Incidental Mutation 'R4076:Zfp608'
ID 316584
Institutional Source Beutler Lab
Gene Symbol Zfp608
Ensembl Gene ENSMUSG00000052713
Gene Name zinc finger protein 608
Synonyms 4932417D18Rik
MMRRC Submission 040975-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.899) question?
Stock # R4076 (G1)
Quality Score 225
Status Not validated
Chromosome 18
Chromosomal Location 55021120-55125627 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 55031180 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Glutamic Acid at position 920 (V920E)
Ref Sequence ENSEMBL: ENSMUSP00000068192 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000064763]
AlphaFold Q56A10
Predicted Effect probably damaging
Transcript: ENSMUST00000064763
AA Change: V920E

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000068192
Gene: ENSMUSG00000052713
AA Change: V920E

DomainStartEndE-ValueType
low complexity region 51 61 N/A INTRINSIC
low complexity region 150 184 N/A INTRINSIC
low complexity region 214 234 N/A INTRINSIC
low complexity region 252 266 N/A INTRINSIC
low complexity region 309 326 N/A INTRINSIC
low complexity region 428 445 N/A INTRINSIC
low complexity region 459 471 N/A INTRINSIC
ZnF_C2H2 552 577 1.86e0 SMART
low complexity region 624 636 N/A INTRINSIC
low complexity region 706 718 N/A INTRINSIC
low complexity region 734 773 N/A INTRINSIC
low complexity region 807 822 N/A INTRINSIC
low complexity region 833 846 N/A INTRINSIC
low complexity region 934 956 N/A INTRINSIC
coiled coil region 1028 1054 N/A INTRINSIC
low complexity region 1182 1193 N/A INTRINSIC
low complexity region 1255 1268 N/A INTRINSIC
low complexity region 1439 1450 N/A INTRINSIC
low complexity region 1458 1466 N/A INTRINSIC
low complexity region 1486 1502 N/A INTRINSIC
Meta Mutation Damage Score 0.2838 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.9%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acsm4 T A 7: 119,297,981 (GRCm39) L206H probably benign Het
Adam34l A T 8: 44,079,387 (GRCm39) F279Y probably damaging Het
Anxa5 T C 3: 36,504,529 (GRCm39) I277V probably benign Het
Atg12 A G 18: 46,870,491 (GRCm39) F92L probably benign Het
Cd48 T A 1: 171,523,451 (GRCm39) V98D probably damaging Het
Dnah11 A G 12: 118,009,413 (GRCm39) M2083T probably benign Het
Dnah9 T C 11: 65,975,730 (GRCm39) T1440A probably benign Het
Dnali1 T C 4: 124,953,263 (GRCm39) D188G probably damaging Het
Dst A G 1: 34,231,350 (GRCm39) E2656G probably benign Het
Eps15l1 A G 8: 73,134,128 (GRCm39) I482T probably damaging Het
Ercc4 G A 16: 12,948,549 (GRCm39) V499I probably damaging Het
Eva1c T A 16: 90,701,019 (GRCm39) F331Y probably damaging Het
Fcho1 T C 8: 72,163,013 (GRCm39) H672R probably damaging Het
Fras1 G C 5: 96,891,017 (GRCm39) D2849H probably damaging Het
Hdc C T 2: 126,458,181 (GRCm39) R47Q possibly damaging Het
Ighv1-30 C T 12: 114,781,021 (GRCm39) noncoding transcript Het
Krtap31-1 T C 11: 99,799,058 (GRCm39) I87T possibly damaging Het
Lamp3 A G 16: 19,519,466 (GRCm39) L239P possibly damaging Het
Ltb4r2 A T 14: 56,000,398 (GRCm39) R340W probably benign Het
Map10 T C 8: 126,398,584 (GRCm39) V659A probably benign Het
Nars2 T A 7: 96,607,301 (GRCm39) S91T probably damaging Het
Nlrp4c A G 7: 6,075,709 (GRCm39) K667E probably benign Het
Obox3 G T 7: 15,359,724 (GRCm39) T315N possibly damaging Het
Or52e18 A T 7: 104,609,923 (GRCm39) N5K probably damaging Het
Or5b3 G A 19: 13,388,299 (GRCm39) R122H possibly damaging Het
Osgin1 A C 8: 120,171,772 (GRCm39) S189R possibly damaging Het
Pidd1 A G 7: 141,020,739 (GRCm39) F453L probably damaging Het
Pik3c2g A T 6: 139,798,589 (GRCm39) N373I probably damaging Het
Pou2f2 T C 7: 24,796,713 (GRCm39) T270A probably damaging Het
Rad51b T G 12: 79,361,656 (GRCm39) S122R probably damaging Het
Rev1 T G 1: 38,093,319 (GRCm39) K1075T possibly damaging Het
Rrbp1 T G 2: 143,805,030 (GRCm39) Q1045P probably benign Het
Scg2 A C 1: 79,414,574 (GRCm39) F50V probably damaging Het
Slco1a5 A T 6: 142,213,950 (GRCm39) I57K possibly damaging Het
Tfb1m T A 17: 3,571,945 (GRCm39) R257W probably damaging Het
Tm2d3 T A 7: 65,347,498 (GRCm39) L49* probably null Het
Usp31 A G 7: 121,267,005 (GRCm39) probably null Het
Zbtb11 C T 16: 55,818,427 (GRCm39) T617I possibly damaging Het
Other mutations in Zfp608
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00500:Zfp608 APN 18 55,121,405 (GRCm39) missense probably benign
IGL00920:Zfp608 APN 18 55,022,903 (GRCm39) missense probably benign 0.00
IGL01088:Zfp608 APN 18 55,031,159 (GRCm39) missense probably benign 0.03
IGL01447:Zfp608 APN 18 55,032,083 (GRCm39) missense possibly damaging 0.75
IGL01534:Zfp608 APN 18 55,032,004 (GRCm39) missense probably damaging 0.99
IGL01547:Zfp608 APN 18 55,027,521 (GRCm39) critical splice donor site probably null
IGL01933:Zfp608 APN 18 55,120,871 (GRCm39) missense probably benign
IGL01998:Zfp608 APN 18 55,024,890 (GRCm39) missense probably damaging 0.99
IGL02167:Zfp608 APN 18 55,121,296 (GRCm39) missense probably damaging 1.00
IGL02266:Zfp608 APN 18 55,030,653 (GRCm39) missense probably benign 0.08
IGL02335:Zfp608 APN 18 55,030,509 (GRCm39) nonsense probably null
IGL02455:Zfp608 APN 18 55,032,405 (GRCm39) missense probably damaging 1.00
IGL02612:Zfp608 APN 18 55,031,273 (GRCm39) missense probably damaging 1.00
IGL02900:Zfp608 APN 18 55,079,865 (GRCm39) missense probably damaging 1.00
PIT4243001:Zfp608 UTSW 18 55,031,096 (GRCm39) missense probably damaging 1.00
PIT4519001:Zfp608 UTSW 18 55,079,783 (GRCm39) missense possibly damaging 0.71
R0005:Zfp608 UTSW 18 55,028,592 (GRCm39) missense possibly damaging 0.88
R0010:Zfp608 UTSW 18 55,028,286 (GRCm39) splice site probably benign
R0010:Zfp608 UTSW 18 55,028,286 (GRCm39) splice site probably benign
R0064:Zfp608 UTSW 18 55,031,888 (GRCm39) missense probably benign
R0401:Zfp608 UTSW 18 55,032,066 (GRCm39) missense probably benign
R0722:Zfp608 UTSW 18 55,033,306 (GRCm39) missense probably damaging 1.00
R1351:Zfp608 UTSW 18 55,031,463 (GRCm39) missense probably benign 0.00
R1512:Zfp608 UTSW 18 55,079,738 (GRCm39) missense probably damaging 1.00
R1554:Zfp608 UTSW 18 55,031,126 (GRCm39) missense probably damaging 1.00
R1622:Zfp608 UTSW 18 55,121,366 (GRCm39) missense probably benign 0.07
R1669:Zfp608 UTSW 18 55,120,811 (GRCm39) missense probably benign 0.09
R1690:Zfp608 UTSW 18 55,120,706 (GRCm39) missense possibly damaging 0.62
R1721:Zfp608 UTSW 18 55,032,321 (GRCm39) missense probably benign
R1826:Zfp608 UTSW 18 55,031,648 (GRCm39) missense probably benign 0.03
R1864:Zfp608 UTSW 18 55,030,983 (GRCm39) missense probably benign 0.00
R1952:Zfp608 UTSW 18 55,030,851 (GRCm39) nonsense probably null
R2049:Zfp608 UTSW 18 55,028,637 (GRCm39) missense probably damaging 1.00
R2051:Zfp608 UTSW 18 55,121,386 (GRCm39) missense probably benign
R2168:Zfp608 UTSW 18 55,031,125 (GRCm39) nonsense probably null
R2218:Zfp608 UTSW 18 55,120,756 (GRCm39) missense probably benign 0.14
R2283:Zfp608 UTSW 18 55,121,446 (GRCm39) missense probably damaging 1.00
R2399:Zfp608 UTSW 18 55,030,974 (GRCm39) missense probably damaging 1.00
R2520:Zfp608 UTSW 18 55,121,578 (GRCm39) missense possibly damaging 0.92
R2961:Zfp608 UTSW 18 55,031,544 (GRCm39) missense possibly damaging 0.60
R4074:Zfp608 UTSW 18 55,031,180 (GRCm39) missense probably damaging 1.00
R4206:Zfp608 UTSW 18 55,121,267 (GRCm39) missense probably damaging 1.00
R4756:Zfp608 UTSW 18 55,027,544 (GRCm39) missense probably damaging 1.00
R4771:Zfp608 UTSW 18 55,121,372 (GRCm39) missense probably benign
R4820:Zfp608 UTSW 18 55,120,756 (GRCm39) missense probably benign 0.14
R4825:Zfp608 UTSW 18 55,031,041 (GRCm39) missense probably benign 0.01
R4912:Zfp608 UTSW 18 55,079,663 (GRCm39) missense probably damaging 1.00
R4975:Zfp608 UTSW 18 55,022,962 (GRCm39) missense probably damaging 1.00
R5138:Zfp608 UTSW 18 55,024,871 (GRCm39) missense probably damaging 1.00
R5192:Zfp608 UTSW 18 55,031,569 (GRCm39) missense probably damaging 1.00
R5557:Zfp608 UTSW 18 55,120,942 (GRCm39) missense possibly damaging 0.81
R5624:Zfp608 UTSW 18 55,031,344 (GRCm39) missense probably damaging 1.00
R5818:Zfp608 UTSW 18 55,028,468 (GRCm39) missense probably benign 0.02
R5840:Zfp608 UTSW 18 55,031,978 (GRCm39) missense probably damaging 1.00
R5992:Zfp608 UTSW 18 55,032,320 (GRCm39) missense probably benign 0.15
R6106:Zfp608 UTSW 18 55,120,944 (GRCm39) missense possibly damaging 0.54
R6174:Zfp608 UTSW 18 55,121,616 (GRCm39) start gained probably benign
R6181:Zfp608 UTSW 18 55,028,700 (GRCm39) missense possibly damaging 0.56
R6517:Zfp608 UTSW 18 55,032,150 (GRCm39) missense possibly damaging 0.94
R6567:Zfp608 UTSW 18 55,030,628 (GRCm39) missense probably damaging 1.00
R6668:Zfp608 UTSW 18 55,031,091 (GRCm39) missense probably damaging 1.00
R6920:Zfp608 UTSW 18 55,121,337 (GRCm39) missense probably damaging 1.00
R7061:Zfp608 UTSW 18 55,121,069 (GRCm39) missense probably benign
R7074:Zfp608 UTSW 18 55,030,454 (GRCm39) missense possibly damaging 0.69
R7087:Zfp608 UTSW 18 55,032,469 (GRCm39) missense probably damaging 1.00
R7391:Zfp608 UTSW 18 55,030,619 (GRCm39) missense possibly damaging 0.49
R7600:Zfp608 UTSW 18 55,121,092 (GRCm39) missense probably damaging 1.00
R7723:Zfp608 UTSW 18 55,030,673 (GRCm39) missense probably damaging 1.00
R8054:Zfp608 UTSW 18 55,032,618 (GRCm39) missense probably benign 0.28
R8236:Zfp608 UTSW 18 55,032,281 (GRCm39) missense probably damaging 1.00
R8260:Zfp608 UTSW 18 55,030,821 (GRCm39) missense possibly damaging 0.60
R8732:Zfp608 UTSW 18 55,121,072 (GRCm39) missense probably benign 0.06
R8781:Zfp608 UTSW 18 55,031,801 (GRCm39) missense probably damaging 1.00
R8851:Zfp608 UTSW 18 55,032,194 (GRCm39) missense possibly damaging 0.94
R8940:Zfp608 UTSW 18 55,033,301 (GRCm39) missense possibly damaging 0.93
R9051:Zfp608 UTSW 18 55,032,266 (GRCm39) missense probably damaging 1.00
R9091:Zfp608 UTSW 18 55,032,190 (GRCm39) missense probably damaging 1.00
R9092:Zfp608 UTSW 18 55,031,648 (GRCm39) missense probably benign 0.03
R9236:Zfp608 UTSW 18 55,032,354 (GRCm39) missense probably benign 0.39
R9270:Zfp608 UTSW 18 55,032,190 (GRCm39) missense probably damaging 1.00
R9283:Zfp608 UTSW 18 55,030,913 (GRCm39) missense possibly damaging 0.50
R9288:Zfp608 UTSW 18 55,033,341 (GRCm39) missense probably benign 0.39
R9463:Zfp608 UTSW 18 55,030,274 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AGGATGCCCTTTCACAACAC -3'
(R):5'- TAGCAAGGATTTGTCTGGGC -3'

Sequencing Primer
(F):5'- CCGTCTTTGTTAGAAAAGGTATCCG -3'
(R):5'- CCATCTCGGTAAGAGCGAAG -3'
Posted On 2015-05-15