Incidental Mutation 'R4158:Adgrf4'
ID 315640
Institutional Source Beutler Lab
Gene Symbol Adgrf4
Ensembl Gene ENSMUSG00000023918
Gene Name adhesion G protein-coupled receptor F4
Synonyms 4632435A09Rik, Gpr115
MMRRC Submission 041001-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R4158 (G1)
Quality Score 225
Status Validated
Chromosome 17
Chromosomal Location 42967782-43003175 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 42978568 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Histidine to Glutamine at position 258 (H258Q)
Ref Sequence ENSEMBL: ENSMUSP00000133261 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000024711] [ENSMUST00000164524] [ENSMUST00000167993] [ENSMUST00000170723]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000024711
AA Change: H258Q

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000024711
Gene: ENSMUSG00000023918
AA Change: H258Q

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
low complexity region 54 64 N/A INTRINSIC
low complexity region 103 112 N/A INTRINSIC
low complexity region 252 263 N/A INTRINSIC
GPS 349 400 1.25e-8 SMART
Pfam:7tm_2 402 653 5.9e-36 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000164524
SMART Domains Protein: ENSMUSP00000129114
Gene: ENSMUSG00000023918

DomainStartEndE-ValueType
SCOP:g1qd6.1 20 44 1e-2 SMART
low complexity region 54 64 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000167993
AA Change: H258Q

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000132890
Gene: ENSMUSG00000023918
AA Change: H258Q

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
low complexity region 54 64 N/A INTRINSIC
low complexity region 103 112 N/A INTRINSIC
low complexity region 252 263 N/A INTRINSIC
GPS 349 400 1.25e-8 SMART
Pfam:7tm_2 402 653 5.9e-36 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000170723
AA Change: H258Q

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000133261
Gene: ENSMUSG00000023918
AA Change: H258Q

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
low complexity region 54 64 N/A INTRINSIC
low complexity region 103 112 N/A INTRINSIC
low complexity region 252 263 N/A INTRINSIC
GPS 349 400 1.25e-8 SMART
Pfam:7tm_2 402 653 9.2e-36 PFAM
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.4%
  • 20x: 95.5%
Validation Efficiency 97% (38/39)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Sequence analysis of this gene suggests that it is encodes a member of the superfamily of G protein-couple receptors. G protein-coupled receptors typically contain seven hydrophobic transmembrane domains, interact with guanine nucleotide binding regulatory proteins, and detect molecules outside the cell and act to transduce these signals into intracellular responses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2016]
PHENOTYPE: Mice homozygous for a reporter allele exhibit normal viability and fertility. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam34 T C 8: 44,103,854 (GRCm39) H597R probably damaging Het
Ankrd1 T A 19: 36,095,273 (GRCm39) K138N probably damaging Het
Arg1 T C 10: 24,798,575 (GRCm39) E25G probably damaging Het
Arhgef19 T C 4: 140,973,660 (GRCm39) I49T possibly damaging Het
Bsn A G 9: 107,990,145 (GRCm39) V1869A possibly damaging Het
Cep350 G A 1: 155,808,621 (GRCm39) R652W probably damaging Het
Cyp19a1 G A 9: 54,093,980 (GRCm39) T94I probably damaging Het
Dnajc13 G A 9: 104,067,641 (GRCm39) L1173F probably damaging Het
Dse A G 10: 34,029,330 (GRCm39) F587L probably damaging Het
Efcab14 A C 4: 115,597,594 (GRCm39) D63A probably damaging Het
Eomes A G 9: 118,308,031 (GRCm39) T35A probably benign Het
Fbxl20 T C 11: 97,986,220 (GRCm39) probably benign Het
Flcn T C 11: 59,691,947 (GRCm39) N234S probably benign Het
Gm20939 A T 17: 95,184,162 (GRCm39) Y270F possibly damaging Het
Ikzf4 A T 10: 128,479,605 (GRCm39) probably benign Het
Il22b T C 10: 118,129,037 (GRCm39) T151A probably damaging Het
Kcne4 A G 1: 78,795,819 (GRCm39) N156D probably benign Het
Kcnh8 GAGACCAACGAGCAGCTGATGCTTCAGA GAGA 17: 53,032,934 (GRCm39) 74 probably benign Het
Lrrc45 A T 11: 120,609,272 (GRCm39) D377V possibly damaging Het
Magi3 T C 3: 103,958,277 (GRCm39) K603E probably damaging Het
Mocos T C 18: 24,807,303 (GRCm39) I345T probably damaging Het
Nox4 A T 7: 87,046,032 (GRCm39) H557L possibly damaging Het
Oasl1 A G 5: 115,075,073 (GRCm39) K378E possibly damaging Het
Pla2r1 A T 2: 60,252,966 (GRCm39) I1375K probably damaging Het
Ppp6r3 T A 19: 3,562,037 (GRCm39) H208L probably damaging Het
Ptprz1 A T 6: 23,001,683 (GRCm39) K1258* probably null Het
Ptprz1 T C 6: 23,022,204 (GRCm39) I844T possibly damaging Het
Sdk1 A G 5: 142,100,154 (GRCm39) I1395V probably benign Het
Sec31b T C 19: 44,513,625 (GRCm39) N470S probably benign Het
Slc26a7 T C 4: 14,544,197 (GRCm39) T369A probably benign Het
Tex14 T G 11: 87,407,595 (GRCm39) S900R probably benign Het
Ush2a G A 1: 188,460,907 (GRCm39) V2723M probably damaging Het
Vat1l T A 8: 115,098,469 (GRCm39) M413K probably benign Het
Zfp981 C A 4: 146,622,080 (GRCm39) P335Q probably benign Het
Zfp981 T A 4: 146,622,339 (GRCm39) H421Q probably benign Het
Other mutations in Adgrf4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00425:Adgrf4 APN 17 42,977,547 (GRCm39) missense probably damaging 1.00
IGL00474:Adgrf4 APN 17 42,986,650 (GRCm39) missense probably damaging 0.97
IGL00913:Adgrf4 APN 17 42,977,793 (GRCm39) missense possibly damaging 0.81
IGL02134:Adgrf4 APN 17 42,980,581 (GRCm39) missense probably damaging 1.00
IGL02225:Adgrf4 APN 17 42,974,269 (GRCm39) critical splice donor site probably null
IGL02423:Adgrf4 APN 17 42,983,467 (GRCm39) missense probably benign 0.06
IGL02945:Adgrf4 APN 17 42,978,257 (GRCm39) missense probably benign
R0329:Adgrf4 UTSW 17 42,978,204 (GRCm39) missense probably damaging 1.00
R0330:Adgrf4 UTSW 17 42,978,204 (GRCm39) missense probably damaging 1.00
R1595:Adgrf4 UTSW 17 42,978,764 (GRCm39) missense probably benign 0.09
R1739:Adgrf4 UTSW 17 42,977,789 (GRCm39) missense possibly damaging 0.93
R1762:Adgrf4 UTSW 17 42,977,789 (GRCm39) missense possibly damaging 0.93
R1783:Adgrf4 UTSW 17 42,977,789 (GRCm39) missense possibly damaging 0.93
R1785:Adgrf4 UTSW 17 42,977,789 (GRCm39) missense possibly damaging 0.93
R2038:Adgrf4 UTSW 17 42,978,754 (GRCm39) missense probably damaging 1.00
R2069:Adgrf4 UTSW 17 42,977,789 (GRCm39) missense possibly damaging 0.93
R2140:Adgrf4 UTSW 17 42,977,789 (GRCm39) missense possibly damaging 0.93
R2142:Adgrf4 UTSW 17 42,977,789 (GRCm39) missense possibly damaging 0.93
R2230:Adgrf4 UTSW 17 42,977,789 (GRCm39) missense possibly damaging 0.93
R2232:Adgrf4 UTSW 17 42,977,789 (GRCm39) missense possibly damaging 0.93
R2288:Adgrf4 UTSW 17 42,978,402 (GRCm39) missense probably benign
R3107:Adgrf4 UTSW 17 42,977,758 (GRCm39) nonsense probably null
R3732:Adgrf4 UTSW 17 42,983,472 (GRCm39) missense probably damaging 1.00
R4003:Adgrf4 UTSW 17 42,980,650 (GRCm39) missense probably damaging 1.00
R4160:Adgrf4 UTSW 17 42,978,568 (GRCm39) missense probably benign
R4163:Adgrf4 UTSW 17 42,978,477 (GRCm39) missense probably benign
R4865:Adgrf4 UTSW 17 42,978,156 (GRCm39) missense probably damaging 1.00
R4940:Adgrf4 UTSW 17 42,977,420 (GRCm39) missense possibly damaging 0.90
R5411:Adgrf4 UTSW 17 42,978,104 (GRCm39) missense probably damaging 1.00
R5512:Adgrf4 UTSW 17 42,978,176 (GRCm39) missense probably benign 0.03
R6421:Adgrf4 UTSW 17 42,983,392 (GRCm39) missense probably damaging 1.00
R7089:Adgrf4 UTSW 17 42,977,424 (GRCm39) missense possibly damaging 0.95
R7261:Adgrf4 UTSW 17 42,978,326 (GRCm39) missense probably benign 0.01
R7359:Adgrf4 UTSW 17 42,978,003 (GRCm39) missense possibly damaging 0.78
R7502:Adgrf4 UTSW 17 42,980,548 (GRCm39) missense possibly damaging 0.53
R7522:Adgrf4 UTSW 17 42,980,675 (GRCm39) missense probably benign 0.04
R7555:Adgrf4 UTSW 17 42,983,494 (GRCm39) missense probably benign 0.16
R7567:Adgrf4 UTSW 17 42,978,333 (GRCm39) missense probably benign
R7743:Adgrf4 UTSW 17 42,983,453 (GRCm39) nonsense probably null
R8002:Adgrf4 UTSW 17 42,978,683 (GRCm39) missense probably benign 0.05
R8210:Adgrf4 UTSW 17 42,978,441 (GRCm39) missense probably damaging 1.00
R8344:Adgrf4 UTSW 17 42,977,799 (GRCm39) missense probably benign 0.00
R8429:Adgrf4 UTSW 17 42,978,340 (GRCm39) missense probably benign
R9131:Adgrf4 UTSW 17 42,978,258 (GRCm39) missense probably benign 0.00
R9159:Adgrf4 UTSW 17 42,973,293 (GRCm39) missense probably benign
R9214:Adgrf4 UTSW 17 42,978,704 (GRCm39) missense possibly damaging 0.89
R9226:Adgrf4 UTSW 17 42,980,606 (GRCm39) missense probably damaging 1.00
R9237:Adgrf4 UTSW 17 42,980,782 (GRCm39) missense probably benign
R9546:Adgrf4 UTSW 17 42,978,283 (GRCm39) nonsense probably null
X0027:Adgrf4 UTSW 17 42,978,419 (GRCm39) missense probably damaging 0.96
Predicted Primers PCR Primer
(F):5'- TTCAGACCTTCTGGCAAAACC -3'
(R):5'- ACTGCCATTTCAAATTGGGCTTTC -3'

Sequencing Primer
(F):5'- AGGTCATCTATAGGCTTTTGGAG -3'
(R):5'- GCTTTCATTGCCAACAAAAATGC -3'
Posted On 2015-05-14