Incidental Mutation 'R4076:Map10'
ID 316571
Institutional Source Beutler Lab
Gene Symbol Map10
Ensembl Gene ENSMUSG00000050930
Gene Name microtubule-associated protein 10
Synonyms 4933403G14Rik
MMRRC Submission 040975-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.089) question?
Stock # R4076 (G1)
Quality Score 225
Status Not validated
Chromosome 8
Chromosomal Location 126396557-126400098 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 126398584 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 659 (V659A)
Ref Sequence ENSEMBL: ENSMUSP00000061679 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000053078]
AlphaFold Q8BJS7
Predicted Effect probably benign
Transcript: ENSMUST00000053078
AA Change: V659A

PolyPhen 2 Score 0.226 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000061679
Gene: ENSMUSG00000050930
AA Change: V659A

DomainStartEndE-ValueType
low complexity region 38 54 N/A INTRINSIC
low complexity region 68 91 N/A INTRINSIC
Pfam:HPHLAWLY 243 535 1.4e-130 PFAM
Pfam:HPHLAWLY 527 890 9.1e-133 PFAM
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.9%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acsm4 T A 7: 119,297,981 (GRCm39) L206H probably benign Het
Adam34l A T 8: 44,079,387 (GRCm39) F279Y probably damaging Het
Anxa5 T C 3: 36,504,529 (GRCm39) I277V probably benign Het
Atg12 A G 18: 46,870,491 (GRCm39) F92L probably benign Het
Cd48 T A 1: 171,523,451 (GRCm39) V98D probably damaging Het
Dnah11 A G 12: 118,009,413 (GRCm39) M2083T probably benign Het
Dnah9 T C 11: 65,975,730 (GRCm39) T1440A probably benign Het
Dnali1 T C 4: 124,953,263 (GRCm39) D188G probably damaging Het
Dst A G 1: 34,231,350 (GRCm39) E2656G probably benign Het
Eps15l1 A G 8: 73,134,128 (GRCm39) I482T probably damaging Het
Ercc4 G A 16: 12,948,549 (GRCm39) V499I probably damaging Het
Eva1c T A 16: 90,701,019 (GRCm39) F331Y probably damaging Het
Fcho1 T C 8: 72,163,013 (GRCm39) H672R probably damaging Het
Fras1 G C 5: 96,891,017 (GRCm39) D2849H probably damaging Het
Hdc C T 2: 126,458,181 (GRCm39) R47Q possibly damaging Het
Ighv1-30 C T 12: 114,781,021 (GRCm39) noncoding transcript Het
Krtap31-1 T C 11: 99,799,058 (GRCm39) I87T possibly damaging Het
Lamp3 A G 16: 19,519,466 (GRCm39) L239P possibly damaging Het
Ltb4r2 A T 14: 56,000,398 (GRCm39) R340W probably benign Het
Nars2 T A 7: 96,607,301 (GRCm39) S91T probably damaging Het
Nlrp4c A G 7: 6,075,709 (GRCm39) K667E probably benign Het
Obox3 G T 7: 15,359,724 (GRCm39) T315N possibly damaging Het
Or52e18 A T 7: 104,609,923 (GRCm39) N5K probably damaging Het
Or5b3 G A 19: 13,388,299 (GRCm39) R122H possibly damaging Het
Osgin1 A C 8: 120,171,772 (GRCm39) S189R possibly damaging Het
Pidd1 A G 7: 141,020,739 (GRCm39) F453L probably damaging Het
Pik3c2g A T 6: 139,798,589 (GRCm39) N373I probably damaging Het
Pou2f2 T C 7: 24,796,713 (GRCm39) T270A probably damaging Het
Rad51b T G 12: 79,361,656 (GRCm39) S122R probably damaging Het
Rev1 T G 1: 38,093,319 (GRCm39) K1075T possibly damaging Het
Rrbp1 T G 2: 143,805,030 (GRCm39) Q1045P probably benign Het
Scg2 A C 1: 79,414,574 (GRCm39) F50V probably damaging Het
Slco1a5 A T 6: 142,213,950 (GRCm39) I57K possibly damaging Het
Tfb1m T A 17: 3,571,945 (GRCm39) R257W probably damaging Het
Tm2d3 T A 7: 65,347,498 (GRCm39) L49* probably null Het
Usp31 A G 7: 121,267,005 (GRCm39) probably null Het
Zbtb11 C T 16: 55,818,427 (GRCm39) T617I possibly damaging Het
Zfp608 A T 18: 55,031,180 (GRCm39) V920E probably damaging Het
Other mutations in Map10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00813:Map10 APN 8 126,398,671 (GRCm39) missense probably benign 0.00
IGL01567:Map10 APN 8 126,398,232 (GRCm39) missense probably benign 0.32
IGL02566:Map10 APN 8 126,398,494 (GRCm39) missense probably benign
IGL03088:Map10 APN 8 126,397,809 (GRCm39) missense probably benign 0.14
debauched UTSW 8 126,397,984 (GRCm39) missense probably damaging 1.00
R1083:Map10 UTSW 8 126,397,178 (GRCm39) nonsense probably null
R1543:Map10 UTSW 8 126,397,611 (GRCm39) missense probably benign 0.00
R3155:Map10 UTSW 8 126,398,313 (GRCm39) missense possibly damaging 0.79
R4559:Map10 UTSW 8 126,398,553 (GRCm39) missense probably benign
R4856:Map10 UTSW 8 126,397,431 (GRCm39) missense probably damaging 1.00
R4886:Map10 UTSW 8 126,397,431 (GRCm39) missense probably damaging 1.00
R5412:Map10 UTSW 8 126,397,724 (GRCm39) missense probably damaging 1.00
R6034:Map10 UTSW 8 126,399,205 (GRCm39) missense probably damaging 1.00
R6034:Map10 UTSW 8 126,399,205 (GRCm39) missense probably damaging 1.00
R6150:Map10 UTSW 8 126,398,328 (GRCm39) missense probably damaging 0.96
R6351:Map10 UTSW 8 126,397,984 (GRCm39) missense probably damaging 1.00
R6466:Map10 UTSW 8 126,399,123 (GRCm39) nonsense probably null
R6544:Map10 UTSW 8 126,398,113 (GRCm39) missense probably benign 0.00
R6557:Map10 UTSW 8 126,396,991 (GRCm39) missense probably damaging 0.98
R6821:Map10 UTSW 8 126,397,138 (GRCm39) missense probably benign 0.01
R7096:Map10 UTSW 8 126,398,662 (GRCm39) missense probably damaging 0.99
R7128:Map10 UTSW 8 126,398,592 (GRCm39) missense probably benign
R7177:Map10 UTSW 8 126,398,584 (GRCm39) missense probably benign 0.23
R7237:Map10 UTSW 8 126,397,963 (GRCm39) missense probably benign 0.03
R7814:Map10 UTSW 8 126,398,350 (GRCm39) missense probably benign 0.14
R7819:Map10 UTSW 8 126,397,260 (GRCm39) frame shift probably null
R8202:Map10 UTSW 8 126,397,647 (GRCm39) missense possibly damaging 0.95
R8812:Map10 UTSW 8 126,396,664 (GRCm39) missense probably damaging 0.99
R8859:Map10 UTSW 8 126,397,291 (GRCm39) missense probably benign 0.04
R8947:Map10 UTSW 8 126,397,839 (GRCm39) missense probably benign 0.06
R9178:Map10 UTSW 8 126,397,649 (GRCm39) missense probably damaging 0.98
R9698:Map10 UTSW 8 126,398,723 (GRCm39) missense probably benign 0.16
Z1088:Map10 UTSW 8 126,398,670 (GRCm39) frame shift probably null
Z1177:Map10 UTSW 8 126,396,809 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CAGAACCATTGTCACTGCTCTG -3'
(R):5'- TGACTTGCTTGCCCGTGAAC -3'

Sequencing Primer
(F):5'- TCTGAGAGCACCCGTGAG -3'
(R):5'- CGTGAACCCTTTTGCACATG -3'
Posted On 2015-05-15