Incidental Mutation 'R4077:Secisbp2l'
ID 316598
Institutional Source Beutler Lab
Gene Symbol Secisbp2l
Ensembl Gene ENSMUSG00000035093
Gene Name SECIS binding protein 2-like
Synonyms 3110001I20Rik
MMRRC Submission 041622-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.769) question?
Stock # R4077 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 125578906-125624790 bp(-) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) A to G at 125593785 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Gene Model predicted gene model for transcript(s): [ENSMUST00000053699]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000053699
SMART Domains Protein: ENSMUSP00000055772
Gene: ENSMUSG00000035093

DomainStartEndE-ValueType
low complexity region 441 459 N/A INTRINSIC
low complexity region 555 568 N/A INTRINSIC
Pfam:Ribosomal_L7Ae 700 802 7.6e-24 PFAM
low complexity region 821 831 N/A INTRINSIC
low complexity region 970 978 N/A INTRINSIC
low complexity region 985 996 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000136450
Predicted Effect probably benign
Transcript: ENSMUST00000139944
SMART Domains Protein: ENSMUSP00000121529
Gene: ENSMUSG00000035093

DomainStartEndE-ValueType
low complexity region 67 85 N/A INTRINSIC
low complexity region 181 194 N/A INTRINSIC
Pfam:Ribosomal_L7Ae 326 427 3.5e-24 PFAM
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.8%
Validation Efficiency 99% (81/82)
Allele List at MGI
Other mutations in this stock
Total: 71 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abhd12 T A 2: 150,690,379 (GRCm39) probably null Het
Adam33 T C 2: 130,905,444 (GRCm39) probably benign Het
Adrm1b A C 3: 92,336,195 (GRCm39) probably benign Het
Akap8 C T 17: 32,531,272 (GRCm39) R380Q probably damaging Het
Arhgef12 T C 9: 42,886,588 (GRCm39) M1131V probably damaging Het
Atrn T C 2: 130,806,850 (GRCm39) probably null Het
Btaf1 A G 19: 36,963,879 (GRCm39) T817A probably benign Het
C3 C T 17: 57,512,303 (GRCm39) D1542N possibly damaging Het
Cadm3 A G 1: 173,169,236 (GRCm39) V293A probably benign Het
Cdk11b C T 4: 155,724,204 (GRCm39) probably benign Het
Cdnf A G 2: 3,522,060 (GRCm39) Y84C probably damaging Het
Chdh T C 14: 29,757,297 (GRCm39) S407P probably damaging Het
Cmtr1 C A 17: 29,904,949 (GRCm39) T300K probably damaging Het
Dennd2d A T 3: 106,389,939 (GRCm39) probably benign Het
Diaph1 T A 18: 37,986,636 (GRCm39) E1116D possibly damaging Het
Eif1ad3 A G 12: 87,843,401 (GRCm39) K16R unknown Het
Eif1ad3 A T 12: 87,843,710 (GRCm39) D119V possibly damaging Het
Enpp1 A G 10: 24,544,905 (GRCm39) probably null Het
Erbb4 T C 1: 68,079,496 (GRCm39) T1195A probably benign Het
Ermard T A 17: 15,273,638 (GRCm39) S408T probably benign Het
Etl4 A T 2: 20,812,772 (GRCm39) R1442S probably damaging Het
F13b T A 1: 139,429,508 (GRCm39) F9I unknown Het
Fnbp4 C T 2: 90,588,821 (GRCm39) R531* probably null Het
Gdf6 A G 4: 9,844,776 (GRCm39) Y100C probably damaging Het
Gpr3 T C 4: 132,938,226 (GRCm39) T149A probably damaging Het
Grm8 T C 6: 27,760,208 (GRCm39) H374R probably benign Het
Hbs1l T C 10: 21,228,501 (GRCm39) V493A probably damaging Het
Hgs A G 11: 120,368,202 (GRCm39) K277E probably damaging Het
Hnrnpul1 C T 7: 25,426,300 (GRCm39) R517Q probably damaging Het
Hoxa11 A T 6: 52,222,504 (GRCm39) Y66N probably damaging Het
Hsh2d G A 8: 72,954,304 (GRCm39) D229N probably benign Het
Igdcc4 T A 9: 65,039,047 (GRCm39) L944Q probably damaging Het
Ighv3-1 C A 12: 113,928,107 (GRCm39) S84I probably damaging Het
Iqgap2 T C 13: 95,794,375 (GRCm39) D1199G probably damaging Het
Kcnk10 A T 12: 98,401,205 (GRCm39) M490K probably benign Het
Kirrel1 A G 3: 86,992,387 (GRCm39) probably null Het
Lias A T 5: 65,552,768 (GRCm39) T124S probably benign Het
Lrig3 A C 10: 125,845,656 (GRCm39) E695A probably damaging Het
Lrpap1 A G 5: 35,253,381 (GRCm39) I261T possibly damaging Het
Lrrc37a T A 11: 103,388,808 (GRCm39) T2206S unknown Het
Macf1 T A 4: 123,365,884 (GRCm39) Q2959L probably benign Het
Mis12 A G 11: 70,916,134 (GRCm39) T56A probably benign Het
Or10ag56 T A 2: 87,139,208 (GRCm39) M25K probably null Het
Or1l4 T A 2: 37,092,024 (GRCm39) I257N possibly damaging Het
Or4k41 A G 2: 111,279,848 (GRCm39) D121G probably damaging Het
Or5b99 T C 19: 12,977,235 (GRCm39) V295A probably damaging Het
Otof A T 5: 30,576,850 (GRCm39) L134Q possibly damaging Het
Pds5b T A 5: 150,717,824 (GRCm39) V1155E possibly damaging Het
Pdss2 A T 10: 43,278,518 (GRCm39) M342L probably benign Het
Phyhipl C T 10: 70,404,903 (GRCm39) V57I probably damaging Het
Plekha5 T A 6: 140,501,647 (GRCm39) probably null Het
Pnck A T X: 72,701,761 (GRCm39) V93E probably damaging Het
Proser1 A G 3: 53,385,962 (GRCm39) T615A probably damaging Het
Ptprk G A 10: 28,139,508 (GRCm39) V78I probably benign Het
Ptprv A G 1: 135,038,168 (GRCm39) noncoding transcript Het
Ranbp3l A G 15: 9,060,838 (GRCm39) N233S probably damaging Het
Rassf2 G A 2: 131,854,522 (GRCm39) P7S probably benign Het
Sart1 A T 19: 5,432,771 (GRCm39) L521Q possibly damaging Het
Scgb1b21 T A 7: 33,227,118 (GRCm39) noncoding transcript Het
Scyl2 A T 10: 89,476,458 (GRCm39) M889K probably benign Het
Svil A G 18: 5,063,522 (GRCm39) E931G probably benign Het
Syce1 C A 7: 140,359,809 (GRCm39) L83F probably damaging Het
Tdrd1 A G 19: 56,819,505 (GRCm39) M2V probably benign Het
Tjp2 A T 19: 24,086,182 (GRCm39) V780E possibly damaging Het
Tram1 A G 1: 13,636,599 (GRCm39) V358A probably benign Het
Unc13c C T 9: 73,643,821 (GRCm39) W1214* probably null Het
Vps13b T C 15: 35,455,274 (GRCm39) C728R probably damaging Het
Wwox A G 8: 115,166,481 (GRCm39) probably benign Het
Zbtb41 G A 1: 139,357,064 (GRCm39) V440I probably benign Het
Zfp777 T C 6: 48,002,456 (GRCm39) S589G probably benign Het
Zfp955a A G 17: 33,460,675 (GRCm39) Y486H probably benign Het
Other mutations in Secisbp2l
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00421:Secisbp2l APN 2 125,585,776 (GRCm39) missense probably damaging 0.99
IGL00644:Secisbp2l APN 2 125,585,764 (GRCm39) missense probably damaging 1.00
IGL01093:Secisbp2l APN 2 125,582,245 (GRCm39) missense probably benign
IGL01621:Secisbp2l APN 2 125,615,131 (GRCm39) missense probably benign
IGL01955:Secisbp2l APN 2 125,585,732 (GRCm39) critical splice donor site probably null
IGL02036:Secisbp2l APN 2 125,600,127 (GRCm39) missense probably benign
IGL02045:Secisbp2l APN 2 125,617,498 (GRCm39) missense possibly damaging 0.82
IGL02182:Secisbp2l APN 2 125,589,497 (GRCm39) missense probably damaging 1.00
IGL02408:Secisbp2l APN 2 125,582,789 (GRCm39) nonsense probably null
IGL02455:Secisbp2l APN 2 125,615,398 (GRCm39) missense possibly damaging 0.89
IGL02953:Secisbp2l APN 2 125,602,194 (GRCm39) missense probably benign 0.36
Rift UTSW 2 125,610,113 (GRCm39) missense probably damaging 1.00
Seismic UTSW 2 125,587,829 (GRCm39) missense probably damaging 1.00
R0097:Secisbp2l UTSW 2 125,613,376 (GRCm39) missense probably damaging 0.96
R0097:Secisbp2l UTSW 2 125,613,376 (GRCm39) missense probably damaging 0.96
R1415:Secisbp2l UTSW 2 125,582,285 (GRCm39) missense probably benign 0.00
R1626:Secisbp2l UTSW 2 125,617,606 (GRCm39) missense probably damaging 0.99
R1926:Secisbp2l UTSW 2 125,582,597 (GRCm39) missense probably damaging 0.99
R1940:Secisbp2l UTSW 2 125,582,259 (GRCm39) missense probably damaging 1.00
R1970:Secisbp2l UTSW 2 125,589,430 (GRCm39) missense probably damaging 1.00
R2100:Secisbp2l UTSW 2 125,582,657 (GRCm39) missense possibly damaging 0.66
R2240:Secisbp2l UTSW 2 125,582,657 (GRCm39) missense possibly damaging 0.66
R2252:Secisbp2l UTSW 2 125,582,657 (GRCm39) missense possibly damaging 0.66
R2253:Secisbp2l UTSW 2 125,582,657 (GRCm39) missense possibly damaging 0.66
R2472:Secisbp2l UTSW 2 125,582,657 (GRCm39) missense possibly damaging 0.66
R2474:Secisbp2l UTSW 2 125,582,657 (GRCm39) missense possibly damaging 0.66
R2475:Secisbp2l UTSW 2 125,582,657 (GRCm39) missense possibly damaging 0.66
R2990:Secisbp2l UTSW 2 125,582,657 (GRCm39) missense possibly damaging 0.66
R2993:Secisbp2l UTSW 2 125,582,657 (GRCm39) missense possibly damaging 0.66
R3113:Secisbp2l UTSW 2 125,592,206 (GRCm39) missense probably damaging 1.00
R3696:Secisbp2l UTSW 2 125,582,657 (GRCm39) missense possibly damaging 0.66
R3749:Secisbp2l UTSW 2 125,582,657 (GRCm39) missense possibly damaging 0.66
R3750:Secisbp2l UTSW 2 125,582,657 (GRCm39) missense possibly damaging 0.66
R3800:Secisbp2l UTSW 2 125,582,657 (GRCm39) missense possibly damaging 0.66
R3810:Secisbp2l UTSW 2 125,582,657 (GRCm39) missense possibly damaging 0.66
R3812:Secisbp2l UTSW 2 125,582,657 (GRCm39) missense possibly damaging 0.66
R3815:Secisbp2l UTSW 2 125,582,657 (GRCm39) missense possibly damaging 0.66
R3816:Secisbp2l UTSW 2 125,582,657 (GRCm39) missense possibly damaging 0.66
R3817:Secisbp2l UTSW 2 125,582,657 (GRCm39) missense possibly damaging 0.66
R3880:Secisbp2l UTSW 2 125,582,657 (GRCm39) missense possibly damaging 0.66
R4096:Secisbp2l UTSW 2 125,582,657 (GRCm39) missense possibly damaging 0.66
R4097:Secisbp2l UTSW 2 125,582,657 (GRCm39) missense possibly damaging 0.66
R4164:Secisbp2l UTSW 2 125,593,803 (GRCm39) intron probably benign
R4332:Secisbp2l UTSW 2 125,582,657 (GRCm39) missense possibly damaging 0.66
R4418:Secisbp2l UTSW 2 125,594,835 (GRCm39) missense probably benign 0.00
R4598:Secisbp2l UTSW 2 125,582,657 (GRCm39) missense possibly damaging 0.66
R4600:Secisbp2l UTSW 2 125,582,657 (GRCm39) missense possibly damaging 0.66
R4602:Secisbp2l UTSW 2 125,582,657 (GRCm39) missense possibly damaging 0.66
R4603:Secisbp2l UTSW 2 125,582,657 (GRCm39) missense possibly damaging 0.66
R4678:Secisbp2l UTSW 2 125,582,657 (GRCm39) missense possibly damaging 0.66
R4679:Secisbp2l UTSW 2 125,582,657 (GRCm39) missense possibly damaging 0.66
R4684:Secisbp2l UTSW 2 125,587,862 (GRCm39) missense probably damaging 1.00
R4741:Secisbp2l UTSW 2 125,582,657 (GRCm39) missense possibly damaging 0.66
R4749:Secisbp2l UTSW 2 125,582,657 (GRCm39) missense possibly damaging 0.66
R4934:Secisbp2l UTSW 2 125,582,409 (GRCm39) missense probably damaging 0.99
R5245:Secisbp2l UTSW 2 125,589,511 (GRCm39) missense probably damaging 1.00
R5521:Secisbp2l UTSW 2 125,594,897 (GRCm39) missense possibly damaging 0.94
R5547:Secisbp2l UTSW 2 125,582,657 (GRCm39) missense possibly damaging 0.66
R5630:Secisbp2l UTSW 2 125,582,657 (GRCm39) missense possibly damaging 0.66
R5631:Secisbp2l UTSW 2 125,582,657 (GRCm39) missense possibly damaging 0.66
R5632:Secisbp2l UTSW 2 125,582,657 (GRCm39) missense possibly damaging 0.66
R6039:Secisbp2l UTSW 2 125,615,136 (GRCm39) missense probably benign 0.28
R6039:Secisbp2l UTSW 2 125,615,136 (GRCm39) missense probably benign 0.28
R6378:Secisbp2l UTSW 2 125,610,245 (GRCm39) missense possibly damaging 0.78
R6616:Secisbp2l UTSW 2 125,610,146 (GRCm39) missense probably damaging 0.96
R6938:Secisbp2l UTSW 2 125,592,272 (GRCm39) missense probably damaging 1.00
R7287:Secisbp2l UTSW 2 125,582,289 (GRCm39) missense probably benign
R7373:Secisbp2l UTSW 2 125,599,191 (GRCm39) missense probably damaging 0.99
R7403:Secisbp2l UTSW 2 125,602,199 (GRCm39) missense possibly damaging 0.73
R7484:Secisbp2l UTSW 2 125,613,452 (GRCm39) nonsense probably null
R7504:Secisbp2l UTSW 2 125,600,091 (GRCm39) missense probably benign 0.30
R7762:Secisbp2l UTSW 2 125,610,113 (GRCm39) missense probably damaging 1.00
R7769:Secisbp2l UTSW 2 125,613,465 (GRCm39) critical splice acceptor site probably benign
R8018:Secisbp2l UTSW 2 125,587,829 (GRCm39) missense probably damaging 1.00
R8487:Secisbp2l UTSW 2 125,617,502 (GRCm39) nonsense probably null
R8784:Secisbp2l UTSW 2 125,602,263 (GRCm39) nonsense probably null
R8810:Secisbp2l UTSW 2 125,617,596 (GRCm39) missense possibly damaging 0.82
R8872:Secisbp2l UTSW 2 125,594,892 (GRCm39) missense probably benign
R9111:Secisbp2l UTSW 2 125,602,206 (GRCm39) missense probably benign
R9154:Secisbp2l UTSW 2 125,617,623 (GRCm39) missense probably damaging 1.00
R9155:Secisbp2l UTSW 2 125,617,623 (GRCm39) missense probably damaging 1.00
R9589:Secisbp2l UTSW 2 125,589,430 (GRCm39) missense probably damaging 1.00
R9589:Secisbp2l UTSW 2 125,589,425 (GRCm39) missense probably benign 0.03
R9592:Secisbp2l UTSW 2 125,582,561 (GRCm39) missense probably damaging 1.00
R9602:Secisbp2l UTSW 2 125,609,356 (GRCm39) missense probably benign 0.19
R9620:Secisbp2l UTSW 2 125,589,394 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- TGTGCAACTGCTACTGGAG -3'
(R):5'- AGACGTGCCGTATTTGCTTG -3'

Sequencing Primer
(F):5'- AACTGCTACTGGAGGCGCAG -3'
(R):5'- AGTTTGATTGTGACTCTTAGCACTC -3'
Posted On 2015-05-15