|Institutional Source||Beutler Lab|
|Gene Name||WAP four-disulfide core domain 1|
|Is this an essential gene?||Non essential (E-score: 0.000)|
|Stock #||R4080 (G1)|
|Chromosomal Location||119666365-119688222 bp(+) (GRCm38)|
|Type of Mutation||critical splice donor site (2 bp from exon)|
|DNA Base Change (assembly)||T to A at 119683793 bp|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000024107 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000024107] [ENSMUST00000212901]|
|Predicted Effect||probably null
|Coding Region Coverage||
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the WAP-type four disulfide core domain family. The WAP-type four-disulfide core domain contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. This gene is mapped to chromosome 16q24, an area of frequent loss of heterozygosity in cancers, including prostate, breast and hepatocellular cancers and Wilms' tumor. This gene is downregulated in many cancer types and may be involved in the inhibition of cell proliferation. The encoded protein may also play a role in the susceptibility of certain CD4 memory T cells to human immunodeficiency virus infection. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
PHENOTYPE: Homozygous mice for a null allele exhibit decreased susceptibility to influenza A virus infection and enhanced wound healing. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Wfdc1||
(F):5'- ACAGAGAGCTTTATTGTCCAGACAG -3'
(R):5'- AAGGACATGACTGCCCTGAG -3'
(F):5'- GAGCTTTATTGTCCAGACAGCAGTTC -3'
(R):5'- ACTGCCCTGAGCCCCTC -3'