Incidental Mutation 'R4093:Or8s10'
ID 317759
Institutional Source Beutler Lab
Gene Symbol Or8s10
Ensembl Gene ENSMUSG00000063780
Gene Name olfactory receptor family 8 subfamily S member 1
Synonyms MOR160-2, Olfr282, GA_x6K02T2NBG7-5293798-5292872
MMRRC Submission 041627-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.062) question?
Stock # R4093 (G1)
Quality Score 225
Status Validated
Chromosome 15
Chromosomal Location 98335351-98336278 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 98335563 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Proline at position 71 (L71P)
Ref Sequence ENSEMBL: ENSMUSP00000151156 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000075851] [ENSMUST00000205491] [ENSMUST00000213608] [ENSMUST00000215320]
AlphaFold A1L1B4
Predicted Effect probably damaging
Transcript: ENSMUST00000075851
AA Change: L71P

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000075248
Gene: ENSMUSG00000063780
AA Change: L71P

DomainStartEndE-ValueType
Pfam:7tm_4 31 306 7.6e-55 PFAM
Pfam:7TM_GPCR_Srsx 35 217 5.7e-6 PFAM
Pfam:7tm_1 41 288 2.2e-22 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000205491
Predicted Effect probably damaging
Transcript: ENSMUST00000213608
AA Change: L71P

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
Predicted Effect probably damaging
Transcript: ENSMUST00000215320
AA Change: L71P

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
Meta Mutation Damage Score 0.8331 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.5%
Validation Efficiency 92% (69/75)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 66 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Akap9 A G 5: 4,093,996 (GRCm39) M2173V probably damaging Het
Alas1 G T 9: 106,119,000 (GRCm39) probably null Het
Angpt1 T C 15: 42,386,941 (GRCm39) T138A probably damaging Het
Atp2c2 G A 8: 120,476,610 (GRCm39) probably null Het
Cadm2 A G 16: 66,581,675 (GRCm39) V210A possibly damaging Het
Cfap70 A T 14: 20,459,181 (GRCm39) D671E probably damaging Het
Chd2 C T 7: 73,150,764 (GRCm39) E322K possibly damaging Het
Chrnd C T 1: 87,118,729 (GRCm39) Q29* probably null Het
Cip2a T C 16: 48,821,339 (GRCm39) probably benign Het
Cym A G 3: 107,121,582 (GRCm39) S237P probably benign Het
D030068K23Rik A G 8: 109,978,091 (GRCm39) noncoding transcript Het
Gsdma2 T A 11: 98,541,677 (GRCm39) S135T probably benign Het
Hc A T 2: 34,873,819 (GRCm39) Y158* probably null Het
Hoxb3 C A 11: 96,236,926 (GRCm39) H335N probably damaging Het
Htr2a G A 14: 74,943,789 (GRCm39) M456I probably benign Het
Ighv1-19 G A 12: 114,672,350 (GRCm39) T90I probably damaging Het
Kansl3 C A 1: 36,384,035 (GRCm39) S729I probably damaging Het
Kcnab1 T C 3: 65,207,035 (GRCm39) I137T possibly damaging Het
Kcnt1 A T 2: 25,767,927 (GRCm39) E12V probably damaging Het
Klk15 A T 7: 43,588,204 (GRCm39) S171C possibly damaging Het
Lcn2 A T 2: 32,277,728 (GRCm39) M1K probably null Het
Lrig1 T C 6: 94,590,559 (GRCm39) D487G probably benign Het
Lrp8 T A 4: 107,700,468 (GRCm39) C135* probably null Het
Lrrc31 C A 3: 30,749,671 (GRCm39) S54I probably damaging Het
Ltbp4 A G 7: 27,024,641 (GRCm39) V663A possibly damaging Het
Med27 G A 2: 29,267,920 (GRCm39) probably benign Het
Mical1 T C 10: 41,362,933 (GRCm39) probably benign Het
Myt1 A T 2: 181,453,191 (GRCm39) M799L probably damaging Het
Nlrc4 T C 17: 74,752,953 (GRCm39) M477V probably benign Het
Npy4r T C 14: 33,869,098 (GRCm39) I63M probably benign Het
Or2t43 A T 11: 58,457,655 (GRCm39) I172N probably damaging Het
Or52e15 C T 7: 104,645,842 (GRCm39) G90S probably benign Het
Or8b1b T A 9: 38,375,379 (GRCm39) L14Q probably null Het
Piezo1 A C 8: 123,227,899 (GRCm39) probably null Het
Ppp1r12c T C 7: 4,486,366 (GRCm39) E601G probably damaging Het
Proser1 T C 3: 53,387,133 (GRCm39) probably null Het
Psme2 A T 14: 55,825,734 (GRCm39) N143K probably benign Het
Pygo2 C A 3: 89,340,571 (GRCm39) P323Q probably damaging Het
Rab11b T C 17: 33,968,763 (GRCm39) T77A possibly damaging Het
Recql5 A G 11: 115,795,714 (GRCm39) S190P probably benign Het
Serpina12 A G 12: 104,004,183 (GRCm39) F150L probably damaging Het
Sfswap A G 5: 129,637,805 (GRCm39) S821G possibly damaging Het
Slc22a2 C T 17: 12,831,281 (GRCm39) T357M probably damaging Het
Spag6l A C 16: 16,646,888 (GRCm39) N39K probably benign Het
Srl A G 16: 4,315,316 (GRCm39) S109P possibly damaging Het
Tagap A T 17: 8,148,255 (GRCm39) H152L probably damaging Het
Tbx3 T A 5: 119,818,813 (GRCm39) S463T probably benign Het
Tcaf2 A G 6: 42,619,772 (GRCm39) L85P probably damaging Het
Tenm4 A T 7: 96,544,979 (GRCm39) S2332C probably damaging Het
Trim60 A T 8: 65,454,030 (GRCm39) M73K probably benign Het
Trpc1 T C 9: 95,588,918 (GRCm39) T769A probably benign Het
Tubgcp4 T A 2: 121,025,958 (GRCm39) L601Q probably benign Het
Unc5d T C 8: 29,334,865 (GRCm39) Y154C possibly damaging Het
Vmn1r185 A T 7: 26,311,208 (GRCm39) V99E probably damaging Het
Vmn1r57 G T 7: 5,223,856 (GRCm39) S127I possibly damaging Het
Vmn1r62 T A 7: 5,678,943 (GRCm39) M208K probably damaging Het
Vmn2r110 T C 17: 20,803,642 (GRCm39) D311G possibly damaging Het
Vmn2r48 C A 7: 9,676,185 (GRCm39) S432I probably benign Het
Vmn2r48 T A 7: 9,676,186 (GRCm39) S432C probably damaging Het
Vmn2r71 T C 7: 85,270,442 (GRCm39) V536A probably benign Het
Vstm2a A G 11: 16,209,884 (GRCm39) T37A probably damaging Het
Wfs1 T C 5: 37,124,809 (GRCm39) H694R probably damaging Het
Zdbf2 T C 1: 63,348,940 (GRCm39) S2440P possibly damaging Het
Zfp61 A G 7: 23,990,700 (GRCm39) probably null Het
Zfp64 T C 2: 168,767,855 (GRCm39) T586A probably benign Het
Zfp943 T A 17: 22,211,963 (GRCm39) C350S probably damaging Het
Other mutations in Or8s10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01813:Or8s10 APN 15 98,335,530 (GRCm39) missense possibly damaging 0.95
IGL02724:Or8s10 APN 15 98,335,660 (GRCm39) missense probably benign 0.09
IGL03104:Or8s10 APN 15 98,336,127 (GRCm39) missense possibly damaging 0.93
R0611:Or8s10 UTSW 15 98,336,168 (GRCm39) missense possibly damaging 0.95
R3008:Or8s10 UTSW 15 98,335,857 (GRCm39) missense probably damaging 1.00
R4094:Or8s10 UTSW 15 98,335,563 (GRCm39) missense probably damaging 1.00
R4095:Or8s10 UTSW 15 98,335,563 (GRCm39) missense probably damaging 1.00
R4579:Or8s10 UTSW 15 98,335,560 (GRCm39) missense probably damaging 1.00
R4647:Or8s10 UTSW 15 98,335,457 (GRCm39) missense probably benign 0.00
R5290:Or8s10 UTSW 15 98,336,213 (GRCm39) missense probably damaging 1.00
R7991:Or8s10 UTSW 15 98,335,419 (GRCm39) missense probably benign 0.00
R8927:Or8s10 UTSW 15 98,336,519 (GRCm39) splice site probably benign
R9208:Or8s10 UTSW 15 98,335,614 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- TAATGGCCTGGAGCAACCAC -3'
(R):5'- TTTCTCATCACCTGGCCGTAGAG -3'

Sequencing Primer
(F):5'- ACAGCGTCATCACGGAGTTC -3'
(R):5'- CCGTAGAGCAGGGGATGGC -3'
Posted On 2015-05-15