Incidental Mutation 'R1960:Trpm1'
| ID |
318037 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Trpm1
|
| Ensembl Gene |
ENSMUSG00000030523 |
| Gene Name |
transient receptor potential cation channel, subfamily M, member 1 |
| Synonyms |
Mlsn1, melastatin, 4732499L03Rik, LTRPC1 |
| MMRRC Submission |
039974-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R1960 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
7 |
| Chromosomal Location |
63803583-63919523 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 63879978 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Leucine to Glutamine
at position 661
(L661Q)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000146140
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000085222]
[ENSMUST00000205348]
[ENSMUST00000206277]
[ENSMUST00000206263]
[ENSMUST00000206314]
|
| AlphaFold |
Q2TV84 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000085222
AA Change: L777Q
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000082318
Gene: ENSMUSG00000030523
AA Change: L777Q
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
8 |
28 |
N/A |
INTRINSIC |
|
low complexity region
|
183 |
195 |
N/A |
INTRINSIC |
|
low complexity region
|
289 |
307 |
N/A |
INTRINSIC |
|
low complexity region
|
456 |
491 |
N/A |
INTRINSIC |
|
Blast:ANK
|
505 |
533 |
1e-5 |
BLAST |
|
low complexity region
|
621 |
650 |
N/A |
INTRINSIC |
|
low complexity region
|
823 |
835 |
N/A |
INTRINSIC |
|
transmembrane domain
|
876 |
895 |
N/A |
INTRINSIC |
|
Pfam:Ion_trans
|
907 |
1120 |
6e-16 |
PFAM |
|
transmembrane domain
|
1150 |
1167 |
N/A |
INTRINSIC |
|
low complexity region
|
1216 |
1225 |
N/A |
INTRINSIC |
|
PDB:3E7K|H
|
1228 |
1279 |
1e-7 |
PDB |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000107525
AA Change: L777Q
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000103149
Gene: ENSMUSG00000030523
AA Change: L777Q
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
8 |
28 |
N/A |
INTRINSIC |
|
low complexity region
|
183 |
195 |
N/A |
INTRINSIC |
|
low complexity region
|
289 |
307 |
N/A |
INTRINSIC |
|
low complexity region
|
456 |
491 |
N/A |
INTRINSIC |
|
Blast:ANK
|
505 |
533 |
1e-5 |
BLAST |
|
low complexity region
|
621 |
650 |
N/A |
INTRINSIC |
|
low complexity region
|
823 |
835 |
N/A |
INTRINSIC |
|
Pfam:Ion_trans
|
876 |
1138 |
7.6e-22 |
PFAM |
|
transmembrane domain
|
1156 |
1173 |
N/A |
INTRINSIC |
|
Pfam:TRPM_tetra
|
1230 |
1285 |
9.4e-28 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000138074
AA Change: L201Q
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000138609
AA Change: C79S
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000205348
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000205939
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000206000
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000206277
AA Change: L777Q
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000206263
AA Change: L661Q
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000206314
|
| Meta Mutation Damage Score |
0.4440 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.1%
- 20x: 94.9%
|
| Validation Efficiency |
100% (95/95) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the transient receptor potential melastatin subfamily of transient receptor potential ion channels. The encoded protein is a calcium permeable cation channel that is expressed in melanocytes and may play a role in melanin synthesis. Specific mutations in this gene are the cause autosomal recessive complete congenital stationary night blindness-1C. The expression of this protein is inversely correlated with melanoma aggressiveness and as such it is used as a prognostic marker for melanoma metastasis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2011]
PHENOTYPE: Homozygous mutants have defects in rod and cone electrophysiology affecting the photoresponses. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 92 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2410004B18Rik |
C |
T |
3: 145,643,976 (GRCm39) |
P55S |
probably damaging |
Het |
| Adgre4 |
T |
C |
17: 56,098,497 (GRCm39) |
S136P |
probably benign |
Het |
| Aoc1l1 |
C |
T |
6: 48,952,687 (GRCm39) |
T204I |
probably damaging |
Het |
| Arap1 |
C |
A |
7: 101,022,222 (GRCm39) |
A8E |
probably damaging |
Het |
| Arid1a |
A |
T |
4: 133,480,401 (GRCm39) |
H174Q |
possibly damaging |
Het |
| Btbd2 |
A |
G |
10: 80,480,539 (GRCm39) |
I358T |
probably benign |
Het |
| Camkk2 |
G |
A |
5: 122,875,575 (GRCm39) |
R492* |
probably null |
Het |
| Capn3 |
T |
C |
2: 120,294,421 (GRCm39) |
V23A |
probably benign |
Het |
| Carm1 |
T |
G |
9: 21,491,606 (GRCm39) |
V225G |
probably benign |
Het |
| Ccdc113 |
T |
A |
8: 96,267,459 (GRCm39) |
N141K |
probably benign |
Het |
| Ccdc60 |
C |
A |
5: 116,284,243 (GRCm39) |
M298I |
probably benign |
Het |
| Celsr3 |
C |
T |
9: 108,723,016 (GRCm39) |
P2801L |
probably benign |
Het |
| Clec4n |
T |
A |
6: 123,207,505 (GRCm39) |
V23E |
probably damaging |
Het |
| Cmtr2 |
T |
G |
8: 110,948,382 (GRCm39) |
L231V |
probably damaging |
Het |
| Csrnp3 |
T |
G |
2: 65,853,363 (GRCm39) |
V585G |
probably null |
Het |
| Ctnnd2 |
T |
C |
15: 30,647,257 (GRCm39) |
S318P |
probably damaging |
Het |
| Cubn |
A |
T |
2: 13,344,828 (GRCm39) |
|
probably null |
Het |
| Dgkd |
C |
A |
1: 87,857,549 (GRCm39) |
P754T |
possibly damaging |
Het |
| Dnah7a |
A |
G |
1: 53,724,142 (GRCm39) |
S108P |
probably benign |
Het |
| Dnajc24 |
A |
G |
2: 105,832,268 (GRCm39) |
|
probably benign |
Het |
| Dner |
A |
T |
1: 84,423,177 (GRCm39) |
S475R |
probably damaging |
Het |
| Dtnb |
T |
C |
12: 3,831,190 (GRCm39) |
L630P |
probably benign |
Het |
| Dysf |
T |
C |
6: 84,050,885 (GRCm39) |
F411L |
probably benign |
Het |
| Fbh1 |
G |
A |
2: 11,762,339 (GRCm39) |
A566V |
probably damaging |
Het |
| Fbxw19 |
G |
T |
9: 109,315,004 (GRCm39) |
T186K |
probably benign |
Het |
| Flacc1 |
A |
T |
1: 58,698,437 (GRCm39) |
V327D |
possibly damaging |
Het |
| Gm4825 |
A |
G |
15: 85,395,245 (GRCm39) |
|
noncoding transcript |
Het |
| Grhl2 |
T |
A |
15: 37,336,558 (GRCm39) |
V54D |
probably damaging |
Het |
| Hmcn1 |
T |
C |
1: 150,551,742 (GRCm39) |
I2621V |
probably benign |
Het |
| Hmcn1 |
T |
A |
1: 150,553,127 (GRCm39) |
E2521V |
possibly damaging |
Het |
| Kcng1 |
A |
G |
2: 168,104,904 (GRCm39) |
V314A |
probably benign |
Het |
| Kif13a |
G |
A |
13: 47,018,314 (GRCm39) |
|
probably benign |
Het |
| Kif21a |
G |
A |
15: 90,855,051 (GRCm39) |
A703V |
probably damaging |
Het |
| Kifc1 |
A |
G |
17: 34,103,561 (GRCm39) |
|
probably null |
Het |
| Klk13 |
T |
A |
7: 43,370,431 (GRCm39) |
N31K |
possibly damaging |
Het |
| Klri1 |
T |
A |
6: 129,674,347 (GRCm39) |
H221L |
probably benign |
Het |
| Ltbp4 |
G |
A |
7: 27,028,443 (GRCm39) |
P273L |
unknown |
Het |
| Med16 |
T |
C |
10: 79,742,929 (GRCm39) |
H14R |
possibly damaging |
Het |
| Mpeg1 |
G |
A |
19: 12,440,275 (GRCm39) |
V578M |
probably damaging |
Het |
| Mrgpra2a |
T |
A |
7: 47,076,983 (GRCm39) |
I92F |
probably benign |
Het |
| Muc5b |
T |
C |
7: 141,416,374 (GRCm39) |
C3107R |
possibly damaging |
Het |
| Myo5a |
T |
A |
9: 75,055,139 (GRCm39) |
F441I |
probably damaging |
Het |
| Ndst4 |
T |
A |
3: 125,232,331 (GRCm39) |
L300* |
probably null |
Het |
| Nlgn2 |
G |
T |
11: 69,718,136 (GRCm39) |
D356E |
probably damaging |
Het |
| Nlrp2 |
T |
C |
7: 5,330,737 (GRCm39) |
E553G |
probably damaging |
Het |
| Oas1f |
G |
A |
5: 120,994,502 (GRCm39) |
C341Y |
possibly damaging |
Het |
| Olfm5 |
A |
T |
7: 103,809,619 (GRCm39) |
C111S |
possibly damaging |
Het |
| Oplah |
G |
A |
15: 76,181,664 (GRCm39) |
T1119I |
probably damaging |
Het |
| Or2ag15 |
T |
C |
7: 106,340,601 (GRCm39) |
E180G |
probably damaging |
Het |
| Or5d46 |
T |
C |
2: 88,170,545 (GRCm39) |
L212P |
probably damaging |
Het |
| Or6c74 |
C |
T |
10: 129,870,187 (GRCm39) |
Q231* |
probably null |
Het |
| Or6f2 |
A |
T |
7: 139,756,596 (GRCm39) |
I188L |
probably benign |
Het |
| Or8b12c |
A |
G |
9: 37,715,242 (GRCm39) |
I12V |
probably benign |
Het |
| Or8g51 |
T |
A |
9: 38,609,500 (GRCm39) |
H58L |
probably benign |
Het |
| Pde10a |
T |
C |
17: 9,161,750 (GRCm39) |
I477T |
possibly damaging |
Het |
| Pde4b |
A |
G |
4: 102,454,657 (GRCm39) |
E108G |
probably damaging |
Het |
| Pdgfrb |
A |
T |
18: 61,198,855 (GRCm39) |
T338S |
probably benign |
Het |
| Pgghg |
A |
G |
7: 140,523,260 (GRCm39) |
M180V |
probably benign |
Het |
| Phactr4 |
G |
A |
4: 132,104,559 (GRCm39) |
T256I |
probably benign |
Het |
| Pot1b |
A |
T |
17: 55,969,531 (GRCm39) |
Y546N |
probably damaging |
Het |
| Rangap1 |
T |
C |
15: 81,590,704 (GRCm39) |
T463A |
probably benign |
Het |
| Rap1gds1 |
T |
C |
3: 138,756,317 (GRCm39) |
I13V |
probably null |
Het |
| Rbak |
A |
T |
5: 143,160,437 (GRCm39) |
Y205* |
probably null |
Het |
| Reg3b |
A |
T |
6: 78,348,797 (GRCm39) |
K31M |
probably damaging |
Het |
| Rfpl4 |
A |
T |
7: 5,118,533 (GRCm39) |
Y12* |
probably null |
Het |
| Rnase6 |
A |
G |
14: 51,367,889 (GRCm39) |
N94D |
possibly damaging |
Het |
| Rtn4 |
T |
C |
11: 29,686,464 (GRCm39) |
L273P |
probably damaging |
Het |
| Ryr3 |
A |
C |
2: 112,624,812 (GRCm39) |
F2203V |
probably damaging |
Het |
| Sae1 |
A |
T |
7: 16,102,490 (GRCm39) |
D161E |
possibly damaging |
Het |
| Sema5a |
T |
C |
15: 32,562,877 (GRCm39) |
F296S |
possibly damaging |
Het |
| Sh3rf1 |
C |
A |
8: 61,837,897 (GRCm39) |
P814Q |
probably damaging |
Het |
| Slc22a29 |
C |
A |
19: 8,146,557 (GRCm39) |
R415M |
probably benign |
Het |
| Slc25a25 |
C |
T |
2: 32,310,663 (GRCm39) |
|
probably null |
Het |
| Slco4c1 |
T |
A |
1: 96,795,654 (GRCm39) |
M135L |
probably benign |
Het |
| Slfn1 |
A |
G |
11: 83,012,579 (GRCm39) |
I232V |
possibly damaging |
Het |
| Slitrk1 |
T |
A |
14: 109,149,622 (GRCm39) |
N363I |
probably damaging |
Het |
| Srr |
A |
G |
11: 74,799,542 (GRCm39) |
V311A |
probably damaging |
Het |
| Tasor |
T |
C |
14: 27,160,621 (GRCm39) |
S128P |
probably damaging |
Het |
| Tasor |
C |
T |
14: 27,201,746 (GRCm39) |
H1419Y |
possibly damaging |
Het |
| Tenm1 |
T |
C |
X: 41,916,078 (GRCm39) |
D402G |
probably benign |
Het |
| Topors |
T |
C |
4: 40,261,044 (GRCm39) |
R747G |
unknown |
Het |
| Trank1 |
A |
T |
9: 111,220,696 (GRCm39) |
I2478F |
probably damaging |
Het |
| Trim69 |
A |
G |
2: 121,998,165 (GRCm39) |
N46D |
probably benign |
Het |
| Ttbk1 |
A |
C |
17: 46,791,150 (GRCm39) |
F45V |
probably damaging |
Het |
| Ttn |
T |
C |
2: 76,644,649 (GRCm39) |
K4708R |
probably damaging |
Het |
| Unkl |
A |
G |
17: 25,428,619 (GRCm39) |
|
probably benign |
Het |
| Uros |
A |
T |
7: 133,288,735 (GRCm39) |
N257K |
probably benign |
Het |
| Usp25 |
A |
G |
16: 76,873,259 (GRCm39) |
Y439C |
probably damaging |
Het |
| Vgf |
A |
G |
5: 137,061,029 (GRCm39) |
|
probably benign |
Het |
| Vmn2r8 |
A |
T |
5: 108,947,152 (GRCm39) |
D533E |
probably damaging |
Het |
| Vps13a |
A |
T |
19: 16,702,995 (GRCm39) |
Y653N |
probably damaging |
Het |
| Zfp358 |
T |
C |
8: 3,545,742 (GRCm39) |
V135A |
possibly damaging |
Het |
|
| Other mutations in Trpm1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00093:Trpm1
|
APN |
7 |
63,893,198 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00465:Trpm1
|
APN |
7 |
63,897,215 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL01118:Trpm1
|
APN |
7 |
63,885,572 (GRCm39) |
missense |
probably benign |
0.24 |
|
IGL01148:Trpm1
|
APN |
7 |
63,893,312 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01303:Trpm1
|
APN |
7 |
63,860,578 (GRCm39) |
critical splice acceptor site |
probably benign |
0.00 |
|
IGL01432:Trpm1
|
APN |
7 |
63,884,767 (GRCm39) |
missense |
probably benign |
0.18 |
|
IGL01433:Trpm1
|
APN |
7 |
63,854,276 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01506:Trpm1
|
APN |
7 |
63,893,329 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01626:Trpm1
|
APN |
7 |
63,918,637 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01640:Trpm1
|
APN |
7 |
63,876,645 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01899:Trpm1
|
APN |
7 |
63,884,742 (GRCm39) |
missense |
probably benign |
0.24 |
|
IGL01959:Trpm1
|
APN |
7 |
63,858,723 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
IGL02210:Trpm1
|
APN |
7 |
63,860,613 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02268:Trpm1
|
APN |
7 |
63,867,362 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02331:Trpm1
|
APN |
7 |
63,884,800 (GRCm39) |
missense |
probably benign |
0.30 |
|
IGL02334:Trpm1
|
APN |
7 |
63,895,690 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
IGL02407:Trpm1
|
APN |
7 |
63,868,869 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02425:Trpm1
|
APN |
7 |
63,890,175 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02485:Trpm1
|
APN |
7 |
63,918,862 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
IGL02635:Trpm1
|
APN |
7 |
63,848,972 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02640:Trpm1
|
APN |
7 |
63,868,881 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL02827:Trpm1
|
APN |
7 |
63,868,908 (GRCm39) |
missense |
probably null |
1.00 |
|
PIT4458001:Trpm1
|
UTSW |
7 |
63,918,309 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
PIT4544001:Trpm1
|
UTSW |
7 |
63,848,998 (GRCm39) |
intron |
probably benign |
|
|
R0012:Trpm1
|
UTSW |
7 |
63,918,339 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R0014:Trpm1
|
UTSW |
7 |
63,897,970 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0056:Trpm1
|
UTSW |
7 |
63,893,334 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0445:Trpm1
|
UTSW |
7 |
63,894,590 (GRCm39) |
unclassified |
probably benign |
|
|
R0463:Trpm1
|
UTSW |
7 |
63,870,002 (GRCm39) |
missense |
probably benign |
0.05 |
|
R0469:Trpm1
|
UTSW |
7 |
63,873,506 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0510:Trpm1
|
UTSW |
7 |
63,873,506 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1301:Trpm1
|
UTSW |
7 |
63,852,801 (GRCm39) |
splice site |
probably null |
|
|
R1397:Trpm1
|
UTSW |
7 |
63,867,406 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1588:Trpm1
|
UTSW |
7 |
63,873,565 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R1618:Trpm1
|
UTSW |
7 |
63,890,283 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1724:Trpm1
|
UTSW |
7 |
63,885,569 (GRCm39) |
nonsense |
probably null |
|
|
R1827:Trpm1
|
UTSW |
7 |
63,884,755 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1829:Trpm1
|
UTSW |
7 |
63,876,530 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1835:Trpm1
|
UTSW |
7 |
63,880,016 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1864:Trpm1
|
UTSW |
7 |
63,917,764 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1895:Trpm1
|
UTSW |
7 |
63,873,556 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1946:Trpm1
|
UTSW |
7 |
63,873,556 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1959:Trpm1
|
UTSW |
7 |
63,879,978 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1980:Trpm1
|
UTSW |
7 |
63,858,182 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R1989:Trpm1
|
UTSW |
7 |
63,858,780 (GRCm39) |
intron |
probably null |
|
|
R2054:Trpm1
|
UTSW |
7 |
63,890,303 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R2156:Trpm1
|
UTSW |
7 |
63,884,736 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2251:Trpm1
|
UTSW |
7 |
63,859,724 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3051:Trpm1
|
UTSW |
7 |
63,918,849 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3148:Trpm1
|
UTSW |
7 |
63,884,760 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3195:Trpm1
|
UTSW |
7 |
63,849,061 (GRCm39) |
nonsense |
probably null |
|
|
R3615:Trpm1
|
UTSW |
7 |
63,893,318 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3616:Trpm1
|
UTSW |
7 |
63,893,318 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3623:Trpm1
|
UTSW |
7 |
63,894,601 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3624:Trpm1
|
UTSW |
7 |
63,894,601 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3721:Trpm1
|
UTSW |
7 |
63,867,475 (GRCm39) |
intron |
probably benign |
|
|
R3822:Trpm1
|
UTSW |
7 |
63,867,451 (GRCm39) |
intron |
probably benign |
|
|
R4441:Trpm1
|
UTSW |
7 |
63,851,666 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4490:Trpm1
|
UTSW |
7 |
63,858,660 (GRCm39) |
nonsense |
probably null |
|
|
R4666:Trpm1
|
UTSW |
7 |
63,852,782 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4701:Trpm1
|
UTSW |
7 |
63,893,248 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4781:Trpm1
|
UTSW |
7 |
63,884,800 (GRCm39) |
missense |
probably benign |
0.30 |
|
R4811:Trpm1
|
UTSW |
7 |
63,858,054 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5017:Trpm1
|
UTSW |
7 |
63,894,580 (GRCm39) |
unclassified |
probably benign |
|
|
R5030:Trpm1
|
UTSW |
7 |
63,885,579 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5195:Trpm1
|
UTSW |
7 |
63,887,441 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R5238:Trpm1
|
UTSW |
7 |
63,918,702 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5304:Trpm1
|
UTSW |
7 |
63,858,694 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5575:Trpm1
|
UTSW |
7 |
63,870,018 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R5613:Trpm1
|
UTSW |
7 |
63,858,159 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5855:Trpm1
|
UTSW |
7 |
63,918,710 (GRCm39) |
nonsense |
probably null |
|
|
R5947:Trpm1
|
UTSW |
7 |
63,873,547 (GRCm39) |
missense |
probably benign |
0.07 |
|
R5988:Trpm1
|
UTSW |
7 |
63,876,553 (GRCm39) |
missense |
probably benign |
0.16 |
|
R6054:Trpm1
|
UTSW |
7 |
63,918,450 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6088:Trpm1
|
UTSW |
7 |
63,917,724 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6259:Trpm1
|
UTSW |
7 |
63,918,226 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R6379:Trpm1
|
UTSW |
7 |
63,848,942 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6380:Trpm1
|
UTSW |
7 |
63,918,045 (GRCm39) |
missense |
probably benign |
0.24 |
|
R6429:Trpm1
|
UTSW |
7 |
63,918,252 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6600:Trpm1
|
UTSW |
7 |
63,803,781 (GRCm39) |
start codon destroyed |
probably null |
0.56 |
|
R6622:Trpm1
|
UTSW |
7 |
63,890,343 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6939:Trpm1
|
UTSW |
7 |
63,918,045 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6944:Trpm1
|
UTSW |
7 |
63,893,181 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7025:Trpm1
|
UTSW |
7 |
63,876,462 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R7112:Trpm1
|
UTSW |
7 |
63,885,593 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7168:Trpm1
|
UTSW |
7 |
63,918,445 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7219:Trpm1
|
UTSW |
7 |
63,854,333 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R7224:Trpm1
|
UTSW |
7 |
63,868,854 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R7285:Trpm1
|
UTSW |
7 |
63,859,729 (GRCm39) |
nonsense |
probably null |
|
|
R7367:Trpm1
|
UTSW |
7 |
63,918,549 (GRCm39) |
missense |
probably benign |
0.06 |
|
R7449:Trpm1
|
UTSW |
7 |
63,858,723 (GRCm39) |
missense |
probably benign |
0.14 |
|
R7466:Trpm1
|
UTSW |
7 |
63,890,330 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7498:Trpm1
|
UTSW |
7 |
63,858,657 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R7581:Trpm1
|
UTSW |
7 |
63,854,303 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7776:Trpm1
|
UTSW |
7 |
63,897,939 (GRCm39) |
missense |
probably benign |
0.04 |
|
R8062:Trpm1
|
UTSW |
7 |
63,851,689 (GRCm39) |
missense |
probably benign |
0.18 |
|
R8069:Trpm1
|
UTSW |
7 |
63,858,718 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R8157:Trpm1
|
UTSW |
7 |
63,849,017 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8219:Trpm1
|
UTSW |
7 |
63,851,699 (GRCm39) |
missense |
probably benign |
0.35 |
|
R8258:Trpm1
|
UTSW |
7 |
63,918,777 (GRCm39) |
missense |
probably benign |
0.10 |
|
R8259:Trpm1
|
UTSW |
7 |
63,918,777 (GRCm39) |
missense |
probably benign |
0.10 |
|
R8320:Trpm1
|
UTSW |
7 |
63,918,541 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R8536:Trpm1
|
UTSW |
7 |
63,897,155 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8544:Trpm1
|
UTSW |
7 |
63,874,356 (GRCm39) |
splice site |
probably null |
|
|
R8813:Trpm1
|
UTSW |
7 |
63,851,756 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R8912:Trpm1
|
UTSW |
7 |
63,918,628 (GRCm39) |
missense |
probably benign |
0.06 |
|
R8954:Trpm1
|
UTSW |
7 |
63,858,089 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9139:Trpm1
|
UTSW |
7 |
63,848,943 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9205:Trpm1
|
UTSW |
7 |
63,890,319 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R9258:Trpm1
|
UTSW |
7 |
63,884,713 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9283:Trpm1
|
UTSW |
7 |
63,873,623 (GRCm39) |
missense |
probably benign |
0.18 |
|
R9394:Trpm1
|
UTSW |
7 |
63,918,480 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9430:Trpm1
|
UTSW |
7 |
63,873,446 (GRCm39) |
missense |
probably benign |
0.38 |
|
R9537:Trpm1
|
UTSW |
7 |
63,803,616 (GRCm39) |
unclassified |
probably benign |
|
|
R9616:Trpm1
|
UTSW |
7 |
63,858,132 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9774:Trpm1
|
UTSW |
7 |
63,898,041 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
X0026:Trpm1
|
UTSW |
7 |
63,918,658 (GRCm39) |
missense |
probably benign |
0.05 |
|
Z1176:Trpm1
|
UTSW |
7 |
63,854,342 (GRCm39) |
critical splice donor site |
probably null |
|
|
Z1176:Trpm1
|
UTSW |
7 |
63,852,879 (GRCm39) |
critical splice donor site |
probably null |
|
|
Z1177:Trpm1
|
UTSW |
7 |
63,867,439 (GRCm39) |
missense |
unknown |
|
|
| Predicted Primers |
PCR Primer
(F):5'- CAGAGATTTTGGCCAGCTCG -3'
(R):5'- TGCTGCTCAGAATGCAATTTAC -3'
Sequencing Primer
(F):5'- CTCGCTGTGGAGCTGTTAGACC -3'
(R):5'- GCTGCTCAGAATGCAATTTACAACTC -3'
|
| Posted On |
2015-05-19 |
Incidental Mutation