Mutagenetix > Incidental Mutation

Incidental Mutation 'R4093:Vmn2r110'

317766

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r110

Ensembl Gene

ENSMUSG00000091259

Gene Name

vomeronasal 2, receptor 110

Synonyms

EG224582

MMRRC Submission

041627-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.172) question?

Stock #

R4093 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

20573829-20596259 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 20583380 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Glycine at position 311 (D311G)

Ref Sequence

ENSEMBL: ENSMUSP00000129347 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000169559]

AlphaFold

E9PWD5

Predicted Effect

possibly damaging
Transcript: ENSMUST00000169559
AA Change: D311G

PolyPhen 2 Score 0.830 (Sensitivity: 0.84; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000129347
Gene: ENSMUSG00000091259
AA Change: D311G

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	83	467	3.1e-33	PFAM
Pfam:NCD3G	510	563	5.2e-22	PFAM
Pfam:7tm_3	594	831	4.2e-51	PFAM

Meta Mutation Damage Score

0.1795

Coding Region Coverage

1x: 99.2%
3x: 98.6%
10x: 97.3%
20x: 95.5%

Validation Efficiency

92% (69/75)

Allele List at MGI

Other mutations in this stock

Total: 66 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Akap9	A	G	5: 4,043,996	M2173V	probably damaging	Het
Alas1	G	T	9: 106,241,801		probably null	Het
Angpt1	T	C	15: 42,523,545	T138A	probably damaging	Het
Atp2c2	G	A	8: 119,749,871		probably null	Het
C330027C09Rik	T	C	16: 49,000,976		probably benign	Het
Cadm2	A	G	16: 66,784,788	V210A	possibly damaging	Het
Cfap70	A	T	14: 20,409,113	D671E	probably damaging	Het
Chd2	C	T	7: 73,501,016	E322K	possibly damaging	Het
Chrnd	C	T	1: 87,191,007	Q29*	probably null	Het
Cym	A	G	3: 107,214,266	S237P	probably benign	Het
D030068K23Rik	A	G	8: 109,251,459		noncoding transcript	Het
Gsdma2	T	A	11: 98,650,851	S135T	probably benign	Het
Hc	A	T	2: 34,983,807	Y158*	probably null	Het
Hoxb3	C	A	11: 96,346,100	H335N	probably damaging	Het
Htr2a	G	A	14: 74,706,349	M456I	probably benign	Het
Ighv1-19	G	A	12: 114,708,730	T90I	probably damaging	Het
Kansl3	C	A	1: 36,344,954	S729I	probably damaging	Het
Kcnab1	T	C	3: 65,299,614	I137T	possibly damaging	Het
Kcnt1	A	T	2: 25,877,915	E12V	probably damaging	Het
Klk15	A	T	7: 43,938,780	S171C	possibly damaging	Het
Lcn2	A	T	2: 32,387,716	M1K	probably null	Het
Lrig1	T	C	6: 94,613,578	D487G	probably benign	Het
Lrp8	T	A	4: 107,843,271	C135*	probably null	Het
Lrrc31	C	A	3: 30,695,522	S54I	probably damaging	Het
Ltbp4	A	G	7: 27,325,216	V663A	possibly damaging	Het
Med27	G	A	2: 29,377,908		probably benign	Het
Mical1	T	C	10: 41,486,937		probably benign	Het
Myt1	A	T	2: 181,811,398	M799L	probably damaging	Het
Nlrc4	T	C	17: 74,445,958	M477V	probably benign	Het
Npy4r	T	C	14: 34,147,141	I63M	probably benign	Het
Olfr224	A	T	11: 58,566,829	I172N	probably damaging	Het
Olfr282	T	C	15: 98,437,682	L71P	probably damaging	Het
Olfr672	C	T	7: 104,996,635	G90S	probably benign	Het
Olfr904	T	A	9: 38,464,083	L14Q	probably null	Het
Piezo1	A	C	8: 122,501,160		probably null	Het
Ppp1r12c	T	C	7: 4,483,367	E601G	probably damaging	Het
Proser1	T	C	3: 53,479,712		probably null	Het
Psme2	A	T	14: 55,588,277	N143K	probably benign	Het
Pygo2	C	A	3: 89,433,264	P323Q	probably damaging	Het
Rab11b	T	C	17: 33,749,789	T77A	possibly damaging	Het
Recql5	A	G	11: 115,904,888	S190P	probably benign	Het
Serpina12	A	G	12: 104,037,924	F150L	probably damaging	Het
Sfswap	A	G	5: 129,560,741	S821G	possibly damaging	Het
Slc22a2	C	T	17: 12,612,394	T357M	probably damaging	Het
Spag6l	A	C	16: 16,829,024	N39K	probably benign	Het
Srl	A	G	16: 4,497,452	S109P	possibly damaging	Het
Tagap	A	T	17: 7,929,423	H152L	probably damaging	Het
Tbx3	T	A	5: 119,680,748	S463T	probably benign	Het
Tcaf2	A	G	6: 42,642,838	L85P	probably damaging	Het
Tenm4	A	T	7: 96,895,772	S2332C	probably damaging	Het
Trim60	A	T	8: 65,001,378	M73K	probably benign	Het
Trpc1	T	C	9: 95,706,865	T769A	probably benign	Het
Tubgcp4	T	A	2: 121,195,477	L601Q	probably benign	Het
Unc5d	T	C	8: 28,844,837	Y154C	possibly damaging	Het
Vmn1r185	A	T	7: 26,611,783	V99E	probably damaging	Het
Vmn1r57	G	T	7: 5,220,857	S127I	possibly damaging	Het
Vmn1r62	T	A	7: 5,675,944	M208K	probably damaging	Het
Vmn2r48	T	A	7: 9,942,259	S432C	probably damaging	Het
Vmn2r48	C	A	7: 9,942,258	S432I	probably benign	Het
Vmn2r71	T	C	7: 85,621,234	V536A	probably benign	Het
Vstm2a	A	G	11: 16,259,884	T37A	probably damaging	Het
Wfs1	T	C	5: 36,967,465	H694R	probably damaging	Het
Zdbf2	T	C	1: 63,309,781	S2440P	possibly damaging	Het
Zfp61	A	G	7: 24,291,275		probably null	Het
Zfp64	T	C	2: 168,925,935	T586A	probably benign	Het
Zfp943	T	A	17: 21,992,982	C350S	probably damaging	Het

Other mutations in Vmn2r110

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01774:Vmn2r110	APN	17	20583627	missense	probably benign	0.01
IGL01824:Vmn2r110	APN	17	20574667	missense	probably benign	0.44
IGL01879:Vmn2r110	APN	17	20573860	missense	probably benign	0.01
IGL02168:Vmn2r110	APN	17	20583800	splice site	probably benign
IGL02178:Vmn2r110	APN	17	20584444	splice site	probably null
IGL02322:Vmn2r110	APN	17	20573935	missense	probably damaging	1.00
IGL02323:Vmn2r110	APN	17	20596137	missense	probably damaging	0.98
IGL02415:Vmn2r110	APN	17	20583771	missense	probably benign	0.03
IGL02491:Vmn2r110	APN	17	20596138	missense	probably damaging	0.99
IGL02876:Vmn2r110	APN	17	20574296	missense	probably damaging	0.98
IGL03141:Vmn2r110	APN	17	20583714	missense	possibly damaging	0.79
IGL03270:Vmn2r110	APN	17	20583516	missense	probably benign	0.00
IGL03286:Vmn2r110	APN	17	20584206	missense	possibly damaging	0.95
IGL03379:Vmn2r110	APN	17	20583644	missense	probably damaging	0.99
PIT4243001:Vmn2r110	UTSW	17	20582117	missense	probably benign	0.01
R0040:Vmn2r110	UTSW	17	20596084	missense	probably benign	0.10
R0195:Vmn2r110	UTSW	17	20574055	missense	probably benign	0.31
R0716:Vmn2r110	UTSW	17	20573903	missense	probably damaging	0.99
R1199:Vmn2r110	UTSW	17	20583263	missense	probably benign	0.03
R1767:Vmn2r110	UTSW	17	20580578	missense	possibly damaging	0.83
R2212:Vmn2r110	UTSW	17	20573947	splice site	probably null
R3056:Vmn2r110	UTSW	17	20583098	missense	probably damaging	1.00
R4418:Vmn2r110	UTSW	17	20583689	nonsense	probably null
R4598:Vmn2r110	UTSW	17	20583767	nonsense	probably null
R4754:Vmn2r110	UTSW	17	20596196	missense	probably benign	0.00
R5283:Vmn2r110	UTSW	17	20580637	missense	probably benign	0.00
R5421:Vmn2r110	UTSW	17	20583620	missense	probably damaging	1.00
R5672:Vmn2r110	UTSW	17	20596232	missense	probably benign
R5865:Vmn2r110	UTSW	17	20584295	missense	probably benign	0.00
R6642:Vmn2r110	UTSW	17	20583517	missense	possibly damaging	0.94
R6799:Vmn2r110	UTSW	17	20583536	missense	probably benign
R7167:Vmn2r110	UTSW	17	20574179	missense	probably benign	0.01
R7291:Vmn2r110	UTSW	17	20574209	missense	probably benign	0.13
R7320:Vmn2r110	UTSW	17	20596054	missense	probably benign
R7519:Vmn2r110	UTSW	17	20584262	missense	probably benign
R8089:Vmn2r110	UTSW	17	20583545	missense	probably benign	0.00
R8234:Vmn2r110	UTSW	17	20584429	missense	probably benign	0.12
R8272:Vmn2r110	UTSW	17	20596228	missense	probably damaging	0.97
R8307:Vmn2r110	UTSW	17	20583057	missense	probably benign	0.00
R8506:Vmn2r110	UTSW	17	20584365	missense	probably benign	0.00
R8516:Vmn2r110	UTSW	17	20574613	missense	probably damaging	1.00
R8555:Vmn2r110	UTSW	17	20584356	missense	probably damaging	0.97
R8691:Vmn2r110	UTSW	17	20583142	missense	probably benign	0.19
R8859:Vmn2r110	UTSW	17	20574298	missense	probably damaging	0.99
R8935:Vmn2r110	UTSW	17	20583695	missense	probably benign	0.40
R8986:Vmn2r110	UTSW	17	20583561	missense	probably damaging	0.97
R9012:Vmn2r110	UTSW	17	20583365	missense	probably damaging	1.00
R9101:Vmn2r110	UTSW	17	20574209	missense
R9744:Vmn2r110	UTSW	17	20574586	missense	probably damaging	0.98
R9803:Vmn2r110	UTSW	17	20583468	missense	probably benign	0.00
Z1088:Vmn2r110	UTSW	17	20583680	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- GCATTGGATTGACAGTTAGCC -3'
(R):5'- GAAAAGGAGTCTGCATAGCTTTTG -3'

Sequencing Primer
(F):5'- GCATTGGATTGACAGTTAGCCAATAG -3'
(R):5'- CTGCATAGCTTTTGTGAAAATGATCC -3'

Posted On

2015-05-15