|Institutional Source||Beutler Lab|
|Gene Name||interleukin 22 receptor, alpha 2|
|Is this an essential gene?||Non essential (E-score: 0.000)|
|Stock #||R4063 (G1)|
|Chromosomal Location||19621998-19634681 bp(+) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||A to T at 19626652 bp|
|Amino Acid Change||Aspartic acid to Valine at position 73 (D73V)|
|Ref Sequence||ENSEMBL: ENSMUSP00000042642 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000036564]|
|Predicted Effect||possibly damaging
AA Change: D73V
PolyPhen 2 Score 0.883 (Sensitivity: 0.82; Specificity: 0.94)
AA Change: D73V
|Meta Mutation Damage Score||0.1795|
|Coding Region Coverage||
|Validation Efficiency||97% (59/61)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the class II cytokine receptor family. The encoded soluble protein specifically binds to and inhibits interleukin 22 activity by blocking the interaction of interleukin 22 with its cell surface receptor. The encoded protein may be important in the regulation of inflammatory response, and has been implicated in the regulation of tumorigenesis in the colon. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2013]
PHENOTYPE: Mice homozygous for a null mutation display accelerated tumor formation in a colitis associated colon cancer model. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Il22ra2||
(F):5'- CTAACAGCGTGGTTAGCGTG -3'
(R):5'- CCTGAGGATAGCGTCAAGTAAG -3'
(F):5'- CGTGGTTAGCGTGAAGGAAC -3'
(R):5'- CGACCATCCAGAGTTTGTTCAAAGG -3'