Incidental Mutation 'R4077:Zfp777'
ID 316618
Institutional Source Beutler Lab
Gene Symbol Zfp777
Ensembl Gene ENSMUSG00000071477
Gene Name zinc finger protein 777
Synonyms 2500002G23Rik
MMRRC Submission 041622-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.837) question?
Stock # R4077 (G1)
Quality Score 225
Status Validated
Chromosome 6
Chromosomal Location 48001122-48025845 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 48002456 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Glycine at position 589 (S589G)
Ref Sequence ENSEMBL: ENSMUSP00000110230 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000095944] [ENSMUST00000114583]
AlphaFold B9EKF4
Predicted Effect probably benign
Transcript: ENSMUST00000095944
AA Change: S545G

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000093637
Gene: ENSMUSG00000071477
AA Change: S545G

DomainStartEndE-ValueType
Pfam:DUF3669 177 256 4.3e-12 PFAM
KRAB 284 344 1.6e-29 SMART
low complexity region 422 433 N/A INTRINSIC
coiled coil region 454 477 N/A INTRINSIC
low complexity region 489 505 N/A INTRINSIC
low complexity region 520 532 N/A INTRINSIC
low complexity region 539 555 N/A INTRINSIC
ZnF_C2H2 557 579 1.2e-5 SMART
ZnF_C2H2 585 607 3.8e-5 SMART
ZnF_C2H2 646 668 1.1e-6 SMART
ZnF_C2H2 674 696 4.6e-6 SMART
ZnF_C2H2 704 726 3.2e-7 SMART
ZnF_C2H2 732 754 3.3e-6 SMART
ZnF_C2H2 760 782 8.4e-6 SMART
ZnF_C2H2 788 810 4.9e-5 SMART
ZnF_C2H2 816 838 1.1e-4 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000114583
AA Change: S589G

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000110230
Gene: ENSMUSG00000071477
AA Change: S589G

DomainStartEndE-ValueType
low complexity region 2 24 N/A INTRINSIC
Pfam:DUF3669 231 298 4.7e-12 PFAM
KRAB 328 388 3.96e-27 SMART
low complexity region 466 477 N/A INTRINSIC
coiled coil region 498 521 N/A INTRINSIC
low complexity region 533 549 N/A INTRINSIC
low complexity region 564 576 N/A INTRINSIC
low complexity region 583 599 N/A INTRINSIC
ZnF_C2H2 601 623 2.95e-3 SMART
ZnF_C2H2 629 651 8.94e-3 SMART
ZnF_C2H2 690 712 2.43e-4 SMART
ZnF_C2H2 718 740 1.12e-3 SMART
ZnF_C2H2 748 770 7.49e-5 SMART
ZnF_C2H2 776 798 7.9e-4 SMART
ZnF_C2H2 804 826 1.95e-3 SMART
ZnF_C2H2 832 854 1.18e-2 SMART
ZnF_C2H2 860 882 2.53e-2 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000148362
SMART Domains Protein: ENSMUSP00000116303
Gene: ENSMUSG00000071477

DomainStartEndE-ValueType
Pfam:DUF3669 40 107 6.1e-13 PFAM
KRAB 137 197 3.96e-27 SMART
Meta Mutation Damage Score 0.0711 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.8%
Validation Efficiency 99% (81/82)
Allele List at MGI
Other mutations in this stock
Total: 71 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abhd12 T A 2: 150,690,379 (GRCm39) probably null Het
Adam33 T C 2: 130,905,444 (GRCm39) probably benign Het
Adrm1b A C 3: 92,336,195 (GRCm39) probably benign Het
Akap8 C T 17: 32,531,272 (GRCm39) R380Q probably damaging Het
Arhgef12 T C 9: 42,886,588 (GRCm39) M1131V probably damaging Het
Atrn T C 2: 130,806,850 (GRCm39) probably null Het
Btaf1 A G 19: 36,963,879 (GRCm39) T817A probably benign Het
C3 C T 17: 57,512,303 (GRCm39) D1542N possibly damaging Het
Cadm3 A G 1: 173,169,236 (GRCm39) V293A probably benign Het
Cdk11b C T 4: 155,724,204 (GRCm39) probably benign Het
Cdnf A G 2: 3,522,060 (GRCm39) Y84C probably damaging Het
Chdh T C 14: 29,757,297 (GRCm39) S407P probably damaging Het
Cmtr1 C A 17: 29,904,949 (GRCm39) T300K probably damaging Het
Dennd2d A T 3: 106,389,939 (GRCm39) probably benign Het
Diaph1 T A 18: 37,986,636 (GRCm39) E1116D possibly damaging Het
Eif1ad3 A G 12: 87,843,401 (GRCm39) K16R unknown Het
Eif1ad3 A T 12: 87,843,710 (GRCm39) D119V possibly damaging Het
Enpp1 A G 10: 24,544,905 (GRCm39) probably null Het
Erbb4 T C 1: 68,079,496 (GRCm39) T1195A probably benign Het
Ermard T A 17: 15,273,638 (GRCm39) S408T probably benign Het
Etl4 A T 2: 20,812,772 (GRCm39) R1442S probably damaging Het
F13b T A 1: 139,429,508 (GRCm39) F9I unknown Het
Fnbp4 C T 2: 90,588,821 (GRCm39) R531* probably null Het
Gdf6 A G 4: 9,844,776 (GRCm39) Y100C probably damaging Het
Gpr3 T C 4: 132,938,226 (GRCm39) T149A probably damaging Het
Grm8 T C 6: 27,760,208 (GRCm39) H374R probably benign Het
Hbs1l T C 10: 21,228,501 (GRCm39) V493A probably damaging Het
Hgs A G 11: 120,368,202 (GRCm39) K277E probably damaging Het
Hnrnpul1 C T 7: 25,426,300 (GRCm39) R517Q probably damaging Het
Hoxa11 A T 6: 52,222,504 (GRCm39) Y66N probably damaging Het
Hsh2d G A 8: 72,954,304 (GRCm39) D229N probably benign Het
Igdcc4 T A 9: 65,039,047 (GRCm39) L944Q probably damaging Het
Ighv3-1 C A 12: 113,928,107 (GRCm39) S84I probably damaging Het
Iqgap2 T C 13: 95,794,375 (GRCm39) D1199G probably damaging Het
Kcnk10 A T 12: 98,401,205 (GRCm39) M490K probably benign Het
Kirrel1 A G 3: 86,992,387 (GRCm39) probably null Het
Lias A T 5: 65,552,768 (GRCm39) T124S probably benign Het
Lrig3 A C 10: 125,845,656 (GRCm39) E695A probably damaging Het
Lrpap1 A G 5: 35,253,381 (GRCm39) I261T possibly damaging Het
Lrrc37a T A 11: 103,388,808 (GRCm39) T2206S unknown Het
Macf1 T A 4: 123,365,884 (GRCm39) Q2959L probably benign Het
Mis12 A G 11: 70,916,134 (GRCm39) T56A probably benign Het
Or10ag56 T A 2: 87,139,208 (GRCm39) M25K probably null Het
Or1l4 T A 2: 37,092,024 (GRCm39) I257N possibly damaging Het
Or4k41 A G 2: 111,279,848 (GRCm39) D121G probably damaging Het
Or5b99 T C 19: 12,977,235 (GRCm39) V295A probably damaging Het
Otof A T 5: 30,576,850 (GRCm39) L134Q possibly damaging Het
Pds5b T A 5: 150,717,824 (GRCm39) V1155E possibly damaging Het
Pdss2 A T 10: 43,278,518 (GRCm39) M342L probably benign Het
Phyhipl C T 10: 70,404,903 (GRCm39) V57I probably damaging Het
Plekha5 T A 6: 140,501,647 (GRCm39) probably null Het
Pnck A T X: 72,701,761 (GRCm39) V93E probably damaging Het
Proser1 A G 3: 53,385,962 (GRCm39) T615A probably damaging Het
Ptprk G A 10: 28,139,508 (GRCm39) V78I probably benign Het
Ptprv A G 1: 135,038,168 (GRCm39) noncoding transcript Het
Ranbp3l A G 15: 9,060,838 (GRCm39) N233S probably damaging Het
Rassf2 G A 2: 131,854,522 (GRCm39) P7S probably benign Het
Sart1 A T 19: 5,432,771 (GRCm39) L521Q possibly damaging Het
Scgb1b21 T A 7: 33,227,118 (GRCm39) noncoding transcript Het
Scyl2 A T 10: 89,476,458 (GRCm39) M889K probably benign Het
Secisbp2l A G 2: 125,593,785 (GRCm39) probably benign Het
Svil A G 18: 5,063,522 (GRCm39) E931G probably benign Het
Syce1 C A 7: 140,359,809 (GRCm39) L83F probably damaging Het
Tdrd1 A G 19: 56,819,505 (GRCm39) M2V probably benign Het
Tjp2 A T 19: 24,086,182 (GRCm39) V780E possibly damaging Het
Tram1 A G 1: 13,636,599 (GRCm39) V358A probably benign Het
Unc13c C T 9: 73,643,821 (GRCm39) W1214* probably null Het
Vps13b T C 15: 35,455,274 (GRCm39) C728R probably damaging Het
Wwox A G 8: 115,166,481 (GRCm39) probably benign Het
Zbtb41 G A 1: 139,357,064 (GRCm39) V440I probably benign Het
Zfp955a A G 17: 33,460,675 (GRCm39) Y486H probably benign Het
Other mutations in Zfp777
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01530:Zfp777 APN 6 48,020,918 (GRCm39) missense probably damaging 1.00
IGL01916:Zfp777 APN 6 48,002,276 (GRCm39) missense probably damaging 1.00
IGL01959:Zfp777 APN 6 48,021,275 (GRCm39) missense probably benign
IGL02167:Zfp777 APN 6 48,021,460 (GRCm39) missense probably damaging 0.98
IGL03150:Zfp777 APN 6 48,021,059 (GRCm39) missense probably damaging 1.00
R0238:Zfp777 UTSW 6 48,001,903 (GRCm39) missense probably damaging 0.99
R0238:Zfp777 UTSW 6 48,001,903 (GRCm39) missense probably damaging 0.99
R0372:Zfp777 UTSW 6 48,021,410 (GRCm39) missense possibly damaging 0.62
R0762:Zfp777 UTSW 6 48,006,294 (GRCm39) missense probably damaging 1.00
R1300:Zfp777 UTSW 6 48,002,704 (GRCm39) missense probably benign 0.43
R1727:Zfp777 UTSW 6 48,020,824 (GRCm39) missense probably damaging 0.99
R1906:Zfp777 UTSW 6 48,018,995 (GRCm39) missense probably damaging 0.99
R2047:Zfp777 UTSW 6 48,021,280 (GRCm39) missense probably benign
R2097:Zfp777 UTSW 6 48,021,176 (GRCm39) missense probably benign 0.08
R2211:Zfp777 UTSW 6 48,020,819 (GRCm39) missense possibly damaging 0.79
R2898:Zfp777 UTSW 6 48,002,594 (GRCm39) missense probably damaging 0.97
R3123:Zfp777 UTSW 6 48,006,050 (GRCm39) unclassified probably benign
R3832:Zfp777 UTSW 6 48,021,149 (GRCm39) missense probably benign 0.00
R4019:Zfp777 UTSW 6 48,019,046 (GRCm39) missense probably damaging 1.00
R4471:Zfp777 UTSW 6 48,019,041 (GRCm39) missense probably damaging 1.00
R5021:Zfp777 UTSW 6 48,019,061 (GRCm39) missense probably damaging 0.99
R5030:Zfp777 UTSW 6 48,014,601 (GRCm39) missense probably damaging 0.99
R5819:Zfp777 UTSW 6 48,014,522 (GRCm39) missense probably damaging 0.99
R6544:Zfp777 UTSW 6 48,021,419 (GRCm39) missense probably damaging 0.98
R6736:Zfp777 UTSW 6 48,001,790 (GRCm39) missense probably damaging 0.99
R6971:Zfp777 UTSW 6 48,001,625 (GRCm39) missense probably damaging 1.00
R7240:Zfp777 UTSW 6 48,021,383 (GRCm39) missense probably benign 0.00
R7258:Zfp777 UTSW 6 48,002,731 (GRCm39) missense probably damaging 0.99
R7586:Zfp777 UTSW 6 48,006,152 (GRCm39) missense probably benign 0.33
R7833:Zfp777 UTSW 6 48,002,072 (GRCm39) missense probably damaging 0.99
R7947:Zfp777 UTSW 6 48,001,645 (GRCm39) missense probably damaging 1.00
R8136:Zfp777 UTSW 6 48,021,559 (GRCm39) missense probably benign 0.25
R8151:Zfp777 UTSW 6 48,006,075 (GRCm39) nonsense probably null
R8348:Zfp777 UTSW 6 48,006,101 (GRCm39) missense probably damaging 0.99
R8448:Zfp777 UTSW 6 48,006,101 (GRCm39) missense probably damaging 0.99
R8942:Zfp777 UTSW 6 48,006,125 (GRCm39) missense probably benign 0.25
R8983:Zfp777 UTSW 6 48,006,158 (GRCm39) missense probably damaging 1.00
R9205:Zfp777 UTSW 6 48,002,521 (GRCm39) missense probably benign 0.07
R9397:Zfp777 UTSW 6 48,021,190 (GRCm39) missense probably benign 0.00
R9562:Zfp777 UTSW 6 48,021,580 (GRCm39) missense possibly damaging 0.84
R9565:Zfp777 UTSW 6 48,021,580 (GRCm39) missense possibly damaging 0.84
RF008:Zfp777 UTSW 6 48,018,982 (GRCm39) nonsense probably null
Z1177:Zfp777 UTSW 6 48,002,168 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CTTGGGATTGAAGGCTGACC -3'
(R):5'- GAGGCCAGTATGTACCAGAC -3'

Sequencing Primer
(F):5'- ATAGCCGCTGCGTACCC -3'
(R):5'- GCACCCAGCATTCATGG -3'
Posted On 2015-05-15