Incidental Mutation 'R4063:Ugt2a3'
ID 315955
Institutional Source Beutler Lab
Gene Symbol Ugt2a3
Ensembl Gene ENSMUSG00000035780
Gene Name UDP glucuronosyltransferase 2 family, polypeptide A3
Synonyms 2010321J07Rik
MMRRC Submission 041619-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.083) question?
Stock # R4063 (G1)
Quality Score 225
Status Validated
Chromosome 5
Chromosomal Location 87472831-87485054 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 87484725 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Valine at position 100 (I100V)
Ref Sequence ENSEMBL: ENSMUSP00000031195 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000031195]
AlphaFold Q8BWQ1
Predicted Effect probably benign
Transcript: ENSMUST00000031195
AA Change: I100V

PolyPhen 2 Score 0.035 (Sensitivity: 0.94; Specificity: 0.82)
SMART Domains Protein: ENSMUSP00000031195
Gene: ENSMUSG00000035780
AA Change: I100V

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
Pfam:UDPGT 24 526 1.2e-233 PFAM
Pfam:Glyco_tran_28_C 318 454 1.5e-10 PFAM
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.9%
Validation Efficiency 97% (59/61)
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700034J05Rik A T 6: 146,854,606 (GRCm39) F145L probably benign Het
Abcc9 T C 6: 142,551,645 (GRCm39) D1221G possibly damaging Het
Adamtsl4 T C 3: 95,584,864 (GRCm39) K935E probably benign Het
Ago4 A T 4: 126,409,655 (GRCm39) probably benign Het
Arhgef28 T C 13: 98,130,575 (GRCm39) D421G probably benign Het
Armh4 T A 14: 50,011,444 (GRCm39) M88L probably benign Het
Atl2 T C 17: 80,157,588 (GRCm39) *413W probably null Het
B4galt7 C A 13: 55,756,152 (GRCm39) probably null Het
Bltp3b A G 10: 89,651,917 (GRCm39) N247S probably benign Het
C8g A T 2: 25,389,425 (GRCm39) S147T probably damaging Het
Clstn3 A T 6: 124,426,792 (GRCm39) Y510N possibly damaging Het
Cnot2 A G 10: 116,373,301 (GRCm39) V34A possibly damaging Het
Cyb5d2 A T 11: 72,686,606 (GRCm39) probably benign Het
Dnah5 T C 15: 28,421,144 (GRCm39) I3827T probably damaging Het
Dnah7a G T 1: 53,464,376 (GRCm39) Q3672K probably benign Het
Dock1 A T 7: 134,717,021 (GRCm39) Y1219F possibly damaging Het
Espl1 A G 15: 102,221,424 (GRCm39) I944V probably damaging Het
Fat1 A T 8: 45,478,518 (GRCm39) E2521D probably benign Het
Gm10719 G T 9: 3,019,043 (GRCm39) W96L probably damaging Het
H2-M2 G A 17: 37,792,399 (GRCm39) H291Y probably damaging Het
Hmgcl T C 4: 135,686,035 (GRCm39) Y167H probably damaging Het
Il22ra2 A T 10: 19,502,400 (GRCm39) D73V possibly damaging Het
Incenp A T 19: 9,861,142 (GRCm39) M480K unknown Het
Irag1 G T 7: 110,522,984 (GRCm39) A359D probably benign Het
Kdm6a A G X: 18,117,114 (GRCm39) T266A probably benign Het
Lipf A G 19: 33,942,965 (GRCm39) N91S probably benign Het
M1ap A T 6: 82,980,756 (GRCm39) N214I probably damaging Het
Mast3 A G 8: 71,233,838 (GRCm39) V969A probably damaging Het
Mdga1 A G 17: 30,057,005 (GRCm39) C826R probably damaging Het
Msx1 C A 5: 37,981,365 (GRCm39) A105S probably benign Het
Or5ac23 A C 16: 59,149,243 (GRCm39) S210A probably benign Het
Otogl A T 10: 107,626,510 (GRCm39) D1451E probably benign Het
Otop2 G A 11: 115,220,201 (GRCm39) G347D probably damaging Het
Ppp1r13l A T 7: 19,103,978 (GRCm39) H153L probably benign Het
Pramel21 A G 4: 143,342,559 (GRCm39) D222G possibly damaging Het
Pramel29 T C 4: 143,935,265 (GRCm39) K161E possibly damaging Het
Proz A G 8: 13,114,621 (GRCm39) Y85C probably damaging Het
Prss50 A G 9: 110,687,480 (GRCm39) D141G probably benign Het
Rad54l2 T A 9: 106,597,613 (GRCm39) Q131L probably benign Het
Sdha A G 13: 74,472,077 (GRCm39) probably benign Het
Sema3d T A 5: 12,635,091 (GRCm39) I719N probably benign Het
Slc18b1 A T 10: 23,681,879 (GRCm39) I148L probably benign Het
Tacc2 G T 7: 130,330,852 (GRCm39) D2086Y probably damaging Het
Tchh T C 3: 93,354,298 (GRCm39) L1246P unknown Het
Tmprss11d T C 5: 86,457,177 (GRCm39) I161V probably benign Het
Trpc3 T C 3: 36,725,172 (GRCm39) D268G probably damaging Het
Trpm8 G A 1: 88,289,727 (GRCm39) R895H probably damaging Het
Txndc2 A G 17: 65,945,079 (GRCm39) I366T possibly damaging Het
Upp1 C A 11: 9,081,709 (GRCm39) P82Q probably damaging Het
Vim A G 2: 13,584,827 (GRCm39) probably null Het
Vmn2r12 A T 5: 109,240,058 (GRCm39) N168K possibly damaging Het
Zdhhc14 G T 17: 5,802,983 (GRCm39) C362F probably damaging Het
Zfp292 A G 4: 34,810,863 (GRCm39) V727A probably damaging Het
Zswim5 G A 4: 116,735,177 (GRCm39) G174D unknown Het
Other mutations in Ugt2a3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00509:Ugt2a3 APN 5 87,473,514 (GRCm39) missense probably damaging 0.99
IGL00542:Ugt2a3 APN 5 87,484,682 (GRCm39) missense possibly damaging 0.61
IGL01335:Ugt2a3 APN 5 87,484,644 (GRCm39) missense probably damaging 1.00
IGL01369:Ugt2a3 APN 5 87,474,979 (GRCm39) missense probably damaging 1.00
IGL01808:Ugt2a3 APN 5 87,473,414 (GRCm39) missense probably benign 0.09
IGL02380:Ugt2a3 APN 5 87,484,658 (GRCm39) missense probably benign 0.09
IGL03245:Ugt2a3 APN 5 87,484,439 (GRCm39) missense probably damaging 1.00
IGL03260:Ugt2a3 APN 5 87,484,439 (GRCm39) missense probably damaging 1.00
IGL03261:Ugt2a3 APN 5 87,484,439 (GRCm39) missense probably damaging 1.00
IGL03280:Ugt2a3 APN 5 87,484,439 (GRCm39) missense probably damaging 1.00
IGL03302:Ugt2a3 APN 5 87,484,439 (GRCm39) missense probably damaging 1.00
D4186:Ugt2a3 UTSW 5 87,329,613 (GRCm38) missense probably damaging 1.00
R0051:Ugt2a3 UTSW 5 87,484,865 (GRCm39) missense probably damaging 1.00
R0103:Ugt2a3 UTSW 5 87,484,577 (GRCm39) missense possibly damaging 0.89
R0103:Ugt2a3 UTSW 5 87,484,577 (GRCm39) missense possibly damaging 0.89
R0324:Ugt2a3 UTSW 5 87,474,932 (GRCm39) critical splice donor site probably null
R0401:Ugt2a3 UTSW 5 87,484,349 (GRCm39) missense probably benign 0.03
R0506:Ugt2a3 UTSW 5 87,484,508 (GRCm39) missense possibly damaging 0.78
R0903:Ugt2a3 UTSW 5 87,475,570 (GRCm39) missense probably benign 0.00
R0940:Ugt2a3 UTSW 5 87,475,065 (GRCm39) missense possibly damaging 0.95
R1121:Ugt2a3 UTSW 5 87,475,548 (GRCm39) missense probably damaging 0.99
R1296:Ugt2a3 UTSW 5 87,475,005 (GRCm39) missense probably damaging 0.96
R1527:Ugt2a3 UTSW 5 87,473,457 (GRCm39) missense probably damaging 1.00
R2104:Ugt2a3 UTSW 5 87,477,541 (GRCm39) splice site probably null
R2119:Ugt2a3 UTSW 5 87,484,430 (GRCm39) missense probably damaging 0.98
R2374:Ugt2a3 UTSW 5 87,475,050 (GRCm39) missense probably damaging 1.00
R3082:Ugt2a3 UTSW 5 87,473,534 (GRCm39) missense probably benign 0.05
R3853:Ugt2a3 UTSW 5 87,485,018 (GRCm39) missense
R3894:Ugt2a3 UTSW 5 87,477,449 (GRCm39) missense probably benign 0.09
R4274:Ugt2a3 UTSW 5 87,475,548 (GRCm39) missense probably damaging 0.99
R4739:Ugt2a3 UTSW 5 87,475,054 (GRCm39) missense probably damaging 0.97
R4879:Ugt2a3 UTSW 5 87,479,144 (GRCm39) missense probably benign 0.06
R5327:Ugt2a3 UTSW 5 87,479,174 (GRCm39) missense probably damaging 1.00
R5508:Ugt2a3 UTSW 5 87,475,059 (GRCm39) missense probably damaging 0.98
R5866:Ugt2a3 UTSW 5 87,484,406 (GRCm39) missense probably damaging 1.00
R6026:Ugt2a3 UTSW 5 87,484,336 (GRCm39) missense probably benign 0.00
R6268:Ugt2a3 UTSW 5 87,477,472 (GRCm39) missense probably damaging 1.00
R6807:Ugt2a3 UTSW 5 87,484,617 (GRCm39) missense probably benign 0.00
R6980:Ugt2a3 UTSW 5 87,473,491 (GRCm39) missense probably damaging 1.00
R7056:Ugt2a3 UTSW 5 87,484,953 (GRCm39) missense probably damaging 0.98
R7133:Ugt2a3 UTSW 5 87,473,393 (GRCm39) missense possibly damaging 0.61
R7477:Ugt2a3 UTSW 5 87,484,479 (GRCm39) missense possibly damaging 0.90
R7485:Ugt2a3 UTSW 5 87,475,539 (GRCm39) critical splice donor site probably null
R7798:Ugt2a3 UTSW 5 87,475,582 (GRCm39) missense probably damaging 1.00
R7957:Ugt2a3 UTSW 5 87,475,050 (GRCm39) missense probably damaging 1.00
R8803:Ugt2a3 UTSW 5 87,484,389 (GRCm39) missense probably damaging 0.98
R8886:Ugt2a3 UTSW 5 87,484,358 (GRCm39) missense probably damaging 1.00
R8944:Ugt2a3 UTSW 5 87,473,417 (GRCm39) missense possibly damaging 0.81
R9387:Ugt2a3 UTSW 5 87,484,832 (GRCm39) missense probably benign 0.38
R9447:Ugt2a3 UTSW 5 87,473,330 (GRCm39) missense probably benign 0.39
R9524:Ugt2a3 UTSW 5 87,485,018 (GRCm39) missense
Predicted Primers PCR Primer
(F):5'- AAGGGATCTGAAGCACTTCTG -3'
(R):5'- GCCACTGGCTGAATCTAAAGAC -3'

Sequencing Primer
(F):5'- GATCTGAAGCACTTCTGCCACC -3'
(R):5'- CCACTGGCTGAATCTAAAGACTATTC -3'
Posted On 2015-05-15