Incidental Mutation 'R0392:Cyp2j7'
ID 31753
Institutional Source Beutler Lab
Gene Symbol Cyp2j7
Ensembl Gene ENSMUSG00000081362
Gene Name cytochrome P450, family 2, subfamily j, polypeptide 7
Synonyms OTTMUSG00000007941, Cyp2j7-ps
MMRRC Submission 038598-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.063) question?
Stock # R0392 (G1)
Quality Score 225
Status Validated
Chromosome 4
Chromosomal Location 96083434-96124896 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 96087671 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 413 (D413G)
Ref Sequence ENSEMBL: ENSMUSP00000134331 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000162514]
AlphaFold A0A140T8U1
Predicted Effect probably damaging
Transcript: ENSMUST00000162514
AA Change: D413G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000134331
Gene: ENSMUSG00000081362
AA Change: D413G

DomainStartEndE-ValueType
transmembrane domain 10 32 N/A INTRINSIC
Pfam:p450 44 499 3.7e-130 PFAM
Meta Mutation Damage Score 0.8968 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.0%
  • 10x: 95.5%
  • 20x: 90.6%
Validation Efficiency 100% (31/31)
Allele List at MGI
Other mutations in this stock
Total: 31 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930527J03Rik ACCC ACC 1: 178,276,503 (GRCm38) noncoding transcript Het
Bcan T A 3: 87,900,869 (GRCm39) K455* probably null Het
Casp12 T A 9: 5,348,973 (GRCm39) probably benign Het
Ccdc61 T C 7: 18,625,027 (GRCm39) M504V probably benign Het
Cd53 A T 3: 106,670,592 (GRCm39) V147E probably damaging Het
Cyp2b13 T C 7: 25,785,308 (GRCm39) Y226H probably benign Het
Dcbld1 T C 10: 52,193,230 (GRCm39) I254T possibly damaging Het
Ddx39a T G 8: 84,448,366 (GRCm39) M206R probably damaging Het
Dgki T A 6: 36,977,113 (GRCm39) T666S probably damaging Het
Dnaaf8 T C 16: 4,795,363 (GRCm39) noncoding transcript Het
Dnah7a C A 1: 53,543,357 (GRCm39) C2271F probably damaging Het
Emilin3 A G 2: 160,752,799 (GRCm39) probably benign Het
Epha4 T C 1: 77,483,610 (GRCm39) K133R probably benign Het
Gm11146 T A 16: 77,394,054 (GRCm39) probably benign Het
Ift88 A T 14: 57,733,617 (GRCm39) probably benign Het
Ighv10-3 A G 12: 114,487,460 (GRCm39) probably benign Het
Lamp5 T C 2: 135,902,817 (GRCm39) S179P probably damaging Het
Map4 T C 9: 109,907,113 (GRCm39) S788P probably damaging Het
Or5m13 T A 2: 85,749,106 (GRCm39) I279N possibly damaging Het
Otog T C 7: 45,899,499 (GRCm39) W267R probably benign Het
Pafah1b2 T C 9: 45,880,151 (GRCm39) I175M probably benign Het
Pcdhb12 A G 18: 37,570,011 (GRCm39) K386E possibly damaging Het
Pcnt T C 10: 76,220,660 (GRCm39) N2056S probably benign Het
Pold2 T C 11: 5,826,776 (GRCm39) I53V possibly damaging Het
Rsf1 T A 7: 97,328,212 (GRCm39) D1071E probably benign Het
Rtp3 A T 9: 110,818,621 (GRCm39) M20K probably damaging Het
S1pr5 T A 9: 21,156,277 (GRCm39) I50F probably damaging Het
Slc47a1 A G 11: 61,262,608 (GRCm39) S94P probably damaging Het
Slitrk5 G A 14: 111,916,465 (GRCm39) V30I probably benign Het
St8sia5 G A 18: 77,342,102 (GRCm39) V271M probably damaging Het
Sult2b1 G T 7: 45,383,062 (GRCm39) T240N probably damaging Het
Other mutations in Cyp2j7
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00426:Cyp2j7 APN 4 96,115,750 (GRCm39) splice site probably null
IGL00426:Cyp2j7 APN 4 96,115,749 (GRCm39) splice site probably benign
IGL01505:Cyp2j7 APN 4 96,115,917 (GRCm39) critical splice acceptor site probably null
IGL02100:Cyp2j7 APN 4 96,124,793 (GRCm39) missense probably damaging 0.99
IGL02183:Cyp2j7 APN 4 96,118,384 (GRCm39) splice site probably benign
IGL02596:Cyp2j7 APN 4 96,103,659 (GRCm39) missense possibly damaging 0.56
IGL02661:Cyp2j7 APN 4 96,124,887 (GRCm39) missense probably benign
IGL02723:Cyp2j7 APN 4 96,118,366 (GRCm39) missense probably benign 0.33
IGL03053:Cyp2j7 APN 4 96,118,274 (GRCm39) missense probably benign 0.00
IGL03159:Cyp2j7 APN 4 96,115,749 (GRCm39) splice site probably benign
IGL03168:Cyp2j7 APN 4 96,118,274 (GRCm39) missense probably benign 0.00
IGL03174:Cyp2j7 APN 4 96,083,607 (GRCm39) nonsense probably null
PIT4449001:Cyp2j7 UTSW 4 96,103,575 (GRCm39) missense probably damaging 0.96
R0016:Cyp2j7 UTSW 4 96,090,384 (GRCm39) missense probably damaging 0.99
R0016:Cyp2j7 UTSW 4 96,090,384 (GRCm39) missense probably damaging 0.99
R1447:Cyp2j7 UTSW 4 96,083,530 (GRCm39) missense possibly damaging 0.90
R1778:Cyp2j7 UTSW 4 96,087,627 (GRCm39) missense probably damaging 1.00
R1876:Cyp2j7 UTSW 4 96,105,656 (GRCm39) missense probably benign 0.01
R4105:Cyp2j7 UTSW 4 96,087,687 (GRCm39) missense possibly damaging 0.84
R4106:Cyp2j7 UTSW 4 96,087,687 (GRCm39) missense possibly damaging 0.84
R4107:Cyp2j7 UTSW 4 96,087,687 (GRCm39) missense possibly damaging 0.84
R4108:Cyp2j7 UTSW 4 96,087,687 (GRCm39) missense possibly damaging 0.84
R4438:Cyp2j7 UTSW 4 96,105,646 (GRCm39) missense probably benign 0.01
R4660:Cyp2j7 UTSW 4 96,083,579 (GRCm39) missense probably benign 0.29
R6193:Cyp2j7 UTSW 4 96,083,440 (GRCm39) missense probably damaging 1.00
R6380:Cyp2j7 UTSW 4 96,118,211 (GRCm39) critical splice donor site probably null
R6427:Cyp2j7 UTSW 4 96,115,904 (GRCm39) missense probably damaging 0.96
R6624:Cyp2j7 UTSW 4 96,115,855 (GRCm39) missense probably damaging 0.99
R7196:Cyp2j7 UTSW 4 96,103,651 (GRCm39) missense probably benign 0.03
R7417:Cyp2j7 UTSW 4 96,090,225 (GRCm39) critical splice donor site probably null
R7780:Cyp2j7 UTSW 4 96,118,256 (GRCm39) missense probably benign 0.00
R8062:Cyp2j7 UTSW 4 96,103,587 (GRCm39) missense probably null 1.00
R8097:Cyp2j7 UTSW 4 96,103,647 (GRCm39) missense possibly damaging 0.95
R8201:Cyp2j7 UTSW 4 96,083,564 (GRCm39) missense probably damaging 1.00
R8279:Cyp2j7 UTSW 4 96,116,796 (GRCm39) critical splice donor site probably null
R9254:Cyp2j7 UTSW 4 96,105,740 (GRCm39) nonsense probably null
R9328:Cyp2j7 UTSW 4 96,115,869 (GRCm39) missense probably damaging 1.00
R9377:Cyp2j7 UTSW 4 96,124,786 (GRCm39) missense probably benign 0.01
R9489:Cyp2j7 UTSW 4 96,103,591 (GRCm39) missense probably damaging 1.00
R9499:Cyp2j7 UTSW 4 96,115,840 (GRCm39) missense probably damaging 1.00
R9552:Cyp2j7 UTSW 4 96,115,840 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AGAGCACTGGTCATGAAACAGCAC -3'
(R):5'- GAAATGCGCTAAGCAAACACTGTCC -3'

Sequencing Primer
(F):5'- TGAAACAGCACTATGGACATGC -3'
(R):5'- CTGTCCATCAATGATCTGAACAAGG -3'
Posted On 2013-04-24