Incidental Mutation 'R4061:Or52n4'
ID 315860
Institutional Source Beutler Lab
Gene Symbol Or52n4
Ensembl Gene ENSMUSG00000070421
Gene Name olfactory receptor family 52 subfamily N member 4
Synonyms MOR34-5, GA_x6K02T2PBJ9-7273558-7272587, Olfr658
MMRRC Submission 040852-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.050) question?
Stock # R4061 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 104292087-104296512 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) T to A at 104293680 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Stop codon at position 298 (K298*)
Ref Sequence ENSEMBL: ENSMUSP00000147498 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000089296] [ENSMUST00000210641]
AlphaFold Q8VGV5
Predicted Effect probably null
Transcript: ENSMUST00000089296
AA Change: K300*
SMART Domains Protein: ENSMUSP00000086711
Gene: ENSMUSG00000070421
AA Change: K300*

Pfam:7tm_4 35 315 1.9e-108 PFAM
Pfam:7TM_GPCR_Srsx 39 256 3.1e-9 PFAM
Pfam:7tm_1 45 297 1.6e-18 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000210641
AA Change: K298*
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 95.1%
Validation Efficiency 94% (51/54)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700019A02Rik A T 1: 53,197,928 (GRCm39) L140Q probably damaging Het
Adam25 A G 8: 41,206,819 (GRCm39) I28M possibly damaging Het
Anks1b A G 10: 90,143,484 (GRCm39) S464G probably damaging Het
AU040320 T A 4: 126,729,488 (GRCm39) M550K probably damaging Het
Cab39l A G 14: 59,737,056 (GRCm39) K59E possibly damaging Het
Cdc5l C T 17: 45,721,816 (GRCm39) A485T probably benign Het
Csmd1 A G 8: 15,995,158 (GRCm39) S2626P probably benign Het
Ctss C T 3: 95,450,345 (GRCm39) R99W probably benign Het
Deptor A T 15: 55,072,177 (GRCm39) M219L probably benign Het
Disp1 A G 1: 182,869,264 (GRCm39) V1052A probably damaging Het
Esyt3 C T 9: 99,202,891 (GRCm39) S504N probably damaging Het
Fat1 A T 8: 45,478,518 (GRCm39) E2521D probably benign Het
Folh1 T A 7: 86,406,170 (GRCm39) Y301F possibly damaging Het
Gm14443 G A 2: 175,011,402 (GRCm39) T348I probably benign Het
Gtpbp2 G A 17: 46,478,253 (GRCm39) R467H probably damaging Het
Hnrnpll T C 17: 80,340,201 (GRCm39) H526R probably benign Het
Iars2 A T 1: 185,035,583 (GRCm39) H552Q possibly damaging Het
Il18r1 G A 1: 40,514,096 (GRCm39) V101I probably benign Het
Impdh2 A G 9: 108,440,003 (GRCm39) R182G possibly damaging Het
Krt12 A T 11: 99,306,841 (GRCm39) M487K unknown Het
Lmln C A 16: 32,886,761 (GRCm39) Y89* probably null Het
Lrrc38 T A 4: 143,077,076 (GRCm39) L113Q probably damaging Het
Mast3 A G 8: 71,233,838 (GRCm39) V969A probably damaging Het
Muc5ac A G 7: 141,364,867 (GRCm39) D1947G possibly damaging Het
Myh13 A T 11: 67,221,715 (GRCm39) I177F possibly damaging Het
Nfasc T C 1: 132,525,583 (GRCm39) Y904C probably damaging Het
Obscn G A 11: 58,899,358 (GRCm39) P1000S probably damaging Het
Or5t7 T A 2: 86,507,162 (GRCm39) I172F probably damaging Het
Otop2 G A 11: 115,220,201 (GRCm39) G347D probably damaging Het
Pclo A G 5: 14,590,580 (GRCm39) E960G unknown Het
Prl7a1 T C 13: 27,819,832 (GRCm39) I141V possibly damaging Het
Ptpn18 A T 1: 34,512,011 (GRCm39) H45L possibly damaging Het
Sbno1 A T 5: 124,526,635 (GRCm39) M960K probably damaging Het
Slx4ip T A 2: 136,846,937 (GRCm39) S67R probably benign Het
Spata18 A G 5: 73,828,509 (GRCm39) K243E probably damaging Het
Tcp1 A G 17: 13,139,750 (GRCm39) Q265R probably benign Het
Tec C T 5: 72,980,752 (GRCm39) probably benign Het
Thbs4 A G 13: 92,912,605 (GRCm39) probably null Het
Tln1 T A 4: 43,549,177 (GRCm39) Q635L probably damaging Het
Tshz2 A G 2: 169,804,245 (GRCm39) probably benign Het
Uap1 T C 1: 169,986,415 (GRCm39) E189G possibly damaging Het
Usp21 G A 1: 171,112,974 (GRCm39) probably benign Het
Vmn1r118 G T 7: 20,645,933 (GRCm39) Q114K probably damaging Het
Vmn1r38 A T 6: 66,753,832 (GRCm39) C95S possibly damaging Het
Vmn2r12 A T 5: 109,240,058 (GRCm39) N168K possibly damaging Het
Vmn2r84 T A 10: 130,221,898 (GRCm39) E774V probably damaging Het
Other mutations in Or52n4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01404:Or52n4 APN 7 104,293,687 (GRCm39) nonsense probably null
IGL01408:Or52n4 APN 7 104,294,136 (GRCm39) missense possibly damaging 0.61
IGL02612:Or52n4 APN 7 104,293,870 (GRCm39) missense probably benign 0.00
R0241:Or52n4 UTSW 7 104,294,450 (GRCm39) missense probably benign 0.00
R0241:Or52n4 UTSW 7 104,294,450 (GRCm39) missense probably benign 0.00
R1171:Or52n4 UTSW 7 104,294,204 (GRCm39) missense probably damaging 1.00
R1465:Or52n4 UTSW 7 104,294,153 (GRCm39) missense probably benign 0.13
R1465:Or52n4 UTSW 7 104,294,153 (GRCm39) missense probably benign 0.13
R1568:Or52n4 UTSW 7 104,293,977 (GRCm39) missense probably benign 0.28
R1866:Or52n4 UTSW 7 104,294,004 (GRCm39) missense probably benign 0.35
R4233:Or52n4 UTSW 7 104,294,195 (GRCm39) missense probably benign 0.15
R6080:Or52n4 UTSW 7 104,294,517 (GRCm39) missense probably benign 0.01
R6479:Or52n4 UTSW 7 104,294,333 (GRCm39) missense probably benign 0.02
R7222:Or52n4 UTSW 7 104,293,937 (GRCm39) missense probably damaging 1.00
R8064:Or52n4 UTSW 7 104,294,561 (GRCm39) missense probably benign
R8352:Or52n4 UTSW 7 104,293,736 (GRCm39) missense possibly damaging 0.88
R8452:Or52n4 UTSW 7 104,293,736 (GRCm39) missense possibly damaging 0.88
R9016:Or52n4 UTSW 7 104,293,828 (GRCm39) nonsense probably null
R9034:Or52n4 UTSW 7 104,293,835 (GRCm39) missense probably damaging 1.00
R9239:Or52n4 UTSW 7 104,293,746 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer

Sequencing Primer
Posted On 2015-05-15