Mutagenetix > Incidental Mutation

Incidental Mutation 'R4111:Or10g9'

317317

Institutional Source

Beutler Lab

Gene Symbol

Or10g9

Ensembl Gene

ENSMUSG00000059473

Gene Name

olfactory receptor family 10 subfamily G member 9

Synonyms

MOR223-1, Olfr979, GA_x6K02T2PVTD-33699706-33698771

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.072) question?

Stock #

R4111 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

39911502-39912546 bp(-) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

C to A at 39912194 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glutamic Acid to Stop codon at position 110 (E110*)

Ref Sequence

ENSEMBL: ENSMUSP00000148903 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000080835] [ENSMUST00000215523] [ENSMUST00000216463]

AlphaFold

Q8VH10

Predicted Effect

probably null
Transcript: ENSMUST00000080835
AA Change: E110*

SMART Domains

Protein: ENSMUSP00000079648
Gene: ENSMUSG00000059473
AA Change: E110*

Domain	Start	End	E-Value	Type
Pfam:7tm_4	29	304	7.9e-58	PFAM
Pfam:7tm_1	39	287	5.2e-22	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000215523
AA Change: E110*

Predicted Effect

probably benign
Transcript: ENSMUST00000216463

Coding Region Coverage

1x: 99.2%
3x: 98.6%
10x: 97.5%
20x: 96.0%

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 54 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700012B07Rik	G	T	11: 109,684,980 (GRCm39)	C172*	probably null	Het
Acot10	A	T	15: 20,666,612 (GRCm39)	L43Q	probably damaging	Het
Alms1	G	A	6: 85,597,870 (GRCm39)	V1368I	probably benign	Het
Ambra1	T	C	2: 91,730,903 (GRCm39)	S894P	probably damaging	Het
Arhgef12	C	A	9: 42,883,570 (GRCm39)	G1320C	probably damaging	Het
Atg7	G	C	6: 114,690,255 (GRCm39)	G596R	probably damaging	Het
Birc6	T	C	17: 74,873,010 (GRCm39)	V423A	probably damaging	Het
Bltp3a	T	A	17: 28,105,064 (GRCm39)	L586*	probably null	Het
Cdh17	T	C	4: 11,814,628 (GRCm39)	S728P	probably damaging	Het
Ctu2	G	A	8: 123,203,256 (GRCm39)	R24Q	possibly damaging	Het
Dclk3	T	C	9: 111,298,148 (GRCm39)	I564T	probably damaging	Het
Ddx39b	T	A	17: 35,462,340 (GRCm39)	I42N	possibly damaging	Het
Defa39	T	C	8: 22,192,679 (GRCm39)	T106A	possibly damaging	Het
Dip2c	G	T	13: 9,687,137 (GRCm39)	G1254C	probably damaging	Het
Dzip1	T	A	14: 119,114,645 (GRCm39)	K837*	probably null	Het
Epha1	G	A	6: 42,335,772 (GRCm39)	T955M	possibly damaging	Het
Etfbkmt	T	C	6: 149,046,089 (GRCm39)		probably benign	Het
Etfrf1	T	C	6: 145,161,098 (GRCm39)	Y23H	probably damaging	Het
Fat3	G	A	9: 15,909,567 (GRCm39)	S2145F	probably damaging	Het
Gm5611	T	A	9: 16,941,989 (GRCm39)		noncoding transcript	Het
Gpr37l1	T	C	1: 135,095,008 (GRCm39)	T79A	possibly damaging	Het
Hrh3	C	A	2: 179,744,643 (GRCm39)	R99L	possibly damaging	Het
Hyls1	T	A	9: 35,472,714 (GRCm39)	Y234F	probably damaging	Het
Ifnar1	C	A	16: 91,293,046 (GRCm39)	P230T	probably damaging	Het
Impact	T	C	18: 13,109,090 (GRCm39)		probably null	Het
Kcna6	G	C	6: 126,716,737 (GRCm39)	R51G	probably damaging	Het
Lrpprc	G	A	17: 85,033,766 (GRCm39)	T1037M	probably benign	Het
Or4a2	C	A	2: 89,248,444 (GRCm39)	L104F	probably benign	Het
Or5an6	T	C	19: 12,371,665 (GRCm39)	F13L	probably damaging	Het
Or6n2	T	A	1: 173,896,999 (GRCm39)	I45N	probably damaging	Het
Pask	A	G	1: 93,238,540 (GRCm39)	V1315A	probably damaging	Het
Pramel16	T	A	4: 143,676,475 (GRCm39)	I210F	possibly damaging	Het
Prl7a2	A	T	13: 27,849,050 (GRCm39)	Y80N	possibly damaging	Het
Rhox3f	G	T	X: 36,763,672 (GRCm39)	E140*	probably null	Het
Rtn2	T	C	7: 19,020,769 (GRCm39)	S81P	probably damaging	Het
Sbf2	G	A	7: 110,027,449 (GRCm39)	P470S	probably damaging	Het
Sec31b	G	T	19: 44,512,968 (GRCm39)	T507N	possibly damaging	Het
Sox30	A	G	11: 45,908,041 (GRCm39)	Y736C	probably benign	Het
Srsf3-ps	A	T	11: 98,516,223 (GRCm39)	V50D	probably damaging	Het
Synj2	G	A	17: 6,058,240 (GRCm39)	G243S	probably benign	Het
Tbr1	C	T	2: 61,642,076 (GRCm39)	P184L	probably benign	Het
Tns1	T	C	1: 73,981,091 (GRCm39)	N1091S	probably damaging	Het
Trappc10	A	G	10: 78,032,264 (GRCm39)	F1008S	probably benign	Het
Ube4a	T	A	9: 44,860,247 (GRCm39)	I272F	probably damaging	Het
Vmn1r122	A	T	7: 20,867,438 (GRCm39)	S206T	probably damaging	Het
Vmn2r1	A	C	3: 63,997,176 (GRCm39)	K277N	probably benign	Het
Vps13a	T	C	19: 16,617,992 (GRCm39)	E2931G	probably damaging	Het
Wdr70	G	T	15: 8,006,472 (GRCm39)	Q360K	probably benign	Het
Wdr90	G	T	17: 26,068,342 (GRCm39)	Q1329K	possibly damaging	Het
Wrn	T	C	8: 33,842,183 (GRCm39)	N37S	probably benign	Het
Yap1	A	T	9: 7,938,432 (GRCm39)	*358K	probably null	Het
Zfp964	T	A	8: 70,116,754 (GRCm39)	S450R	probably benign	Het
Zkscan2	T	C	7: 123,081,907 (GRCm39)		probably benign	Het
Zmynd10	A	T	9: 107,426,251 (GRCm39)	K133*	probably null	Het

Other mutations in Or10g9

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02718:Or10g9	APN	9	39,912,182 (GRCm39)	missense	probably damaging	1.00
IGL02939:Or10g9	APN	9	39,912,194 (GRCm39)	missense	probably benign	0.26
IGL02991:Or10g9	UTSW	9	39,911,698 (GRCm39)	missense	probably damaging	1.00
R1388:Or10g9	UTSW	9	39,911,948 (GRCm39)	missense	probably damaging	0.99
R1572:Or10g9	UTSW	9	39,912,490 (GRCm39)	missense	probably benign	0.35
R2089:Or10g9	UTSW	9	39,912,500 (GRCm39)	missense	probably benign	0.01
R2091:Or10g9	UTSW	9	39,912,500 (GRCm39)	missense	probably benign	0.01
R2091:Or10g9	UTSW	9	39,912,500 (GRCm39)	missense	probably benign	0.01
R2179:Or10g9	UTSW	9	39,912,220 (GRCm39)	missense	probably benign	0.44
R3424:Or10g9	UTSW	9	39,911,830 (GRCm39)	missense	probably damaging	0.97
R3964:Or10g9	UTSW	9	39,911,767 (GRCm39)	missense	possibly damaging	0.95
R3965:Or10g9	UTSW	9	39,911,767 (GRCm39)	missense	possibly damaging	0.95
R4537:Or10g9	UTSW	9	39,911,616 (GRCm39)	missense	probably benign	0.01
R4737:Or10g9	UTSW	9	39,911,718 (GRCm39)	missense	probably damaging	0.96
R4926:Or10g9	UTSW	9	39,912,319 (GRCm39)	splice site	probably null
R5303:Or10g9	UTSW	9	39,911,884 (GRCm39)	missense	probably damaging	1.00
R5587:Or10g9	UTSW	9	39,911,917 (GRCm39)	missense	possibly damaging	0.90
R6387:Or10g9	UTSW	9	39,912,148 (GRCm39)	missense	probably damaging	0.99
R6394:Or10g9	UTSW	9	39,912,001 (GRCm39)	missense	probably benign	0.04
R6765:Or10g9	UTSW	9	39,912,493 (GRCm39)	missense	probably damaging	1.00
R7312:Or10g9	UTSW	9	39,912,106 (GRCm39)	missense	probably benign	0.22
R7463:Or10g9	UTSW	9	39,911,860 (GRCm39)	missense	probably benign	0.07
R7486:Or10g9	UTSW	9	39,912,181 (GRCm39)	missense	probably benign	0.39
R7581:Or10g9	UTSW	9	39,911,718 (GRCm39)	missense	probably damaging	0.96
R8364:Or10g9	UTSW	9	39,911,660 (GRCm39)	missense	probably benign	0.22
R8414:Or10g9	UTSW	9	39,912,241 (GRCm39)	missense	probably benign	0.19
R9049:Or10g9	UTSW	9	39,911,919 (GRCm39)	missense	possibly damaging	0.56
R9567:Or10g9	UTSW	9	39,912,367 (GRCm39)	missense	possibly damaging	0.95
R9632:Or10g9	UTSW	9	39,912,172 (GRCm39)	missense	probably damaging	1.00
R9710:Or10g9	UTSW	9	39,912,172 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- GTGCATCACAGAAATAATGCTGG -3'
(R):5'- GCTGGGCAACTTCCTGATTC -3'

Sequencing Primer
(F):5'- CATCACAGAAATAATGCTGGATCTGG -3'
(R):5'- ATGGTAATCAGGGTGGACTCC -3'

Posted On

2015-05-15