Mutagenetix > Incidental Mutation

Incidental Mutation 'R4157:Oog2'

315572

Institutional Source

Beutler Lab

Gene Symbol

Oog2

Ensembl Gene

ENSMUSG00000066030

Gene Name

oogenesin 2

Synonyms

MMRRC Submission

041000-MU

Accession Numbers

Is this an essential gene?

Non essential (E-score: 0.000) question?

Stock #

R4157 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

144190719-144196934 bp(+) (GRCm38)

Type of Mutation

intron

DNA Base Change (assembly)

A to G at 144193953 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000115150 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000080405] [ENSMUST00000143978]

AlphaFold

Q7TPX8

Predicted Effect

probably benign
Transcript: ENSMUST00000080405

SMART Domains

Protein: ENSMUSP00000079267
Gene: ENSMUSG00000066030

Domain	Start	End	E-Value	Type
SCOP:d1a4ya_	204	391	2e-7	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000129781

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000141847

Predicted Effect

probably benign
Transcript: ENSMUST00000143978

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 99.3%
3x: 98.7%
10x: 97.6%
20x: 96.1%

Validation Efficiency

95% (52/55)

Allele List at MGI

Other mutations in this stock

Total: 47 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700123L14Rik	C	G	6: 96,165,283	W260S	possibly damaging	Het
Adamts7	G	T	9: 90,188,361	R585L	probably damaging	Het
Adamtsl5	C	T	10: 80,345,322	R75Q	probably null	Het
Ankrd26	T	A	6: 118,507,821	Q1485L	probably damaging	Het
Apbb2	G	A	5: 66,302,604	R717*	probably null	Het
Arl6ip1	AAAATAAATAAATAAATAAATAAATA	AAAATAAATAAATAAATAAATAAATAAATA	7: 118,121,899		probably benign	Het
Atp8b5	A	G	4: 43,365,591	E735G	probably damaging	Het
Bcl11b	A	T	12: 107,917,425		probably null	Het
C4b	A	G	17: 34,742,855	I139T	probably damaging	Het
Ccpg1	C	A	9: 73,012,167	Q355K	probably benign	Het
Cdk8	A	T	5: 146,299,449		probably benign	Het
Ctif	T	C	18: 75,435,270	H599R	probably benign	Het
Degs1	A	G	1: 182,282,627	I26T	possibly damaging	Het
Dnajc4	T	C	19: 6,989,840	N72S	probably damaging	Het
Ecd	A	G	14: 20,324,564	S503P	probably damaging	Het
Gm1141	T	C	X: 71,939,555	C378R	possibly damaging	Het
Gm3486	G	A	14: 41,486,386	L123F	probably benign	Het
Inpp5f	C	T	7: 128,679,699		probably benign	Het
Irx4	A	T	13: 73,265,543	Q44L	probably benign	Het
Krt9	T	A	11: 100,188,649	Y639F	unknown	Het
Lgals9	C	A	11: 78,973,107	V71L	possibly damaging	Het
Mdga1	T	C	17: 29,833,343	N143S	probably benign	Het
Ndufs4	A	T	13: 114,307,854	S129R	probably benign	Het
Orm2	T	A	4: 63,363,985	F133L	probably null	Het
Pidd1	A	G	7: 141,441,366	V333A	possibly damaging	Het
Ppp4r3a	A	G	12: 101,055,619	F341L	probably damaging	Het
Rab11fip1	A	T	8: 27,152,147	S875T	probably damaging	Het
Rpap1	C	T	2: 119,774,179	R416H	probably damaging	Het
Rpl31-ps17	C	T	12: 54,701,612		noncoding transcript	Het
Shroom3	G	T	5: 92,943,086	V1151F	probably damaging	Het
Snx22	T	C	9: 66,068,211	Y92C	probably damaging	Het
Srgn	A	G	10: 62,497,834	F55L	possibly damaging	Het
Swt1	A	T	1: 151,403,044	V454E	probably damaging	Het
Tmem54	G	A	4: 129,110,711	R151Q	probably damaging	Het
Tns1	T	A	1: 73,914,631	N1848Y	probably damaging	Het
Tns2	C	T	15: 102,108,934	R281C	probably damaging	Het
Top2b	A	G	14: 16,384,491	N80S	probably benign	Het
Trim7	T	C	11: 48,848,093	V313A	probably benign	Het
Uaca	A	G	9: 60,871,753	S1141G	probably benign	Het
Ubr3	T	C	2: 69,959,669		probably null	Het
Utp20	A	G	10: 88,761,867	V121A	probably benign	Het
Wdr20	G	A	12: 110,738,174	R49H	possibly damaging	Het
Ylpm1	T	C	12: 85,057,403		probably benign	Het
Zfp398	A	T	6: 47,835,909	T5S	probably benign	Het
Zfp410	G	A	12: 84,327,432	R181H	probably damaging	Het
Zfp523	C	T	17: 28,202,283	A367V	probably benign	Het
Zfp748	G	A	13: 67,542,106	S345L	possibly damaging	Het

Other mutations in Oog2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00843:Oog2	APN	4	144195172	missense	probably damaging	1.00
IGL01317:Oog2	APN	4	144195267	missense	probably benign	0.16
IGL01697:Oog2	APN	4	144195184	missense	possibly damaging	0.90
IGL02237:Oog2	APN	4	144196446	missense	possibly damaging	0.95
IGL02411:Oog2	APN	4	144195048	missense	probably damaging	0.99
IGL02476:Oog2	APN	4	144195229	missense	probably benign	0.02
IGL03284:Oog2	APN	4	144196607	unclassified	probably benign
IGL03394:Oog2	APN	4	144194006	missense	probably benign	0.17
R0538:Oog2	UTSW	4	144196084	nonsense	probably null
R0892:Oog2	UTSW	4	144196499	missense	probably benign	0.00
R1024:Oog2	UTSW	4	144196286	missense	probably damaging	1.00
R4156:Oog2	UTSW	4	144193953	intron	probably benign
R4166:Oog2	UTSW	4	144194841	missense	probably damaging	1.00
R4167:Oog2	UTSW	4	144196212	missense	probably benign	0.18
R4732:Oog2	UTSW	4	144193941	intron	probably benign
R4734:Oog2	UTSW	4	144196451	missense	probably benign	0.00
R4741:Oog2	UTSW	4	144195145	missense	possibly damaging	0.94
R4909:Oog2	UTSW	4	144195099	missense	possibly damaging	0.78
R4954:Oog2	UTSW	4	144190732	start gained	probably benign
R6437:Oog2	UTSW	4	144195108	splice site	probably null
R6487:Oog2	UTSW	4	144196485	missense	possibly damaging	0.48
R6946:Oog2	UTSW	4	144196464	missense	possibly damaging	0.95
R7000:Oog2	UTSW	4	144195327	missense	probably damaging	1.00
R7167:Oog2	UTSW	4	144195175	missense	probably benign	0.04
R7303:Oog2	UTSW	4	144195342	missense	probably benign	0.04
R7399:Oog2	UTSW	4	144195281	missense	probably benign	0.01
R8004:Oog2	UTSW	4	144194251	missense	probably benign	0.00
R8141:Oog2	UTSW	4	144194207	missense	probably damaging	0.97
R8411:Oog2	UTSW	4	144194173	missense	probably damaging	1.00
R8932:Oog2	UTSW	4	144194115	missense	probably benign	0.00
R9290:Oog2	UTSW	4	144196445	missense	probably benign	0.02
R9348:Oog2	UTSW	4	144195219	missense	probably damaging	1.00
R9614:Oog2	UTSW	4	144196137	missense	probably damaging	1.00
RF009:Oog2	UTSW	4	144195285	missense	probably benign	0.36
Z1177:Oog2	UTSW	4	144194015	missense	probably damaging	0.99

Predicted Primers

PCR Primer
(F):5'- GGATTAGACATATTATGGTGGCACAG -3'
(R):5'- GCCTCCTTAAACATCACTGGG -3'

Sequencing Primer
(F):5'- ACATGTAATCTCAGCACTTGGC -3'
(R):5'- CATCACTGGGAACATCATATTGGGC -3'

Posted On

2015-05-14