Incidental Mutation 'R0390:Ubr5'
| ID |
31639 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Ubr5
|
| Ensembl Gene |
ENSMUSG00000037487 |
| Gene Name |
ubiquitin protein ligase E3 component n-recognin 5 |
| Synonyms |
Edd1, Edd, 4432411E13Rik |
| MMRRC Submission |
038596-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R0390 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
15 |
| Chromosomal Location |
37967572-38079098 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to T
at 38030916 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Leucine to Isoleucine
at position 426
(L426I)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000154293
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000110336]
[ENSMUST00000226414]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000110336
AA Change: L420I
PolyPhen 2
Score 0.036 (Sensitivity: 0.94; Specificity: 0.82)
|
| SMART Domains |
Protein: ENSMUSP00000105965
Gene: ENSMUSG00000037487
AA Change: L420I
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
94 |
111 |
N/A |
INTRINSIC |
|
low complexity region
|
129 |
156 |
N/A |
INTRINSIC |
|
Pfam:E3_UbLigase_EDD
|
179 |
230 |
9.7e-35 |
PFAM |
|
low complexity region
|
282 |
323 |
N/A |
INTRINSIC |
|
low complexity region
|
614 |
628 |
N/A |
INTRINSIC |
|
low complexity region
|
860 |
870 |
N/A |
INTRINSIC |
|
low complexity region
|
933 |
950 |
N/A |
INTRINSIC |
|
low complexity region
|
970 |
999 |
N/A |
INTRINSIC |
|
low complexity region
|
1140 |
1151 |
N/A |
INTRINSIC |
|
ZnF_UBR1
|
1177 |
1244 |
5.42e-27 |
SMART |
|
low complexity region
|
1396 |
1405 |
N/A |
INTRINSIC |
|
low complexity region
|
1524 |
1537 |
N/A |
INTRINSIC |
|
low complexity region
|
1567 |
1613 |
N/A |
INTRINSIC |
|
low complexity region
|
1641 |
1657 |
N/A |
INTRINSIC |
|
low complexity region
|
1662 |
1687 |
N/A |
INTRINSIC |
|
low complexity region
|
1726 |
1742 |
N/A |
INTRINSIC |
|
low complexity region
|
1759 |
1789 |
N/A |
INTRINSIC |
|
low complexity region
|
1879 |
1890 |
N/A |
INTRINSIC |
|
low complexity region
|
1972 |
1983 |
N/A |
INTRINSIC |
|
low complexity region
|
1986 |
1997 |
N/A |
INTRINSIC |
|
Blast:HECTc
|
2271 |
2313 |
2e-6 |
BLAST |
|
low complexity region
|
2329 |
2366 |
N/A |
INTRINSIC |
|
PolyA
|
2389 |
2452 |
3.97e-33 |
SMART |
|
HECTc
|
2432 |
2798 |
1e-151 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000226414
AA Change: L426I
PolyPhen 2
Score 0.194 (Sensitivity: 0.92; Specificity: 0.87)
|
| Meta Mutation Damage Score |
0.0711 |
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.1%
- 10x: 95.9%
- 20x: 92.0%
|
| Validation Efficiency |
98% (110/112) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a progestin-induced protein, which belongs to the HECT (homology to E6-AP carboxyl terminus) family. The HECT family proteins function as E3 ubiquitin-protein ligases, targeting specific proteins for ubiquitin-mediated proteolysis. This gene is localized to chromosome 8q22 which is disrupted in a variety of cancers. This gene potentially has a role in regulation of cell proliferation or differentiation. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous null mice display embryonic lethality during organogenesis, impaired growth of the allantois, failure or impairment of chorioallantoic fusion, impaired angiogenesis in the yolk sac and allantois, decreased cell proliferation, and increased apoptosis. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(151) : Targeted(3) Gene trapped(148)
|
| Other mutations in this stock |
Total: 110 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adam18 |
C |
T |
8: 25,164,070 (GRCm39) |
G38R |
probably benign |
Het |
| Ap2m1 |
T |
C |
16: 20,359,849 (GRCm39) |
M183T |
probably damaging |
Het |
| Apob |
A |
T |
12: 8,038,678 (GRCm39) |
I364F |
probably damaging |
Het |
| Arl6 |
A |
T |
16: 59,442,784 (GRCm39) |
|
probably benign |
Het |
| Cand2 |
A |
G |
6: 115,751,614 (GRCm39) |
M15V |
possibly damaging |
Het |
| Cbl |
A |
G |
9: 44,112,302 (GRCm39) |
F131S |
probably damaging |
Het |
| Ccdc74a |
A |
G |
16: 17,468,340 (GRCm39) |
S321G |
probably benign |
Het |
| Cdc14b |
T |
C |
13: 64,358,006 (GRCm39) |
|
probably benign |
Het |
| Cep152 |
T |
C |
2: 125,418,789 (GRCm39) |
|
probably benign |
Het |
| Cep290 |
A |
G |
10: 100,344,620 (GRCm39) |
E479G |
probably benign |
Het |
| Chrm2 |
T |
G |
6: 36,501,046 (GRCm39) |
I301R |
probably benign |
Het |
| Clec2e |
A |
G |
6: 129,070,431 (GRCm39) |
W197R |
probably damaging |
Het |
| Cnot10 |
G |
T |
9: 114,458,218 (GRCm39) |
S96* |
probably null |
Het |
| Col19a1 |
A |
G |
1: 24,328,736 (GRCm39) |
|
probably benign |
Het |
| Csmd2 |
T |
C |
4: 128,027,466 (GRCm39) |
|
probably benign |
Het |
| Cthrc1 |
A |
T |
15: 38,950,159 (GRCm39) |
*172L |
probably null |
Het |
| Cul9 |
A |
T |
17: 46,839,515 (GRCm39) |
I821N |
probably benign |
Het |
| Daam1 |
G |
C |
12: 72,022,078 (GRCm39) |
|
probably benign |
Het |
| Dhx58 |
A |
T |
11: 100,590,090 (GRCm39) |
I398N |
probably damaging |
Het |
| Dip2b |
T |
A |
15: 100,091,794 (GRCm39) |
H844Q |
probably damaging |
Het |
| Dmac2 |
A |
G |
7: 25,320,454 (GRCm39) |
D50G |
probably damaging |
Het |
| Dmxl1 |
C |
A |
18: 50,012,429 (GRCm39) |
Q1529K |
probably benign |
Het |
| Dtna |
C |
T |
18: 23,730,558 (GRCm39) |
P315L |
probably damaging |
Het |
| Ep300 |
T |
C |
15: 81,524,317 (GRCm39) |
S1382P |
unknown |
Het |
| Fat2 |
A |
T |
11: 55,201,603 (GRCm39) |
N490K |
probably damaging |
Het |
| Flg2 |
T |
A |
3: 93,107,662 (GRCm39) |
|
probably benign |
Het |
| Gpatch1 |
T |
C |
7: 34,980,806 (GRCm39) |
|
probably benign |
Het |
| Grin2a |
C |
A |
16: 9,397,449 (GRCm39) |
K879N |
possibly damaging |
Het |
| Hacd3 |
A |
C |
9: 64,908,304 (GRCm39) |
I164S |
possibly damaging |
Het |
| Hinfp |
A |
C |
9: 44,210,245 (GRCm39) |
C197G |
probably damaging |
Het |
| Hsd17b12 |
T |
C |
2: 93,945,335 (GRCm39) |
|
probably benign |
Het |
| Hsd3b1 |
A |
T |
3: 98,760,355 (GRCm39) |
L212Q |
probably damaging |
Het |
| Ifrd1 |
C |
T |
12: 40,264,093 (GRCm39) |
|
probably null |
Het |
| Igf2bp2 |
A |
G |
16: 21,900,551 (GRCm39) |
F129L |
possibly damaging |
Het |
| Kirrel3 |
T |
A |
9: 34,931,459 (GRCm39) |
I409N |
probably damaging |
Het |
| Klhdc10 |
T |
C |
6: 30,447,411 (GRCm39) |
I204T |
probably damaging |
Het |
| Kpna6 |
A |
T |
4: 129,551,597 (GRCm39) |
S65R |
possibly damaging |
Het |
| Lama3 |
A |
T |
18: 12,540,620 (GRCm39) |
D308V |
probably benign |
Het |
| Larp4b |
T |
A |
13: 9,208,143 (GRCm39) |
|
probably null |
Het |
| Lgr6 |
C |
T |
1: 134,921,748 (GRCm39) |
A199T |
probably damaging |
Het |
| Lyzl1 |
A |
T |
18: 4,169,175 (GRCm39) |
T11S |
probably benign |
Het |
| Man1c1 |
A |
G |
4: 134,305,626 (GRCm39) |
L366P |
probably damaging |
Het |
| Mef2a |
A |
G |
7: 66,901,472 (GRCm39) |
M100T |
probably damaging |
Het |
| Mettl13 |
G |
A |
1: 162,366,458 (GRCm39) |
H474Y |
possibly damaging |
Het |
| Minar2 |
T |
A |
18: 59,208,760 (GRCm39) |
V136E |
probably damaging |
Het |
| Mmp3 |
A |
G |
9: 7,451,320 (GRCm39) |
D352G |
probably benign |
Het |
| Mns1 |
T |
C |
9: 72,360,086 (GRCm39) |
I412T |
probably damaging |
Het |
| Mon2 |
T |
C |
10: 122,842,926 (GRCm39) |
D1501G |
probably null |
Het |
| Mylk |
G |
T |
16: 34,695,990 (GRCm39) |
G242W |
probably damaging |
Het |
| Nav1 |
T |
C |
1: 135,377,704 (GRCm39) |
D1715G |
possibly damaging |
Het |
| Nckap1l |
T |
C |
15: 103,362,310 (GRCm39) |
S2P |
probably damaging |
Het |
| Nek3 |
A |
T |
8: 22,618,745 (GRCm39) |
|
probably benign |
Het |
| Nfrkb |
A |
G |
9: 31,300,193 (GRCm39) |
|
probably benign |
Het |
| Nlrp4d |
T |
C |
7: 10,122,705 (GRCm39) |
D53G |
probably benign |
Het |
| Nol8 |
T |
C |
13: 49,815,628 (GRCm39) |
S561P |
probably damaging |
Het |
| Nuf2 |
A |
C |
1: 169,352,866 (GRCm39) |
|
probably benign |
Het |
| Odad3 |
T |
A |
9: 21,903,004 (GRCm39) |
H442L |
probably benign |
Het |
| Ofcc1 |
T |
A |
13: 40,168,789 (GRCm39) |
D866V |
possibly damaging |
Het |
| Optn |
A |
G |
2: 5,051,006 (GRCm39) |
L125P |
probably benign |
Het |
| Or5k3 |
A |
G |
16: 58,969,662 (GRCm39) |
I150V |
probably benign |
Het |
| Otoa |
T |
A |
7: 120,730,564 (GRCm39) |
F588Y |
probably benign |
Het |
| Pappa |
T |
A |
4: 65,269,850 (GRCm39) |
|
probably null |
Het |
| Pde5a |
T |
G |
3: 122,629,232 (GRCm39) |
C635W |
probably damaging |
Het |
| Pdgfb |
A |
T |
15: 79,887,620 (GRCm39) |
|
probably null |
Het |
| Pih1d2 |
T |
A |
9: 50,532,346 (GRCm39) |
C135S |
probably damaging |
Het |
| Plcg1 |
G |
T |
2: 160,594,286 (GRCm39) |
C361F |
probably damaging |
Het |
| Ppp4r4 |
T |
C |
12: 103,567,619 (GRCm39) |
|
probably benign |
Het |
| Pramel26 |
T |
A |
4: 143,538,269 (GRCm39) |
D234V |
probably benign |
Het |
| Prdm10 |
G |
A |
9: 31,260,564 (GRCm39) |
|
probably null |
Het |
| Prex2 |
T |
A |
1: 11,159,930 (GRCm39) |
|
probably null |
Het |
| Prss56 |
T |
G |
1: 87,112,452 (GRCm39) |
|
probably null |
Het |
| Prtg |
A |
G |
9: 72,752,240 (GRCm39) |
K209E |
probably benign |
Het |
| Ptprc |
G |
A |
1: 138,050,313 (GRCm39) |
T36I |
possibly damaging |
Het |
| Rasgrp4 |
A |
G |
7: 28,845,285 (GRCm39) |
Y302C |
probably damaging |
Het |
| Rb1cc1 |
T |
A |
1: 6,318,858 (GRCm39) |
M759K |
probably damaging |
Het |
| Rbm15b |
T |
A |
9: 106,763,197 (GRCm39) |
M324L |
probably benign |
Het |
| Rcbtb2 |
T |
C |
14: 73,415,987 (GRCm39) |
V500A |
probably damaging |
Het |
| Rgs6 |
A |
G |
12: 83,180,451 (GRCm39) |
K434R |
probably damaging |
Het |
| Rims1 |
C |
T |
1: 22,635,607 (GRCm39) |
A125T |
possibly damaging |
Het |
| Robo3 |
A |
G |
9: 37,333,473 (GRCm39) |
V746A |
probably benign |
Het |
| Rtl1 |
C |
T |
12: 109,557,820 (GRCm39) |
E1340K |
unknown |
Het |
| Sacs |
G |
A |
14: 61,443,089 (GRCm39) |
D1712N |
possibly damaging |
Het |
| Samd4b |
G |
A |
7: 28,103,402 (GRCm39) |
P19S |
probably benign |
Het |
| Samhd1 |
T |
C |
2: 156,956,151 (GRCm39) |
Y347C |
probably damaging |
Het |
| Sema6d |
T |
A |
2: 124,500,410 (GRCm39) |
I393N |
probably damaging |
Het |
| Sigmar1 |
C |
T |
4: 41,741,243 (GRCm39) |
A4T |
probably benign |
Het |
| Skint9 |
C |
A |
4: 112,246,376 (GRCm39) |
L245F |
probably benign |
Het |
| Slc35f5 |
T |
C |
1: 125,512,832 (GRCm39) |
L372P |
probably damaging |
Het |
| Smc1b |
A |
T |
15: 84,950,478 (GRCm39) |
I1182N |
probably damaging |
Het |
| Smyd3 |
A |
G |
1: 178,785,138 (GRCm39) |
|
probably benign |
Het |
| Sptlc1 |
T |
C |
13: 53,491,648 (GRCm39) |
D417G |
probably benign |
Het |
| Sv2c |
T |
C |
13: 96,225,216 (GRCm39) |
N31S |
probably benign |
Het |
| Tjp1 |
T |
C |
7: 64,964,738 (GRCm39) |
D811G |
probably damaging |
Het |
| Top2b |
A |
G |
14: 16,418,442 (GRCm38) |
T1221A |
probably benign |
Het |
| Tph2 |
T |
C |
10: 115,010,014 (GRCm39) |
D182G |
probably damaging |
Het |
| Traf6 |
C |
T |
2: 101,518,933 (GRCm39) |
Q141* |
probably null |
Het |
| Ttn |
T |
C |
2: 76,587,275 (GRCm39) |
D21574G |
probably damaging |
Het |
| Uba2 |
T |
A |
7: 33,850,446 (GRCm39) |
N367I |
probably benign |
Het |
| Ube2b |
T |
C |
11: 51,879,429 (GRCm39) |
|
probably benign |
Het |
| Ugt2a2 |
T |
A |
5: 87,612,007 (GRCm39) |
H301L |
probably benign |
Het |
| Upf2 |
T |
A |
2: 6,023,705 (GRCm39) |
|
probably benign |
Het |
| Utrn |
T |
C |
10: 12,585,804 (GRCm39) |
D991G |
probably benign |
Het |
| Vmn2r25 |
T |
C |
6: 123,800,140 (GRCm39) |
D734G |
probably damaging |
Het |
| Vmn2r68 |
C |
G |
7: 84,882,466 (GRCm39) |
|
probably null |
Het |
| Vmn2r68 |
T |
A |
7: 84,882,457 (GRCm39) |
|
probably benign |
Het |
| Vwf |
T |
A |
6: 125,603,324 (GRCm39) |
Y891* |
probably null |
Het |
| Wwox |
C |
T |
8: 115,433,018 (GRCm39) |
T228I |
probably benign |
Het |
| Zer1 |
C |
T |
2: 29,998,225 (GRCm39) |
|
probably benign |
Het |
| Zfp180 |
C |
T |
7: 23,804,132 (GRCm39) |
H184Y |
possibly damaging |
Het |
| Zfp68 |
A |
T |
5: 138,605,487 (GRCm39) |
Y279N |
probably benign |
Het |
|
| Other mutations in Ubr5 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00089:Ubr5
|
APN |
15 |
37,984,280 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00548:Ubr5
|
APN |
15 |
38,004,565 (GRCm39) |
missense |
probably benign |
0.11 |
|
IGL00675:Ubr5
|
APN |
15 |
38,018,528 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
IGL00770:Ubr5
|
APN |
15 |
38,006,785 (GRCm39) |
missense |
probably benign |
0.27 |
|
IGL00774:Ubr5
|
APN |
15 |
38,006,785 (GRCm39) |
missense |
probably benign |
0.27 |
|
IGL00919:Ubr5
|
APN |
15 |
38,041,086 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00962:Ubr5
|
APN |
15 |
37,986,178 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01328:Ubr5
|
APN |
15 |
37,981,767 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
IGL01359:Ubr5
|
APN |
15 |
37,973,250 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL01394:Ubr5
|
APN |
15 |
38,009,875 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
IGL01674:Ubr5
|
APN |
15 |
37,998,623 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01981:Ubr5
|
APN |
15 |
37,996,842 (GRCm39) |
missense |
probably benign |
0.08 |
|
IGL01993:Ubr5
|
APN |
15 |
37,973,256 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02159:Ubr5
|
APN |
15 |
37,991,623 (GRCm39) |
splice site |
probably benign |
|
|
IGL02252:Ubr5
|
APN |
15 |
38,025,138 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02442:Ubr5
|
APN |
15 |
38,038,145 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL02502:Ubr5
|
APN |
15 |
38,030,933 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02503:Ubr5
|
APN |
15 |
38,018,558 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02503:Ubr5
|
APN |
15 |
38,018,564 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
IGL02546:Ubr5
|
APN |
15 |
38,008,991 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02556:Ubr5
|
APN |
15 |
38,002,692 (GRCm39) |
missense |
probably benign |
0.18 |
|
IGL02647:Ubr5
|
APN |
15 |
37,992,326 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02679:Ubr5
|
APN |
15 |
38,002,558 (GRCm39) |
missense |
probably benign |
0.36 |
|
IGL02726:Ubr5
|
APN |
15 |
38,000,806 (GRCm39) |
splice site |
probably benign |
|
|
IGL02884:Ubr5
|
APN |
15 |
37,998,620 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02972:Ubr5
|
APN |
15 |
38,042,196 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03000:Ubr5
|
APN |
15 |
38,025,096 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03028:Ubr5
|
APN |
15 |
38,047,837 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03057:Ubr5
|
APN |
15 |
38,041,150 (GRCm39) |
splice site |
probably benign |
|
|
IGL03085:Ubr5
|
APN |
15 |
38,029,812 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03198:Ubr5
|
APN |
15 |
38,045,964 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03368:Ubr5
|
APN |
15 |
37,998,560 (GRCm39) |
missense |
probably damaging |
0.96 |
|
Anchovy
|
UTSW |
15 |
37,980,076 (GRCm39) |
missense |
probably null |
|
|
P0016:Ubr5
|
UTSW |
15 |
38,000,822 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4142001:Ubr5
|
UTSW |
15 |
38,042,153 (GRCm39) |
missense |
|
|
|
R0133:Ubr5
|
UTSW |
15 |
37,996,815 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0173:Ubr5
|
UTSW |
15 |
38,004,919 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0234:Ubr5
|
UTSW |
15 |
37,968,737 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0234:Ubr5
|
UTSW |
15 |
37,968,737 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0314:Ubr5
|
UTSW |
15 |
37,997,431 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0379:Ubr5
|
UTSW |
15 |
38,019,201 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0415:Ubr5
|
UTSW |
15 |
37,973,224 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0531:Ubr5
|
UTSW |
15 |
37,991,588 (GRCm39) |
missense |
probably benign |
0.34 |
|
R0650:Ubr5
|
UTSW |
15 |
38,031,051 (GRCm39) |
splice site |
probably benign |
|
|
R0720:Ubr5
|
UTSW |
15 |
37,973,235 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1183:Ubr5
|
UTSW |
15 |
37,997,419 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R1302:Ubr5
|
UTSW |
15 |
38,041,723 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R1442:Ubr5
|
UTSW |
15 |
38,015,168 (GRCm39) |
splice site |
probably benign |
|
|
R1507:Ubr5
|
UTSW |
15 |
37,981,114 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1575:Ubr5
|
UTSW |
15 |
38,041,085 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1577:Ubr5
|
UTSW |
15 |
38,030,974 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R1622:Ubr5
|
UTSW |
15 |
38,009,357 (GRCm39) |
unclassified |
probably benign |
|
|
R1721:Ubr5
|
UTSW |
15 |
38,042,090 (GRCm39) |
missense |
probably benign |
0.18 |
|
R1799:Ubr5
|
UTSW |
15 |
37,989,621 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1840:Ubr5
|
UTSW |
15 |
37,981,161 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R1867:Ubr5
|
UTSW |
15 |
38,042,090 (GRCm39) |
missense |
probably benign |
0.18 |
|
R1868:Ubr5
|
UTSW |
15 |
38,042,090 (GRCm39) |
missense |
probably benign |
0.18 |
|
R2065:Ubr5
|
UTSW |
15 |
38,041,086 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2107:Ubr5
|
UTSW |
15 |
37,989,546 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2201:Ubr5
|
UTSW |
15 |
38,002,543 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R2261:Ubr5
|
UTSW |
15 |
37,988,528 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2441:Ubr5
|
UTSW |
15 |
37,989,589 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2512:Ubr5
|
UTSW |
15 |
38,002,563 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3008:Ubr5
|
UTSW |
15 |
38,031,089 (GRCm39) |
missense |
probably benign |
|
|
R3412:Ubr5
|
UTSW |
15 |
38,004,479 (GRCm39) |
splice site |
probably benign |
|
|
R3898:Ubr5
|
UTSW |
15 |
37,997,983 (GRCm39) |
missense |
probably benign |
0.02 |
|
R3900:Ubr5
|
UTSW |
15 |
38,019,486 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4032:Ubr5
|
UTSW |
15 |
38,025,081 (GRCm39) |
missense |
|
|
|
R4352:Ubr5
|
UTSW |
15 |
38,041,817 (GRCm39) |
missense |
probably benign |
0.31 |
|
R4362:Ubr5
|
UTSW |
15 |
38,078,647 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4467:Ubr5
|
UTSW |
15 |
38,004,580 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4507:Ubr5
|
UTSW |
15 |
38,013,786 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4683:Ubr5
|
UTSW |
15 |
38,038,211 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4771:Ubr5
|
UTSW |
15 |
38,018,541 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R4878:Ubr5
|
UTSW |
15 |
38,006,808 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4999:Ubr5
|
UTSW |
15 |
38,009,912 (GRCm39) |
missense |
probably benign |
0.06 |
|
R5057:Ubr5
|
UTSW |
15 |
38,004,353 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5177:Ubr5
|
UTSW |
15 |
38,006,761 (GRCm39) |
missense |
probably benign |
0.22 |
|
R5186:Ubr5
|
UTSW |
15 |
37,998,160 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5378:Ubr5
|
UTSW |
15 |
37,989,822 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5486:Ubr5
|
UTSW |
15 |
38,008,983 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5494:Ubr5
|
UTSW |
15 |
38,019,525 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R5617:Ubr5
|
UTSW |
15 |
38,030,901 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R5636:Ubr5
|
UTSW |
15 |
37,984,240 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5655:Ubr5
|
UTSW |
15 |
38,015,337 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5715:Ubr5
|
UTSW |
15 |
38,002,477 (GRCm39) |
missense |
probably benign |
0.06 |
|
R5781:Ubr5
|
UTSW |
15 |
38,006,785 (GRCm39) |
missense |
probably benign |
0.27 |
|
R6645:Ubr5
|
UTSW |
15 |
38,029,750 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6774:Ubr5
|
UTSW |
15 |
38,015,379 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6823:Ubr5
|
UTSW |
15 |
37,989,842 (GRCm39) |
missense |
probably benign |
0.08 |
|
R6877:Ubr5
|
UTSW |
15 |
38,002,814 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7105:Ubr5
|
UTSW |
15 |
38,009,019 (GRCm39) |
missense |
|
|
|
R7166:Ubr5
|
UTSW |
15 |
37,976,389 (GRCm39) |
missense |
|
|
|
R7514:Ubr5
|
UTSW |
15 |
37,988,481 (GRCm39) |
missense |
|
|
|
R7523:Ubr5
|
UTSW |
15 |
38,004,299 (GRCm39) |
missense |
|
|
|
R7631:Ubr5
|
UTSW |
15 |
38,029,751 (GRCm39) |
missense |
|
|
|
R7709:Ubr5
|
UTSW |
15 |
37,980,076 (GRCm39) |
missense |
probably null |
|
|
R7710:Ubr5
|
UTSW |
15 |
37,980,076 (GRCm39) |
missense |
probably null |
|
|
R7712:Ubr5
|
UTSW |
15 |
37,980,076 (GRCm39) |
missense |
probably null |
|
|
R7803:Ubr5
|
UTSW |
15 |
37,980,076 (GRCm39) |
missense |
probably null |
|
|
R7816:Ubr5
|
UTSW |
15 |
37,980,076 (GRCm39) |
missense |
probably null |
|
|
R7817:Ubr5
|
UTSW |
15 |
37,980,076 (GRCm39) |
missense |
probably null |
|
|
R7821:Ubr5
|
UTSW |
15 |
37,997,431 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7824:Ubr5
|
UTSW |
15 |
37,991,566 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7841:Ubr5
|
UTSW |
15 |
37,981,150 (GRCm39) |
missense |
|
|
|
R7869:Ubr5
|
UTSW |
15 |
37,980,076 (GRCm39) |
missense |
probably null |
|
|
R7896:Ubr5
|
UTSW |
15 |
38,041,817 (GRCm39) |
missense |
probably benign |
0.31 |
|
R8191:Ubr5
|
UTSW |
15 |
38,006,751 (GRCm39) |
missense |
|
|
|
R8342:Ubr5
|
UTSW |
15 |
38,025,081 (GRCm39) |
missense |
|
|
|
R8745:Ubr5
|
UTSW |
15 |
38,025,039 (GRCm39) |
missense |
|
|
|
R8811:Ubr5
|
UTSW |
15 |
38,041,123 (GRCm39) |
missense |
|
|
|
R8904:Ubr5
|
UTSW |
15 |
38,042,153 (GRCm39) |
missense |
|
|
|
R8955:Ubr5
|
UTSW |
15 |
38,029,825 (GRCm39) |
missense |
|
|
|
R8956:Ubr5
|
UTSW |
15 |
38,015,367 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9051:Ubr5
|
UTSW |
15 |
38,002,503 (GRCm39) |
missense |
|
|
|
R9102:Ubr5
|
UTSW |
15 |
38,018,596 (GRCm39) |
missense |
|
|
|
R9183:Ubr5
|
UTSW |
15 |
37,997,420 (GRCm39) |
missense |
|
|
|
R9235:Ubr5
|
UTSW |
15 |
38,045,982 (GRCm39) |
missense |
|
|
|
R9392:Ubr5
|
UTSW |
15 |
37,984,251 (GRCm39) |
missense |
|
|
|
R9473:Ubr5
|
UTSW |
15 |
38,002,617 (GRCm39) |
missense |
|
|
|
R9596:Ubr5
|
UTSW |
15 |
37,986,213 (GRCm39) |
missense |
|
|
|
R9659:Ubr5
|
UTSW |
15 |
37,984,254 (GRCm39) |
missense |
|
|
|
R9683:Ubr5
|
UTSW |
15 |
37,978,271 (GRCm39) |
missense |
|
|
|
RF024:Ubr5
|
UTSW |
15 |
38,028,896 (GRCm39) |
missense |
|
|
|
X0024:Ubr5
|
UTSW |
15 |
37,992,304 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Ubr5
|
UTSW |
15 |
38,040,999 (GRCm39) |
missense |
|
|
|
| Predicted Primers |
PCR Primer
(F):5'- GGCTACAGCCATACCATGAACATGC -3'
(R):5'- CTGAGCCTTACAGAAATGCCCAGG -3'
Sequencing Primer
(F):5'- ctctcacctccacacatcc -3'
(R):5'- CCTTACAGAAATGCCCAGGTATATTG -3'
|
| Posted On |
2013-04-24 |
Incidental Mutation