Incidental Mutation 'R4094:Cdc25b'
ID 317779
Institutional Source Beutler Lab
Gene Symbol Cdc25b
Ensembl Gene ENSMUSG00000027330
Gene Name cell division cycle 25B
Synonyms
MMRRC Submission 041628-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R4094 (G1)
Quality Score 225
Status Not validated
Chromosome 2
Chromosomal Location 131028869-131040417 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 131031037 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Valine at position 121 (M121V)
Ref Sequence ENSEMBL: ENSMUSP00000078784 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000028801] [ENSMUST00000028804] [ENSMUST00000079857]
AlphaFold P30306
Predicted Effect probably benign
Transcript: ENSMUST00000028801
SMART Domains Protein: ENSMUSP00000028801
Gene: ENSMUSG00000027329

DomainStartEndE-ValueType
Pfam:CH_2 13 109 9.3e-36 PFAM
Pfam:CAMSAP_CH 14 96 7.9e-24 PFAM
coiled coil region 182 234 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000028804
AA Change: M121V

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000028804
Gene: ENSMUSG00000027330
AA Change: M121V

DomainStartEndE-ValueType
low complexity region 86 105 N/A INTRINSIC
Pfam:M-inducer_phosp 111 379 3.3e-103 PFAM
RHOD 417 531 4.29e-26 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000079857
AA Change: M121V

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000078784
Gene: ENSMUSG00000027330
AA Change: M121V

DomainStartEndE-ValueType
low complexity region 86 105 N/A INTRINSIC
Pfam:M-inducer_phosp 111 354 2.4e-78 PFAM
RHOD 391 505 4.29e-26 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000125423
Predicted Effect noncoding transcript
Transcript: ENSMUST00000132727
Predicted Effect noncoding transcript
Transcript: ENSMUST00000138669
Predicted Effect noncoding transcript
Transcript: ENSMUST00000141732
Predicted Effect noncoding transcript
Transcript: ENSMUST00000145556
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.5%
  • 20x: 95.8%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] CDC25B is a member of the CDC25 family of phosphatases. CDC25B activates the cyclin dependent kinase CDC2 by removing two phosphate groups and it is required for entry into mitosis. CDC25B shuttles between the nucleus and the cytoplasm due to nuclear localization and nuclear export signals. The protein is nuclear in the M and G1 phases of the cell cycle and moves to the cytoplasm during S and G2. CDC25B has oncogenic properties, although its role in tumor formation has not been determined. Multiple transcript variants for this gene exist. [provided by RefSeq, Jul 2008]
PHENOTYPE: The resumption of meiosis during oocyte maturation is blocked in homozygous mutant female mice, resulting in female infertility. Male mice do not show an overt reproductive phenotype. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 57 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca6 A G 11: 110,071,192 (GRCm39) C1500R probably damaging Het
Amz1 A T 5: 140,737,921 (GRCm39) M93L probably damaging Het
Asb18 A T 1: 89,942,147 (GRCm39) N51K probably damaging Het
Bcl11b G T 12: 107,883,094 (GRCm39) P335Q probably damaging Het
Bsn A C 9: 107,991,069 (GRCm39) V1561G probably damaging Het
Cadm2 A T 16: 66,679,685 (GRCm39) N49K probably damaging Het
Cct8 T G 16: 87,284,516 (GRCm39) I283L possibly damaging Het
Cpne4 A G 9: 104,563,734 (GRCm39) D37G probably damaging Het
Cym A G 3: 107,121,582 (GRCm39) S237P probably benign Het
Dhx35 T A 2: 158,684,276 (GRCm39) I517N probably damaging Het
Ehf T C 2: 103,121,095 (GRCm39) probably benign Het
Erp29 A G 5: 121,590,345 (GRCm39) probably benign Het
Fgd6 C A 10: 93,879,296 (GRCm39) P50Q probably damaging Het
Fhip1b T C 7: 105,037,425 (GRCm39) D386G probably damaging Het
Foxn3 G T 12: 99,162,700 (GRCm39) D400E probably damaging Het
Frmd4a A G 2: 4,615,843 (GRCm39) Y1031C probably damaging Het
Gna13 T A 11: 109,287,242 (GRCm39) I355N probably damaging Het
Hgs T A 11: 120,359,859 (GRCm39) L21* probably null Het
Htr2a G A 14: 74,943,789 (GRCm39) M456I probably benign Het
Itga2 T C 13: 115,007,161 (GRCm39) D389G probably benign Het
Kdm1b T C 13: 47,216,496 (GRCm39) C289R probably damaging Het
Kdm4c T A 4: 74,229,915 (GRCm39) D237E probably benign Het
Lilrb4b A T 10: 51,357,506 (GRCm39) E114V probably damaging Het
Loxl1 G A 9: 58,219,739 (GRCm39) T144I probably damaging Het
Macf1 C T 4: 123,353,062 (GRCm39) R1784Q probably benign Het
Maml2 G A 9: 13,531,449 (GRCm39) S221N probably benign Het
Map3k1 A G 13: 111,892,696 (GRCm39) M853T possibly damaging Het
Micu3 T G 8: 40,788,929 (GRCm39) S147A probably null Het
Nccrp1 T C 7: 28,243,651 (GRCm39) Y261C possibly damaging Het
Or51aa5 T A 7: 103,167,244 (GRCm39) I116F possibly damaging Het
Or5m5 A G 2: 85,814,562 (GRCm39) Y126C probably damaging Het
Or8k18 T C 2: 86,085,674 (GRCm39) D121G probably damaging Het
Or8s10 T C 15: 98,335,563 (GRCm39) L71P probably damaging Het
Pclo C A 5: 14,905,659 (GRCm39) T4963N unknown Het
Pdxk T C 10: 78,300,644 (GRCm39) H13R probably damaging Het
Plcg1 A G 2: 160,589,761 (GRCm39) E95G probably damaging Het
Ppargc1a T C 5: 51,647,406 (GRCm39) N276S possibly damaging Het
Prr12 A G 7: 44,697,371 (GRCm39) L848P unknown Het
Ptcd2 A G 13: 99,468,957 (GRCm39) I202T probably damaging Het
Rab27a A C 9: 72,982,826 (GRCm39) I44L probably damaging Het
Rbfox2 A T 15: 77,016,925 (GRCm39) S82T probably damaging Het
Rsbn1 T A 3: 103,835,974 (GRCm39) F337L probably damaging Het
Samd8 T C 14: 21,843,113 (GRCm39) I414T probably damaging Het
Sema3e A G 5: 14,283,704 (GRCm39) I478V probably benign Het
Sfswap A G 5: 129,637,805 (GRCm39) S821G possibly damaging Het
Slc2a3 A T 6: 122,712,527 (GRCm39) I239N probably benign Het
Spc25 G A 2: 69,032,975 (GRCm39) S50L probably damaging Het
St8sia4 A T 1: 95,555,411 (GRCm39) S206R possibly damaging Het
Syngr3 G A 17: 24,908,817 (GRCm39) probably benign Het
Tigd4 A G 3: 84,501,947 (GRCm39) D288G probably damaging Het
Trim34b A G 7: 103,983,795 (GRCm39) M251V probably benign Het
Ttll5 A T 12: 86,003,376 (GRCm39) R214* probably null Het
Ttn T C 2: 76,730,860 (GRCm39) probably benign Het
Vmp1 A G 11: 86,534,406 (GRCm39) I167T probably benign Het
Zfp64 T C 2: 168,767,855 (GRCm39) T586A probably benign Het
Zfp943 T A 17: 22,211,963 (GRCm39) C350S probably damaging Het
Zscan4f A T 7: 11,135,185 (GRCm39) N197I probably damaging Het
Other mutations in Cdc25b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03230:Cdc25b APN 2 131,030,060 (GRCm39) missense probably benign 0.00
R0471:Cdc25b UTSW 2 131,039,204 (GRCm39) missense probably damaging 0.99
R0639:Cdc25b UTSW 2 131,039,182 (GRCm39) missense probably benign 0.00
R0645:Cdc25b UTSW 2 131,033,533 (GRCm39) missense probably benign 0.06
R0673:Cdc25b UTSW 2 131,039,182 (GRCm39) missense probably benign 0.00
R1574:Cdc25b UTSW 2 131,033,057 (GRCm39) splice site probably benign
R4433:Cdc25b UTSW 2 131,033,618 (GRCm39) missense probably benign 0.02
R4722:Cdc25b UTSW 2 131,035,271 (GRCm39) missense probably damaging 1.00
R4817:Cdc25b UTSW 2 131,035,223 (GRCm39) missense probably damaging 1.00
R4957:Cdc25b UTSW 2 131,035,525 (GRCm39) missense possibly damaging 0.80
R5345:Cdc25b UTSW 2 131,034,516 (GRCm39) missense probably benign 0.18
R5407:Cdc25b UTSW 2 131,035,567 (GRCm39) missense probably damaging 1.00
R5562:Cdc25b UTSW 2 131,036,678 (GRCm39) missense probably damaging 1.00
R5594:Cdc25b UTSW 2 131,033,538 (GRCm39) missense probably damaging 1.00
R5792:Cdc25b UTSW 2 131,033,679 (GRCm39) missense probably damaging 1.00
R5831:Cdc25b UTSW 2 131,029,301 (GRCm39) critical splice donor site probably null
R7204:Cdc25b UTSW 2 131,033,552 (GRCm39) missense probably damaging 1.00
R7292:Cdc25b UTSW 2 131,033,093 (GRCm39) missense probably damaging 1.00
R7399:Cdc25b UTSW 2 131,036,574 (GRCm39) missense probably damaging 1.00
R7501:Cdc25b UTSW 2 131,036,080 (GRCm39) missense probably damaging 1.00
R7772:Cdc25b UTSW 2 131,031,029 (GRCm39) missense probably damaging 1.00
R8186:Cdc25b UTSW 2 131,031,050 (GRCm39) missense probably benign 0.05
R8783:Cdc25b UTSW 2 131,033,772 (GRCm39) missense probably benign 0.05
R8985:Cdc25b UTSW 2 131,035,180 (GRCm39) missense probably damaging 1.00
R9141:Cdc25b UTSW 2 131,033,857 (GRCm39) critical splice donor site probably null
R9153:Cdc25b UTSW 2 131,034,564 (GRCm39) missense possibly damaging 0.84
Predicted Primers PCR Primer
(F):5'- GCAATGTCCCATGCTTAGGG -3'
(R):5'- TTCCCTGTAAGAAAGCAGGATAC -3'

Sequencing Primer
(F):5'- CCCATGCTTAGGGTTCATAAGTAG -3'
(R):5'- TGCAGAGATCTGAGTTCAGTACCC -3'
Posted On 2015-05-15