Mutagenetix > Incidental Mutations

Incidental Mutation 'R4091:Vmn2r84'

317625

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r84

Ensembl Gene

ENSMUSG00000070601

Gene Name

vomeronasal 2, receptor 84

Synonyms

EG625068

MMRRC Submission

041626-MU

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.083) question?

Stock #

R4091 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

130385316-130394241 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 130391369 bp

Zygosity

Heterozygous

Amino Acid Change

Methionine to Lysine at position 200 (M200K)

Ref Sequence

ENSEMBL: ENSMUSP00000092079 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000094502]

Predicted Effect

probably damaging
Transcript: ENSMUST00000094502
AA Change: M200K

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)

SMART Domains

Protein: ENSMUSP00000092079
Gene: ENSMUSG00000070601
AA Change: M200K

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC
Pfam:ANF_receptor	77	448	1.3e-27	PFAM
Pfam:NCD3G	508	561	6.9e-21	PFAM
Pfam:7tm_3	594	830	4.6e-55	PFAM

Meta Mutation Damage Score

0.6467

Coding Region Coverage

1x: 99.2%
3x: 98.7%
10x: 97.6%
20x: 96.1%

Validation Efficiency

98% (61/62)

Allele List at MGI

Other mutations in this stock

Total: 58 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4932414N04Rik	T	C	2: 68,745,378	S674P	possibly damaging	Het
4932438A13Rik	G	A	3: 37,030,589	A3897T	probably benign	Het
A530099J19Rik	T	A	13: 19,729,465		noncoding transcript	Het
Abca3	C	T	17: 24,397,482	T966M	probably damaging	Het
Adam2	A	T	14: 66,029,723	Y696N	probably damaging	Het
Aes	G	A	10: 81,565,584	G162D	probably damaging	Het
Alas1	G	T	9: 106,241,801		probably null	Het
Arhgap25	G	T	6: 87,463,035	S543R	probably benign	Het
Bckdk	C	A	7: 127,905,418	R105S	probably damaging	Het
Carns1	C	T	19: 4,171,683	R191Q	probably damaging	Het
Casp8ap2	C	A	4: 32,643,611	P895T	probably damaging	Het
Col12a1	T	A	9: 79,702,364	I287F	probably damaging	Het
Cystm1	A	G	18: 36,366,547	N5S	unknown	Het
Dnah8	T	C	17: 30,769,839	V3261A	probably damaging	Het
Dnajc11	A	G	4: 151,978,093		probably benign	Het
Dock4	T	C	12: 40,844,267	S1847P	probably damaging	Het
Dync2h1	A	G	9: 7,131,881	V1642A	probably benign	Het
Eftud2	T	C	11: 102,839,416		probably null	Het
Fam221b	A	G	4: 43,665,987	I208T	probably benign	Het
Gpr37l1	T	C	1: 135,161,563	I255V	probably benign	Het
Grm7	G	A	6: 110,914,340	S178N	probably damaging	Het
Hspa12b	T	A	2: 131,133,488		probably null	Het
Kctd3	A	T	1: 188,995,720		probably benign	Het
Kynu	G	A	2: 43,679,872	V389M	possibly damaging	Het
Lcat	A	G	8: 105,939,906	L328P	probably benign	Het
Lrrn2	C	T	1: 132,937,652	Q152*	probably null	Het
Maml1	G	A	11: 50,291,829	P78L	probably benign	Het
Mef2b	G	A	8: 70,165,102	V37M	probably damaging	Het
Mindy2	A	T	9: 70,634,060	M281K	probably damaging	Het
Mon2	C	T	10: 123,038,510	R311H	probably damaging	Het
Mtr	A	T	13: 12,231,057	V394E	probably damaging	Het
Myh14	T	A	7: 44,632,991	T745S	possibly damaging	Het
Nme9	T	A	9: 99,464,527	D131E	possibly damaging	Het
Nphp4	C	A	4: 152,547,018	Q792K	probably damaging	Het
Nrxn2	T	A	19: 6,473,414	C479S	probably damaging	Het
Nsmf	T	C	2: 25,060,859	I406T	probably damaging	Het
Olfr1431	A	T	19: 12,209,779	D71V	probably damaging	Het
Olfr517	G	A	7: 108,868,443	A237V	probably damaging	Het
Olfr945	T	A	9: 39,258,034	I213F	possibly damaging	Het
Pbrm1	A	G	14: 31,036,003	T197A	probably benign	Het
Pla2r1	T	A	2: 60,432,593	N1034I	probably damaging	Het
Rps6-ps2	A	G	8: 88,806,691		noncoding transcript	Het
Rufy4	T	C	1: 74,147,663	C537R	probably damaging	Het
Rxfp1	A	T	3: 79,644,761	D744E	probably benign	Het
Samd9l	T	C	6: 3,376,887	N125D	probably benign	Het
Serpina3a	G	A	12: 104,116,366	V133I	probably benign	Het
Slc22a30	C	T	19: 8,404,545	V121M	probably damaging	Het
Smarcc1	T	A	9: 110,164,829	D247E	possibly damaging	Het
Smg9	T	A	7: 24,420,867	L422Q	probably null	Het
Speer3	C	G	5: 13,796,380	A238G	possibly damaging	Het
Ttc23l	CT	CTTGGATT	15: 10,537,562		probably benign	Het
Ttc23l	G	A	15: 10,537,566	S206L	probably benign	Het
Utrn	T	A	10: 12,710,171	D954V	probably benign	Het
Vmn1r227	T	A	17: 20,735,516		noncoding transcript	Het
Vmn2r11	A	C	5: 109,054,750		probably null	Het
Vmn2r88	T	A	14: 51,415,426	Y469N	probably damaging	Het
Wdcp	A	G	12: 4,855,279	N600S	probably null	Het
Wdfy4	T	G	14: 33,125,880	R838S	possibly damaging	Het

Other mutations in Vmn2r84

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01461:Vmn2r84	APN	10	130391225	missense	possibly damaging	0.65
IGL01590:Vmn2r84	APN	10	130386095	missense	probably damaging	1.00
IGL01639:Vmn2r84	APN	10	130389272	nonsense	probably null
IGL01843:Vmn2r84	APN	10	130386279	missense	probably benign
IGL01911:Vmn2r84	APN	10	130386408	missense	probably damaging	0.99
IGL01937:Vmn2r84	APN	10	130385886	missense	probably damaging	1.00
IGL01977:Vmn2r84	APN	10	130394066	missense	probably benign	0.11
IGL02177:Vmn2r84	APN	10	130392012	missense	probably benign	0.00
IGL02291:Vmn2r84	APN	10	130390748	missense	probably damaging	1.00
IGL02590:Vmn2r84	APN	10	130391487	splice site	probably benign
IGL02727:Vmn2r84	APN	10	130394126	missense	possibly damaging	0.95
IGL02900:Vmn2r84	APN	10	130387992	splice site	probably benign
IGL03383:Vmn2r84	APN	10	130386687	missense	probably damaging	1.00
PIT4378001:Vmn2r84	UTSW	10	130385915	missense	probably damaging	1.00
R0076:Vmn2r84	UTSW	10	130394193	missense	probably damaging	1.00
R0089:Vmn2r84	UTSW	10	130386719	splice site	probably benign
R0153:Vmn2r84	UTSW	10	130392008	missense	probably benign	0.06
R0611:Vmn2r84	UTSW	10	130386122	missense	probably damaging	1.00
R0883:Vmn2r84	UTSW	10	130391115	missense	probably damaging	0.99
R1237:Vmn2r84	UTSW	10	130387856	splice site	probably null
R1295:Vmn2r84	UTSW	10	130389139	missense	probably benign	0.12
R1401:Vmn2r84	UTSW	10	130391990	missense	possibly damaging	0.89
R1521:Vmn2r84	UTSW	10	130389268	missense	probably benign	0.10
R1590:Vmn2r84	UTSW	10	130391480	critical splice acceptor site	probably null
R1710:Vmn2r84	UTSW	10	130391099	missense	probably benign	0.02
R1891:Vmn2r84	UTSW	10	130386069	missense	possibly damaging	0.78
R1956:Vmn2r84	UTSW	10	130390808	missense	probably benign	0.01
R1957:Vmn2r84	UTSW	10	130390808	missense	probably benign	0.01
R1962:Vmn2r84	UTSW	10	130390722	missense	probably damaging	0.99
R1994:Vmn2r84	UTSW	10	130386009	missense	probably damaging	1.00
R2124:Vmn2r84	UTSW	10	130391231	missense	probably damaging	0.99
R2409:Vmn2r84	UTSW	10	130392071	missense	probably damaging	0.99
R2474:Vmn2r84	UTSW	10	130386523	missense	possibly damaging	0.50
R2851:Vmn2r84	UTSW	10	130394167	missense	probably benign	0.05
R3508:Vmn2r84	UTSW	10	130390908	missense	probably damaging	1.00
R3792:Vmn2r84	UTSW	10	130385800	makesense	probably null
R4051:Vmn2r84	UTSW	10	130390898	missense	probably damaging	1.00
R4061:Vmn2r84	UTSW	10	130386029	missense	probably damaging	1.00
R4190:Vmn2r84	UTSW	10	130391294	nonsense	probably null
R4520:Vmn2r84	UTSW	10	130386522	missense	probably damaging	1.00
R4584:Vmn2r84	UTSW	10	130390713	missense	probably benign	0.00
R4588:Vmn2r84	UTSW	10	130385940	missense	probably damaging	0.98
R4655:Vmn2r84	UTSW	10	130394104	nonsense	probably null
R4860:Vmn2r84	UTSW	10	130385843	missense	probably damaging	0.99
R4860:Vmn2r84	UTSW	10	130385843	missense	probably damaging	0.99
R5022:Vmn2r84	UTSW	10	130386548	missense	probably damaging	1.00
R5146:Vmn2r84	UTSW	10	130386102	missense	probably damaging	1.00
R5237:Vmn2r84	UTSW	10	130385994	missense	probably damaging	0.99
R5695:Vmn2r84	UTSW	10	130389195	missense	probably benign	0.12
R5793:Vmn2r84	UTSW	10	130385885	missense	probably damaging	0.99
R6210:Vmn2r84	UTSW	10	130386245	missense	probably damaging	1.00
R6286:Vmn2r84	UTSW	10	130390868	missense	possibly damaging	0.65
R6580:Vmn2r84	UTSW	10	130389241	missense	possibly damaging	0.93
R6607:Vmn2r84	UTSW	10	130390862	missense	possibly damaging	0.87
R6818:Vmn2r84	UTSW	10	130386278	missense	probably benign	0.09
R6956:Vmn2r84	UTSW	10	130389267	missense	probably damaging	0.98
R6994:Vmn2r84	UTSW	10	130391007	missense	possibly damaging	0.90
R7075:Vmn2r84	UTSW	10	130391072	missense	probably damaging	0.99
R7225:Vmn2r84	UTSW	10	130386683	missense	probably damaging	0.99
R7252:Vmn2r84	UTSW	10	130386410	missense	probably damaging	1.00
R7263:Vmn2r84	UTSW	10	130389208	missense	probably damaging	1.00
R7297:Vmn2r84	UTSW	10	130391250	missense	probably benign	0.19
R7439:Vmn2r84	UTSW	10	130392113	missense	possibly damaging	0.90
R7441:Vmn2r84	UTSW	10	130392113	missense	possibly damaging	0.90
R7857:Vmn2r84	UTSW	10	130390869	missense	probably benign	0.00
R8263:Vmn2r84	UTSW	10	130391168	missense	probably damaging	1.00
R8555:Vmn2r84	UTSW	10	130394231	missense	probably benign	0.28
R8766:Vmn2r84	UTSW	10	130386372	missense	probably damaging	0.98
Z1177:Vmn2r84	UTSW	10	130391902	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- AACAACCTTTGCTGAAGATGTC -3'
(R):5'- GGAGTTCTTAAAGGTGGGTAGCAC -3'

Sequencing Primer
(F):5'- CCTTTGCTGAAGATGTCATAATTTG -3'
(R):5'- CTTAAAGGTGGGTAGCACTAATTG -3'

Posted On

2015-05-15