Incidental Mutation 'R4093:Vmn2r71'
| ID |
317735 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r71
|
| Ensembl Gene |
ENSMUSG00000091205 |
| Gene Name |
vomeronasal 2, receptor 71 |
| Synonyms |
EG233445 |
| MMRRC Submission |
041627-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.067)
|
| Stock # |
R4093 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
7 |
| Chromosomal Location |
85264670-85273755 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 85270442 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Alanine
at position 536
(V536A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000132337
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000172338]
|
| AlphaFold |
L7N2D8 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000172338
AA Change: V536A
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000132337
Gene: ENSMUSG00000091205
AA Change: V536A
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
77 |
468 |
2.1e-31 |
PFAM |
|
Pfam:NCD3G
|
511 |
563 |
8.7e-20 |
PFAM |
|
Pfam:7tm_3
|
593 |
831 |
2e-55 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000208273
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000208545
|
| Meta Mutation Damage Score |
0.0898 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.3%
- 20x: 95.5%
|
| Validation Efficiency |
92% (69/75) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 66 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Akap9 |
A |
G |
5: 4,093,996 (GRCm39) |
M2173V |
probably damaging |
Het |
| Alas1 |
G |
T |
9: 106,119,000 (GRCm39) |
|
probably null |
Het |
| Angpt1 |
T |
C |
15: 42,386,941 (GRCm39) |
T138A |
probably damaging |
Het |
| Atp2c2 |
G |
A |
8: 120,476,610 (GRCm39) |
|
probably null |
Het |
| Cadm2 |
A |
G |
16: 66,581,675 (GRCm39) |
V210A |
possibly damaging |
Het |
| Cfap70 |
A |
T |
14: 20,459,181 (GRCm39) |
D671E |
probably damaging |
Het |
| Chd2 |
C |
T |
7: 73,150,764 (GRCm39) |
E322K |
possibly damaging |
Het |
| Chrnd |
C |
T |
1: 87,118,729 (GRCm39) |
Q29* |
probably null |
Het |
| Cip2a |
T |
C |
16: 48,821,339 (GRCm39) |
|
probably benign |
Het |
| Cym |
A |
G |
3: 107,121,582 (GRCm39) |
S237P |
probably benign |
Het |
| D030068K23Rik |
A |
G |
8: 109,978,091 (GRCm39) |
|
noncoding transcript |
Het |
| Gsdma2 |
T |
A |
11: 98,541,677 (GRCm39) |
S135T |
probably benign |
Het |
| Hc |
A |
T |
2: 34,873,819 (GRCm39) |
Y158* |
probably null |
Het |
| Hoxb3 |
C |
A |
11: 96,236,926 (GRCm39) |
H335N |
probably damaging |
Het |
| Htr2a |
G |
A |
14: 74,943,789 (GRCm39) |
M456I |
probably benign |
Het |
| Ighv1-19 |
G |
A |
12: 114,672,350 (GRCm39) |
T90I |
probably damaging |
Het |
| Kansl3 |
C |
A |
1: 36,384,035 (GRCm39) |
S729I |
probably damaging |
Het |
| Kcnab1 |
T |
C |
3: 65,207,035 (GRCm39) |
I137T |
possibly damaging |
Het |
| Kcnt1 |
A |
T |
2: 25,767,927 (GRCm39) |
E12V |
probably damaging |
Het |
| Klk15 |
A |
T |
7: 43,588,204 (GRCm39) |
S171C |
possibly damaging |
Het |
| Lcn2 |
A |
T |
2: 32,277,728 (GRCm39) |
M1K |
probably null |
Het |
| Lrig1 |
T |
C |
6: 94,590,559 (GRCm39) |
D487G |
probably benign |
Het |
| Lrp8 |
T |
A |
4: 107,700,468 (GRCm39) |
C135* |
probably null |
Het |
| Lrrc31 |
C |
A |
3: 30,749,671 (GRCm39) |
S54I |
probably damaging |
Het |
| Ltbp4 |
A |
G |
7: 27,024,641 (GRCm39) |
V663A |
possibly damaging |
Het |
| Med27 |
G |
A |
2: 29,267,920 (GRCm39) |
|
probably benign |
Het |
| Mical1 |
T |
C |
10: 41,362,933 (GRCm39) |
|
probably benign |
Het |
| Myt1 |
A |
T |
2: 181,453,191 (GRCm39) |
M799L |
probably damaging |
Het |
| Nlrc4 |
T |
C |
17: 74,752,953 (GRCm39) |
M477V |
probably benign |
Het |
| Npy4r |
T |
C |
14: 33,869,098 (GRCm39) |
I63M |
probably benign |
Het |
| Or2t43 |
A |
T |
11: 58,457,655 (GRCm39) |
I172N |
probably damaging |
Het |
| Or52e15 |
C |
T |
7: 104,645,842 (GRCm39) |
G90S |
probably benign |
Het |
| Or8b1b |
T |
A |
9: 38,375,379 (GRCm39) |
L14Q |
probably null |
Het |
| Or8s10 |
T |
C |
15: 98,335,563 (GRCm39) |
L71P |
probably damaging |
Het |
| Piezo1 |
A |
C |
8: 123,227,899 (GRCm39) |
|
probably null |
Het |
| Ppp1r12c |
T |
C |
7: 4,486,366 (GRCm39) |
E601G |
probably damaging |
Het |
| Proser1 |
T |
C |
3: 53,387,133 (GRCm39) |
|
probably null |
Het |
| Psme2 |
A |
T |
14: 55,825,734 (GRCm39) |
N143K |
probably benign |
Het |
| Pygo2 |
C |
A |
3: 89,340,571 (GRCm39) |
P323Q |
probably damaging |
Het |
| Rab11b |
T |
C |
17: 33,968,763 (GRCm39) |
T77A |
possibly damaging |
Het |
| Recql5 |
A |
G |
11: 115,795,714 (GRCm39) |
S190P |
probably benign |
Het |
| Serpina12 |
A |
G |
12: 104,004,183 (GRCm39) |
F150L |
probably damaging |
Het |
| Sfswap |
A |
G |
5: 129,637,805 (GRCm39) |
S821G |
possibly damaging |
Het |
| Slc22a2 |
C |
T |
17: 12,831,281 (GRCm39) |
T357M |
probably damaging |
Het |
| Spag6l |
A |
C |
16: 16,646,888 (GRCm39) |
N39K |
probably benign |
Het |
| Srl |
A |
G |
16: 4,315,316 (GRCm39) |
S109P |
possibly damaging |
Het |
| Tagap |
A |
T |
17: 8,148,255 (GRCm39) |
H152L |
probably damaging |
Het |
| Tbx3 |
T |
A |
5: 119,818,813 (GRCm39) |
S463T |
probably benign |
Het |
| Tcaf2 |
A |
G |
6: 42,619,772 (GRCm39) |
L85P |
probably damaging |
Het |
| Tenm4 |
A |
T |
7: 96,544,979 (GRCm39) |
S2332C |
probably damaging |
Het |
| Trim60 |
A |
T |
8: 65,454,030 (GRCm39) |
M73K |
probably benign |
Het |
| Trpc1 |
T |
C |
9: 95,588,918 (GRCm39) |
T769A |
probably benign |
Het |
| Tubgcp4 |
T |
A |
2: 121,025,958 (GRCm39) |
L601Q |
probably benign |
Het |
| Unc5d |
T |
C |
8: 29,334,865 (GRCm39) |
Y154C |
possibly damaging |
Het |
| Vmn1r185 |
A |
T |
7: 26,311,208 (GRCm39) |
V99E |
probably damaging |
Het |
| Vmn1r57 |
G |
T |
7: 5,223,856 (GRCm39) |
S127I |
possibly damaging |
Het |
| Vmn1r62 |
T |
A |
7: 5,678,943 (GRCm39) |
M208K |
probably damaging |
Het |
| Vmn2r110 |
T |
C |
17: 20,803,642 (GRCm39) |
D311G |
possibly damaging |
Het |
| Vmn2r48 |
C |
A |
7: 9,676,185 (GRCm39) |
S432I |
probably benign |
Het |
| Vmn2r48 |
T |
A |
7: 9,676,186 (GRCm39) |
S432C |
probably damaging |
Het |
| Vstm2a |
A |
G |
11: 16,209,884 (GRCm39) |
T37A |
probably damaging |
Het |
| Wfs1 |
T |
C |
5: 37,124,809 (GRCm39) |
H694R |
probably damaging |
Het |
| Zdbf2 |
T |
C |
1: 63,348,940 (GRCm39) |
S2440P |
possibly damaging |
Het |
| Zfp61 |
A |
G |
7: 23,990,700 (GRCm39) |
|
probably null |
Het |
| Zfp64 |
T |
C |
2: 168,767,855 (GRCm39) |
T586A |
probably benign |
Het |
| Zfp943 |
T |
A |
17: 22,211,963 (GRCm39) |
C350S |
probably damaging |
Het |
|
| Other mutations in Vmn2r71 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00922:Vmn2r71
|
APN |
7 |
85,267,901 (GRCm39) |
missense |
probably benign |
|
|
IGL00960:Vmn2r71
|
APN |
7 |
85,273,582 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01372:Vmn2r71
|
APN |
7 |
85,270,022 (GRCm39) |
splice site |
probably benign |
|
|
IGL01690:Vmn2r71
|
APN |
7 |
85,264,782 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01909:Vmn2r71
|
APN |
7 |
85,270,001 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01950:Vmn2r71
|
APN |
7 |
85,264,827 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02570:Vmn2r71
|
APN |
7 |
85,264,748 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL02650:Vmn2r71
|
APN |
7 |
85,273,535 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02901:Vmn2r71
|
APN |
7 |
85,268,470 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03128:Vmn2r71
|
APN |
7 |
85,268,795 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03328:Vmn2r71
|
APN |
7 |
85,273,499 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0533:Vmn2r71
|
UTSW |
7 |
85,268,426 (GRCm39) |
frame shift |
probably null |
|
|
R0707:Vmn2r71
|
UTSW |
7 |
85,268,640 (GRCm39) |
missense |
probably benign |
|
|
R0841:Vmn2r71
|
UTSW |
7 |
85,267,749 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R0865:Vmn2r71
|
UTSW |
7 |
85,268,516 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0883:Vmn2r71
|
UTSW |
7 |
85,272,842 (GRCm39) |
missense |
probably benign |
0.19 |
|
R0939:Vmn2r71
|
UTSW |
7 |
85,272,889 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R1597:Vmn2r71
|
UTSW |
7 |
85,273,352 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R1646:Vmn2r71
|
UTSW |
7 |
85,270,476 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1719:Vmn2r71
|
UTSW |
7 |
85,270,435 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1860:Vmn2r71
|
UTSW |
7 |
85,264,782 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2013:Vmn2r71
|
UTSW |
7 |
85,269,845 (GRCm39) |
missense |
probably benign |
0.38 |
|
R2014:Vmn2r71
|
UTSW |
7 |
85,269,845 (GRCm39) |
missense |
probably benign |
0.38 |
|
R2015:Vmn2r71
|
UTSW |
7 |
85,269,845 (GRCm39) |
missense |
probably benign |
0.38 |
|
R2050:Vmn2r71
|
UTSW |
7 |
85,273,681 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2084:Vmn2r71
|
UTSW |
7 |
85,267,945 (GRCm39) |
missense |
probably benign |
0.03 |
|
R2221:Vmn2r71
|
UTSW |
7 |
85,273,301 (GRCm39) |
missense |
probably benign |
0.40 |
|
R2223:Vmn2r71
|
UTSW |
7 |
85,273,301 (GRCm39) |
missense |
probably benign |
0.40 |
|
R2245:Vmn2r71
|
UTSW |
7 |
85,273,388 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3115:Vmn2r71
|
UTSW |
7 |
85,272,866 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R3122:Vmn2r71
|
UTSW |
7 |
85,264,828 (GRCm39) |
nonsense |
probably null |
|
|
R3609:Vmn2r71
|
UTSW |
7 |
85,268,870 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4305:Vmn2r71
|
UTSW |
7 |
85,273,360 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4306:Vmn2r71
|
UTSW |
7 |
85,273,360 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4334:Vmn2r71
|
UTSW |
7 |
85,269,042 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4569:Vmn2r71
|
UTSW |
7 |
85,273,402 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R4622:Vmn2r71
|
UTSW |
7 |
85,269,817 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4915:Vmn2r71
|
UTSW |
7 |
85,270,476 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4956:Vmn2r71
|
UTSW |
7 |
85,268,436 (GRCm39) |
missense |
probably benign |
0.19 |
|
R5005:Vmn2r71
|
UTSW |
7 |
85,273,352 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5045:Vmn2r71
|
UTSW |
7 |
85,273,597 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5153:Vmn2r71
|
UTSW |
7 |
85,268,430 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R5236:Vmn2r71
|
UTSW |
7 |
85,272,877 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5373:Vmn2r71
|
UTSW |
7 |
85,267,750 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R5405:Vmn2r71
|
UTSW |
7 |
85,268,622 (GRCm39) |
missense |
probably benign |
|
|
R5831:Vmn2r71
|
UTSW |
7 |
85,272,922 (GRCm39) |
missense |
probably benign |
0.16 |
|
R6061:Vmn2r71
|
UTSW |
7 |
85,268,482 (GRCm39) |
missense |
probably benign |
|
|
R6518:Vmn2r71
|
UTSW |
7 |
85,270,436 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6751:Vmn2r71
|
UTSW |
7 |
85,269,095 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6920:Vmn2r71
|
UTSW |
7 |
85,273,108 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7358:Vmn2r71
|
UTSW |
7 |
85,273,468 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R7453:Vmn2r71
|
UTSW |
7 |
85,273,297 (GRCm39) |
missense |
probably benign |
0.21 |
|
R7560:Vmn2r71
|
UTSW |
7 |
85,273,115 (GRCm39) |
missense |
probably benign |
0.06 |
|
R7871:Vmn2r71
|
UTSW |
7 |
85,272,869 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R8267:Vmn2r71
|
UTSW |
7 |
85,264,704 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8377:Vmn2r71
|
UTSW |
7 |
85,264,707 (GRCm39) |
missense |
probably benign |
|
|
R9278:Vmn2r71
|
UTSW |
7 |
85,269,788 (GRCm39) |
missense |
probably benign |
0.19 |
|
R9319:Vmn2r71
|
UTSW |
7 |
85,273,694 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9329:Vmn2r71
|
UTSW |
7 |
85,267,950 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9368:Vmn2r71
|
UTSW |
7 |
85,273,442 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9636:Vmn2r71
|
UTSW |
7 |
85,268,388 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R9756:Vmn2r71
|
UTSW |
7 |
85,268,573 (GRCm39) |
nonsense |
probably null |
|
|
X0025:Vmn2r71
|
UTSW |
7 |
85,267,873 (GRCm39) |
missense |
probably benign |
|
|
Z1186:Vmn2r71
|
UTSW |
7 |
85,273,094 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- ACAAGGTCTTTCAGTGGATCTCTG -3'
(R):5'- CCAGGGATCTACAATAGTGAGG -3'
Sequencing Primer
(F):5'- GGATCTCTGTTGTGGGAATCAC -3'
(R):5'- ACAATAGTGAGGCAAAAATACAGTTC -3'
|
| Posted On |
2015-05-15 |
Incidental Mutation