Mutagenetix > Incidental Mutation

Incidental Mutation 'R4082:Vmn2r117'

316963

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r117

Ensembl Gene

ENSMUSG00000091407

Gene Name

vomeronasal 2, receptor 117

Synonyms

EG619788

MMRRC Submission

041624-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.087) question?

Stock #

R4082 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

23459675-23479597 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 23460106 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Valine to Isoleucine at position 715 (V715I)

Ref Sequence

ENSEMBL: ENSMUSP00000126885 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000171996]

AlphaFold

K7N6V1

Predicted Effect

probably benign
Transcript: ENSMUST00000171996
AA Change: V715I

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)

SMART Domains

Protein: ENSMUSP00000126885
Gene: ENSMUSG00000091407
AA Change: V715I

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	73	471	2.6e-28	PFAM
Pfam:NCD3G	512	565	5e-20	PFAM
Pfam:7tm_3	595	833	8.2e-54	PFAM

Coding Region Coverage

1x: 99.2%
3x: 98.6%
10x: 97.3%
20x: 95.4%

Validation Efficiency

99% (73/74)

Allele List at MGI

Other mutations in this stock

Total: 65 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1110008L16Rik	G	T	12: 55,304,613	V236F	possibly damaging	Het
1700021P04Rik	T	G	19: 24,066,002		noncoding transcript	Het
a	A	T	2: 155,045,758	D46V	probably damaging	Het
Aass	A	T	6: 23,109,498	D324E	possibly damaging	Het
Abca12	G	T	1: 71,267,463	T2028K	possibly damaging	Het
Abt1	T	C	13: 23,422,146	T213A	probably benign	Het
Adcy1	A	C	11: 7,064,117	Y173S	probably damaging	Het
Aim2	T	C	1: 173,459,851		probably null	Het
Akr1d1	G	A	6: 37,557,489	V193M	probably damaging	Het
Cars	C	T	7: 143,569,497	E461K	probably damaging	Het
Ccdc80	T	C	16: 45,122,927	L800P	probably damaging	Het
Ccl22	A	G	8: 94,746,908	Y27C	probably damaging	Het
Cdc123	G	A	2: 5,810,755		probably benign	Het
Cldn11	A	T	3: 31,163,129	I149F	probably benign	Het
Col14a1	T	C	15: 55,437,033	Y986H	unknown	Het
Col6a3	G	A	1: 90,821,883	L410F	probably damaging	Het
Crocc	T	C	4: 141,033,971		probably null	Het
Cubn	A	G	2: 13,428,563		probably benign	Het
Cwc25	G	T	11: 97,753,918	Q205K	probably benign	Het
Cyp2e1	T	C	7: 140,771,078	I321T	possibly damaging	Het
Eps8l1	T	A	7: 4,470,798		probably null	Het
Fasl	C	T	1: 161,781,851	V189M	probably damaging	Het
Fbxw5	T	C	2: 25,504,631		probably null	Het
Flg2	A	C	3: 93,203,521	E952A	unknown	Het
Gpd1l	A	T	9: 114,917,078	L90Q	probably damaging	Het
Grik4	G	T	9: 42,597,884	F414L	probably benign	Het
Kcnh8	GAGACCAACGAGCAGCTGATGCTTCAGA	GAGA	17: 52,725,906	74	probably benign	Het
Klhl3	C	T	13: 58,018,797	G407S	probably null	Het
Lmbr1	T	C	5: 29,258,755	E157G	probably damaging	Het
Lrp2	T	A	2: 69,513,273	H914L	probably damaging	Het
Mrpl20	A	T	4: 155,808,513	D67V	probably damaging	Het
Myo15	A	G	11: 60,487,196	T1346A	possibly damaging	Het
Naip5	A	T	13: 100,245,830	C124S	probably damaging	Het
Olfr1123	T	A	2: 87,418,457	Y134*	probably null	Het
Olfr654	T	A	7: 104,588,623	V290D	probably damaging	Het
Olfr702	T	C	7: 106,824,038	T163A	possibly damaging	Het
Osbp	A	G	19: 11,978,666	D385G	probably benign	Het
Paip1	G	A	13: 119,457,004	D460N	probably damaging	Het
Pde3b	T	C	7: 114,494,588	S356P	probably benign	Het
Pms2	A	G	5: 143,931,019	M814V	probably damaging	Het
Polg	C	A	7: 79,464,828	K128N	probably damaging	Het
Polk	G	T	13: 96,483,673	T694K	probably benign	Het
Pom121	T	C	5: 135,388,637	K342R	unknown	Het
Pou5f2	T	C	13: 78,025,905	L322P	probably damaging	Het
Ptpn6	T	C	6: 124,728,419	D183G	probably damaging	Het
Pygb	G	A	2: 150,826,471		probably null	Het
Ralgds	C	T	2: 28,552,271		probably benign	Het
Ret	T	C	6: 118,153,966	T1079A	possibly damaging	Het
Rspo2	A	C	15: 43,022,537	V241G	probably benign	Het
Smg1	T	A	7: 118,160,246		probably benign	Het
Snph	T	C	2: 151,593,802	D402G	probably damaging	Het
Spta1	A	G	1: 174,214,066	D1334G	probably benign	Het
Stard13	C	A	5: 151,092,829		probably null	Het
Sufu	A	G	19: 46,425,102	M141V	probably damaging	Het
Sytl2	T	A	7: 90,408,427	V831D	possibly damaging	Het
Tc2n	T	C	12: 101,651,155	E335G	possibly damaging	Het
Tex11	C	A	X: 100,933,415	A487S	possibly damaging	Het
Tmcc1	T	A	6: 116,043,480	H118L	probably damaging	Het
Tulp4	C	T	17: 6,231,780	H695Y	probably damaging	Het
Vmn1r209	A	C	13: 22,805,615	L302V	probably null	Het
Vopp1	A	T	6: 57,789,979	Y37*	probably null	Het
Xrn1	A	G	9: 95,981,920	T528A	probably benign	Het
Zfhx2	T	C	14: 55,065,205	D1774G	probably benign	Het
Zfp955b	T	A	17: 33,302,155	D199E	probably benign	Het
Zp2	T	C	7: 120,135,252	S525G	probably benign	Het

Other mutations in Vmn2r117

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00990:Vmn2r117	APN	17	23477840	missense	probably damaging	1.00
IGL00990:Vmn2r117	APN	17	23475429	missense	probably damaging	1.00
IGL00990:Vmn2r117	APN	17	23479546	missense	probably benign
IGL01078:Vmn2r117	APN	17	23477804	missense	probably damaging	1.00
IGL01139:Vmn2r117	APN	17	23477804	missense	probably damaging	1.00
IGL01374:Vmn2r117	APN	17	23478382	missense	possibly damaging	0.46
IGL01779:Vmn2r117	APN	17	23477241	missense	probably benign	0.00
IGL02283:Vmn2r117	APN	17	23475382	missense	probably damaging	0.99
IGL02527:Vmn2r117	APN	17	23477225	missense	possibly damaging	0.65
IGL02612:Vmn2r117	APN	17	23459784	missense	possibly damaging	0.91
IGL02887:Vmn2r117	APN	17	23475578	splice site	probably benign
IGL03167:Vmn2r117	APN	17	23477707	missense	probably damaging	1.00
R0315:Vmn2r117	UTSW	17	23460165	missense	probably benign	0.11
R0610:Vmn2r117	UTSW	17	23475514	missense	probably benign	0.00
R0747:Vmn2r117	UTSW	17	23475503	nonsense	probably null
R1411:Vmn2r117	UTSW	17	23460553	missense	probably damaging	1.00
R1471:Vmn2r117	UTSW	17	23478473	missense	probably benign	0.00
R1853:Vmn2r117	UTSW	17	23477455	missense	probably damaging	0.99
R1925:Vmn2r117	UTSW	17	23478389	missense	probably benign	0.00
R1940:Vmn2r117	UTSW	17	23477480	missense	probably damaging	1.00
R2005:Vmn2r117	UTSW	17	23477644	missense	probably damaging	1.00
R2082:Vmn2r117	UTSW	17	23460256	missense	possibly damaging	0.55
R2698:Vmn2r117	UTSW	17	23459911	missense	probably damaging	0.98
R2972:Vmn2r117	UTSW	17	23459856	missense	probably damaging	1.00
R2973:Vmn2r117	UTSW	17	23459856	missense	probably damaging	1.00
R2974:Vmn2r117	UTSW	17	23459856	missense	probably damaging	1.00
R3160:Vmn2r117	UTSW	17	23460378	missense	probably damaging	1.00
R3161:Vmn2r117	UTSW	17	23460378	missense	probably damaging	1.00
R3162:Vmn2r117	UTSW	17	23460378	missense	probably damaging	1.00
R3847:Vmn2r117	UTSW	17	23460415	missense	probably damaging	0.97
R3848:Vmn2r117	UTSW	17	23460415	missense	probably damaging	0.97
R4320:Vmn2r117	UTSW	17	23479513	frame shift	probably null
R4560:Vmn2r117	UTSW	17	23459877	missense	probably damaging	1.00
R4658:Vmn2r117	UTSW	17	23478416	missense	probably benign	0.01
R4881:Vmn2r117	UTSW	17	23477885	missense	probably damaging	1.00
R4908:Vmn2r117	UTSW	17	23459838	missense	probably damaging	1.00
R4910:Vmn2r117	UTSW	17	23479513	frame shift	probably null
R5078:Vmn2r117	UTSW	17	23460148	missense	probably damaging	1.00
R5327:Vmn2r117	UTSW	17	23477874	nonsense	probably null
R5774:Vmn2r117	UTSW	17	23477202	missense	probably damaging	0.98
R6014:Vmn2r117	UTSW	17	23479561	missense	probably damaging	0.97
R6390:Vmn2r117	UTSW	17	23460114	missense	possibly damaging	0.95
R6520:Vmn2r117	UTSW	17	23460219	missense	probably damaging	0.99
R6674:Vmn2r117	UTSW	17	23460049	nonsense	probably null
R6736:Vmn2r117	UTSW	17	23478308	missense	probably damaging	0.99
R6909:Vmn2r117	UTSW	17	23479505	missense	possibly damaging	0.67
R6913:Vmn2r117	UTSW	17	23479563	missense	probably damaging	0.99
R7220:Vmn2r117	UTSW	17	23477203	missense	probably damaging	1.00
R7260:Vmn2r117	UTSW	17	23475385	missense	probably benign	0.06
R7440:Vmn2r117	UTSW	17	23475565	missense	probably benign	0.26
R7443:Vmn2r117	UTSW	17	23460133	missense	probably benign	0.25
R7443:Vmn2r117	UTSW	17	23460345	missense	probably damaging	1.00
R7449:Vmn2r117	UTSW	17	23459895	missense	probably damaging	1.00
R7644:Vmn2r117	UTSW	17	23477291	missense	probably damaging	0.98
R7914:Vmn2r117	UTSW	17	23460126	missense	possibly damaging	0.95
R8001:Vmn2r117	UTSW	17	23479407	missense	possibly damaging	0.89
R8029:Vmn2r117	UTSW	17	23477770	missense	probably benign	0.00
R8340:Vmn2r117	UTSW	17	23460537	missense	probably benign	0.01
R8519:Vmn2r117	UTSW	17	23479468	missense	probably benign
R8723:Vmn2r117	UTSW	17	23477369	missense	probably damaging	1.00
R8914:Vmn2r117	UTSW	17	23460169	missense	probably benign	0.02
R9010:Vmn2r117	UTSW	17	23460471	missense	probably benign	0.10
R9129:Vmn2r117	UTSW	17	23459944	nonsense	probably null
R9244:Vmn2r117	UTSW	17	23477615	missense	probably damaging	0.98
R9464:Vmn2r117	UTSW	17	23477604	missense	probably benign	0.23
R9620:Vmn2r117	UTSW	17	23478476	missense	probably damaging	0.97
V5622:Vmn2r117	UTSW	17	23477840	missense	probably damaging	1.00
V5622:Vmn2r117	UTSW	17	23479505	missense	possibly damaging	0.67
Z1176:Vmn2r117	UTSW	17	23459766	missense	probably benign	0.00

Predicted Primers

Posted On

2015-05-15