Incidental Mutation 'R4080:Nktr'
ID 316824
Institutional Source Beutler Lab
Gene Symbol Nktr
Ensembl Gene ENSMUSG00000032525
Gene Name natural killer tumor recognition sequence
Synonyms 5330401F18Rik, D9Wsu172e
MMRRC Submission 040856-MU
Accession Numbers
Essential gene? Possibly essential (E-score: 0.541) question?
Stock # R4080 (G1)
Quality Score 225
Status Not validated
Chromosome 9
Chromosomal Location 121719169-121756843 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to C at 121741126 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Threonine to Proline at position 127 (T127P)
Ref Sequence ENSEMBL: ENSMUSP00000035112 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000035112] [ENSMUST00000182179] [ENSMUST00000182225] [ENSMUST00000182311] [ENSMUST00000182763] [ENSMUST00000183070]
AlphaFold P30415
Predicted Effect probably damaging
Transcript: ENSMUST00000035112
AA Change: T127P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000035112
Gene: ENSMUSG00000032525
AA Change: T127P

DomainStartEndE-ValueType
Pfam:Pro_isomerase 10 175 1.7e-48 PFAM
low complexity region 195 229 N/A INTRINSIC
low complexity region 277 294 N/A INTRINSIC
low complexity region 346 360 N/A INTRINSIC
low complexity region 427 459 N/A INTRINSIC
low complexity region 477 503 N/A INTRINSIC
low complexity region 509 565 N/A INTRINSIC
low complexity region 677 726 N/A INTRINSIC
low complexity region 736 749 N/A INTRINSIC
low complexity region 797 812 N/A INTRINSIC
low complexity region 900 914 N/A INTRINSIC
low complexity region 921 929 N/A INTRINSIC
low complexity region 948 958 N/A INTRINSIC
low complexity region 983 1003 N/A INTRINSIC
low complexity region 1189 1200 N/A INTRINSIC
low complexity region 1229 1236 N/A INTRINSIC
low complexity region 1316 1453 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000182086
Predicted Effect probably benign
Transcript: ENSMUST00000182179
SMART Domains Protein: ENSMUSP00000138437
Gene: ENSMUSG00000032525

DomainStartEndE-ValueType
Pfam:Pro_isomerase 10 103 1.9e-21 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000182225
AA Change: T127P

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000138168
Gene: ENSMUSG00000032525
AA Change: T127P

DomainStartEndE-ValueType
Pfam:Pro_isomerase 10 175 2.1e-47 PFAM
low complexity region 184 215 N/A INTRINSIC
low complexity region 252 269 N/A INTRINSIC
low complexity region 321 335 N/A INTRINSIC
low complexity region 402 434 N/A INTRINSIC
low complexity region 452 478 N/A INTRINSIC
low complexity region 484 540 N/A INTRINSIC
low complexity region 652 701 N/A INTRINSIC
low complexity region 711 724 N/A INTRINSIC
low complexity region 772 787 N/A INTRINSIC
low complexity region 875 889 N/A INTRINSIC
low complexity region 896 904 N/A INTRINSIC
low complexity region 923 933 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000182311
AA Change: T91P

PolyPhen 2 Score 0.991 (Sensitivity: 0.71; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000138690
Gene: ENSMUSG00000032525
AA Change: T91P

DomainStartEndE-ValueType
Pfam:Pro_isomerase 10 54 2.9e-8 PFAM
Pfam:Pro_isomerase 44 99 7.1e-13 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000182763
SMART Domains Protein: ENSMUSP00000138272
Gene: ENSMUSG00000032525

DomainStartEndE-ValueType
Pfam:Pro_isomerase 10 68 3.1e-9 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000182904
Predicted Effect probably benign
Transcript: ENSMUST00000183070
SMART Domains Protein: ENSMUSP00000138611
Gene: ENSMUSG00000032525

DomainStartEndE-ValueType
Pfam:Pro_isomerase 10 103 1.9e-21 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000216573
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.9%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a membrane-anchored protein with a hydrophobic amino terminal domain and a cyclophilin-like PPIase domain. It is present on the surface of natural killer cells and facilitates their binding to targets. Its expression is regulated by IL2 activation of the cells. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 67 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aass A T 6: 23,109,498 (GRCm38) D324E possibly damaging Het
Adam7 T C 14: 68,520,539 (GRCm38) T245A probably benign Het
Adgrf3 G A 5: 30,197,369 (GRCm38) Q554* probably null Het
Aim2 T C 1: 173,459,851 (GRCm38) probably null Het
Arhgef1 G T 7: 24,925,846 (GRCm38) D850Y probably damaging Het
Aspm C A 1: 139,470,755 (GRCm38) Q1024K probably damaging Het
C7 T C 15: 4,990,464 (GRCm38) S734G probably benign Het
Ccdc158 A T 5: 92,623,396 (GRCm38) S987T probably benign Het
Chrna2 C A 14: 66,143,424 (GRCm38) Y47* probably null Het
Chrna2 G T 14: 66,143,417 (GRCm38) G45V probably benign Het
Clec2g C A 6: 128,981,324 (GRCm38) Q117K probably damaging Het
Cntnap5a A G 1: 116,101,574 (GRCm38) S253G probably benign Het
Cttn T A 7: 144,457,724 (GRCm38) D116V probably damaging Het
Cyp2c40 A G 19: 39,802,529 (GRCm38) V286A probably benign Het
Dcbld2 T A 16: 58,465,373 (GRCm38) S632T probably damaging Het
Dscam A T 16: 96,683,772 (GRCm38) N1118K probably benign Het
Eif2a C T 3: 58,539,629 (GRCm38) T92M possibly damaging Het
Frmpd1 T A 4: 45,284,382 (GRCm38) C1068S probably benign Het
Fstl1 G A 16: 37,822,603 (GRCm38) V110I probably benign Het
Gpat2 T C 2: 127,433,622 (GRCm38) I465T probably damaging Het
Gpr137 C T 19: 6,940,423 (GRCm38) probably benign Het
Hgsnat A G 8: 25,946,343 (GRCm38) I561T probably benign Het
Ift74 T A 4: 94,652,912 (GRCm38) probably null Het
Ilf3 A G 9: 21,403,134 (GRCm38) probably null Het
Kcnh8 GAGACCAACGAGCAGCTGATGCTTCAGA GAGA 17: 52,725,906 (GRCm38) 74 probably benign Het
Klk14 G A 7: 43,692,077 (GRCm38) C51Y probably damaging Het
Lrrc41 C A 4: 116,080,546 (GRCm38) probably null Het
Myh11 C A 16: 14,224,059 (GRCm38) R700L possibly damaging Het
Myo16 A G 8: 10,562,240 (GRCm38) D1295G probably damaging Het
Myo5b A G 18: 74,740,488 (GRCm38) M1488V probably benign Het
Naip6 A T 13: 100,299,307 (GRCm38) Y903N probably damaging Het
Nek6 A G 2: 38,550,637 (GRCm38) H19R probably damaging Het
Noc4l A T 5: 110,649,872 (GRCm38) D335E probably benign Het
Nsd1 A G 13: 55,301,809 (GRCm38) D1993G probably damaging Het
Or1ad1 G A 11: 50,984,856 (GRCm38) D52N probably damaging Het
Or5h22 A T 16: 59,074,256 (GRCm38) F275I probably damaging Het
Pabpc2 A T 18: 39,775,530 (GRCm38) Q616L possibly damaging Het
Pcdhga4 A T 18: 37,685,779 (GRCm38) D127V probably damaging Het
Phrf1 T C 7: 141,259,720 (GRCm38) probably benign Het
Phtf2 T A 5: 20,813,296 (GRCm38) I16F probably damaging Het
Plekhg3 G T 12: 76,577,981 (GRCm38) R1200L probably benign Het
Plod3 G C 5: 136,988,146 (GRCm38) A50P probably benign Het
Prorp G T 12: 55,304,613 (GRCm38) V236F possibly damaging Het
Prss12 A G 3: 123,485,485 (GRCm38) N404D probably benign Het
Ptch2 C G 4: 117,111,206 (GRCm38) A926G probably damaging Het
Ptpa T C 2: 30,443,305 (GRCm38) F6L probably damaging Het
Reck T C 4: 43,942,293 (GRCm38) I853T possibly damaging Het
Reep6 G A 10: 80,330,162 (GRCm38) probably benign Het
Rex2 T A 4: 147,058,697 (GRCm38) S547R probably benign Het
Rgs22 C T 15: 36,107,076 (GRCm38) E55K probably damaging Het
Rtl6 T C 15: 84,557,001 (GRCm38) T65A possibly damaging Het
Scarb1 G T 5: 125,277,795 (GRCm38) P491Q probably damaging Het
Scfd1 A G 12: 51,431,519 (GRCm38) S505G probably benign Het
Scube1 T G 15: 83,608,747 (GRCm38) Q904P probably damaging Het
Sis T C 3: 72,921,184 (GRCm38) Y1186C probably damaging Het
Spta1 A G 1: 174,214,066 (GRCm38) D1334G probably benign Het
Spty2d1 T C 7: 46,998,581 (GRCm38) E200G probably damaging Het
Stard13 C A 5: 151,092,829 (GRCm38) probably null Het
Sybu T C 15: 44,718,943 (GRCm38) K95R probably damaging Het
Trappc9 T A 15: 72,941,947 (GRCm38) D488V probably damaging Het
Txk G A 5: 72,700,663 (GRCm38) P381S probably damaging Het
Ubr2 A T 17: 46,988,722 (GRCm38) M198K probably benign Het
Unc5a A T 13: 55,004,481 (GRCm38) T786S possibly damaging Het
Unc93b1 G A 19: 3,941,959 (GRCm38) R231Q probably damaging Het
Wfdc1 T A 8: 119,683,793 (GRCm38) probably null Het
Zfp667 T G 7: 6,305,106 (GRCm38) C258G possibly damaging Het
Zfr G A 15: 12,162,233 (GRCm38) R823H probably benign Het
Other mutations in Nktr
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01333:Nktr APN 9 121,731,564 (GRCm38) missense possibly damaging 0.94
IGL01402:Nktr APN 9 121,741,152 (GRCm38) splice site probably null
IGL01404:Nktr APN 9 121,741,152 (GRCm38) splice site probably null
IGL02945:Nktr APN 9 121,728,631 (GRCm38) missense probably damaging 1.00
IGL03334:Nktr APN 9 121,748,176 (GRCm38) missense probably benign 0.18
IGL03134:Nktr UTSW 9 121,746,466 (GRCm38) missense probably damaging 1.00
PIT4131001:Nktr UTSW 9 121,741,621 (GRCm38) missense probably damaging 1.00
R0010:Nktr UTSW 9 121,741,166 (GRCm38) splice site probably benign
R0158:Nktr UTSW 9 121,750,691 (GRCm38) unclassified probably benign
R0399:Nktr UTSW 9 121,731,484 (GRCm38) missense probably damaging 0.98
R0503:Nktr UTSW 9 121,750,740 (GRCm38) unclassified probably benign
R0585:Nktr UTSW 9 121,754,280 (GRCm38) utr 3 prime probably benign
R0606:Nktr UTSW 9 121,749,290 (GRCm38) unclassified probably benign
R1248:Nktr UTSW 9 121,727,370 (GRCm38) missense probably damaging 1.00
R1899:Nktr UTSW 9 121,748,866 (GRCm38) unclassified probably benign
R1912:Nktr UTSW 9 121,750,240 (GRCm38) unclassified probably benign
R2049:Nktr UTSW 9 121,741,694 (GRCm38) missense probably damaging 1.00
R2279:Nktr UTSW 9 121,731,537 (GRCm38) missense possibly damaging 0.93
R2912:Nktr UTSW 9 121,749,604 (GRCm38) unclassified probably benign
R2913:Nktr UTSW 9 121,749,604 (GRCm38) unclassified probably benign
R2914:Nktr UTSW 9 121,749,604 (GRCm38) unclassified probably benign
R3939:Nktr UTSW 9 121,749,069 (GRCm38) unclassified probably benign
R4471:Nktr UTSW 9 121,748,896 (GRCm38) unclassified probably benign
R4472:Nktr UTSW 9 121,748,896 (GRCm38) unclassified probably benign
R4506:Nktr UTSW 9 121,748,883 (GRCm38) unclassified probably benign
R4556:Nktr UTSW 9 121,741,123 (GRCm38) missense probably damaging 0.98
R4736:Nktr UTSW 9 121,749,739 (GRCm38) unclassified probably benign
R4749:Nktr UTSW 9 121,741,693 (GRCm38) missense probably damaging 1.00
R4943:Nktr UTSW 9 121,719,954 (GRCm38) intron probably benign
R5084:Nktr UTSW 9 121,748,110 (GRCm38) missense possibly damaging 0.86
R5250:Nktr UTSW 9 121,749,792 (GRCm38) unclassified probably benign
R5288:Nktr UTSW 9 121,748,593 (GRCm38) missense probably benign 0.23
R5324:Nktr UTSW 9 121,727,346 (GRCm38) missense probably damaging 1.00
R5330:Nktr UTSW 9 121,752,768 (GRCm38) intron probably benign
R5331:Nktr UTSW 9 121,752,768 (GRCm38) intron probably benign
R5502:Nktr UTSW 9 121,748,606 (GRCm38) unclassified probably benign
R5587:Nktr UTSW 9 121,748,489 (GRCm38) unclassified probably benign
R5664:Nktr UTSW 9 121,749,417 (GRCm38) nonsense probably null
R6005:Nktr UTSW 9 121,748,394 (GRCm38) unclassified probably benign
R6057:Nktr UTSW 9 121,748,389 (GRCm38) unclassified probably benign
R6083:Nktr UTSW 9 121,750,136 (GRCm38) unclassified probably benign
R6274:Nktr UTSW 9 121,731,565 (GRCm38) missense probably damaging 1.00
R6445:Nktr UTSW 9 121,748,414 (GRCm38) unclassified probably benign
R6467:Nktr UTSW 9 121,731,519 (GRCm38) missense probably damaging 1.00
R6911:Nktr UTSW 9 121,754,326 (GRCm38) nonsense probably null
R6960:Nktr UTSW 9 121,742,692 (GRCm38) missense probably damaging 0.99
R7226:Nktr UTSW 9 121,746,533 (GRCm38) missense probably damaging 0.99
R7324:Nktr UTSW 9 121,748,291 (GRCm38) missense possibly damaging 0.66
R7324:Nktr UTSW 9 121,727,361 (GRCm38) missense probably damaging 1.00
R7451:Nktr UTSW 9 121,729,656 (GRCm38) missense probably damaging 0.99
R7464:Nktr UTSW 9 121,750,327 (GRCm38) missense unknown
R7537:Nktr UTSW 9 121,749,279 (GRCm38) missense unknown
R8126:Nktr UTSW 9 121,746,448 (GRCm38) missense probably damaging 1.00
R8163:Nktr UTSW 9 121,750,863 (GRCm38) unclassified probably benign
R8812:Nktr UTSW 9 121,750,251 (GRCm38) missense unknown
R8829:Nktr UTSW 9 121,754,264 (GRCm38) missense unknown
R8945:Nktr UTSW 9 121,746,492 (GRCm38) missense possibly damaging 0.70
R9158:Nktr UTSW 9 121,753,088 (GRCm38) missense unknown
R9252:Nktr UTSW 9 121,750,349 (GRCm38) missense unknown
R9378:Nktr UTSW 9 121,748,198 (GRCm38) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TCCTCACATAATCCTGCTGGG -3'
(R):5'- CAGCTGCTGGCCATTTTAGG -3'

Sequencing Primer
(F):5'- AGTAAAATGGCTACTATTGGTGTTTG -3'
(R):5'- CTGCTAAGAGAGGACACTTCATACTG -3'
Posted On 2015-05-15