Incidental Mutation 'R4174:Cep70'
ID318238
Institutional Source Beutler Lab
Gene Symbol Cep70
Ensembl Gene ENSMUSG00000056267
Gene Namecentrosomal protein 70
SynonymsC030018L16Rik, 6720484E09Rik
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.242) question?
Stock #R4174 (G1)
Quality Score225
Status Not validated
Chromosome9
Chromosomal Location99243367-99300404 bp(+) (GRCm38)
Type of Mutationstart gained
DNA Base Change (assembly) T to C at 99246313 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000139816 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000093795] [ENSMUST00000185799] [ENSMUST00000190078] [ENSMUST00000190715] [ENSMUST00000191014] [ENSMUST00000191335]
Predicted Effect probably benign
Transcript: ENSMUST00000093795
SMART Domains Protein: ENSMUSP00000091312
Gene: ENSMUSG00000056267

DomainStartEndE-ValueType
coiled coil region 96 210 N/A INTRINSIC
coiled coil region 278 299 N/A INTRINSIC
low complexity region 319 335 N/A INTRINSIC
low complexity region 528 544 N/A INTRINSIC
low complexity region 591 602 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000185799
SMART Domains Protein: ENSMUSP00000139458
Gene: ENSMUSG00000056267

DomainStartEndE-ValueType
coiled coil region 96 156 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000188515
Predicted Effect noncoding transcript
Transcript: ENSMUST00000189371
Predicted Effect probably benign
Transcript: ENSMUST00000190078
Predicted Effect probably benign
Transcript: ENSMUST00000190715
SMART Domains Protein: ENSMUSP00000140377
Gene: ENSMUSG00000056267

DomainStartEndE-ValueType
coiled coil region 96 157 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000191014
Predicted Effect probably benign
Transcript: ENSMUST00000191335
SMART Domains Protein: ENSMUSP00000139816
Gene: ENSMUSG00000056267

DomainStartEndE-ValueType
coiled coil region 96 210 N/A INTRINSIC
coiled coil region 278 299 N/A INTRINSIC
low complexity region 319 335 N/A INTRINSIC
low complexity region 528 544 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000195852
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.4%
  • 20x: 95.6%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 17 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aff3 T C 1: 38,207,927 H859R probably damaging Het
Agap2 T C 10: 127,090,514 V876A probably damaging Het
Akip1 C T 7: 109,707,509 Q138* probably null Het
Ddx23 G A 15: 98,658,251 S62F unknown Het
Gabrp A G 11: 33,568,092 I72T probably damaging Het
Gpsm2 C T 3: 108,702,509 A102T probably damaging Het
Metap2 A G 10: 93,879,565 C112R possibly damaging Het
Olfr48 T G 2: 89,844,778 D65A probably damaging Het
Olfr901 T A 9: 38,431,020 I246K probably damaging Het
Pde12 A T 14: 26,668,989 D188E probably benign Het
Pirb A T 7: 3,716,032 probably null Het
Rreb1 T A 13: 37,930,150 L495Q possibly damaging Het
Slc12a5 T C 2: 164,979,490 I275T probably damaging Het
Tas2r122 A G 6: 132,711,876 I18T probably damaging Het
Tdrkh A G 3: 94,428,233 T378A possibly damaging Het
Ubr1 C T 2: 120,946,622 probably null Het
Zglp1 A G 9: 21,066,070 F150L possibly damaging Het
Other mutations in Cep70
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01445:Cep70 APN 9 99298500 unclassified probably benign
IGL02719:Cep70 APN 9 99275722 missense probably damaging 0.99
IGL02878:Cep70 APN 9 99281107 splice site probably benign
IGL02969:Cep70 APN 9 99298504 missense possibly damaging 0.88
R0426:Cep70 UTSW 9 99297684 missense probably benign 0.02
R0970:Cep70 UTSW 9 99275599 missense possibly damaging 0.93
R1238:Cep70 UTSW 9 99254265 missense probably benign 0.05
R1462:Cep70 UTSW 9 99263720 missense probably benign 0.20
R1462:Cep70 UTSW 9 99263720 missense probably benign 0.20
R2141:Cep70 UTSW 9 99296385 missense probably damaging 1.00
R3922:Cep70 UTSW 9 99275579 makesense probably null
R3964:Cep70 UTSW 9 99298534 missense probably damaging 1.00
R3965:Cep70 UTSW 9 99298534 missense probably damaging 1.00
R4044:Cep70 UTSW 9 99262609 missense possibly damaging 0.66
R4659:Cep70 UTSW 9 99296341 missense possibly damaging 0.86
R4672:Cep70 UTSW 9 99254312 missense possibly damaging 0.66
R4839:Cep70 UTSW 9 99296085 missense probably benign 0.16
R5108:Cep70 UTSW 9 99263812 splice site probably null
R5288:Cep70 UTSW 9 99281075 missense probably damaging 1.00
R5386:Cep70 UTSW 9 99281075 missense probably damaging 1.00
R5802:Cep70 UTSW 9 99296405 missense probably damaging 0.96
R5934:Cep70 UTSW 9 99254265 missense probably benign 0.05
R6076:Cep70 UTSW 9 99298505 missense probably damaging 1.00
R6848:Cep70 UTSW 9 99262901 missense probably benign 0.34
R6977:Cep70 UTSW 9 99291676 missense probably damaging 1.00
R7286:Cep70 UTSW 9 99275585 missense probably damaging 1.00
R7437:Cep70 UTSW 9 99291529 missense probably damaging 1.00
R7754:Cep70 UTSW 9 99281092 missense probably damaging 1.00
R7879:Cep70 UTSW 9 99262633 missense possibly damaging 0.54
R7962:Cep70 UTSW 9 99262633 missense possibly damaging 0.54
R8063:Cep70 UTSW 9 99296122 missense probably benign 0.02
Predicted Primers
Posted On2015-06-10