6998:Vmn2r50 UTSW 7 9,771,684 (GRCm39) missense probably benign 0.03
R7019:Vmn2r50 UTSW 7 9,784,172 (GRCm39) missense probably benign 0.01
R7027:Vmn2r50 UTSW 7 9,781,539 (GRCm39) missense probably damaging 1.00
R7231:Vmn2r50 UTSW 7 9,787,010 (GRCm39) missense probably benign 0.04
R7343:Vmn2r50 UTSW 7 9,784,277 (GRCm39) critical splice acceptor site probably null
R7554:Vmn2r50 UTSW 7 9,784,066 (GRCm39) missense probably null 0.00
R7704:Vmn2r50 UTSW 7 9,781,665 (GRCm39) missense probably benign 0.05
R7768:Vmn2r50 UTSW 7 9,771,298 (GRCm39) missense probably damaging 0.99
R7773:Vmn2r50 UTSW 7 9,771,562 (GRCm39) missense possibly damaging 0.70
R7975:Vmn2r50 UTSW 7 9,771,272 (GRCm39) missense probably benign 0.39
R7987:Vmn2r50 UTSW 7 9,772,016 (GRCm39) missense probably benign 0.14
R7996:Vmn2r50 UTSW 7 9,781,795 (GRCm39) missense probably damaging 0.99
R8062:Vmn2r50 UTSW 7 9,774,240 (GRCm39) critical splice donor site probably null
R8396:Vmn2r50 UTSW 7 9,781,639 (GRCm39) nonsense probably null
R8466:Vmn2r50 UTSW 7 9,783,997 (GRCm39) missense probably damaging 0.97
R8985:Vmn2r50 UTSW 7 9,779,974 (GRCm39) missense probably damaging 1.00
R9068:Vmn2r50 UTSW 7 9,772,061 (GRCm39) missense possibly damaging 0.46
R9155:Vmn2r50 UTSW 7 9,781,571 (GRCm39) missense probably damaging 1.00
R9238:Vmn2r50 UTSW 7 9,781,503 (GRCm39) missense probably benign 0.01
R9576:Vmn2r50 UTSW 7 9,771,190 (GRCm39) missense probably benign
R9626:Vmn2r50 UTSW 7 9,771,960 (GRCm39) nonsense probably null
R9631:Vmn2r50 UTSW 7 9,786,990 (GRCm39) nonsense probably null
X0067:Vmn2r50 UTSW 7 9,786,954 (GRCm39) missense probably damaging 0.99
Z1088:Vmn2r50 UTSW 7 9,780,086 (GRCm39) missense probably benign 0.01
Z1088:Vmn2r50 UTSW 7 9,771,427 (GRCm39) missense possibly damaging 0.91
Predicted Primers PCR Primer
(F):5'- ATGAGGGTTAAGTCACAGGATATGTTG -3'
(R):5'- GGGAAATGTCAATCAGATAGTGTGC -3'

Sequencing Primer
(F):5'- CACAGGATATGTTGTTTGTTTTTGC -3'
(R):5'- GTCAATCAGATAGTGTGCAAAAATG -3'
Posted On 2015-05-14