Incidental Mutation 'R4086:Gkn3'
ID 317361
Institutional Source Beutler Lab
Gene Symbol Gkn3
Ensembl Gene ENSMUSG00000030048
Gene Name gastrokine 3
Synonyms 1190003M12Rik
MMRRC Submission 041625-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.054) question?
Stock # R4086 (G1)
Quality Score 211
Status Validated
Chromosome 6
Chromosomal Location 87360301-87365917 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 87360507 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Alanine to Threonine at position 163 (A163T)
Ref Sequence ENSEMBL: ENSMUSP00000032127 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000032127] [ENSMUST00000032128]
AlphaFold Q9D0T7
Predicted Effect probably damaging
Transcript: ENSMUST00000032127
AA Change: A163T

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000032127
Gene: ENSMUSG00000030048
AA Change: A163T

DomainStartEndE-ValueType
transmembrane domain 13 32 N/A INTRINSIC
BRICHOS 63 155 1.47e-26 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000032128
SMART Domains Protein: ENSMUSP00000032128
Gene: ENSMUSG00000030049

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
BRICHOS 54 151 6.63e-34 SMART
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.5%
  • 20x: 95.8%
Validation Efficiency 100% (58/58)
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acbd7 G A 2: 3,341,488 (GRCm39) probably null Het
Acss3 T G 10: 106,889,313 (GRCm39) Y169S probably damaging Het
Adcy7 A G 8: 89,042,414 (GRCm39) D427G probably benign Het
Adrm1 A G 2: 179,814,627 (GRCm39) probably benign Het
Arfgef1 T C 1: 10,233,984 (GRCm39) I1103M probably benign Het
Arhgap32 A C 9: 32,158,362 (GRCm39) probably benign Het
Arhgef28 T C 13: 98,103,712 (GRCm39) R767G probably damaging Het
BC046251 A G 7: 65,231,896 (GRCm39) noncoding transcript Het
Brwd1 T C 16: 95,847,572 (GRCm39) S683G probably benign Het
Calcoco1 C G 15: 102,618,834 (GRCm39) probably benign Het
Carmil1 G T 13: 24,208,444 (GRCm39) P834T possibly damaging Het
Cldn34c4 A T X: 126,629,011 (GRCm39) V153E probably damaging Het
Col24a1 G A 3: 145,167,192 (GRCm39) G1090R probably damaging Het
Csmd1 T A 8: 16,042,738 (GRCm39) I2332F probably damaging Het
Ets2 C A 16: 95,510,833 (GRCm39) D30E probably damaging Het
Fam181b T C 7: 92,729,788 (GRCm39) V187A probably benign Het
Fat3 G A 9: 15,909,567 (GRCm39) S2145F probably damaging Het
Fbxo41 C T 6: 85,455,528 (GRCm39) R552Q possibly damaging Het
Fstl5 G T 3: 76,555,593 (GRCm39) C53F probably damaging Het
Ftsj3 T C 11: 106,140,395 (GRCm39) Y791C probably damaging Het
Gm15446 A G 5: 110,091,121 (GRCm39) K458E probably benign Het
Hecw2 T C 1: 53,870,815 (GRCm39) I1389V probably damaging Het
Ipo9 A G 1: 135,316,428 (GRCm39) probably benign Het
Krtap31-1 C T 11: 99,799,145 (GRCm39) T116I possibly damaging Het
Mafa T G 15: 75,618,986 (GRCm39) K262N probably damaging Het
Nxph4 T C 10: 127,362,555 (GRCm39) Y112C probably damaging Het
Or5ak4 C A 2: 85,162,170 (GRCm39) W24L probably benign Het
Or6c70 A G 10: 129,710,167 (GRCm39) V153A possibly damaging Het
Pgls G A 8: 72,048,734 (GRCm39) A142T probably damaging Het
Phlpp1 A G 1: 106,274,891 (GRCm39) I885V probably benign Het
Prkcq A G 2: 11,288,679 (GRCm39) D544G probably damaging Het
Rnf44 T C 13: 54,830,148 (GRCm39) N254D possibly damaging Het
Septin10 A T 10: 59,028,045 (GRCm39) L92* probably null Het
Slc14a2 A T 18: 78,248,998 (GRCm39) I156N probably damaging Het
Sos1 A G 17: 80,756,781 (GRCm39) V257A probably benign Het
Sypl2 A G 3: 108,124,992 (GRCm39) I123T possibly damaging Het
Thap12 A G 7: 98,365,701 (GRCm39) D623G possibly damaging Het
Traf3ip3 A G 1: 192,863,628 (GRCm39) V414A probably damaging Het
Trim14 T A 4: 46,523,709 (GRCm39) T110S probably benign Het
Trim30d T C 7: 104,137,007 (GRCm39) N66D probably damaging Het
Trim65 G A 11: 116,017,305 (GRCm39) Q386* probably null Het
Ube2u T A 4: 100,407,039 (GRCm39) I187N probably benign Het
Vmn1r90 G A 7: 14,297,219 (GRCm39) probably benign Het
Wbp2nl A G 15: 82,192,762 (GRCm39) M149V probably benign Het
Xpo4 C T 14: 57,880,490 (GRCm39) probably benign Het
Zbtb21 A T 16: 97,753,963 (GRCm39) Y135N probably damaging Het
Zbtb22 T A 17: 34,137,142 (GRCm39) V429D probably damaging Het
Zfp281 T A 1: 136,553,859 (GRCm39) I279N probably damaging Het
Zhx1 T C 15: 57,916,317 (GRCm39) E643G possibly damaging Het
Zzef1 C T 11: 72,765,879 (GRCm39) H1469Y probably benign Het
Other mutations in Gkn3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02170:Gkn3 APN 6 87,360,493 (GRCm39) missense possibly damaging 0.70
IGL02746:Gkn3 APN 6 87,364,339 (GRCm39) splice site probably benign
IGL03345:Gkn3 APN 6 87,365,798 (GRCm39) missense probably null 0.09
R1758:Gkn3 UTSW 6 87,365,817 (GRCm39) start codon destroyed probably benign
R2303:Gkn3 UTSW 6 87,360,507 (GRCm39) missense probably damaging 1.00
R2304:Gkn3 UTSW 6 87,360,507 (GRCm39) missense probably damaging 1.00
R2363:Gkn3 UTSW 6 87,360,507 (GRCm39) missense probably damaging 1.00
R2365:Gkn3 UTSW 6 87,360,507 (GRCm39) missense probably damaging 1.00
R2897:Gkn3 UTSW 6 87,360,507 (GRCm39) missense probably damaging 1.00
R2898:Gkn3 UTSW 6 87,360,507 (GRCm39) missense probably damaging 1.00
R2983:Gkn3 UTSW 6 87,360,507 (GRCm39) missense probably damaging 1.00
R3031:Gkn3 UTSW 6 87,360,507 (GRCm39) missense probably damaging 1.00
R3426:Gkn3 UTSW 6 87,360,507 (GRCm39) missense probably damaging 1.00
R3433:Gkn3 UTSW 6 87,360,507 (GRCm39) missense probably damaging 1.00
R4085:Gkn3 UTSW 6 87,360,507 (GRCm39) missense probably damaging 1.00
R4087:Gkn3 UTSW 6 87,360,507 (GRCm39) missense probably damaging 1.00
R4088:Gkn3 UTSW 6 87,360,507 (GRCm39) missense probably damaging 1.00
R4089:Gkn3 UTSW 6 87,360,507 (GRCm39) missense probably damaging 1.00
R4090:Gkn3 UTSW 6 87,360,507 (GRCm39) missense probably damaging 1.00
R4163:Gkn3 UTSW 6 87,360,507 (GRCm39) missense probably damaging 1.00
R4164:Gkn3 UTSW 6 87,360,507 (GRCm39) missense probably damaging 1.00
R4720:Gkn3 UTSW 6 87,360,507 (GRCm39) missense probably damaging 1.00
R4721:Gkn3 UTSW 6 87,360,507 (GRCm39) missense probably damaging 1.00
R4722:Gkn3 UTSW 6 87,360,507 (GRCm39) missense probably damaging 1.00
R4723:Gkn3 UTSW 6 87,360,507 (GRCm39) missense probably damaging 1.00
R4766:Gkn3 UTSW 6 87,360,507 (GRCm39) missense probably damaging 1.00
R4941:Gkn3 UTSW 6 87,360,507 (GRCm39) missense probably damaging 1.00
R5004:Gkn3 UTSW 6 87,360,507 (GRCm39) missense probably damaging 1.00
R5163:Gkn3 UTSW 6 87,360,507 (GRCm39) missense probably damaging 1.00
R6078:Gkn3 UTSW 6 87,360,507 (GRCm39) missense probably damaging 1.00
R6079:Gkn3 UTSW 6 87,360,507 (GRCm39) missense probably damaging 1.00
R6502:Gkn3 UTSW 6 87,365,786 (GRCm39) missense probably benign 0.01
R6924:Gkn3 UTSW 6 87,365,784 (GRCm39) missense probably benign 0.05
R7695:Gkn3 UTSW 6 87,361,422 (GRCm39) missense probably damaging 1.00
R9240:Gkn3 UTSW 6 87,365,789 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- TCCATGGGAAGCCAACATGTG -3'
(R):5'- TCTTCAAGACACAAGGGTCCC -3'

Sequencing Primer
(F):5'- TGTGGAGCACAGAGGACTGC -3'
(R):5'- CACACTGGGCTAAGGGGTTAC -3'
Posted On 2015-05-15