Incidental Mutation 'R0391:Tshz1'
ID 31739
Institutional Source Beutler Lab
Gene Symbol Tshz1
Ensembl Gene ENSMUSG00000046982
Gene Name teashirt zinc finger family member 1
Synonyms Mtsh1, teashirt1, Sdccag33, D18Bwg1409e, Tsh1, NY-CO-33, 5730407I04Rik
MMRRC Submission 038597-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R0391 (G1)
Quality Score 225
Status Validated
Chromosome 18
Chromosomal Location 84011627-84086404 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to G at 84016049 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Serine at position 78 (F78S)
Ref Sequence ENSEMBL: ENSMUSP00000089388 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000060303]
AlphaFold Q5DTH5
Predicted Effect possibly damaging
Transcript: ENSMUST00000060303
AA Change: F78S

PolyPhen 2 Score 0.931 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000089388
Gene: ENSMUSG00000046982
AA Change: F78S

DomainStartEndE-ValueType
low complexity region 18 29 N/A INTRINSIC
low complexity region 89 100 N/A INTRINSIC
low complexity region 153 195 N/A INTRINSIC
ZnF_C2H2 246 270 1.86e0 SMART
ZnF_C2H2 307 331 3.83e-2 SMART
ZnF_C2H2 416 440 5.34e0 SMART
low complexity region 497 515 N/A INTRINSIC
HOX 890 964 4.15e-4 SMART
ZnF_C2H2 976 998 4.34e-1 SMART
ZnF_C2H2 1044 1067 4.47e-3 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000175783
SMART Domains Protein: ENSMUSP00000135640
Gene: ENSMUSG00000046982

DomainStartEndE-ValueType
ZnF_C2H2 43 67 1.7e-4 SMART
ZnF_C2H2 152 176 2.3e-2 SMART
low complexity region 233 251 N/A INTRINSIC
HOX 626 700 2.1e-6 SMART
ZnF_C2H2 712 734 1.9e-3 SMART
ZnF_C2H2 780 803 1.8e-5 SMART
Meta Mutation Damage Score 0.0939 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.2%
  • 10x: 95.9%
  • 20x: 91.8%
Validation Efficiency 97% (97/100)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a colon cancer antigen that was defined by serological analysis of recombinant cDNA expression libraries. The encoded protein is a member of the teashirt C2H2-type zinc-finger protein family and may be involved in transcriptional regulation of developmental processes. Mutations in this gene may be associated with congenital aural atresia syndrome. [provided by RefSeq, Jan 2012]
PHENOTYPE: Mice homozygous for a null allele die shortly after birth of respiratory distress, have defects in soft palate formation, have altered axial skeleton and have middle ear defects. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 97 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9530002B09Rik T A 4: 122,701,177 (GRCm38) probably benign Het
Abcc2 G A 19: 43,821,605 (GRCm38) probably benign Het
Abcc8 C G 7: 46,122,173 (GRCm38) G838A probably damaging Het
Akr1c21 G A 13: 4,581,200 (GRCm38) A245T probably damaging Het
Anapc15-ps T C 10: 95,673,277 (GRCm38) E47G probably damaging Het
Apoa1 A G 9: 46,229,842 (GRCm38) T79A probably benign Het
Atp6v1b1 A G 6: 83,756,921 (GRCm38) H378R possibly damaging Het
C4b A G 17: 34,735,614 (GRCm38) probably benign Het
Catsperd A T 17: 56,662,821 (GRCm38) E638D probably benign Het
Cckar C T 5: 53,706,253 (GRCm38) probably null Het
Cfap100 C T 6: 90,405,339 (GRCm38) probably benign Het
Chd1 G T 17: 15,749,894 (GRCm38) G970C probably damaging Het
Col14a1 A G 15: 55,446,259 (GRCm38) probably benign Het
Col17a1 C T 19: 47,663,824 (GRCm38) V698M probably damaging Het
Cpeb1 T C 7: 81,361,725 (GRCm38) D156G possibly damaging Het
Cryl1 A G 14: 57,303,775 (GRCm38) Y151H possibly damaging Het
Csmd3 C A 15: 47,657,573 (GRCm38) V1881L probably damaging Het
Ctnnal1 C T 4: 56,847,921 (GRCm38) A73T probably damaging Het
Cyp2c37 T C 19: 39,994,506 (GRCm38) S180P probably damaging Het
Cyp2c54 T C 19: 40,072,169 (GRCm38) T123A possibly damaging Het
Dennd6b T C 15: 89,187,214 (GRCm38) D304G probably damaging Het
Dnmt3l T C 10: 78,051,916 (GRCm38) probably benign Het
Eci1 G A 17: 24,433,260 (GRCm38) probably null Het
Efhc1 A G 1: 20,960,188 (GRCm38) Y115C probably damaging Het
Ern1 T A 11: 106,407,178 (GRCm38) K706* probably null Het
Fam129c T A 8: 71,602,499 (GRCm38) probably benign Het
Ghrl T C 6: 113,719,338 (GRCm38) E31G probably damaging Het
Gpr108 A C 17: 57,243,101 (GRCm38) V179G probably benign Het
Henmt1 A G 3: 108,958,535 (GRCm38) probably benign Het
Ift172 A G 5: 31,286,667 (GRCm38) V69A probably damaging Het
Il17ra T C 6: 120,476,979 (GRCm38) probably benign Het
Il17rb T C 14: 30,004,347 (GRCm38) N95D probably benign Het
Il17rb G T 14: 30,006,155 (GRCm38) probably null Het
Iqub G A 6: 24,446,155 (GRCm38) L757F probably benign Het
Itpr1 T C 6: 108,378,167 (GRCm38) V473A probably benign Het
Itpr2 T G 6: 146,229,773 (GRCm38) N1978H probably damaging Het
Klk1b26 T A 7: 44,012,727 (GRCm38) F3Y probably damaging Het
Lars A G 18: 42,251,363 (GRCm38) V50A probably benign Het
Lax1 G T 1: 133,680,066 (GRCm38) H312Q probably benign Het
Lctl T C 9: 64,122,314 (GRCm38) probably benign Het
Lrp2 G A 2: 69,460,337 (GRCm38) probably benign Het
Lrp2 T A 2: 69,456,858 (GRCm38) D3745V probably damaging Het
Lvrn A T 18: 46,850,466 (GRCm38) H92L probably benign Het
March1 A G 8: 66,418,973 (GRCm38) T385A probably damaging Het
Marf1 C T 16: 14,142,534 (GRCm38) A549T probably damaging Het
Mbd5 T C 2: 49,272,416 (GRCm38) V970A possibly damaging Het
Mccc1 A G 3: 35,963,570 (GRCm38) probably benign Het
Mpp4 A T 1: 59,143,829 (GRCm38) probably benign Het
Mrnip G A 11: 50,199,920 (GRCm38) A304T probably damaging Het
Muc5b T C 7: 141,865,082 (GRCm38) S3922P possibly damaging Het
Myh3 T A 11: 67,096,507 (GRCm38) probably benign Het
Nbea A T 3: 56,037,277 (GRCm38) H555Q probably damaging Het
Nlrp9c A T 7: 26,371,476 (GRCm38) probably benign Het
Nmur1 A T 1: 86,387,678 (GRCm38) V178E probably damaging Het
Nod2 T G 8: 88,663,778 (GRCm38) S238A probably benign Het
Ogfod1 A T 8: 94,063,023 (GRCm38) T451S probably damaging Het
Olfr145 G A 9: 37,897,842 (GRCm38) G146D probably benign Het
Olfr23 T C 11: 73,941,109 (GRCm38) F288L probably damaging Het
Olfr372 C T 8: 72,058,400 (GRCm38) T240M probably damaging Het
Olfr716 T A 7: 107,148,187 (GRCm38) Y290* probably null Het
Pcdh20 T C 14: 88,468,668 (GRCm38) I399V probably benign Het
Pdlim1 G T 19: 40,243,573 (GRCm38) H120Q probably damaging Het
Plg T C 17: 12,419,081 (GRCm38) V798A probably damaging Het
Polr2c A G 8: 94,857,775 (GRCm38) I39V possibly damaging Het
Ppfia2 C A 10: 106,830,714 (GRCm38) probably benign Het
Ppp1r3a A T 6: 14,719,697 (GRCm38) I406N probably benign Het
Psg28 A T 7: 18,426,173 (GRCm38) M366K probably benign Het
Rad54b T C 4: 11,601,702 (GRCm38) I419T probably damaging Het
Rnf43 A G 11: 87,731,282 (GRCm38) Q403R possibly damaging Het
Sema6a G A 18: 47,290,045 (GRCm38) probably null Het
Slc28a3 A G 13: 58,569,415 (GRCm38) probably benign Het
Smad2 A T 18: 76,289,037 (GRCm38) probably null Het
Smad4 G A 18: 73,658,649 (GRCm38) P274S probably benign Het
Smchd1 A T 17: 71,403,154 (GRCm38) V906D probably damaging Het
Soat2 C A 15: 102,158,753 (GRCm38) R320S possibly damaging Het
Spata33 C T 8: 123,221,887 (GRCm38) A57V probably damaging Het
Stab1 A G 14: 31,143,418 (GRCm38) L1814P probably benign Het
Stab2 T C 10: 86,947,144 (GRCm38) K680R probably benign Het
Stil A G 4: 115,041,172 (GRCm38) probably null Het
Sympk T A 7: 19,046,849 (GRCm38) L759H probably benign Het
Tet1 A T 10: 62,814,546 (GRCm38) probably null Het
Tfpi2 A T 6: 3,965,460 (GRCm38) N117K probably benign Het
Tle3 A G 9: 61,416,661 (GRCm38) Y766C probably damaging Het
Trpt1 C A 19: 6,997,930 (GRCm38) probably null Het
Ttc1 T C 11: 43,738,808 (GRCm38) D177G probably damaging Het
Ttc13 T A 8: 124,674,401 (GRCm38) Y741F probably damaging Het
Ulk3 C T 9: 57,594,832 (GRCm38) S462L probably benign Het
Utrn C T 10: 12,525,333 (GRCm38) probably benign Het
V1rd19 A C 7: 24,003,585 (GRCm38) T159P probably damaging Het
Vars T C 17: 35,011,486 (GRCm38) V515A possibly damaging Het
Vmn1r85 A G 7: 13,084,588 (GRCm38) Y210H probably benign Het
Vmn2r89 A G 14: 51,455,978 (GRCm38) T262A probably damaging Het
Vps53 G A 11: 76,121,579 (GRCm38) T209I probably benign Het
Wdfy2 T C 14: 62,925,133 (GRCm38) F95L possibly damaging Het
Wwp1 G T 4: 19,627,911 (GRCm38) S694Y probably damaging Het
Zbtb8b T A 4: 129,432,670 (GRCm38) D201V probably damaging Het
Zmym5 A C 14: 56,804,451 (GRCm38) N123K possibly damaging Het
Other mutations in Tshz1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01486:Tshz1 APN 18 84,013,509 (GRCm38) missense possibly damaging 0.94
IGL02934:Tshz1 APN 18 84,013,090 (GRCm38) missense probably damaging 1.00
ANU18:Tshz1 UTSW 18 84,014,661 (GRCm38) missense probably damaging 1.00
PIT4810001:Tshz1 UTSW 18 84,013,250 (GRCm38) missense possibly damaging 0.85
R0052:Tshz1 UTSW 18 84,014,945 (GRCm38) missense possibly damaging 0.76
R0052:Tshz1 UTSW 18 84,014,945 (GRCm38) missense possibly damaging 0.76
R0364:Tshz1 UTSW 18 84,016,124 (GRCm38) missense probably benign 0.31
R0515:Tshz1 UTSW 18 84,015,965 (GRCm38) missense probably benign
R0942:Tshz1 UTSW 18 84,013,053 (GRCm38) missense probably damaging 0.99
R0943:Tshz1 UTSW 18 84,015,231 (GRCm38) missense probably benign 0.04
R1472:Tshz1 UTSW 18 84,013,805 (GRCm38) missense possibly damaging 0.93
R1895:Tshz1 UTSW 18 84,013,433 (GRCm38) missense probably damaging 1.00
R2022:Tshz1 UTSW 18 84,013,862 (GRCm38) missense probably damaging 0.98
R2860:Tshz1 UTSW 18 84,014,980 (GRCm38) missense probably damaging 1.00
R2861:Tshz1 UTSW 18 84,014,980 (GRCm38) missense probably damaging 1.00
R4027:Tshz1 UTSW 18 84,014,829 (GRCm38) missense possibly damaging 0.74
R4028:Tshz1 UTSW 18 84,014,829 (GRCm38) missense possibly damaging 0.74
R4030:Tshz1 UTSW 18 84,014,829 (GRCm38) missense possibly damaging 0.74
R4031:Tshz1 UTSW 18 84,014,829 (GRCm38) missense possibly damaging 0.74
R4119:Tshz1 UTSW 18 84,014,189 (GRCm38) missense probably benign 0.00
R4233:Tshz1 UTSW 18 84,016,195 (GRCm38) missense probably benign 0.00
R4573:Tshz1 UTSW 18 84,015,082 (GRCm38) missense probably damaging 1.00
R4604:Tshz1 UTSW 18 84,013,374 (GRCm38) missense probably damaging 1.00
R4960:Tshz1 UTSW 18 84,014,862 (GRCm38) missense probably benign 0.08
R5085:Tshz1 UTSW 18 84,013,928 (GRCm38) missense probably benign 0.01
R5124:Tshz1 UTSW 18 84,015,467 (GRCm38) missense probably damaging 1.00
R5150:Tshz1 UTSW 18 84,013,215 (GRCm38) nonsense probably null
R5357:Tshz1 UTSW 18 84,015,080 (GRCm38) missense probably damaging 1.00
R5530:Tshz1 UTSW 18 84,013,268 (GRCm38) missense probably damaging 1.00
R5718:Tshz1 UTSW 18 84,014,524 (GRCm38) missense probably damaging 1.00
R5750:Tshz1 UTSW 18 84,013,961 (GRCm38) missense possibly damaging 0.93
R5778:Tshz1 UTSW 18 84,015,680 (GRCm38) missense probably damaging 1.00
R6052:Tshz1 UTSW 18 84,014,069 (GRCm38) missense probably damaging 1.00
R6279:Tshz1 UTSW 18 84,015,311 (GRCm38) missense probably damaging 1.00
R6393:Tshz1 UTSW 18 84,013,220 (GRCm38) missense probably damaging 1.00
R6407:Tshz1 UTSW 18 84,015,966 (GRCm38) missense possibly damaging 0.55
R6425:Tshz1 UTSW 18 84,015,563 (GRCm38) missense probably damaging 0.99
R6998:Tshz1 UTSW 18 84,015,841 (GRCm38) missense probably benign 0.00
R7165:Tshz1 UTSW 18 84,015,927 (GRCm38) missense probably damaging 1.00
R7233:Tshz1 UTSW 18 84,014,819 (GRCm38) missense possibly damaging 0.63
R7330:Tshz1 UTSW 18 84,014,831 (GRCm38) missense probably damaging 0.96
R7491:Tshz1 UTSW 18 84,015,641 (GRCm38) missense probably damaging 1.00
R7579:Tshz1 UTSW 18 84,014,665 (GRCm38) nonsense probably null
R7592:Tshz1 UTSW 18 84,014,048 (GRCm38) missense probably damaging 1.00
R7659:Tshz1 UTSW 18 84,016,075 (GRCm38) missense probably damaging 0.97
R7702:Tshz1 UTSW 18 84,014,336 (GRCm38) missense probably damaging 1.00
R7844:Tshz1 UTSW 18 84,014,171 (GRCm38) missense probably benign 0.00
R7908:Tshz1 UTSW 18 84,014,607 (GRCm38) nonsense probably null
R7941:Tshz1 UTSW 18 84,015,392 (GRCm38) missense possibly damaging 0.91
R7947:Tshz1 UTSW 18 84,015,657 (GRCm38) missense probably damaging 1.00
R8435:Tshz1 UTSW 18 84,014,024 (GRCm38) missense probably damaging 1.00
R8750:Tshz1 UTSW 18 84,015,037 (GRCm38) missense probably damaging 1.00
R8774:Tshz1 UTSW 18 84,014,976 (GRCm38) missense possibly damaging 0.96
R8774-TAIL:Tshz1 UTSW 18 84,014,976 (GRCm38) missense possibly damaging 0.96
R9029:Tshz1 UTSW 18 84,013,514 (GRCm38) missense probably damaging 0.98
R9031:Tshz1 UTSW 18 84,014,862 (GRCm38) missense probably benign 0.08
R9573:Tshz1 UTSW 18 84,014,279 (GRCm38) missense probably benign 0.45
R9584:Tshz1 UTSW 18 84,014,964 (GRCm38) missense probably damaging 1.00
R9596:Tshz1 UTSW 18 84,013,779 (GRCm38) missense possibly damaging 0.92
R9701:Tshz1 UTSW 18 84,014,454 (GRCm38) missense possibly damaging 0.96
Predicted Primers PCR Primer
(F):5'- AATGCTAGGCTAGACCAGCAGGAC -3'
(R):5'- GCATGATCGACTCCTCTGACTGTG -3'

Sequencing Primer
(F):5'- CTCTGAGAATAAGTTCGCATACACG -3'
(R):5'- TAGCTTACGTTCCCGAGGAAG -3'
Posted On 2013-04-24