Mutagenetix > Incidental Mutation

Incidental Mutation 'R4109:Ifi206'

317195

Institutional Source

Beutler Lab

Gene Symbol

Ifi206

Ensembl Gene

ENSMUSG00000037849

Gene Name

interferon activated gene 206

Synonyms

Pyblhin-C, Gm4955

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.175) question?

Stock #

R4109 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

173296051-173318607 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to G at 173308554 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Proline at position 481 (T481P)

Ref Sequence

ENSEMBL: ENSMUSP00000134646 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000160565]

AlphaFold

G3UZV2

Predicted Effect

probably benign
Transcript: ENSMUST00000160565
AA Change: T481P

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)

SMART Domains

Protein: ENSMUSP00000134646
Gene: ENSMUSG00000037849
AA Change: T481P

Domain	Start	End	E-Value	Type
PYRIN	6	84	5.7e-21	SMART
low complexity region	97	108	N/A	INTRINSIC
internal_repeat_1	154	349	6.25e-15	PROSPERO
internal_repeat_1	342	575	6.25e-15	PROSPERO

Coding Region Coverage

1x: 99.2%
3x: 98.6%
10x: 97.5%
20x: 96.1%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 28 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2010315B03Rik	A	T	9: 124,057,733 (GRCm39)	D59E	probably benign	Het
Acads	T	C	5: 115,248,913 (GRCm39)	*302W	probably null	Het
Aldh1l1	A	G	6: 90,539,626 (GRCm39)	E185G	probably benign	Het
Arhgap20	A	G	9: 51,727,985 (GRCm39)	H66R	possibly damaging	Het
Arhgap31	A	G	16: 38,422,788 (GRCm39)	S1093P	probably damaging	Het
Atg2a	A	G	19: 6,308,404 (GRCm39)	T1646A	possibly damaging	Het
Cd200r1	C	G	16: 44,610,447 (GRCm39)	T185S	possibly damaging	Het
Cnbd2	T	C	2: 156,177,318 (GRCm39)	V92A	probably damaging	Het
Col1a2	A	T	6: 4,510,705 (GRCm39)	R52*	probably null	Het
Eml5	T	C	12: 98,807,807 (GRCm39)		probably null	Het
Nfya	G	T	17: 48,699,912 (GRCm39)	Y37*	probably null	Het
Nos1ap	A	T	1: 170,146,237 (GRCm39)	M439K	probably benign	Het
Paxbp1	T	A	16: 90,813,786 (GRCm39)	T864S	probably benign	Het
Ryr3	C	G	2: 112,506,218 (GRCm39)	R3443P	probably damaging	Het
Satb1	A	G	17: 52,111,378 (GRCm39)	V160A	probably damaging	Het
Scn3a	A	G	2: 65,325,379 (GRCm39)	I1046T	probably benign	Het
Setd1b	TCCACCACCACCACCACCACCACCA	TCCACCACCACCACCACCACCA	5: 123,290,137 (GRCm39)		probably benign	Het
Slc19a3	A	T	1: 83,000,678 (GRCm39)	F113Y	probably damaging	Het
Slc1a7	T	C	4: 107,825,858 (GRCm39)	V39A	probably benign	Het
Spire1	T	C	18: 67,630,287 (GRCm39)	Q338R	probably damaging	Het
Supt16	T	C	14: 52,400,188 (GRCm39)	E985G	probably damaging	Het
Tmprss11f	T	C	5: 86,677,795 (GRCm39)	K325E	possibly damaging	Het
Tpo	G	A	12: 30,142,585 (GRCm39)	P713L	probably damaging	Het
Trav13-2	A	C	14: 53,872,698 (GRCm39)	H58P	probably benign	Het
Trbv13-2	A	T	6: 41,098,578 (GRCm39)	Y51F	probably benign	Het
Ttn	G	C	2: 76,581,215 (GRCm39)	A23226G	probably damaging	Het
Ttn	C	T	2: 76,608,809 (GRCm39)	V15990I	probably benign	Het
Zan	G	A	5: 137,456,881 (GRCm39)	T1285I	unknown	Het

Other mutations in Ifi206

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01509:Ifi206	APN	1	173,313,142 (GRCm39)	missense	probably benign	0.00
IGL02044:Ifi206	APN	1	173,308,557 (GRCm39)	missense	probably benign	0.41
IGL02118:Ifi206	APN	1	173,309,334 (GRCm39)	missense	probably benign	0.05
IGL02476:Ifi206	APN	1	173,309,132 (GRCm39)	missense	probably benign	0.02
IGL02824:Ifi206	APN	1	173,309,438 (GRCm39)	missense	possibly damaging	0.95
IGL03375:Ifi206	APN	1	173,308,344 (GRCm39)	missense	probably benign	0.06
PIT4142001:Ifi206	UTSW	1	173,308,730 (GRCm39)	missense	probably benign	0.02
R0069:Ifi206	UTSW	1	173,314,413 (GRCm39)	missense	probably damaging	1.00
R0741:Ifi206	UTSW	1	173,301,315 (GRCm39)	missense	probably benign	0.41
R1572:Ifi206	UTSW	1	173,314,419 (GRCm39)	missense	probably benign	0.10
R1742:Ifi206	UTSW	1	173,309,537 (GRCm39)	missense	probably benign	0.06
R4707:Ifi206	UTSW	1	173,308,432 (GRCm39)	missense	probably benign	0.00
R4783:Ifi206	UTSW	1	173,308,432 (GRCm39)	missense	probably benign	0.00
R4785:Ifi206	UTSW	1	173,308,432 (GRCm39)	missense	probably benign	0.00
R4805:Ifi206	UTSW	1	173,308,952 (GRCm39)	missense	possibly damaging	0.55
R4918:Ifi206	UTSW	1	173,309,610 (GRCm39)	missense	possibly damaging	0.73
R5043:Ifi206	UTSW	1	173,314,284 (GRCm39)	missense	probably damaging	1.00
R5080:Ifi206	UTSW	1	173,301,414 (GRCm39)	missense	possibly damaging	0.61
R5419:Ifi206	UTSW	1	173,308,797 (GRCm39)	missense	probably benign	0.05
R5420:Ifi206	UTSW	1	173,308,599 (GRCm39)	missense	possibly damaging	0.84
R5777:Ifi206	UTSW	1	173,308,928 (GRCm39)	missense	possibly damaging	0.55
R5988:Ifi206	UTSW	1	173,308,906 (GRCm39)	missense	possibly damaging	0.90
R6772:Ifi206	UTSW	1	173,308,773 (GRCm39)	missense	unknown
R6782:Ifi206	UTSW	1	173,308,923 (GRCm39)	missense	unknown
R6806:Ifi206	UTSW	1	173,309,137 (GRCm39)	missense	probably benign	0.06
R7042:Ifi206	UTSW	1	173,308,808 (GRCm39)	missense
R7091:Ifi206	UTSW	1	173,301,441 (GRCm39)	missense	unknown
R7292:Ifi206	UTSW	1	173,301,428 (GRCm39)	missense	unknown
R7429:Ifi206	UTSW	1	173,308,157 (GRCm39)	missense
R7499:Ifi206	UTSW	1	173,309,607 (GRCm39)	missense
R7772:Ifi206	UTSW	1	173,308,640 (GRCm39)	missense
R7853:Ifi206	UTSW	1	173,299,100 (GRCm39)	nonsense	probably null
R7971:Ifi206	UTSW	1	173,298,976 (GRCm39)	missense	unknown
R8079:Ifi206	UTSW	1	173,308,724 (GRCm39)	missense
R8205:Ifi206	UTSW	1	173,309,450 (GRCm39)	missense
R8289:Ifi206	UTSW	1	173,308,032 (GRCm39)	missense
R8390:Ifi206	UTSW	1	173,308,511 (GRCm39)	missense
R8500:Ifi206	UTSW	1	173,314,311 (GRCm39)	missense
R8712:Ifi206	UTSW	1	173,308,074 (GRCm39)	missense
R8753:Ifi206	UTSW	1	173,301,223 (GRCm39)	missense	unknown
R8875:Ifi206	UTSW	1	173,301,353 (GRCm39)	missense	unknown
R9128:Ifi206	UTSW	1	173,299,022 (GRCm39)	missense	unknown
R9369:Ifi206	UTSW	1	173,301,489 (GRCm39)	missense	unknown
R9569:Ifi206	UTSW	1	173,314,209 (GRCm39)	missense
R9676:Ifi206	UTSW	1	173,308,718 (GRCm39)	missense
R9695:Ifi206	UTSW	1	173,301,249 (GRCm39)	missense	unknown
R9776:Ifi206	UTSW	1	173,308,075 (GRCm39)	missense
X0052:Ifi206	UTSW	1	173,309,535 (GRCm39)	missense	possibly damaging	0.89
Z1088:Ifi206	UTSW	1	173,301,577 (GRCm39)	missense	probably damaging	1.00
Z1176:Ifi206	UTSW	1	173,309,614 (GRCm39)	missense

Predicted Primers

PCR Primer
(F):5'- ATAACTGCTGGATATTGTTGCTGC -3'
(R):5'- AACAGTGCCAAGAAGTGCCC -3'

Sequencing Primer
(F):5'- CTGCAGACATCTGAGGACTGTTAC -3'
(R):5'- AAGAAGTGCCCAGTCCCTTTTG -3'

Posted On

2015-05-15