Incidental Mutation 'R4081:Vmn2r106'
| ID |
316902 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r106
|
| Ensembl Gene |
ENSMUSG00000091656 |
| Gene Name |
vomeronasal 2, receptor 106 |
| Synonyms |
EG224576 |
| MMRRC Submission |
040977-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.166)
|
| Stock # |
R4081 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
17 |
| Chromosomal Location |
20487809-20505692 bp(-) (GRCm39) |
| Type of Mutation |
nonsense |
| DNA Base Change (assembly) |
A to T
at 20487818 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Tyrosine to Stop codon
at position 860
(Y860*)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000126534
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000167464]
|
| AlphaFold |
E9PY92 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000167464
AA Change: Y860*
|
| SMART Domains |
Protein: ENSMUSP00000126534
Gene: ENSMUSG00000091656
AA Change: Y860*
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
83 |
471 |
3.8e-37 |
PFAM |
|
Pfam:NCD3G
|
514 |
567 |
5.7e-22 |
PFAM |
|
Pfam:7tm_3
|
596 |
835 |
1.3e-49 |
PFAM |
|
| Meta Mutation Damage Score |
0.9755 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.7%
- 10x: 97.5%
- 20x: 96.0%
|
| Validation Efficiency |
98% (58/59) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 51 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Aass |
A |
T |
6: 23,109,497 (GRCm39) |
D324E |
possibly damaging |
Het |
| Adad1 |
A |
G |
3: 37,118,512 (GRCm39) |
|
probably null |
Het |
| Aim2 |
T |
C |
1: 173,287,417 (GRCm39) |
|
probably null |
Het |
| Arhgef1 |
G |
T |
7: 24,625,271 (GRCm39) |
D850Y |
probably damaging |
Het |
| Ccnf |
T |
C |
17: 24,442,872 (GRCm39) |
*778W |
probably null |
Het |
| Cd53 |
T |
C |
3: 106,669,461 (GRCm39) |
H179R |
probably benign |
Het |
| Cit |
G |
T |
5: 116,086,109 (GRCm39) |
R891L |
probably damaging |
Het |
| Clec4b1 |
T |
C |
6: 123,046,733 (GRCm39) |
|
probably null |
Het |
| Cntrl |
C |
A |
2: 35,051,938 (GRCm39) |
|
probably benign |
Het |
| Cntrl |
A |
G |
2: 35,065,137 (GRCm39) |
D2148G |
probably damaging |
Het |
| Cpa5 |
T |
C |
6: 30,631,228 (GRCm39) |
S381P |
probably benign |
Het |
| Crybg1 |
A |
T |
10: 43,851,035 (GRCm39) |
V1612D |
probably damaging |
Het |
| Cwc25 |
G |
T |
11: 97,644,744 (GRCm39) |
Q205K |
probably benign |
Het |
| Cyp2d11 |
A |
T |
15: 82,276,002 (GRCm39) |
I193N |
possibly damaging |
Het |
| Gdi2 |
T |
A |
13: 3,598,866 (GRCm39) |
C17S |
probably benign |
Het |
| Gm5436 |
T |
A |
12: 84,305,489 (GRCm39) |
|
noncoding transcript |
Het |
| Ifit1bl1 |
T |
C |
19: 34,572,040 (GRCm39) |
Y139C |
possibly damaging |
Het |
| Insr |
A |
T |
8: 3,261,391 (GRCm39) |
M321K |
probably benign |
Het |
| Ippk |
T |
A |
13: 49,599,852 (GRCm39) |
L237Q |
probably damaging |
Het |
| Itpr1 |
T |
A |
6: 108,368,796 (GRCm39) |
I149N |
probably damaging |
Het |
| Kcnh8 |
GAGACCAACGAGCAGCTGATGCTTCAGA |
GAGA |
17: 53,032,934 (GRCm39) |
74 |
probably benign |
Het |
| Klk14 |
G |
A |
7: 43,341,501 (GRCm39) |
C51Y |
probably damaging |
Het |
| Lrp2 |
T |
A |
2: 69,343,617 (GRCm39) |
H914L |
probably damaging |
Het |
| Myd88 |
G |
T |
9: 119,169,053 (GRCm39) |
|
probably benign |
Het |
| Myh2 |
T |
C |
11: 67,081,256 (GRCm39) |
S1291P |
probably benign |
Het |
| Mylk3 |
G |
A |
8: 86,055,311 (GRCm39) |
L549F |
probably damaging |
Het |
| Otog |
T |
C |
7: 45,937,723 (GRCm39) |
S1811P |
possibly damaging |
Het |
| Phrf1 |
T |
C |
7: 140,838,970 (GRCm39) |
|
probably benign |
Het |
| Plod3 |
G |
C |
5: 137,017,000 (GRCm39) |
A50P |
probably benign |
Het |
| Prorp |
G |
T |
12: 55,351,398 (GRCm39) |
V236F |
possibly damaging |
Het |
| Ptprh |
T |
A |
7: 4,583,987 (GRCm39) |
T202S |
probably damaging |
Het |
| Ptprr |
A |
T |
10: 116,072,615 (GRCm39) |
K329N |
probably benign |
Het |
| Rgl3 |
T |
A |
9: 21,898,971 (GRCm39) |
H156L |
possibly damaging |
Het |
| Sema6b |
A |
G |
17: 56,435,307 (GRCm39) |
V312A |
probably damaging |
Het |
| Sez6l |
T |
C |
5: 112,609,032 (GRCm39) |
I606V |
probably benign |
Het |
| Slco1a1 |
T |
C |
6: 141,881,688 (GRCm39) |
E148G |
probably damaging |
Het |
| Snph |
T |
C |
2: 151,435,722 (GRCm39) |
D402G |
probably damaging |
Het |
| Sohlh1 |
A |
G |
2: 25,735,734 (GRCm39) |
V135A |
probably benign |
Het |
| Sox14 |
T |
C |
9: 99,757,277 (GRCm39) |
E154G |
possibly damaging |
Het |
| Spta1 |
A |
G |
1: 174,041,632 (GRCm39) |
D1334G |
probably benign |
Het |
| Stard13 |
C |
A |
5: 151,016,294 (GRCm39) |
|
probably null |
Het |
| Szt2 |
A |
G |
4: 118,230,764 (GRCm39) |
|
probably benign |
Het |
| Tab2 |
G |
A |
10: 7,795,595 (GRCm39) |
P296S |
probably damaging |
Het |
| Tbx15 |
A |
G |
3: 99,220,370 (GRCm39) |
D48G |
possibly damaging |
Het |
| Tex10 |
T |
C |
4: 48,468,873 (GRCm39) |
S101G |
probably benign |
Het |
| Tex11 |
C |
A |
X: 99,977,021 (GRCm39) |
A487S |
possibly damaging |
Het |
| Tulp4 |
C |
T |
17: 6,282,055 (GRCm39) |
H695Y |
probably damaging |
Het |
| Vmn1r66 |
A |
G |
7: 10,008,733 (GRCm39) |
I100T |
probably damaging |
Het |
| Vwa3b |
C |
T |
1: 37,074,905 (GRCm39) |
T24I |
probably damaging |
Het |
| Zfp541 |
G |
A |
7: 15,806,060 (GRCm39) |
S65N |
probably benign |
Het |
| Zfp992 |
C |
T |
4: 146,551,976 (GRCm39) |
H566Y |
probably damaging |
Het |
|
| Other mutations in Vmn2r106 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00979:Vmn2r106
|
APN |
17 |
20,497,837 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
IGL01313:Vmn2r106
|
APN |
17 |
20,498,651 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01419:Vmn2r106
|
APN |
17 |
20,499,807 (GRCm39) |
missense |
probably benign |
0.06 |
|
IGL01574:Vmn2r106
|
APN |
17 |
20,488,572 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL01796:Vmn2r106
|
APN |
17 |
20,488,314 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
IGL01893:Vmn2r106
|
APN |
17 |
20,497,730 (GRCm39) |
missense |
probably benign |
0.06 |
|
IGL01895:Vmn2r106
|
APN |
17 |
20,499,227 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL02378:Vmn2r106
|
APN |
17 |
20,497,791 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02430:Vmn2r106
|
APN |
17 |
20,499,158 (GRCm39) |
missense |
probably benign |
0.38 |
|
IGL02664:Vmn2r106
|
APN |
17 |
20,488,344 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
IGL03308:Vmn2r106
|
APN |
17 |
20,498,785 (GRCm39) |
nonsense |
probably null |
|
|
IGL03384:Vmn2r106
|
APN |
17 |
20,488,405 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0401:Vmn2r106
|
UTSW |
17 |
20,499,281 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R0842:Vmn2r106
|
UTSW |
17 |
20,488,465 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0964:Vmn2r106
|
UTSW |
17 |
20,487,859 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1235:Vmn2r106
|
UTSW |
17 |
20,499,741 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1709:Vmn2r106
|
UTSW |
17 |
20,499,373 (GRCm39) |
missense |
probably benign |
0.12 |
|
R1712:Vmn2r106
|
UTSW |
17 |
20,498,997 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1770:Vmn2r106
|
UTSW |
17 |
20,488,560 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2049:Vmn2r106
|
UTSW |
17 |
20,488,566 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R2245:Vmn2r106
|
UTSW |
17 |
20,488,423 (GRCm39) |
missense |
probably benign |
0.13 |
|
R2336:Vmn2r106
|
UTSW |
17 |
20,488,470 (GRCm39) |
missense |
probably benign |
0.18 |
|
R2910:Vmn2r106
|
UTSW |
17 |
20,498,946 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3025:Vmn2r106
|
UTSW |
17 |
20,499,147 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3944:Vmn2r106
|
UTSW |
17 |
20,487,913 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4153:Vmn2r106
|
UTSW |
17 |
20,488,080 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4356:Vmn2r106
|
UTSW |
17 |
20,499,910 (GRCm39) |
missense |
probably benign |
0.06 |
|
R4426:Vmn2r106
|
UTSW |
17 |
20,505,641 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4590:Vmn2r106
|
UTSW |
17 |
20,497,728 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4661:Vmn2r106
|
UTSW |
17 |
20,487,885 (GRCm39) |
missense |
probably benign |
0.10 |
|
R5106:Vmn2r106
|
UTSW |
17 |
20,499,395 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R5341:Vmn2r106
|
UTSW |
17 |
20,497,788 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5509:Vmn2r106
|
UTSW |
17 |
20,498,684 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5826:Vmn2r106
|
UTSW |
17 |
20,499,133 (GRCm39) |
missense |
probably benign |
|
|
R5859:Vmn2r106
|
UTSW |
17 |
20,505,583 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R5937:Vmn2r106
|
UTSW |
17 |
20,505,667 (GRCm39) |
nonsense |
probably null |
|
|
R5972:Vmn2r106
|
UTSW |
17 |
20,498,738 (GRCm39) |
missense |
probably benign |
|
|
R6056:Vmn2r106
|
UTSW |
17 |
20,487,806 (GRCm39) |
splice site |
probably null |
|
|
R6108:Vmn2r106
|
UTSW |
17 |
20,488,638 (GRCm39) |
missense |
probably benign |
0.11 |
|
R6114:Vmn2r106
|
UTSW |
17 |
20,488,638 (GRCm39) |
missense |
probably benign |
0.11 |
|
R6115:Vmn2r106
|
UTSW |
17 |
20,488,638 (GRCm39) |
missense |
probably benign |
0.11 |
|
R6132:Vmn2r106
|
UTSW |
17 |
20,488,666 (GRCm39) |
missense |
probably benign |
|
|
R6208:Vmn2r106
|
UTSW |
17 |
20,488,591 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6217:Vmn2r106
|
UTSW |
17 |
20,488,501 (GRCm39) |
missense |
probably benign |
0.10 |
|
R6289:Vmn2r106
|
UTSW |
17 |
20,488,725 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6378:Vmn2r106
|
UTSW |
17 |
20,498,667 (GRCm39) |
missense |
probably benign |
0.19 |
|
R6390:Vmn2r106
|
UTSW |
17 |
20,488,725 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6391:Vmn2r106
|
UTSW |
17 |
20,488,725 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6392:Vmn2r106
|
UTSW |
17 |
20,488,725 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6405:Vmn2r106
|
UTSW |
17 |
20,499,361 (GRCm39) |
missense |
probably benign |
0.22 |
|
R6427:Vmn2r106
|
UTSW |
17 |
20,488,725 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6428:Vmn2r106
|
UTSW |
17 |
20,488,725 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6435:Vmn2r106
|
UTSW |
17 |
20,488,725 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6436:Vmn2r106
|
UTSW |
17 |
20,488,725 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6437:Vmn2r106
|
UTSW |
17 |
20,488,725 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6511:Vmn2r106
|
UTSW |
17 |
20,488,725 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6512:Vmn2r106
|
UTSW |
17 |
20,488,725 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6587:Vmn2r106
|
UTSW |
17 |
20,488,725 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6703:Vmn2r106
|
UTSW |
17 |
20,488,725 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6730:Vmn2r106
|
UTSW |
17 |
20,499,096 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R6961:Vmn2r106
|
UTSW |
17 |
20,488,646 (GRCm39) |
nonsense |
probably null |
|
|
R7054:Vmn2r106
|
UTSW |
17 |
20,499,182 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7379:Vmn2r106
|
UTSW |
17 |
20,488,037 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R7402:Vmn2r106
|
UTSW |
17 |
20,487,883 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7497:Vmn2r106
|
UTSW |
17 |
20,488,201 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7692:Vmn2r106
|
UTSW |
17 |
20,505,490 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R8539:Vmn2r106
|
UTSW |
17 |
20,499,271 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8827:Vmn2r106
|
UTSW |
17 |
20,487,868 (GRCm39) |
missense |
probably benign |
0.05 |
|
R8872:Vmn2r106
|
UTSW |
17 |
20,488,401 (GRCm39) |
missense |
probably benign |
0.19 |
|
R9118:Vmn2r106
|
UTSW |
17 |
20,505,667 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9254:Vmn2r106
|
UTSW |
17 |
20,496,066 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9379:Vmn2r106
|
UTSW |
17 |
20,496,066 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9571:Vmn2r106
|
UTSW |
17 |
20,505,641 (GRCm39) |
missense |
probably benign |
0.17 |
|
| Predicted Primers |
PCR Primer
(F):5'- CATAGACTTTTAAGGAGCCAGAAG -3'
(R):5'- TTTCAGTCTACCACAGCACC -3'
Sequencing Primer
(F):5'- CCAGAAGGCAGATGTGGTTTTAATAC -3'
(R):5'- CACAGCACCAAGGGGAAGTTC -3'
|
| Posted On |
2015-05-15 |
Incidental Mutation