Incidental Mutation 'R0393:Or10ag52'
ID 31776
Institutional Source Beutler Lab
Gene Symbol Or10ag52
Ensembl Gene ENSMUSG00000070857
Gene Name olfactory receptor family 10 subfamily AG member 52
Synonyms GA_x6K02T2Q125-48697747-48698727, MOR264-25, Olfr1113
MMRRC Submission 038599-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.065) question?
Stock # R0393 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 87043238-87044218 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 87044037 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Phenylalanine at position 267 (Y267F)
Ref Sequence ENSEMBL: ENSMUSP00000150991 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000079966] [ENSMUST00000215611]
AlphaFold Q7TR54
Predicted Effect probably benign
Transcript: ENSMUST00000079966
AA Change: Y267F

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000078883
Gene: ENSMUSG00000070857
AA Change: Y267F

DomainStartEndE-ValueType
Pfam:7tm_4 46 323 6.7e-53 PFAM
Pfam:7tm_1 56 305 2e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000215611
AA Change: Y267F

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.3%
  • 10x: 96.3%
  • 20x: 92.9%
Validation Efficiency 100% (59/59)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc9 C T 6: 142,591,604 (GRCm39) probably benign Het
Akr1b7 T G 6: 34,392,335 (GRCm39) Y49* probably null Het
Ankrd10 G T 8: 11,685,482 (GRCm39) R46S possibly damaging Het
Atp13a5 A G 16: 29,085,681 (GRCm39) probably benign Het
Baz1a A G 12: 54,965,221 (GRCm39) probably null Het
Bicd2 C T 13: 49,533,346 (GRCm39) T644M probably damaging Het
Ccr9 A T 9: 123,609,035 (GRCm39) H239L probably benign Het
Cd180 A T 13: 102,842,408 (GRCm39) N485Y probably damaging Het
Ces1d T A 8: 93,919,400 (GRCm39) S131C probably damaging Het
Cnpy2 T A 10: 128,162,076 (GRCm39) S116R probably benign Het
Crym T C 7: 119,788,972 (GRCm39) K285R probably benign Het
Cyp2a4 A T 7: 26,012,293 (GRCm39) I359F possibly damaging Het
Cyp2b10 T A 7: 25,614,359 (GRCm39) probably benign Het
Dcpp3 A T 17: 24,136,925 (GRCm39) probably benign Het
Dnah8 T A 17: 30,927,364 (GRCm39) I1340K probably benign Het
Fbln1 T C 15: 85,111,277 (GRCm39) C144R probably damaging Het
Gm1553 T C 10: 82,328,010 (GRCm39) R66G unknown Het
Il10rb G A 16: 91,208,898 (GRCm39) V103I probably benign Het
Irak1bp1 T A 9: 82,728,614 (GRCm39) W182R probably benign Het
Kcna3 T C 3: 106,944,315 (GRCm39) S193P probably damaging Het
Kif14 C T 1: 136,410,156 (GRCm39) H628Y probably damaging Het
Krt31 A G 11: 99,941,079 (GRCm39) L77P probably damaging Het
Krt36 C T 11: 99,994,940 (GRCm39) A211T possibly damaging Het
L3mbtl2 C T 15: 81,552,942 (GRCm39) A125V probably damaging Het
Lmo7 A G 14: 102,137,892 (GRCm39) T743A probably benign Het
Lyst C T 13: 13,821,664 (GRCm39) T1346M probably benign Het
Mapkbp1 T A 2: 119,843,384 (GRCm39) probably null Het
Mif T C 10: 75,695,638 (GRCm39) D55G probably benign Het
Mlh3 G T 12: 85,314,361 (GRCm39) C608* probably null Het
Mlip A T 9: 77,146,859 (GRCm39) C85S probably benign Het
Mug1 T C 6: 121,826,809 (GRCm39) S211P possibly damaging Het
Mybl2 T A 2: 162,903,528 (GRCm39) probably benign Het
Myh8 C T 11: 67,196,843 (GRCm39) probably benign Het
Nanos1 A G 19: 60,745,368 (GRCm39) Y222C probably damaging Het
Or2n1e G T 17: 38,585,774 (GRCm39) M37I probably benign Het
Or5d16 T C 2: 87,773,909 (GRCm39) D21G possibly damaging Het
Papolb A G 5: 142,515,211 (GRCm39) V144A probably damaging Het
Pctp A G 11: 89,876,945 (GRCm39) S185P probably benign Het
Plod1 A T 4: 148,003,298 (GRCm39) L509Q probably null Het
Ppp1r13b C A 12: 111,802,122 (GRCm39) M290I probably benign Het
Ralb G C 1: 119,405,856 (GRCm39) probably null Het
Rxylt1 T C 10: 121,931,841 (GRCm39) probably benign Het
Slc4a8 T A 15: 100,672,519 (GRCm39) D18E probably damaging Het
Speg A C 1: 75,400,568 (GRCm39) H2576P possibly damaging Het
Spock1 T C 13: 57,588,349 (GRCm39) D241G probably damaging Het
Tcam1 T A 11: 106,175,040 (GRCm39) V165E probably benign Het
Thbs1 T A 2: 117,943,472 (GRCm39) V30E possibly damaging Het
Tll2 A G 19: 41,077,265 (GRCm39) Y834H possibly damaging Het
Trpm6 G A 19: 18,756,008 (GRCm39) D84N probably damaging Het
Ubr1 T A 2: 120,737,427 (GRCm39) Q1039L probably damaging Het
Ubr4 A G 4: 139,138,171 (GRCm39) probably benign Het
Vmn1r74 T C 7: 11,581,242 (GRCm39) Y181H possibly damaging Het
Vmn2r13 T C 5: 109,304,395 (GRCm39) T679A probably benign Het
Vmn2r91 A T 17: 18,325,712 (GRCm39) Y110F probably damaging Het
Zbtb40 A C 4: 136,745,842 (GRCm39) S64A probably benign Het
Zfp184 T A 13: 22,131,252 (GRCm39) probably benign Het
Other mutations in Or10ag52
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02325:Or10ag52 APN 2 87,043,850 (GRCm39) missense probably damaging 0.96
IGL02523:Or10ag52 APN 2 87,043,664 (GRCm39) missense probably benign 0.26
IGL03112:Or10ag52 APN 2 87,043,944 (GRCm39) missense probably damaging 1.00
IGL03137:Or10ag52 APN 2 87,043,500 (GRCm39) missense probably benign 0.42
R1758:Or10ag52 UTSW 2 87,043,758 (GRCm39) missense probably benign 0.13
R1920:Or10ag52 UTSW 2 87,043,721 (GRCm39) missense probably benign 0.09
R1992:Or10ag52 UTSW 2 87,043,588 (GRCm39) nonsense probably null
R3742:Or10ag52 UTSW 2 87,043,340 (GRCm39) missense probably benign 0.00
R5615:Or10ag52 UTSW 2 87,044,083 (GRCm39) missense probably benign 0.00
R5665:Or10ag52 UTSW 2 87,044,072 (GRCm39) missense probably benign 0.05
R5749:Or10ag52 UTSW 2 87,043,287 (GRCm39) missense probably benign
R6752:Or10ag52 UTSW 2 87,043,388 (GRCm39) missense probably benign
R7986:Or10ag52 UTSW 2 87,043,922 (GRCm39) missense probably benign 0.12
R8161:Or10ag52 UTSW 2 87,044,148 (GRCm39) missense probably damaging 0.96
R8283:Or10ag52 UTSW 2 87,043,683 (GRCm39) missense probably benign 0.04
R9185:Or10ag52 UTSW 2 87,044,174 (GRCm39) missense probably benign 0.01
Z1088:Or10ag52 UTSW 2 87,044,122 (GRCm39) missense possibly damaging 0.48
Predicted Primers PCR Primer
(F):5'- ACTCAAGTTGGCATGTGGGAACATC -3'
(R):5'- GGACATTTTGGCACCAGGAAAGAAC -3'

Sequencing Primer
(F):5'- GTGGGAACATCTTTGTGAATGAAC -3'
(R):5'- TGACTCACAATGCTAACAATCTGG -3'
Posted On 2013-04-24