Incidental Mutation 'R4158:Tex14'
ID 315637
Institutional Source Beutler Lab
Gene Symbol Tex14
Ensembl Gene ENSMUSG00000010342
Gene Name testis expressed gene 14
Synonyms
MMRRC Submission 041001-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.159) question?
Stock # R4158 (G1)
Quality Score 225
Status Validated
Chromosome 11
Chromosomal Location 87295891-87446649 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to G at 87407595 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Arginine at position 900 (S900R)
Ref Sequence ENSEMBL: ENSMUSP00000054444 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000060835]
AlphaFold Q7M6U3
Predicted Effect probably benign
Transcript: ENSMUST00000060835
AA Change: S900R

PolyPhen 2 Score 0.061 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000054444
Gene: ENSMUSG00000010342
AA Change: S900R

DomainStartEndE-ValueType
ANK 22 51 7.99e2 SMART
ANK 55 84 6.36e-3 SMART
ANK 88 117 3.49e0 SMART
Pfam:Pkinase 251 504 3.5e-19 PFAM
Pfam:Pkinase_Tyr 254 503 8.1e-28 PFAM
coiled coil region 659 684 N/A INTRINSIC
coiled coil region 740 776 N/A INTRINSIC
low complexity region 1219 1236 N/A INTRINSIC
coiled coil region 1289 1309 N/A INTRINSIC
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.4%
  • 20x: 95.5%
Validation Efficiency 97% (38/39)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is necessary for intercellular bridges in germ cells, which are required for spermatogenesis. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2011]
PHENOTYPE: Males homozygous for a targeted allele are infertile due to spermatogenic failure. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam34 T C 8: 44,103,854 (GRCm39) H597R probably damaging Het
Adgrf4 G T 17: 42,978,568 (GRCm39) H258Q probably benign Het
Ankrd1 T A 19: 36,095,273 (GRCm39) K138N probably damaging Het
Arg1 T C 10: 24,798,575 (GRCm39) E25G probably damaging Het
Arhgef19 T C 4: 140,973,660 (GRCm39) I49T possibly damaging Het
Bsn A G 9: 107,990,145 (GRCm39) V1869A possibly damaging Het
Cep350 G A 1: 155,808,621 (GRCm39) R652W probably damaging Het
Cyp19a1 G A 9: 54,093,980 (GRCm39) T94I probably damaging Het
Dnajc13 G A 9: 104,067,641 (GRCm39) L1173F probably damaging Het
Dse A G 10: 34,029,330 (GRCm39) F587L probably damaging Het
Efcab14 A C 4: 115,597,594 (GRCm39) D63A probably damaging Het
Eomes A G 9: 118,308,031 (GRCm39) T35A probably benign Het
Fbxl20 T C 11: 97,986,220 (GRCm39) probably benign Het
Flcn T C 11: 59,691,947 (GRCm39) N234S probably benign Het
Gm20939 A T 17: 95,184,162 (GRCm39) Y270F possibly damaging Het
Ikzf4 A T 10: 128,479,605 (GRCm39) probably benign Het
Il22b T C 10: 118,129,037 (GRCm39) T151A probably damaging Het
Kcne4 A G 1: 78,795,819 (GRCm39) N156D probably benign Het
Kcnh8 GAGACCAACGAGCAGCTGATGCTTCAGA GAGA 17: 53,032,934 (GRCm39) 74 probably benign Het
Lrrc45 A T 11: 120,609,272 (GRCm39) D377V possibly damaging Het
Magi3 T C 3: 103,958,277 (GRCm39) K603E probably damaging Het
Mocos T C 18: 24,807,303 (GRCm39) I345T probably damaging Het
Nox4 A T 7: 87,046,032 (GRCm39) H557L possibly damaging Het
Oasl1 A G 5: 115,075,073 (GRCm39) K378E possibly damaging Het
Pla2r1 A T 2: 60,252,966 (GRCm39) I1375K probably damaging Het
Ppp6r3 T A 19: 3,562,037 (GRCm39) H208L probably damaging Het
Ptprz1 A T 6: 23,001,683 (GRCm39) K1258* probably null Het
Ptprz1 T C 6: 23,022,204 (GRCm39) I844T possibly damaging Het
Sdk1 A G 5: 142,100,154 (GRCm39) I1395V probably benign Het
Sec31b T C 19: 44,513,625 (GRCm39) N470S probably benign Het
Slc26a7 T C 4: 14,544,197 (GRCm39) T369A probably benign Het
Ush2a G A 1: 188,460,907 (GRCm39) V2723M probably damaging Het
Vat1l T A 8: 115,098,469 (GRCm39) M413K probably benign Het
Zfp981 C A 4: 146,622,080 (GRCm39) P335Q probably benign Het
Zfp981 T A 4: 146,622,339 (GRCm39) H421Q probably benign Het
Other mutations in Tex14
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00272:Tex14 APN 11 87,426,469 (GRCm39) missense probably damaging 0.98
IGL00494:Tex14 APN 11 87,446,310 (GRCm39) missense probably damaging 1.00
IGL01604:Tex14 APN 11 87,400,524 (GRCm39) missense possibly damaging 0.63
IGL02690:Tex14 APN 11 87,377,100 (GRCm39) missense probably benign 0.11
IGL02888:Tex14 APN 11 87,418,738 (GRCm39) critical splice donor site probably null
IGL03073:Tex14 APN 11 87,426,435 (GRCm39) missense probably damaging 0.99
IGL03109:Tex14 APN 11 87,434,191 (GRCm39) missense probably damaging 1.00
IGL03047:Tex14 UTSW 11 87,427,530 (GRCm39) missense probably damaging 1.00
R0141:Tex14 UTSW 11 87,383,857 (GRCm39) splice site probably null
R0455:Tex14 UTSW 11 87,405,131 (GRCm39) missense possibly damaging 0.93
R0624:Tex14 UTSW 11 87,411,525 (GRCm39) missense probably benign 0.19
R0718:Tex14 UTSW 11 87,390,439 (GRCm39) missense probably benign 0.20
R1077:Tex14 UTSW 11 87,410,571 (GRCm39) splice site probably benign
R1118:Tex14 UTSW 11 87,413,343 (GRCm39) missense probably benign 0.07
R1120:Tex14 UTSW 11 87,429,502 (GRCm39) splice site probably benign
R1168:Tex14 UTSW 11 87,427,568 (GRCm39) missense probably benign 0.11
R1190:Tex14 UTSW 11 87,385,934 (GRCm39) splice site probably null
R1470:Tex14 UTSW 11 87,440,355 (GRCm39) splice site probably benign
R1563:Tex14 UTSW 11 87,427,634 (GRCm39) missense probably damaging 0.99
R1607:Tex14 UTSW 11 87,445,754 (GRCm39) missense probably damaging 1.00
R1696:Tex14 UTSW 11 87,402,371 (GRCm39) missense possibly damaging 0.49
R1873:Tex14 UTSW 11 87,390,431 (GRCm39) missense probably damaging 1.00
R1894:Tex14 UTSW 11 87,365,274 (GRCm39) missense probably damaging 1.00
R1911:Tex14 UTSW 11 87,385,861 (GRCm39) missense probably damaging 1.00
R1955:Tex14 UTSW 11 87,400,447 (GRCm39) missense probably damaging 1.00
R1971:Tex14 UTSW 11 87,402,431 (GRCm39) missense probably damaging 1.00
R1990:Tex14 UTSW 11 87,440,296 (GRCm39) missense probably damaging 1.00
R1991:Tex14 UTSW 11 87,440,296 (GRCm39) missense probably damaging 1.00
R1993:Tex14 UTSW 11 87,427,581 (GRCm39) missense possibly damaging 0.57
R2106:Tex14 UTSW 11 87,377,076 (GRCm39) missense possibly damaging 0.47
R2118:Tex14 UTSW 11 87,410,569 (GRCm39) splice site probably benign
R2860:Tex14 UTSW 11 87,365,243 (GRCm39) missense probably damaging 1.00
R2861:Tex14 UTSW 11 87,365,243 (GRCm39) missense probably damaging 1.00
R4016:Tex14 UTSW 11 87,429,449 (GRCm39) splice site probably null
R4089:Tex14 UTSW 11 87,403,029 (GRCm39) missense probably damaging 1.00
R4533:Tex14 UTSW 11 87,427,655 (GRCm39) nonsense probably null
R4713:Tex14 UTSW 11 87,427,691 (GRCm39) missense probably damaging 0.99
R4758:Tex14 UTSW 11 87,405,311 (GRCm39) missense probably benign 0.00
R4880:Tex14 UTSW 11 87,377,121 (GRCm39) missense possibly damaging 0.95
R4953:Tex14 UTSW 11 87,427,727 (GRCm39) critical splice donor site probably null
R5092:Tex14 UTSW 11 87,405,668 (GRCm39) missense probably benign 0.03
R5119:Tex14 UTSW 11 87,324,639 (GRCm39) missense probably damaging 1.00
R5322:Tex14 UTSW 11 87,402,298 (GRCm39) missense probably benign 0.04
R5470:Tex14 UTSW 11 87,442,430 (GRCm39) missense probably damaging 0.99
R5607:Tex14 UTSW 11 87,413,404 (GRCm39) missense probably benign 0.00
R5642:Tex14 UTSW 11 87,405,046 (GRCm39) missense probably benign
R5643:Tex14 UTSW 11 87,426,452 (GRCm39) missense probably damaging 1.00
R5786:Tex14 UTSW 11 87,405,121 (GRCm39) missense probably damaging 0.97
R6478:Tex14 UTSW 11 87,405,199 (GRCm39) missense probably benign
R6560:Tex14 UTSW 11 87,388,688 (GRCm39) missense possibly damaging 0.95
R6661:Tex14 UTSW 11 87,385,842 (GRCm39) missense probably damaging 1.00
R7037:Tex14 UTSW 11 87,388,741 (GRCm39) missense probably damaging 1.00
R7156:Tex14 UTSW 11 87,375,545 (GRCm39) missense probably damaging 0.99
R7465:Tex14 UTSW 11 87,405,256 (GRCm39) missense possibly damaging 0.48
R7675:Tex14 UTSW 11 87,400,504 (GRCm39) missense probably damaging 1.00
R7725:Tex14 UTSW 11 87,385,868 (GRCm39) missense probably damaging 0.99
R7911:Tex14 UTSW 11 87,424,428 (GRCm39) critical splice donor site probably null
R8015:Tex14 UTSW 11 87,400,426 (GRCm39) missense probably benign 0.13
R8226:Tex14 UTSW 11 87,375,585 (GRCm39) missense probably damaging 0.96
R8283:Tex14 UTSW 11 87,365,241 (GRCm39) missense probably damaging 1.00
R8292:Tex14 UTSW 11 87,388,664 (GRCm39) missense probably damaging 1.00
R8833:Tex14 UTSW 11 87,383,878 (GRCm39) missense probably benign 0.22
R8932:Tex14 UTSW 11 87,324,675 (GRCm39) missense possibly damaging 0.65
R9023:Tex14 UTSW 11 87,365,239 (GRCm39) missense
R9144:Tex14 UTSW 11 87,413,423 (GRCm39) critical splice donor site probably null
R9610:Tex14 UTSW 11 87,377,084 (GRCm39) missense probably damaging 1.00
R9611:Tex14 UTSW 11 87,377,084 (GRCm39) missense probably damaging 1.00
RF018:Tex14 UTSW 11 87,405,572 (GRCm39) missense probably benign 0.01
X0017:Tex14 UTSW 11 87,426,375 (GRCm39) nonsense probably null
Z1176:Tex14 UTSW 11 87,390,419 (GRCm39) missense possibly damaging 0.95
Z1176:Tex14 UTSW 11 87,375,633 (GRCm39) missense probably benign 0.08
Z1177:Tex14 UTSW 11 87,404,981 (GRCm39) missense probably damaging 0.96
Predicted Primers PCR Primer
(F):5'- GGGCTGAGTACTTAGACTCCAC -3'
(R):5'- AAGCTGTCATCCATTTGGCTTG -3'

Sequencing Primer
(F):5'- CTGAGTACTTAGACTCCACATTTTTG -3'
(R):5'- GTGATGTCTCCTGCAGGTTTCC -3'
Posted On 2015-05-14