Incidental Mutation 'R4076:Scg2'
ID 316546
Institutional Source Beutler Lab
Gene Symbol Scg2
Ensembl Gene ENSMUSG00000050711
Gene Name secretogranin II
Synonyms SgII, Chgc
MMRRC Submission 040975-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R4076 (G1)
Quality Score 225
Status Not validated
Chromosome 1
Chromosomal Location 79412386-79417837 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to C at 79414574 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Valine at position 50 (F50V)
Ref Sequence ENSEMBL: ENSMUSP00000139740 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000049972] [ENSMUST00000185234]
AlphaFold Q03517
Predicted Effect probably benign
Transcript: ENSMUST00000049972
AA Change: F50V

PolyPhen 2 Score 0.188 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000062556
Gene: ENSMUSG00000050711
AA Change: F50V

DomainStartEndE-ValueType
Pfam:Granin 27 614 7.2e-235 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000185234
AA Change: F50V

PolyPhen 2 Score 0.969 (Sensitivity: 0.77; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000139740
Gene: ENSMUSG00000050711
AA Change: F50V

DomainStartEndE-ValueType
Pfam:Granin 27 319 1.4e-123 PFAM
Pfam:Granin 316 574 7.1e-91 PFAM
Meta Mutation Damage Score 0.2026 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.9%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. Studies in rodents suggest that the full-length protein, secretogranin II, is involved in the packaging or sorting of peptide hormones and neuropeptides into secretory vesicles. The full-length protein is cleaved to produce the active peptide secretoneurin, which exerts chemotaxic effects on specific cell types, and EM66, whose function is unknown. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acsm4 T A 7: 119,297,981 (GRCm39) L206H probably benign Het
Adam34l A T 8: 44,079,387 (GRCm39) F279Y probably damaging Het
Anxa5 T C 3: 36,504,529 (GRCm39) I277V probably benign Het
Atg12 A G 18: 46,870,491 (GRCm39) F92L probably benign Het
Cd48 T A 1: 171,523,451 (GRCm39) V98D probably damaging Het
Dnah11 A G 12: 118,009,413 (GRCm39) M2083T probably benign Het
Dnah9 T C 11: 65,975,730 (GRCm39) T1440A probably benign Het
Dnali1 T C 4: 124,953,263 (GRCm39) D188G probably damaging Het
Dst A G 1: 34,231,350 (GRCm39) E2656G probably benign Het
Eps15l1 A G 8: 73,134,128 (GRCm39) I482T probably damaging Het
Ercc4 G A 16: 12,948,549 (GRCm39) V499I probably damaging Het
Eva1c T A 16: 90,701,019 (GRCm39) F331Y probably damaging Het
Fcho1 T C 8: 72,163,013 (GRCm39) H672R probably damaging Het
Fras1 G C 5: 96,891,017 (GRCm39) D2849H probably damaging Het
Hdc C T 2: 126,458,181 (GRCm39) R47Q possibly damaging Het
Ighv1-30 C T 12: 114,781,021 (GRCm39) noncoding transcript Het
Krtap31-1 T C 11: 99,799,058 (GRCm39) I87T possibly damaging Het
Lamp3 A G 16: 19,519,466 (GRCm39) L239P possibly damaging Het
Ltb4r2 A T 14: 56,000,398 (GRCm39) R340W probably benign Het
Map10 T C 8: 126,398,584 (GRCm39) V659A probably benign Het
Nars2 T A 7: 96,607,301 (GRCm39) S91T probably damaging Het
Nlrp4c A G 7: 6,075,709 (GRCm39) K667E probably benign Het
Obox3 G T 7: 15,359,724 (GRCm39) T315N possibly damaging Het
Or52e18 A T 7: 104,609,923 (GRCm39) N5K probably damaging Het
Or5b3 G A 19: 13,388,299 (GRCm39) R122H possibly damaging Het
Osgin1 A C 8: 120,171,772 (GRCm39) S189R possibly damaging Het
Pidd1 A G 7: 141,020,739 (GRCm39) F453L probably damaging Het
Pik3c2g A T 6: 139,798,589 (GRCm39) N373I probably damaging Het
Pou2f2 T C 7: 24,796,713 (GRCm39) T270A probably damaging Het
Rad51b T G 12: 79,361,656 (GRCm39) S122R probably damaging Het
Rev1 T G 1: 38,093,319 (GRCm39) K1075T possibly damaging Het
Rrbp1 T G 2: 143,805,030 (GRCm39) Q1045P probably benign Het
Slco1a5 A T 6: 142,213,950 (GRCm39) I57K possibly damaging Het
Tfb1m T A 17: 3,571,945 (GRCm39) R257W probably damaging Het
Tm2d3 T A 7: 65,347,498 (GRCm39) L49* probably null Het
Usp31 A G 7: 121,267,005 (GRCm39) probably null Het
Zbtb11 C T 16: 55,818,427 (GRCm39) T617I possibly damaging Het
Zfp608 A T 18: 55,031,180 (GRCm39) V920E probably damaging Het
Other mutations in Scg2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01347:Scg2 APN 1 79,414,538 (GRCm39) missense probably benign 0.16
IGL02083:Scg2 APN 1 79,413,941 (GRCm39) missense probably benign 0.00
IGL02316:Scg2 APN 1 79,413,398 (GRCm39) missense probably damaging 1.00
IGL02338:Scg2 APN 1 79,414,210 (GRCm39) missense possibly damaging 0.93
R0281:Scg2 UTSW 1 79,413,229 (GRCm39) missense possibly damaging 0.95
R0384:Scg2 UTSW 1 79,413,266 (GRCm39) missense probably benign 0.42
R0501:Scg2 UTSW 1 79,413,320 (GRCm39) missense probably damaging 1.00
R0909:Scg2 UTSW 1 79,413,499 (GRCm39) missense possibly damaging 0.74
R1773:Scg2 UTSW 1 79,413,352 (GRCm39) missense probably benign 0.04
R2254:Scg2 UTSW 1 79,414,217 (GRCm39) missense probably damaging 1.00
R4074:Scg2 UTSW 1 79,414,574 (GRCm39) missense probably damaging 0.97
R4097:Scg2 UTSW 1 79,413,538 (GRCm39) missense probably damaging 0.99
R4560:Scg2 UTSW 1 79,412,898 (GRCm39) missense probably damaging 1.00
R4621:Scg2 UTSW 1 79,414,381 (GRCm39) missense probably benign 0.08
R4876:Scg2 UTSW 1 79,413,636 (GRCm39) missense probably damaging 1.00
R4944:Scg2 UTSW 1 79,414,193 (GRCm39) nonsense probably null
R5829:Scg2 UTSW 1 79,414,637 (GRCm39) missense probably damaging 1.00
R6158:Scg2 UTSW 1 79,413,117 (GRCm39) missense probably damaging 1.00
R6248:Scg2 UTSW 1 79,414,023 (GRCm39) missense probably benign 0.29
R6365:Scg2 UTSW 1 79,413,017 (GRCm39) missense probably benign
R6459:Scg2 UTSW 1 79,414,007 (GRCm39) missense probably damaging 1.00
R6676:Scg2 UTSW 1 79,413,499 (GRCm39) missense possibly damaging 0.74
R6693:Scg2 UTSW 1 79,413,737 (GRCm39) missense probably benign 0.01
R7259:Scg2 UTSW 1 79,414,702 (GRCm39) missense probably benign
R7393:Scg2 UTSW 1 79,412,948 (GRCm39) missense probably damaging 1.00
R7578:Scg2 UTSW 1 79,414,612 (GRCm39) missense probably damaging 0.99
R7608:Scg2 UTSW 1 79,413,898 (GRCm39) missense probably benign 0.00
R8166:Scg2 UTSW 1 79,413,300 (GRCm39) missense possibly damaging 0.56
R8247:Scg2 UTSW 1 79,414,236 (GRCm39) missense possibly damaging 0.92
R8296:Scg2 UTSW 1 79,413,222 (GRCm39) missense probably benign 0.13
R8308:Scg2 UTSW 1 79,414,576 (GRCm39) missense probably benign 0.18
R8789:Scg2 UTSW 1 79,413,500 (GRCm39) missense probably benign 0.05
R9252:Scg2 UTSW 1 79,414,069 (GRCm39) missense probably damaging 0.98
R9286:Scg2 UTSW 1 79,413,653 (GRCm39) missense probably damaging 1.00
R9489:Scg2 UTSW 1 79,412,936 (GRCm39) missense probably damaging 1.00
R9605:Scg2 UTSW 1 79,412,936 (GRCm39) missense probably damaging 1.00
Z1176:Scg2 UTSW 1 79,414,506 (GRCm39) missense probably benign 0.17
Predicted Primers PCR Primer
(F):5'- GCCTCGAGTATTATCCGCATCC -3'
(R):5'- CGTGCCTTCAAGCTCGTATC -3'

Sequencing Primer
(F):5'- GAGTATTATCCGCATCCACTCG -3'
(R):5'- GTGCCTTCAAGCTCGTATCATCTG -3'
Posted On 2015-05-15