Mutagenetix > Incidental Mutation

Incidental Mutation 'R0391:Tle3'

31702

Institutional Source

Beutler Lab

Gene Symbol

Tle3

Ensembl Gene

ENSMUSG00000032280

Gene Name

transducin-like enhancer of split 3

Synonyms

2610103N05Rik, ESG, Grg3a, Grg3b

MMRRC Submission

038597-MU

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

R0391 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

61372366-61418497 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 61416661 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Cysteine at position 766 (Y766C)

Ref Sequence

ENSEMBL: ENSMUSP00000136010 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000034820] [ENSMUST00000159050] [ENSMUST00000159386] [ENSMUST00000159630] [ENSMUST00000160882] [ENSMUST00000161207] [ENSMUST00000161689] [ENSMUST00000162127] [ENSMUST00000162583] [ENSMUST00000178113] [ENSMUST00000162973]

AlphaFold

Q08122

Predicted Effect

probably damaging
Transcript: ENSMUST00000034820
AA Change: Y747C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000034820
Gene: ENSMUSG00000032280
AA Change: Y747C

Domain	Start	End	E-Value	Type
Pfam:TLE_N	1	136	4.3e-77	PFAM
low complexity region	161	179	N/A	INTRINSIC
low complexity region	195	207	N/A	INTRINSIC
low complexity region	283	302	N/A	INTRINSIC
WD40	468	505	2.96e-2	SMART
WD40	511	552	4.48e-2	SMART
WD40	557	596	2.84e-4	SMART
WD40	599	638	7.55e-9	SMART
WD40	641	679	3.07e1	SMART
WD40	681	720	4.18e-2	SMART
WD40	721	761	1.79e-1	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000159050
AA Change: Y750C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000125032
Gene: ENSMUSG00000032280
AA Change: Y750C

Domain	Start	End	E-Value	Type
Pfam:TLE_N	1	136	2.1e-77	PFAM
low complexity region	161	179	N/A	INTRINSIC
low complexity region	195	207	N/A	INTRINSIC
low complexity region	283	302	N/A	INTRINSIC
WD40	471	508	2.96e-2	SMART
WD40	514	555	4.48e-2	SMART
WD40	560	599	2.84e-4	SMART
WD40	602	641	7.55e-9	SMART
WD40	644	682	3.07e1	SMART
WD40	684	723	4.18e-2	SMART
WD40	724	764	1.79e-1	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000159140

Predicted Effect

probably damaging
Transcript: ENSMUST00000159386
AA Change: Y743C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000125049
Gene: ENSMUSG00000032280
AA Change: Y743C

Domain	Start	End	E-Value	Type
Pfam:TLE_N	1	136	2.1e-77	PFAM
low complexity region	161	179	N/A	INTRINSIC
low complexity region	195	207	N/A	INTRINSIC
low complexity region	283	302	N/A	INTRINSIC
WD40	464	501	2.96e-2	SMART
WD40	507	548	4.48e-2	SMART
WD40	553	592	2.84e-4	SMART
WD40	595	634	7.55e-9	SMART
WD40	637	675	3.07e1	SMART
WD40	677	716	4.18e-2	SMART
WD40	717	757	1.79e-1	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000159630
AA Change: Y695C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000123723
Gene: ENSMUSG00000032280
AA Change: Y695C

Domain	Start	End	E-Value	Type
Pfam:TLE_N	1	79	1.7e-43	PFAM
low complexity region	104	122	N/A	INTRINSIC
low complexity region	138	150	N/A	INTRINSIC
low complexity region	226	245	N/A	INTRINSIC
WD40	416	453	2.96e-2	SMART
WD40	459	500	4.48e-2	SMART
WD40	505	544	2.84e-4	SMART
WD40	547	586	7.55e-9	SMART
WD40	589	627	3.07e1	SMART
WD40	629	668	4.18e-2	SMART
WD40	669	709	1.79e-1	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000160882
AA Change: Y765C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000124131
Gene: ENSMUSG00000032280
AA Change: Y765C

Domain	Start	End	E-Value	Type
Pfam:TLE_N	1	146	4.8e-76	PFAM
low complexity region	171	189	N/A	INTRINSIC
low complexity region	205	217	N/A	INTRINSIC
low complexity region	293	312	N/A	INTRINSIC
WD40	486	523	2.96e-2	SMART
WD40	529	570	4.48e-2	SMART
WD40	575	614	2.84e-4	SMART
WD40	617	656	7.55e-9	SMART
WD40	659	697	3.07e1	SMART
WD40	699	738	4.18e-2	SMART
WD40	739	779	1.79e-1	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000161207
AA Change: Y745C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000124557
Gene: ENSMUSG00000032280
AA Change: Y745C

Domain	Start	End	E-Value	Type
Pfam:TLE_N	1	129	1e-73	PFAM
low complexity region	154	172	N/A	INTRINSIC
low complexity region	188	200	N/A	INTRINSIC
low complexity region	276	295	N/A	INTRINSIC
WD40	466	503	2.96e-2	SMART
WD40	509	550	4.48e-2	SMART
WD40	555	594	2.84e-4	SMART
WD40	597	636	7.55e-9	SMART
WD40	639	677	3.07e1	SMART
WD40	679	718	4.18e-2	SMART
WD40	719	759	1.79e-1	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000161689
AA Change: Y699C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000125011
Gene: ENSMUSG00000032280
AA Change: Y699C

Domain	Start	End	E-Value	Type
Pfam:TLE_N	1	80	4.8e-44	PFAM
low complexity region	105	123	N/A	INTRINSIC
low complexity region	139	151	N/A	INTRINSIC
low complexity region	227	246	N/A	INTRINSIC
WD40	420	457	2.96e-2	SMART
WD40	463	504	4.48e-2	SMART
WD40	509	548	2.84e-4	SMART
WD40	551	590	7.55e-9	SMART
WD40	593	631	3.07e1	SMART
WD40	633	672	4.18e-2	SMART
WD40	673	713	1.79e-1	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000162127
AA Change: Y685C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000124150
Gene: ENSMUSG00000032280
AA Change: Y685C

Domain	Start	End	E-Value	Type
Pfam:TLE_N	1	83	1.2e-37	PFAM
low complexity region	108	126	N/A	INTRINSIC
low complexity region	142	154	N/A	INTRINSIC
low complexity region	230	249	N/A	INTRINSIC
WD40	406	443	2.96e-2	SMART
WD40	449	490	4.48e-2	SMART
WD40	495	534	2.84e-4	SMART
WD40	537	576	7.55e-9	SMART
WD40	579	617	3.07e1	SMART
WD40	619	658	4.18e-2	SMART
WD40	659	699	1.79e-1	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000162281

Predicted Effect

probably damaging
Transcript: ENSMUST00000162583
AA Change: Y752C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000124977
Gene: ENSMUSG00000032280
AA Change: Y752C

Domain	Start	End	E-Value	Type
Pfam:TLE_N	1	136	3.9e-77	PFAM
low complexity region	161	179	N/A	INTRINSIC
low complexity region	195	207	N/A	INTRINSIC
low complexity region	283	302	N/A	INTRINSIC
WD40	473	510	2.96e-2	SMART
WD40	516	557	4.48e-2	SMART
WD40	562	601	2.84e-4	SMART
WD40	604	643	7.55e-9	SMART
WD40	646	684	3.07e1	SMART
WD40	686	725	4.18e-2	SMART
WD40	726	766	1.79e-1	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000178113
AA Change: Y766C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000136010
Gene: ENSMUSG00000032280
AA Change: Y766C

Domain	Start	End	E-Value	Type
Pfam:TLE_N	1	143	6e-73	PFAM
low complexity region	171	189	N/A	INTRINSIC
low complexity region	204	218	N/A	INTRINSIC
low complexity region	294	313	N/A	INTRINSIC
WD40	487	524	2.96e-2	SMART
WD40	530	571	4.48e-2	SMART
WD40	576	615	2.84e-4	SMART
WD40	618	657	7.55e-9	SMART
WD40	660	698	3.07e1	SMART
WD40	700	739	4.18e-2	SMART
WD40	740	780	1.79e-1	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000162973
AA Change: Y755C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000124173
Gene: ENSMUSG00000032280
AA Change: Y755C

Domain	Start	End	E-Value	Type
Pfam:TLE_N	1	136	3.9e-77	PFAM
low complexity region	161	179	N/A	INTRINSIC
low complexity region	195	207	N/A	INTRINSIC
low complexity region	283	302	N/A	INTRINSIC
WD40	476	513	2.96e-2	SMART
WD40	519	560	4.48e-2	SMART
WD40	565	604	2.84e-4	SMART
WD40	607	646	7.55e-9	SMART
WD40	649	687	3.07e1	SMART
WD40	689	728	4.18e-2	SMART
WD40	729	769	1.79e-1	SMART

Meta Mutation Damage Score

0.4362

Coding Region Coverage

1x: 99.1%
3x: 98.2%
10x: 95.9%
20x: 91.8%

Validation Efficiency

97% (97/100)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a transcriptional co-repressor protein that belongs to the transducin-like enhancer family of proteins. The members of this family function in the Notch signaling pathway that regulates determination of cell fate during development. Expression of this gene has been associated with a favorable outcome to chemotherapy with taxanes for ovarian carcinoma. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Sep 2013]
PHENOTYPE: Mice homzoygous for a gene trap allele exhibit embryonic lethality. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 97 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
9530002B09Rik	T	A	4: 122,701,177 (GRCm38)		probably benign	Het
Abcc2	G	A	19: 43,821,605 (GRCm38)		probably benign	Het
Abcc8	C	G	7: 46,122,173 (GRCm38)	G838A	probably damaging	Het
Akr1c21	G	A	13: 4,581,200 (GRCm38)	A245T	probably damaging	Het
Anapc15-ps	T	C	10: 95,673,277 (GRCm38)	E47G	probably damaging	Het
Apoa1	A	G	9: 46,229,842 (GRCm38)	T79A	probably benign	Het
Atp6v1b1	A	G	6: 83,756,921 (GRCm38)	H378R	possibly damaging	Het
C4b	A	G	17: 34,735,614 (GRCm38)		probably benign	Het
Catsperd	A	T	17: 56,662,821 (GRCm38)	E638D	probably benign	Het
Cckar	C	T	5: 53,706,253 (GRCm38)		probably null	Het
Cfap100	C	T	6: 90,405,339 (GRCm38)		probably benign	Het
Chd1	G	T	17: 15,749,894 (GRCm38)	G970C	probably damaging	Het
Col14a1	A	G	15: 55,446,259 (GRCm38)		probably benign	Het
Col17a1	C	T	19: 47,663,824 (GRCm38)	V698M	probably damaging	Het
Cpeb1	T	C	7: 81,361,725 (GRCm38)	D156G	possibly damaging	Het
Cryl1	A	G	14: 57,303,775 (GRCm38)	Y151H	possibly damaging	Het
Csmd3	C	A	15: 47,657,573 (GRCm38)	V1881L	probably damaging	Het
Ctnnal1	C	T	4: 56,847,921 (GRCm38)	A73T	probably damaging	Het
Cyp2c37	T	C	19: 39,994,506 (GRCm38)	S180P	probably damaging	Het
Cyp2c54	T	C	19: 40,072,169 (GRCm38)	T123A	possibly damaging	Het
Dennd6b	T	C	15: 89,187,214 (GRCm38)	D304G	probably damaging	Het
Dnmt3l	T	C	10: 78,051,916 (GRCm38)		probably benign	Het
Eci1	G	A	17: 24,433,260 (GRCm38)		probably null	Het
Efhc1	A	G	1: 20,960,188 (GRCm38)	Y115C	probably damaging	Het
Ern1	T	A	11: 106,407,178 (GRCm38)	K706*	probably null	Het
Fam129c	T	A	8: 71,602,499 (GRCm38)		probably benign	Het
Ghrl	T	C	6: 113,719,338 (GRCm38)	E31G	probably damaging	Het
Gpr108	A	C	17: 57,243,101 (GRCm38)	V179G	probably benign	Het
Henmt1	A	G	3: 108,958,535 (GRCm38)		probably benign	Het
Ift172	A	G	5: 31,286,667 (GRCm38)	V69A	probably damaging	Het
Il17ra	T	C	6: 120,476,979 (GRCm38)		probably benign	Het
Il17rb	G	T	14: 30,006,155 (GRCm38)		probably null	Het
Il17rb	T	C	14: 30,004,347 (GRCm38)	N95D	probably benign	Het
Iqub	G	A	6: 24,446,155 (GRCm38)	L757F	probably benign	Het
Itpr1	T	C	6: 108,378,167 (GRCm38)	V473A	probably benign	Het
Itpr2	T	G	6: 146,229,773 (GRCm38)	N1978H	probably damaging	Het
Klk1b26	T	A	7: 44,012,727 (GRCm38)	F3Y	probably damaging	Het
Lars	A	G	18: 42,251,363 (GRCm38)	V50A	probably benign	Het
Lax1	G	T	1: 133,680,066 (GRCm38)	H312Q	probably benign	Het
Lctl	T	C	9: 64,122,314 (GRCm38)		probably benign	Het
Lrp2	G	A	2: 69,460,337 (GRCm38)		probably benign	Het
Lrp2	T	A	2: 69,456,858 (GRCm38)	D3745V	probably damaging	Het
Lvrn	A	T	18: 46,850,466 (GRCm38)	H92L	probably benign	Het
March1	A	G	8: 66,418,973 (GRCm38)	T385A	probably damaging	Het
Marf1	C	T	16: 14,142,534 (GRCm38)	A549T	probably damaging	Het
Mbd5	T	C	2: 49,272,416 (GRCm38)	V970A	possibly damaging	Het
Mccc1	A	G	3: 35,963,570 (GRCm38)		probably benign	Het
Mpp4	A	T	1: 59,143,829 (GRCm38)		probably benign	Het
Mrnip	G	A	11: 50,199,920 (GRCm38)	A304T	probably damaging	Het
Muc5b	T	C	7: 141,865,082 (GRCm38)	S3922P	possibly damaging	Het
Myh3	T	A	11: 67,096,507 (GRCm38)		probably benign	Het
Nbea	A	T	3: 56,037,277 (GRCm38)	H555Q	probably damaging	Het
Nlrp9c	A	T	7: 26,371,476 (GRCm38)		probably benign	Het
Nmur1	A	T	1: 86,387,678 (GRCm38)	V178E	probably damaging	Het
Nod2	T	G	8: 88,663,778 (GRCm38)	S238A	probably benign	Het
Ogfod1	A	T	8: 94,063,023 (GRCm38)	T451S	probably damaging	Het
Olfr145	G	A	9: 37,897,842 (GRCm38)	G146D	probably benign	Het
Olfr23	T	C	11: 73,941,109 (GRCm38)	F288L	probably damaging	Het
Olfr372	C	T	8: 72,058,400 (GRCm38)	T240M	probably damaging	Het
Olfr716	T	A	7: 107,148,187 (GRCm38)	Y290*	probably null	Het
Pcdh20	T	C	14: 88,468,668 (GRCm38)	I399V	probably benign	Het
Pdlim1	G	T	19: 40,243,573 (GRCm38)	H120Q	probably damaging	Het
Plg	T	C	17: 12,419,081 (GRCm38)	V798A	probably damaging	Het
Polr2c	A	G	8: 94,857,775 (GRCm38)	I39V	possibly damaging	Het
Ppfia2	C	A	10: 106,830,714 (GRCm38)		probably benign	Het
Ppp1r3a	A	T	6: 14,719,697 (GRCm38)	I406N	probably benign	Het
Psg28	A	T	7: 18,426,173 (GRCm38)	M366K	probably benign	Het
Rad54b	T	C	4: 11,601,702 (GRCm38)	I419T	probably damaging	Het
Rnf43	A	G	11: 87,731,282 (GRCm38)	Q403R	possibly damaging	Het
Sema6a	G	A	18: 47,290,045 (GRCm38)		probably null	Het
Slc28a3	A	G	13: 58,569,415 (GRCm38)		probably benign	Het
Smad2	A	T	18: 76,289,037 (GRCm38)		probably null	Het
Smad4	G	A	18: 73,658,649 (GRCm38)	P274S	probably benign	Het
Smchd1	A	T	17: 71,403,154 (GRCm38)	V906D	probably damaging	Het
Soat2	C	A	15: 102,158,753 (GRCm38)	R320S	possibly damaging	Het
Spata33	C	T	8: 123,221,887 (GRCm38)	A57V	probably damaging	Het
Stab1	A	G	14: 31,143,418 (GRCm38)	L1814P	probably benign	Het
Stab2	T	C	10: 86,947,144 (GRCm38)	K680R	probably benign	Het
Stil	A	G	4: 115,041,172 (GRCm38)		probably null	Het
Sympk	T	A	7: 19,046,849 (GRCm38)	L759H	probably benign	Het
Tet1	A	T	10: 62,814,546 (GRCm38)		probably null	Het
Tfpi2	A	T	6: 3,965,460 (GRCm38)	N117K	probably benign	Het
Trpt1	C	A	19: 6,997,930 (GRCm38)		probably null	Het
Tshz1	A	G	18: 84,016,049 (GRCm38)	F78S	possibly damaging	Het
Ttc1	T	C	11: 43,738,808 (GRCm38)	D177G	probably damaging	Het
Ttc13	T	A	8: 124,674,401 (GRCm38)	Y741F	probably damaging	Het
Ulk3	C	T	9: 57,594,832 (GRCm38)	S462L	probably benign	Het
Utrn	C	T	10: 12,525,333 (GRCm38)		probably benign	Het
V1rd19	A	C	7: 24,003,585 (GRCm38)	T159P	probably damaging	Het
Vars	T	C	17: 35,011,486 (GRCm38)	V515A	possibly damaging	Het
Vmn1r85	A	G	7: 13,084,588 (GRCm38)	Y210H	probably benign	Het
Vmn2r89	A	G	14: 51,455,978 (GRCm38)	T262A	probably damaging	Het
Vps53	G	A	11: 76,121,579 (GRCm38)	T209I	probably benign	Het
Wdfy2	T	C	14: 62,925,133 (GRCm38)	F95L	possibly damaging	Het
Wwp1	G	T	4: 19,627,911 (GRCm38)	S694Y	probably damaging	Het
Zbtb8b	T	A	4: 129,432,670 (GRCm38)	D201V	probably damaging	Het
Zmym5	A	C	14: 56,804,451 (GRCm38)	N123K	possibly damaging	Het

Other mutations in Tle3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00494:Tle3	APN	9	61,408,757 (GRCm38)	splice site	probably benign
IGL00671:Tle3	APN	9	61,412,370 (GRCm38)	missense	probably damaging	1.00
IGL01583:Tle3	APN	9	61,410,025 (GRCm38)	missense	probably benign	0.00
IGL01684:Tle3	APN	9	61,403,446 (GRCm38)	intron	probably benign
IGL02109:Tle3	APN	9	61,413,050 (GRCm38)	missense	probably damaging	1.00
IGL02386:Tle3	APN	9	61,394,659 (GRCm38)	missense	possibly damaging	0.88
IGL02517:Tle3	APN	9	61,414,781 (GRCm38)	missense	probably damaging	1.00
IGL02930:Tle3	APN	9	61,394,699 (GRCm38)	missense	possibly damaging	0.52
IGL03103:Tle3	APN	9	61,393,242 (GRCm38)	missense	possibly damaging	0.46
R0395:Tle3	UTSW	9	61,410,071 (GRCm38)	missense	probably damaging	0.99
R0621:Tle3	UTSW	9	61,410,105 (GRCm38)	nonsense	probably null
R1836:Tle3	UTSW	9	61,414,023 (GRCm38)	missense	probably damaging	1.00
R1921:Tle3	UTSW	9	61,411,340 (GRCm38)	critical splice donor site	probably null
R1978:Tle3	UTSW	9	61,394,633 (GRCm38)	missense	probably damaging	1.00
R3434:Tle3	UTSW	9	61,414,094 (GRCm38)	splice site	probably null
R4242:Tle3	UTSW	9	61,407,423 (GRCm38)	missense	probably benign
R4587:Tle3	UTSW	9	61,374,013 (GRCm38)	missense	probably damaging	0.99
R4811:Tle3	UTSW	9	61,373,997 (GRCm38)	unclassified	probably benign
R4877:Tle3	UTSW	9	61,373,499 (GRCm38)	intron	probably benign
R4913:Tle3	UTSW	9	61,373,993 (GRCm38)	missense	probably damaging	1.00
R5387:Tle3	UTSW	9	61,407,489 (GRCm38)	splice site	probably null
R5745:Tle3	UTSW	9	61,414,851 (GRCm38)	missense	probably damaging	1.00
R5752:Tle3	UTSW	9	61,407,471 (GRCm38)	missense	probably damaging	1.00
R5917:Tle3	UTSW	9	61,408,908 (GRCm38)	missense	probably benign	0.19
R6000:Tle3	UTSW	9	61,374,014 (GRCm38)	missense	probably damaging	1.00
R6339:Tle3	UTSW	9	61,401,924 (GRCm38)	splice site	probably null
R7210:Tle3	UTSW	9	61,412,305 (GRCm38)	missense	probably damaging	1.00
R7460:Tle3	UTSW	9	61,413,084 (GRCm38)	missense	probably damaging	0.99
R7545:Tle3	UTSW	9	61,394,702 (GRCm38)	missense	possibly damaging	0.62
R7698:Tle3	UTSW	9	61,412,856 (GRCm38)	missense	probably damaging	1.00
R7916:Tle3	UTSW	9	61,407,128 (GRCm38)	missense	probably benign
R8075:Tle3	UTSW	9	61,374,559 (GRCm38)	missense	probably benign	0.05
R8941:Tle3	UTSW	9	61,412,913 (GRCm38)	missense	probably damaging	1.00
R9018:Tle3	UTSW	9	61,412,468 (GRCm38)	missense	probably damaging	1.00
R9060:Tle3	UTSW	9	61,375,539 (GRCm38)	missense	probably damaging	1.00
R9109:Tle3	UTSW	9	61,412,280 (GRCm38)	missense	possibly damaging	0.55
R9122:Tle3	UTSW	9	61,407,473 (GRCm38)	unclassified	probably benign
R9298:Tle3	UTSW	9	61,412,280 (GRCm38)	missense	possibly damaging	0.55

Predicted Primers

PCR Primer
(F):5'- GCTCAGGAGGTGTTCCAGATGAAG -3'
(R):5'- TGTCAGACACATCAATCCACGAAGG -3'

Sequencing Primer
(F):5'- GAAGTGGGCCTCTTTCTACCAG -3'
(R):5'- CGTGCGTCCTCTCCACC -3'

Posted On

2013-04-24