Incidental Mutation 'R4195:Or11i1'
ID 318526
Institutional Source Beutler Lab
Gene Symbol Or11i1
Ensembl Gene ENSMUSG00000043529
Gene Name olfactory receptor family 11 subfamily I member 1
Synonyms GA_x6K02T2N6GK-529983-529033, Olfr266, MOR122-2
MMRRC Submission 041026-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.077) question?
Stock # R4195 (G1)
Quality Score 225
Status Validated
Chromosome 3
Chromosomal Location 106728923-106729873 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) A to T at 106729328 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Stop codon at position 182 (C182*)
Ref Sequence ENSEMBL: ENSMUSP00000150519 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000059486] [ENSMUST00000213616] [ENSMUST00000216610]
AlphaFold Q8VFC3
Predicted Effect probably null
Transcript: ENSMUST00000059486
AA Change: C182*
SMART Domains Protein: ENSMUSP00000054070
Gene: ENSMUSG00000043529
AA Change: C182*

Pfam:7tm_4 34 311 1.2e-58 PFAM
Pfam:7tm_1 44 293 5.4e-21 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000213616
AA Change: C182*
Predicted Effect probably null
Transcript: ENSMUST00000216610
AA Change: C182*
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.1%
  • 20x: 94.8%
Validation Efficiency 98% (40/41)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acmsd T G 1: 127,676,931 (GRCm39) L152R probably damaging Het
Actg2 T G 6: 83,500,155 (GRCm39) T39P probably damaging Het
Agap1 A G 1: 89,762,261 (GRCm39) E531G probably damaging Het
Alox12b A G 11: 69,060,426 (GRCm39) S661G probably benign Het
Apod T C 16: 31,116,392 (GRCm39) M113V probably benign Het
Atl3 A G 19: 7,495,911 (GRCm39) I171V possibly damaging Het
Atrn C A 2: 130,775,332 (GRCm39) T145K probably damaging Het
Cacna1f A G X: 7,475,169 (GRCm39) H57R probably damaging Het
Cdhr18 C A 14: 13,829,772 (GRCm38) V657L probably benign Het
Cldn9 T C 17: 23,902,148 (GRCm39) E159G probably damaging Het
Cnnm4 C A 1: 36,538,589 (GRCm39) H590Q probably benign Het
Col19a1 G A 1: 24,573,133 (GRCm39) S213L unknown Het
Cse1l A G 2: 166,771,899 (GRCm39) T387A probably damaging Het
Eif4enif1 T C 11: 3,193,186 (GRCm39) V675A possibly damaging Het
Fbll1 A G 11: 35,688,493 (GRCm39) S257P possibly damaging Het
Fbll1 T A 11: 35,688,699 (GRCm39) H188L possibly damaging Het
Frem2 A G 3: 53,446,689 (GRCm39) F2360L possibly damaging Het
G3bp2 A G 5: 92,203,275 (GRCm39) S349P probably damaging Het
Gm2396 A G 9: 88,799,715 (GRCm39) noncoding transcript Het
Gm6569 C T 15: 73,708,092 (GRCm39) P22L probably damaging Het
Itih2 T C 2: 10,120,096 (GRCm39) N314D probably damaging Het
Lman2l A C 1: 36,464,022 (GRCm39) I266M probably damaging Het
Mrps9 T G 1: 42,940,254 (GRCm39) probably benign Het
Mtmr11 T C 3: 96,075,207 (GRCm39) probably benign Het
Neb G T 2: 52,161,571 (GRCm39) R2074S probably damaging Het
Neb A T 2: 52,180,847 (GRCm39) H1226Q probably damaging Het
Nmi A C 2: 51,838,632 (GRCm39) S301A probably benign Het
Pclo A G 5: 14,727,577 (GRCm39) probably benign Het
Pkd1l1 T A 11: 8,859,929 (GRCm39) I560F probably damaging Het
Polr1e T C 4: 45,019,327 (GRCm39) Y59H probably damaging Het
Slc30a4 G A 2: 122,527,190 (GRCm39) T401M probably damaging Het
Tas1r3 T C 4: 155,947,442 (GRCm39) E81G probably damaging Het
Zfp990 A T 4: 145,263,547 (GRCm39) probably null Het
Zzz3 A G 3: 152,134,102 (GRCm39) T387A probably benign Het
Other mutations in Or11i1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01869:Or11i1 APN 3 106,729,342 (GRCm39) missense probably benign 0.25
IGL01954:Or11i1 APN 3 106,729,311 (GRCm39) missense possibly damaging 0.82
IGL02371:Or11i1 APN 3 106,729,362 (GRCm39) missense probably damaging 1.00
IGL02792:Or11i1 APN 3 106,729,456 (GRCm39) missense probably damaging 0.98
PIT4131001:Or11i1 UTSW 3 106,729,282 (GRCm39) missense probably benign 0.00
R0540:Or11i1 UTSW 3 106,729,829 (GRCm39) missense probably damaging 0.99
R1925:Or11i1 UTSW 3 106,729,688 (GRCm39) missense probably damaging 0.98
R2026:Or11i1 UTSW 3 106,729,027 (GRCm39) missense probably benign 0.01
R4735:Or11i1 UTSW 3 106,728,996 (GRCm39) missense probably damaging 1.00
R4789:Or11i1 UTSW 3 106,729,624 (GRCm39) missense possibly damaging 0.95
R4789:Or11i1 UTSW 3 106,729,608 (GRCm39) missense possibly damaging 0.94
R4922:Or11i1 UTSW 3 106,729,576 (GRCm39) missense probably damaging 0.99
R6318:Or11i1 UTSW 3 106,729,503 (GRCm39) missense probably damaging 1.00
R6359:Or11i1 UTSW 3 106,729,731 (GRCm39) missense probably damaging 0.99
R6505:Or11i1 UTSW 3 106,729,638 (GRCm39) missense possibly damaging 0.87
R7605:Or11i1 UTSW 3 106,729,337 (GRCm39) missense probably damaging 1.00
R8529:Or11i1 UTSW 3 106,729,109 (GRCm39) nonsense probably null
R8998:Or11i1 UTSW 3 106,728,999 (GRCm39) missense probably damaging 0.99
R8999:Or11i1 UTSW 3 106,728,999 (GRCm39) missense probably damaging 0.99
R9255:Or11i1 UTSW 3 106,729,737 (GRCm39) missense probably benign 0.00
R9260:Or11i1 UTSW 3 106,729,510 (GRCm39) missense probably damaging 1.00
R9771:Or11i1 UTSW 3 106,729,060 (GRCm39) missense possibly damaging 0.77
Z1176:Or11i1 UTSW 3 106,729,359 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer

Sequencing Primer
Posted On 2015-06-10