Incidental Mutation 'R4172:Zfp445'
ID 318183
Institutional Source Beutler Lab
Gene Symbol Zfp445
Ensembl Gene ENSMUSG00000047036
Gene Name zinc finger protein 445
Synonyms ZNF168
MMRRC Submission 044391-MU
Accession Numbers
Essential gene? Possibly essential (E-score: 0.656) question?
Stock # R4172 (G1)
Quality Score 225
Status Not validated
Chromosome 9
Chromosomal Location 122673594-122695071 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 122681002 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Leucine at position 980 (M980L)
Ref Sequence ENSEMBL: ENSMUSP00000151198 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000056467] [ENSMUST00000213971] [ENSMUST00000214626] [ENSMUST00000216063]
AlphaFold Q8R2V3
Predicted Effect probably benign
Transcript: ENSMUST00000056467
AA Change: M980L

PolyPhen 2 Score 0.015 (Sensitivity: 0.96; Specificity: 0.79)
SMART Domains Protein: ENSMUSP00000055738
Gene: ENSMUSG00000047036
AA Change: M980L

DomainStartEndE-ValueType
SCAN 48 160 1.07e-59 SMART
KRAB 219 278 6.74e-30 SMART
low complexity region 320 334 N/A INTRINSIC
low complexity region 419 430 N/A INTRINSIC
ZnF_C2H2 470 492 2.09e-3 SMART
ZnF_C2H2 498 520 3.16e-3 SMART
ZnF_C2H2 553 575 1.41e0 SMART
ZnF_C2H2 581 603 1.04e-3 SMART
ZnF_C2H2 634 656 1.6e-4 SMART
ZnF_C2H2 662 686 6.78e-3 SMART
ZnF_C2H2 718 740 1.67e-2 SMART
ZnF_C2H2 746 768 1.2e-3 SMART
ZnF_C2H2 796 818 2.02e-1 SMART
ZnF_C2H2 824 846 2.95e-3 SMART
ZnF_C2H2 933 955 2.49e-1 SMART
ZnF_C2H2 961 983 4.61e-5 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000213573
Predicted Effect probably benign
Transcript: ENSMUST00000213971
Predicted Effect noncoding transcript
Transcript: ENSMUST00000214162
Predicted Effect probably benign
Transcript: ENSMUST00000214626
Predicted Effect probably benign
Transcript: ENSMUST00000216063
AA Change: M980L

PolyPhen 2 Score 0.015 (Sensitivity: 0.96; Specificity: 0.79)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000216243
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.4%
  • 20x: 95.7%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Akip1 C T 7: 109,306,716 (GRCm39) Q138* probably null Het
Cdc5l A G 17: 45,730,698 (GRCm39) I196T probably damaging Het
Dnah7b G T 1: 46,266,106 (GRCm39) R2225L probably damaging Het
Gfra2 C A 14: 71,133,521 (GRCm39) T117K possibly damaging Het
Gle1 T C 2: 29,828,538 (GRCm39) I120T probably benign Het
Guf1 T A 5: 69,715,572 (GRCm39) N52K possibly damaging Het
Helq T C 5: 100,919,713 (GRCm39) K813E probably benign Het
Ighv7-4 A T 12: 114,186,635 (GRCm39) F46I probably damaging Het
Il6st G A 13: 112,631,861 (GRCm39) D467N probably benign Het
Jak1 C A 4: 101,016,329 (GRCm39) V812L probably benign Het
Kank4 G T 4: 98,667,358 (GRCm39) T363K probably damaging Het
Lcat C A 8: 106,669,059 (GRCm39) W72L possibly damaging Het
Map2 T C 1: 66,452,759 (GRCm39) S392P possibly damaging Het
Mtmr2 T C 9: 13,711,358 (GRCm39) F456L probably damaging Het
Myh8 A T 11: 67,183,247 (GRCm39) R709W probably damaging Het
Nop14 T C 5: 34,807,951 (GRCm39) N337S probably damaging Het
Npbwr1 A G 1: 5,987,155 (GRCm39) Y120H probably damaging Het
Or4c58 T G 2: 89,675,122 (GRCm39) D65A probably damaging Het
Oxsm A T 14: 16,242,079 (GRCm38) V230E probably damaging Het
Paox G A 7: 139,713,941 (GRCm39) G234R probably damaging Het
Polq C T 16: 36,881,120 (GRCm39) H1095Y probably benign Het
Rad51c T C 11: 87,293,572 (GRCm39) T77A probably damaging Het
Ryr3 C A 2: 112,624,815 (GRCm39) V2202F probably damaging Het
Shroom3 G T 5: 93,090,945 (GRCm39) V1151F probably damaging Het
Snx27 T C 3: 94,410,794 (GRCm39) H452R probably benign Het
Son C T 16: 91,456,250 (GRCm39) H1666Y probably damaging Het
Spata25 C A 2: 164,669,408 (GRCm39) W201L possibly damaging Het
Spint2 A G 7: 28,963,097 (GRCm39) V67A probably damaging Het
Srgap1 T C 10: 121,691,268 (GRCm39) Y322C probably benign Het
Synm T C 7: 67,385,109 (GRCm39) Y409C probably damaging Het
Tex11 C A X: 99,977,021 (GRCm39) A487S possibly damaging Het
Tpm1 T C 9: 66,930,649 (GRCm39) N283D probably benign Het
Trpv6 T C 6: 41,602,432 (GRCm39) D318G probably damaging Het
Ube2j2 A G 4: 156,033,543 (GRCm39) D39G probably damaging Het
Ubr1 C T 2: 120,777,103 (GRCm39) probably null Het
Vwa5a T C 9: 38,635,166 (GRCm39) F224L probably damaging Het
Other mutations in Zfp445
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02427:Zfp445 APN 9 122,681,295 (GRCm39) missense probably benign 0.02
IGL02608:Zfp445 APN 9 122,690,940 (GRCm39) missense probably damaging 0.98
IGL03216:Zfp445 APN 9 122,681,043 (GRCm39) missense probably damaging 0.99
IGL03218:Zfp445 APN 9 122,686,594 (GRCm39) missense probably benign 0.00
Nonpareil UTSW 9 122,681,410 (GRCm39) missense probably benign 0.02
R0080:Zfp445 UTSW 9 122,681,421 (GRCm39) missense probably damaging 0.98
R0082:Zfp445 UTSW 9 122,681,421 (GRCm39) missense probably damaging 0.98
R0453:Zfp445 UTSW 9 122,682,578 (GRCm39) missense possibly damaging 0.92
R0610:Zfp445 UTSW 9 122,682,046 (GRCm39) missense probably benign 0.44
R0730:Zfp445 UTSW 9 122,690,823 (GRCm39) missense probably damaging 1.00
R1622:Zfp445 UTSW 9 122,681,614 (GRCm39) missense possibly damaging 0.90
R1719:Zfp445 UTSW 9 122,681,707 (GRCm39) missense probably damaging 1.00
R2108:Zfp445 UTSW 9 122,681,305 (GRCm39) missense probably benign 0.13
R2117:Zfp445 UTSW 9 122,682,502 (GRCm39) nonsense probably null
R2143:Zfp445 UTSW 9 122,682,547 (GRCm39) missense possibly damaging 0.70
R2162:Zfp445 UTSW 9 122,681,541 (GRCm39) missense probably damaging 0.99
R3620:Zfp445 UTSW 9 122,681,833 (GRCm39) missense probably benign
R3621:Zfp445 UTSW 9 122,681,833 (GRCm39) missense probably benign
R3745:Zfp445 UTSW 9 122,683,791 (GRCm39) missense probably benign 0.00
R3829:Zfp445 UTSW 9 122,682,142 (GRCm39) missense probably benign
R3831:Zfp445 UTSW 9 122,681,541 (GRCm39) missense probably damaging 0.99
R4180:Zfp445 UTSW 9 122,681,589 (GRCm39) missense probably benign 0.00
R4747:Zfp445 UTSW 9 122,686,215 (GRCm39) missense possibly damaging 0.81
R4923:Zfp445 UTSW 9 122,681,358 (GRCm39) missense probably benign
R5010:Zfp445 UTSW 9 122,681,410 (GRCm39) missense probably benign 0.02
R5578:Zfp445 UTSW 9 122,682,402 (GRCm39) missense probably benign 0.00
R5759:Zfp445 UTSW 9 122,682,211 (GRCm39) missense probably benign 0.00
R5864:Zfp445 UTSW 9 122,682,552 (GRCm39) missense probably benign 0.00
R5865:Zfp445 UTSW 9 122,682,552 (GRCm39) missense probably benign 0.00
R5987:Zfp445 UTSW 9 122,682,951 (GRCm39) missense probably benign
R6481:Zfp445 UTSW 9 122,686,631 (GRCm39) missense probably benign 0.00
R6738:Zfp445 UTSW 9 122,691,123 (GRCm39) missense probably damaging 0.96
R6917:Zfp445 UTSW 9 122,691,359 (GRCm39) splice site probably null
R7137:Zfp445 UTSW 9 122,683,843 (GRCm39) missense probably damaging 1.00
R7224:Zfp445 UTSW 9 122,681,208 (GRCm39) missense probably benign 0.28
R8056:Zfp445 UTSW 9 122,681,032 (GRCm39) missense possibly damaging 0.95
R8263:Zfp445 UTSW 9 122,681,878 (GRCm39) missense probably benign 0.00
R8313:Zfp445 UTSW 9 122,682,695 (GRCm39) missense possibly damaging 0.48
R8929:Zfp445 UTSW 9 122,682,732 (GRCm39) missense probably benign 0.11
R9250:Zfp445 UTSW 9 122,681,092 (GRCm39) missense possibly damaging 0.91
R9361:Zfp445 UTSW 9 122,690,887 (GRCm39) missense probably damaging 0.99
R9396:Zfp445 UTSW 9 122,681,581 (GRCm39) missense probably benign 0.00
R9549:Zfp445 UTSW 9 122,685,844 (GRCm39) missense probably damaging 1.00
R9618:Zfp445 UTSW 9 122,685,788 (GRCm39) missense probably damaging 0.99
R9730:Zfp445 UTSW 9 122,681,490 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- CTAAAAGACCCCAGAGAACTTTCTG -3'
(R):5'- TGTGCCCACCAAGAAGAAAG -3'

Sequencing Primer
(F):5'- GAAGACTGAGAAATTCCTGAGTTTTG -3'
(R):5'- GAAAGCCTGCCACAAATGCAG -3'
Posted On 2015-06-10