Incidental Mutation 'R4063:Or5ac23'
ID 315985
Institutional Source Beutler Lab
Gene Symbol Or5ac23
Ensembl Gene ENSMUSG00000094422
Gene Name olfactory receptor family 5 subfamily AC member 23
Synonyms Olfr205, MOR182-11P, GA_x54KRFPKG5P-55543875-55542958
MMRRC Submission 041619-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.099) question?
Stock # R4063 (G1)
Quality Score 225
Status Validated
Chromosome 16
Chromosomal Location 59148953-59149870 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to C at 59149243 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Alanine at position 210 (S210A)
Ref Sequence ENSEMBL: ENSMUSP00000149415 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000074125] [ENSMUST00000213910]
AlphaFold Q7TS37
Predicted Effect probably benign
Transcript: ENSMUST00000074125
AA Change: S210A

PolyPhen 2 Score 0.045 (Sensitivity: 0.94; Specificity: 0.83)
SMART Domains Protein: ENSMUSP00000073762
Gene: ENSMUSG00000094422
AA Change: S210A

DomainStartEndE-ValueType
Pfam:7tm_4 30 305 1.6e-49 PFAM
Pfam:7TM_GPCR_Srsx 34 302 1.6e-7 PFAM
Pfam:7tm_1 40 289 7.8e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213910
AA Change: S210A

PolyPhen 2 Score 0.045 (Sensitivity: 0.94; Specificity: 0.83)
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.9%
Validation Efficiency 97% (59/61)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700034J05Rik A T 6: 146,854,606 (GRCm39) F145L probably benign Het
Abcc9 T C 6: 142,551,645 (GRCm39) D1221G possibly damaging Het
Adamtsl4 T C 3: 95,584,864 (GRCm39) K935E probably benign Het
Ago4 A T 4: 126,409,655 (GRCm39) probably benign Het
Arhgef28 T C 13: 98,130,575 (GRCm39) D421G probably benign Het
Armh4 T A 14: 50,011,444 (GRCm39) M88L probably benign Het
Atl2 T C 17: 80,157,588 (GRCm39) *413W probably null Het
B4galt7 C A 13: 55,756,152 (GRCm39) probably null Het
Bltp3b A G 10: 89,651,917 (GRCm39) N247S probably benign Het
C8g A T 2: 25,389,425 (GRCm39) S147T probably damaging Het
Clstn3 A T 6: 124,426,792 (GRCm39) Y510N possibly damaging Het
Cnot2 A G 10: 116,373,301 (GRCm39) V34A possibly damaging Het
Cyb5d2 A T 11: 72,686,606 (GRCm39) probably benign Het
Dnah5 T C 15: 28,421,144 (GRCm39) I3827T probably damaging Het
Dnah7a G T 1: 53,464,376 (GRCm39) Q3672K probably benign Het
Dock1 A T 7: 134,717,021 (GRCm39) Y1219F possibly damaging Het
Espl1 A G 15: 102,221,424 (GRCm39) I944V probably damaging Het
Fat1 A T 8: 45,478,518 (GRCm39) E2521D probably benign Het
Gm10719 G T 9: 3,019,043 (GRCm39) W96L probably damaging Het
H2-M2 G A 17: 37,792,399 (GRCm39) H291Y probably damaging Het
Hmgcl T C 4: 135,686,035 (GRCm39) Y167H probably damaging Het
Il22ra2 A T 10: 19,502,400 (GRCm39) D73V possibly damaging Het
Incenp A T 19: 9,861,142 (GRCm39) M480K unknown Het
Irag1 G T 7: 110,522,984 (GRCm39) A359D probably benign Het
Kdm6a A G X: 18,117,114 (GRCm39) T266A probably benign Het
Lipf A G 19: 33,942,965 (GRCm39) N91S probably benign Het
M1ap A T 6: 82,980,756 (GRCm39) N214I probably damaging Het
Mast3 A G 8: 71,233,838 (GRCm39) V969A probably damaging Het
Mdga1 A G 17: 30,057,005 (GRCm39) C826R probably damaging Het
Msx1 C A 5: 37,981,365 (GRCm39) A105S probably benign Het
Otogl A T 10: 107,626,510 (GRCm39) D1451E probably benign Het
Otop2 G A 11: 115,220,201 (GRCm39) G347D probably damaging Het
Ppp1r13l A T 7: 19,103,978 (GRCm39) H153L probably benign Het
Pramel21 A G 4: 143,342,559 (GRCm39) D222G possibly damaging Het
Pramel29 T C 4: 143,935,265 (GRCm39) K161E possibly damaging Het
Proz A G 8: 13,114,621 (GRCm39) Y85C probably damaging Het
Prss50 A G 9: 110,687,480 (GRCm39) D141G probably benign Het
Rad54l2 T A 9: 106,597,613 (GRCm39) Q131L probably benign Het
Sdha A G 13: 74,472,077 (GRCm39) probably benign Het
Sema3d T A 5: 12,635,091 (GRCm39) I719N probably benign Het
Slc18b1 A T 10: 23,681,879 (GRCm39) I148L probably benign Het
Tacc2 G T 7: 130,330,852 (GRCm39) D2086Y probably damaging Het
Tchh T C 3: 93,354,298 (GRCm39) L1246P unknown Het
Tmprss11d T C 5: 86,457,177 (GRCm39) I161V probably benign Het
Trpc3 T C 3: 36,725,172 (GRCm39) D268G probably damaging Het
Trpm8 G A 1: 88,289,727 (GRCm39) R895H probably damaging Het
Txndc2 A G 17: 65,945,079 (GRCm39) I366T possibly damaging Het
Ugt2a3 T C 5: 87,484,725 (GRCm39) I100V probably benign Het
Upp1 C A 11: 9,081,709 (GRCm39) P82Q probably damaging Het
Vim A G 2: 13,584,827 (GRCm39) probably null Het
Vmn2r12 A T 5: 109,240,058 (GRCm39) N168K possibly damaging Het
Zdhhc14 G T 17: 5,802,983 (GRCm39) C362F probably damaging Het
Zfp292 A G 4: 34,810,863 (GRCm39) V727A probably damaging Het
Zswim5 G A 4: 116,735,177 (GRCm39) G174D unknown Het
Other mutations in Or5ac23
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02475:Or5ac23 APN 16 59,149,088 (GRCm39) missense probably benign 0.21
IGL03236:Or5ac23 APN 16 59,149,200 (GRCm39) missense probably damaging 0.97
R0054:Or5ac23 UTSW 16 59,149,428 (GRCm39) missense possibly damaging 0.57
R0054:Or5ac23 UTSW 16 59,149,428 (GRCm39) missense possibly damaging 0.57
R0167:Or5ac23 UTSW 16 59,149,337 (GRCm39) nonsense probably null
R0178:Or5ac23 UTSW 16 59,149,783 (GRCm39) missense probably damaging 1.00
R0371:Or5ac23 UTSW 16 59,149,585 (GRCm39) missense possibly damaging 0.60
R0577:Or5ac23 UTSW 16 59,149,061 (GRCm39) missense probably benign 0.01
R0597:Or5ac23 UTSW 16 59,149,123 (GRCm39) missense probably damaging 1.00
R0967:Or5ac23 UTSW 16 59,149,546 (GRCm39) missense possibly damaging 0.66
R1670:Or5ac23 UTSW 16 59,149,607 (GRCm39) missense probably benign 0.03
R1702:Or5ac23 UTSW 16 59,149,504 (GRCm39) missense probably benign 0.12
R1995:Or5ac23 UTSW 16 59,149,654 (GRCm39) missense probably damaging 1.00
R2239:Or5ac23 UTSW 16 59,149,738 (GRCm39) missense probably damaging 0.99
R4400:Or5ac23 UTSW 16 59,148,961 (GRCm39) missense probably benign
R4666:Or5ac23 UTSW 16 59,149,573 (GRCm39) missense possibly damaging 0.91
R4795:Or5ac23 UTSW 16 59,149,213 (GRCm39) missense probably benign 0.09
R5327:Or5ac23 UTSW 16 59,149,461 (GRCm39) missense probably benign 0.01
R5471:Or5ac23 UTSW 16 59,148,994 (GRCm39) missense probably damaging 1.00
R5770:Or5ac23 UTSW 16 59,149,514 (GRCm39) nonsense probably null
R6195:Or5ac23 UTSW 16 59,149,785 (GRCm39) missense possibly damaging 0.81
R6702:Or5ac23 UTSW 16 59,148,961 (GRCm39) missense probably benign
R7686:Or5ac23 UTSW 16 59,149,379 (GRCm39) missense probably damaging 1.00
R7908:Or5ac23 UTSW 16 59,149,606 (GRCm39) missense possibly damaging 0.48
R7911:Or5ac23 UTSW 16 59,149,606 (GRCm39) missense possibly damaging 0.48
R7912:Or5ac23 UTSW 16 59,149,606 (GRCm39) missense possibly damaging 0.48
R7913:Or5ac23 UTSW 16 59,149,606 (GRCm39) missense possibly damaging 0.48
R7998:Or5ac23 UTSW 16 59,149,633 (GRCm39) missense probably benign 0.09
R8772:Or5ac23 UTSW 16 59,149,051 (GRCm39) missense probably damaging 1.00
R9563:Or5ac23 UTSW 16 59,149,765 (GRCm39) missense probably benign 0.00
X0026:Or5ac23 UTSW 16 59,149,713 (GRCm39) missense probably benign 0.09
Predicted Primers PCR Primer
(F):5'- CTGGTTTTCACCTGGTGCAG -3'
(R):5'- CCAAGAGACTCTGCACTGTGTTC -3'

Sequencing Primer
(F):5'- TGGTGCAGACCCATGACTCAC -3'
(R):5'- AGAGACTCTGCACTGTGTTCATCAG -3'
Posted On 2015-05-15