Incidental Mutation 'R4077:Igdcc4'
ID 316627
Institutional Source Beutler Lab
Gene Symbol Igdcc4
Ensembl Gene ENSMUSG00000032816
Gene Name immunoglobulin superfamily, DCC subclass, member 4
Synonyms WI-18508, Nope, 9330155G14Rik, WI-16786
MMRRC Submission 041622-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.294) question?
Stock # R4077 (G1)
Quality Score 225
Status Validated
Chromosome 9
Chromosomal Location 65008768-65045222 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 65039047 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Glutamine at position 944 (L944Q)
Ref Sequence ENSEMBL: ENSMUSP00000076878 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000035499] [ENSMUST00000077696] [ENSMUST00000166273] [ENSMUST00000213533]
AlphaFold Q9EQS9
Predicted Effect probably damaging
Transcript: ENSMUST00000035499
AA Change: L898Q

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000045387
Gene: ENSMUSG00000032816
AA Change: L898Q

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
IG 40 139 5e0 SMART
IGc2 154 218 1.3e-11 SMART
IGc2 255 318 1.13e-11 SMART
low complexity region 322 335 N/A INTRINSIC
IGc2 346 411 1.34e-13 SMART
FN3 428 511 3.58e-12 SMART
FN3 526 610 9.54e-8 SMART
FN3 630 726 7.34e-9 SMART
FN3 750 832 1.05e-9 SMART
FN3 848 932 2.14e-10 SMART
low complexity region 958 978 N/A INTRINSIC
low complexity region 1085 1100 N/A INTRINSIC
low complexity region 1154 1168 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000077696
AA Change: L944Q

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000076878
Gene: ENSMUSG00000032816
AA Change: L944Q

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
IG 40 139 5e0 SMART
IGc2 154 218 1.3e-11 SMART
IGc2 255 458 7.02e-8 SMART
FN3 475 558 3.58e-12 SMART
FN3 573 656 1.1e-7 SMART
FN3 676 772 7.34e-9 SMART
FN3 796 878 1.05e-9 SMART
FN3 894 978 2.14e-10 SMART
low complexity region 1004 1024 N/A INTRINSIC
low complexity region 1131 1146 N/A INTRINSIC
low complexity region 1200 1214 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000166273
SMART Domains Protein: ENSMUSP00000132576
Gene: ENSMUSG00000032816

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
Blast:IG 40 83 3e-22 BLAST
low complexity region 142 156 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000213423
Predicted Effect probably damaging
Transcript: ENSMUST00000213533
AA Change: L897Q

PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000214978
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.8%
Validation Efficiency 99% (81/82)
Allele List at MGI
Other mutations in this stock
Total: 71 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abhd12 T A 2: 150,690,379 (GRCm39) probably null Het
Adam33 T C 2: 130,905,444 (GRCm39) probably benign Het
Adrm1b A C 3: 92,336,195 (GRCm39) probably benign Het
Akap8 C T 17: 32,531,272 (GRCm39) R380Q probably damaging Het
Arhgef12 T C 9: 42,886,588 (GRCm39) M1131V probably damaging Het
Atrn T C 2: 130,806,850 (GRCm39) probably null Het
Btaf1 A G 19: 36,963,879 (GRCm39) T817A probably benign Het
C3 C T 17: 57,512,303 (GRCm39) D1542N possibly damaging Het
Cadm3 A G 1: 173,169,236 (GRCm39) V293A probably benign Het
Cdk11b C T 4: 155,724,204 (GRCm39) probably benign Het
Cdnf A G 2: 3,522,060 (GRCm39) Y84C probably damaging Het
Chdh T C 14: 29,757,297 (GRCm39) S407P probably damaging Het
Cmtr1 C A 17: 29,904,949 (GRCm39) T300K probably damaging Het
Dennd2d A T 3: 106,389,939 (GRCm39) probably benign Het
Diaph1 T A 18: 37,986,636 (GRCm39) E1116D possibly damaging Het
Eif1ad3 A G 12: 87,843,401 (GRCm39) K16R unknown Het
Eif1ad3 A T 12: 87,843,710 (GRCm39) D119V possibly damaging Het
Enpp1 A G 10: 24,544,905 (GRCm39) probably null Het
Erbb4 T C 1: 68,079,496 (GRCm39) T1195A probably benign Het
Ermard T A 17: 15,273,638 (GRCm39) S408T probably benign Het
Etl4 A T 2: 20,812,772 (GRCm39) R1442S probably damaging Het
F13b T A 1: 139,429,508 (GRCm39) F9I unknown Het
Fnbp4 C T 2: 90,588,821 (GRCm39) R531* probably null Het
Gdf6 A G 4: 9,844,776 (GRCm39) Y100C probably damaging Het
Gpr3 T C 4: 132,938,226 (GRCm39) T149A probably damaging Het
Grm8 T C 6: 27,760,208 (GRCm39) H374R probably benign Het
Hbs1l T C 10: 21,228,501 (GRCm39) V493A probably damaging Het
Hgs A G 11: 120,368,202 (GRCm39) K277E probably damaging Het
Hnrnpul1 C T 7: 25,426,300 (GRCm39) R517Q probably damaging Het
Hoxa11 A T 6: 52,222,504 (GRCm39) Y66N probably damaging Het
Hsh2d G A 8: 72,954,304 (GRCm39) D229N probably benign Het
Ighv3-1 C A 12: 113,928,107 (GRCm39) S84I probably damaging Het
Iqgap2 T C 13: 95,794,375 (GRCm39) D1199G probably damaging Het
Kcnk10 A T 12: 98,401,205 (GRCm39) M490K probably benign Het
Kirrel1 A G 3: 86,992,387 (GRCm39) probably null Het
Lias A T 5: 65,552,768 (GRCm39) T124S probably benign Het
Lrig3 A C 10: 125,845,656 (GRCm39) E695A probably damaging Het
Lrpap1 A G 5: 35,253,381 (GRCm39) I261T possibly damaging Het
Lrrc37a T A 11: 103,388,808 (GRCm39) T2206S unknown Het
Macf1 T A 4: 123,365,884 (GRCm39) Q2959L probably benign Het
Mis12 A G 11: 70,916,134 (GRCm39) T56A probably benign Het
Or10ag56 T A 2: 87,139,208 (GRCm39) M25K probably null Het
Or1l4 T A 2: 37,092,024 (GRCm39) I257N possibly damaging Het
Or4k41 A G 2: 111,279,848 (GRCm39) D121G probably damaging Het
Or5b99 T C 19: 12,977,235 (GRCm39) V295A probably damaging Het
Otof A T 5: 30,576,850 (GRCm39) L134Q possibly damaging Het
Pds5b T A 5: 150,717,824 (GRCm39) V1155E possibly damaging Het
Pdss2 A T 10: 43,278,518 (GRCm39) M342L probably benign Het
Phyhipl C T 10: 70,404,903 (GRCm39) V57I probably damaging Het
Plekha5 T A 6: 140,501,647 (GRCm39) probably null Het
Pnck A T X: 72,701,761 (GRCm39) V93E probably damaging Het
Proser1 A G 3: 53,385,962 (GRCm39) T615A probably damaging Het
Ptprk G A 10: 28,139,508 (GRCm39) V78I probably benign Het
Ptprv A G 1: 135,038,168 (GRCm39) noncoding transcript Het
Ranbp3l A G 15: 9,060,838 (GRCm39) N233S probably damaging Het
Rassf2 G A 2: 131,854,522 (GRCm39) P7S probably benign Het
Sart1 A T 19: 5,432,771 (GRCm39) L521Q possibly damaging Het
Scgb1b21 T A 7: 33,227,118 (GRCm39) noncoding transcript Het
Scyl2 A T 10: 89,476,458 (GRCm39) M889K probably benign Het
Secisbp2l A G 2: 125,593,785 (GRCm39) probably benign Het
Svil A G 18: 5,063,522 (GRCm39) E931G probably benign Het
Syce1 C A 7: 140,359,809 (GRCm39) L83F probably damaging Het
Tdrd1 A G 19: 56,819,505 (GRCm39) M2V probably benign Het
Tjp2 A T 19: 24,086,182 (GRCm39) V780E possibly damaging Het
Tram1 A G 1: 13,636,599 (GRCm39) V358A probably benign Het
Unc13c C T 9: 73,643,821 (GRCm39) W1214* probably null Het
Vps13b T C 15: 35,455,274 (GRCm39) C728R probably damaging Het
Wwox A G 8: 115,166,481 (GRCm39) probably benign Het
Zbtb41 G A 1: 139,357,064 (GRCm39) V440I probably benign Het
Zfp777 T C 6: 48,002,456 (GRCm39) S589G probably benign Het
Zfp955a A G 17: 33,460,675 (GRCm39) Y486H probably benign Het
Other mutations in Igdcc4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01152:Igdcc4 APN 9 65,042,446 (GRCm39) missense probably damaging 1.00
IGL01285:Igdcc4 APN 9 65,031,273 (GRCm39) missense probably damaging 1.00
IGL01412:Igdcc4 APN 9 65,021,731 (GRCm39) splice site probably benign
IGL01485:Igdcc4 APN 9 65,029,889 (GRCm39) missense probably benign 0.02
IGL01552:Igdcc4 APN 9 65,029,784 (GRCm39) intron probably benign
IGL01651:Igdcc4 APN 9 65,031,394 (GRCm39) missense possibly damaging 0.63
IGL01751:Igdcc4 APN 9 65,039,014 (GRCm39) missense probably damaging 1.00
IGL02164:Igdcc4 APN 9 65,032,064 (GRCm39) splice site probably benign
IGL02468:Igdcc4 APN 9 65,034,114 (GRCm39) missense probably damaging 1.00
IGL02616:Igdcc4 APN 9 65,040,360 (GRCm39) missense probably damaging 1.00
IGL02685:Igdcc4 APN 9 65,041,107 (GRCm39) missense possibly damaging 0.81
IGL02734:Igdcc4 APN 9 65,038,738 (GRCm39) missense possibly damaging 0.47
IGL02893:Igdcc4 APN 9 65,040,353 (GRCm39) missense probably damaging 1.00
R0006:Igdcc4 UTSW 9 65,042,382 (GRCm39) splice site probably benign
R0583:Igdcc4 UTSW 9 65,029,095 (GRCm39) missense possibly damaging 0.85
R0939:Igdcc4 UTSW 9 65,038,755 (GRCm39) critical splice donor site probably null
R1075:Igdcc4 UTSW 9 65,038,932 (GRCm39) missense possibly damaging 0.90
R1110:Igdcc4 UTSW 9 65,034,208 (GRCm39) missense possibly damaging 0.91
R1183:Igdcc4 UTSW 9 65,029,182 (GRCm39) missense possibly damaging 0.91
R1318:Igdcc4 UTSW 9 65,040,972 (GRCm39) missense probably damaging 1.00
R1507:Igdcc4 UTSW 9 65,041,026 (GRCm39) missense probably damaging 1.00
R1548:Igdcc4 UTSW 9 65,042,509 (GRCm39) missense probably benign 0.08
R1640:Igdcc4 UTSW 9 65,030,077 (GRCm39) missense probably damaging 1.00
R1681:Igdcc4 UTSW 9 65,036,077 (GRCm39) missense probably damaging 1.00
R1687:Igdcc4 UTSW 9 65,038,945 (GRCm39) missense probably damaging 1.00
R1716:Igdcc4 UTSW 9 65,034,179 (GRCm39) missense probably damaging 1.00
R1964:Igdcc4 UTSW 9 65,030,051 (GRCm39) missense probably benign
R1996:Igdcc4 UTSW 9 65,029,101 (GRCm39) missense probably damaging 1.00
R2150:Igdcc4 UTSW 9 65,032,617 (GRCm39) missense possibly damaging 0.92
R2278:Igdcc4 UTSW 9 65,038,025 (GRCm39) missense probably damaging 1.00
R3085:Igdcc4 UTSW 9 65,039,340 (GRCm39) missense probably damaging 1.00
R4011:Igdcc4 UTSW 9 65,042,761 (GRCm39) missense probably benign
R4191:Igdcc4 UTSW 9 65,031,433 (GRCm39) missense probably benign 0.13
R4293:Igdcc4 UTSW 9 65,031,892 (GRCm39) critical splice acceptor site probably null
R4589:Igdcc4 UTSW 9 65,037,910 (GRCm39) missense probably damaging 1.00
R4931:Igdcc4 UTSW 9 65,031,297 (GRCm39) missense possibly damaging 0.66
R5093:Igdcc4 UTSW 9 65,030,039 (GRCm39) missense possibly damaging 0.51
R5106:Igdcc4 UTSW 9 65,031,983 (GRCm39) missense probably damaging 1.00
R5546:Igdcc4 UTSW 9 65,036,077 (GRCm39) missense probably damaging 1.00
R5634:Igdcc4 UTSW 9 65,041,828 (GRCm39) missense probably benign 0.18
R5810:Igdcc4 UTSW 9 65,035,977 (GRCm39) missense probably damaging 1.00
R6395:Igdcc4 UTSW 9 65,042,400 (GRCm39) missense probably damaging 1.00
R6475:Igdcc4 UTSW 9 65,027,603 (GRCm39) missense probably damaging 1.00
R6776:Igdcc4 UTSW 9 65,042,700 (GRCm39) missense probably benign 0.02
R6828:Igdcc4 UTSW 9 65,029,979 (GRCm39) missense probably benign
R6914:Igdcc4 UTSW 9 65,027,550 (GRCm39) missense probably benign 0.00
R6942:Igdcc4 UTSW 9 65,027,550 (GRCm39) missense probably benign 0.00
R7072:Igdcc4 UTSW 9 65,038,013 (GRCm39) missense probably damaging 1.00
R7234:Igdcc4 UTSW 9 65,042,750 (GRCm39) nonsense probably null
R7448:Igdcc4 UTSW 9 65,031,276 (GRCm39) missense possibly damaging 0.52
R7562:Igdcc4 UTSW 9 65,031,306 (GRCm39) missense probably damaging 1.00
R7607:Igdcc4 UTSW 9 65,041,040 (GRCm39) missense possibly damaging 0.85
R7734:Igdcc4 UTSW 9 65,039,035 (GRCm39) missense probably damaging 0.99
R7807:Igdcc4 UTSW 9 65,041,077 (GRCm39) missense probably benign 0.00
R7852:Igdcc4 UTSW 9 65,027,540 (GRCm39) missense probably benign 0.04
R7904:Igdcc4 UTSW 9 65,041,801 (GRCm39) missense probably benign 0.00
R8133:Igdcc4 UTSW 9 65,039,023 (GRCm39) missense possibly damaging 0.54
R8147:Igdcc4 UTSW 9 65,031,253 (GRCm39) missense probably benign 0.42
R8230:Igdcc4 UTSW 9 65,030,020 (GRCm39) missense probably damaging 1.00
R8822:Igdcc4 UTSW 9 65,031,298 (GRCm39) missense possibly damaging 0.50
R8846:Igdcc4 UTSW 9 65,037,898 (GRCm39) missense probably benign 0.12
R9250:Igdcc4 UTSW 9 65,038,932 (GRCm39) missense possibly damaging 0.90
R9613:Igdcc4 UTSW 9 65,027,522 (GRCm39) missense possibly damaging 0.87
R9681:Igdcc4 UTSW 9 65,041,858 (GRCm39) missense possibly damaging 0.89
Predicted Primers PCR Primer
(F):5'- TAGGGCTGTGTCTCTGACTCTC -3'
(R):5'- TGTCACTCTCTAGGCCATGG -3'

Sequencing Primer
(F):5'- GTGTCTCTGACTCTCCACCC -3'
(R):5'- CATGGACCTCTGCACTGAAGATG -3'
Posted On 2015-05-15