Incidental Mutation 'R4158:Il22b'
ID 315634
Institutional Source Beutler Lab
Gene Symbol Il22b
Ensembl Gene ENSMUSG00000090461
Gene Name interleukin 22B
Synonyms Iltifb, IL-TIFb
MMRRC Submission 041001-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.073) question?
Stock # R4158 (G1)
Quality Score 149
Status Validated
Chromosome 10
Chromosomal Location 118125534-118130943 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 118129037 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 151 (T151A)
Ref Sequence ENSEMBL: ENSMUSP00000128415 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000163808]
AlphaFold Q9JJY8
Predicted Effect probably damaging
Transcript: ENSMUST00000163808
AA Change: T151A

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000128415
Gene: ENSMUSG00000090461
AA Change: T151A

DomainStartEndE-ValueType
IL10 49 179 5.21e-1 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000179123
Meta Mutation Damage Score 0.1124 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.4%
  • 20x: 95.5%
Validation Efficiency 97% (38/39)
Allele List at MGI
Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam34 T C 8: 44,103,854 (GRCm39) H597R probably damaging Het
Adgrf4 G T 17: 42,978,568 (GRCm39) H258Q probably benign Het
Ankrd1 T A 19: 36,095,273 (GRCm39) K138N probably damaging Het
Arg1 T C 10: 24,798,575 (GRCm39) E25G probably damaging Het
Arhgef19 T C 4: 140,973,660 (GRCm39) I49T possibly damaging Het
Bsn A G 9: 107,990,145 (GRCm39) V1869A possibly damaging Het
Cep350 G A 1: 155,808,621 (GRCm39) R652W probably damaging Het
Cyp19a1 G A 9: 54,093,980 (GRCm39) T94I probably damaging Het
Dnajc13 G A 9: 104,067,641 (GRCm39) L1173F probably damaging Het
Dse A G 10: 34,029,330 (GRCm39) F587L probably damaging Het
Efcab14 A C 4: 115,597,594 (GRCm39) D63A probably damaging Het
Eomes A G 9: 118,308,031 (GRCm39) T35A probably benign Het
Fbxl20 T C 11: 97,986,220 (GRCm39) probably benign Het
Flcn T C 11: 59,691,947 (GRCm39) N234S probably benign Het
Gm20939 A T 17: 95,184,162 (GRCm39) Y270F possibly damaging Het
Ikzf4 A T 10: 128,479,605 (GRCm39) probably benign Het
Kcne4 A G 1: 78,795,819 (GRCm39) N156D probably benign Het
Kcnh8 GAGACCAACGAGCAGCTGATGCTTCAGA GAGA 17: 53,032,934 (GRCm39) 74 probably benign Het
Lrrc45 A T 11: 120,609,272 (GRCm39) D377V possibly damaging Het
Magi3 T C 3: 103,958,277 (GRCm39) K603E probably damaging Het
Mocos T C 18: 24,807,303 (GRCm39) I345T probably damaging Het
Nox4 A T 7: 87,046,032 (GRCm39) H557L possibly damaging Het
Oasl1 A G 5: 115,075,073 (GRCm39) K378E possibly damaging Het
Pla2r1 A T 2: 60,252,966 (GRCm39) I1375K probably damaging Het
Ppp6r3 T A 19: 3,562,037 (GRCm39) H208L probably damaging Het
Ptprz1 A T 6: 23,001,683 (GRCm39) K1258* probably null Het
Ptprz1 T C 6: 23,022,204 (GRCm39) I844T possibly damaging Het
Sdk1 A G 5: 142,100,154 (GRCm39) I1395V probably benign Het
Sec31b T C 19: 44,513,625 (GRCm39) N470S probably benign Het
Slc26a7 T C 4: 14,544,197 (GRCm39) T369A probably benign Het
Tex14 T G 11: 87,407,595 (GRCm39) S900R probably benign Het
Ush2a G A 1: 188,460,907 (GRCm39) V2723M probably damaging Het
Vat1l T A 8: 115,098,469 (GRCm39) M413K probably benign Het
Zfp981 C A 4: 146,622,080 (GRCm39) P335Q probably benign Het
Zfp981 T A 4: 146,622,339 (GRCm39) H421Q probably benign Het
Other mutations in Il22b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01796:Il22b APN 10 118,126,069 (GRCm39) missense possibly damaging 0.70
IGL02149:Il22b APN 10 118,130,902 (GRCm39) utr 5 prime probably benign
IGL02965:Il22b APN 10 118,130,762 (GRCm39) missense probably damaging 0.98
R0310:Il22b UTSW 10 118,129,090 (GRCm39) missense probably benign 0.41
R0730:Il22b UTSW 10 118,130,142 (GRCm39) missense probably benign 0.01
R1078:Il22b UTSW 10 118,126,056 (GRCm39) makesense probably null
R4067:Il22b UTSW 10 118,126,115 (GRCm39) missense probably damaging 0.99
R4911:Il22b UTSW 10 118,130,894 (GRCm39) start codon destroyed probably null 0.99
R5433:Il22b UTSW 10 118,130,789 (GRCm39) missense probably damaging 0.96
R5778:Il22b UTSW 10 118,130,768 (GRCm39) nonsense probably null
R7295:Il22b UTSW 10 118,130,848 (GRCm39) nonsense probably null
R9313:Il22b UTSW 10 118,130,138 (GRCm39) missense probably damaging 1.00
R9485:Il22b UTSW 10 118,130,314 (GRCm39) missense probably benign
R9566:Il22b UTSW 10 118,130,860 (GRCm39) missense probably damaging 1.00
R9796:Il22b UTSW 10 118,130,081 (GRCm39) missense probably benign 0.19
Predicted Primers PCR Primer
(F):5'- TGCTAGCTCCAGAATTGTGAC -3'
(R):5'- AAATCTAGGTCACAGCGGGC -3'

Sequencing Primer
(F):5'- AGATTGAAAGATCTATAGACCCAGC -3'
(R):5'- GGGCAAAAATGACTGAACGCCTC -3'
Posted On 2015-05-14