Incidental Mutation 'R4198:Trim29'
ID 318636
Institutional Source Beutler Lab
Gene Symbol Trim29
Ensembl Gene ENSMUSG00000032013
Gene Name tripartite motif-containing 29
Synonyms 4732461M22Rik, 1110047J21Rik, 2810431N19Rik
MMRRC Submission 041640-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R4198 (G1)
Quality Score 225
Status Not validated
Chromosome 9
Chromosomal Location 43222145-43247412 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) G to T at 43222677 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Stop codon at position 169 (E169*)
Ref Sequence ENSEMBL: ENSMUSP00000034511 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000034511]
AlphaFold Q8R2Q0
Predicted Effect probably null
Transcript: ENSMUST00000034511
AA Change: E169*
SMART Domains Protein: ENSMUSP00000034511
Gene: ENSMUSG00000032013
AA Change: E169*

DomainStartEndE-ValueType
Blast:BBOX 168 216 3e-25 BLAST
BBOX 220 260 1.93e-11 SMART
low complexity region 399 410 N/A INTRINSIC
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 95.4%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the TRIM protein family. It has multiple zinc finger motifs and a leucine zipper motif. It has been proposed to form homo- or heterodimers which are involved in nucleic acid binding. Thus, it may act as a transcriptional regulatory factor involved in carcinogenesis and/or differentiation. It may also function in the suppression of radiosensitivity since it is associated with ataxia telangiectasia phenotype. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aox1 G A 1: 58,124,766 (GRCm39) M1002I probably benign Het
Ap2b1 C A 11: 83,233,429 (GRCm39) Q481K probably damaging Het
Arhgap31 G A 16: 38,444,275 (GRCm39) A194V probably damaging Het
Atp10a A G 7: 58,463,434 (GRCm39) D989G probably damaging Het
Ccny G A 18: 9,332,928 (GRCm39) T201I probably damaging Het
Cdca5 T C 19: 6,140,382 (GRCm39) V181A possibly damaging Het
Ces1g A G 8: 94,032,496 (GRCm39) I488T probably benign Het
Csmd2 A G 4: 128,404,717 (GRCm39) T2368A probably benign Het
Cux1 T A 5: 136,315,702 (GRCm39) I1113F probably damaging Het
Dnah3 C T 7: 119,522,061 (GRCm39) G4033D probably damaging Het
Foxg1 T A 12: 49,432,082 (GRCm39) S272T possibly damaging Het
Fyco1 T C 9: 123,655,699 (GRCm39) N1020D probably benign Het
Gprc5c T G 11: 114,754,686 (GRCm39) L121R probably damaging Het
Hyou1 G A 9: 44,300,156 (GRCm39) R815H probably damaging Het
Kera T C 10: 97,448,835 (GRCm39) *352Q probably null Het
Kirrel1 C T 3: 86,996,458 (GRCm39) M380I probably null Het
Lnpk T C 2: 74,399,453 (GRCm39) E30G probably damaging Het
Map2 C T 1: 66,464,457 (GRCm39) R128C probably damaging Het
Or1i2 A T 10: 78,447,901 (GRCm39) D191E possibly damaging Het
Or1o2 T A 17: 37,543,025 (GRCm39) M79L probably benign Het
Or2y11 G A 11: 49,443,461 (GRCm39) V296M possibly damaging Het
Or51h7 A G 7: 102,591,004 (GRCm39) F260S probably damaging Het
Pabir3 G A X: 52,382,376 (GRCm39) R94H possibly damaging Het
Ror2 A G 13: 53,264,680 (GRCm39) M792T probably benign Het
Serpinb9d A G 13: 33,386,948 (GRCm39) I339V probably benign Het
Serpinb9d A G 13: 33,386,657 (GRCm39) probably null Het
Slc1a1 A G 19: 28,878,852 (GRCm39) K197R probably benign Het
Snx20 A G 8: 89,354,226 (GRCm39) V168A possibly damaging Het
Sowaha T C 11: 53,369,395 (GRCm39) E447G possibly damaging Het
Stard8 AGAGGAGGAGGAGGAGGAGGA AGAGGAGGAGGAGGAGGA X: 98,110,114 (GRCm39) probably benign Het
Stx19 G T 16: 62,643,039 (GRCm39) C285F possibly damaging Het
Syp A G X: 7,506,166 (GRCm39) probably null Het
Tbkbp1 C T 11: 97,039,894 (GRCm39) probably null Het
Ttll12 T C 15: 83,461,214 (GRCm39) N602D probably damaging Het
Zfp26 T C 9: 20,348,012 (GRCm39) T851A probably benign Het
Zfp316 T C 5: 143,240,226 (GRCm39) M598V probably benign Het
Zhx2 A G 15: 57,685,125 (GRCm39) I165V probably benign Het
Other mutations in Trim29
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02364:Trim29 APN 9 43,222,599 (GRCm39) missense probably benign 0.05
IGL02387:Trim29 APN 9 43,236,149 (GRCm39) missense probably benign 0.02
R1770:Trim29 UTSW 9 43,243,673 (GRCm39) missense probably damaging 1.00
R1883:Trim29 UTSW 9 43,222,702 (GRCm39) missense probably damaging 1.00
R1962:Trim29 UTSW 9 43,222,615 (GRCm39) missense probably benign
R4200:Trim29 UTSW 9 43,222,677 (GRCm39) nonsense probably null
R4303:Trim29 UTSW 9 43,222,419 (GRCm39) missense probably damaging 1.00
R4863:Trim29 UTSW 9 43,240,872 (GRCm39) missense possibly damaging 0.89
R4934:Trim29 UTSW 9 43,222,265 (GRCm39) missense probably benign 0.36
R6171:Trim29 UTSW 9 43,230,674 (GRCm39) missense probably damaging 1.00
R6737:Trim29 UTSW 9 43,230,681 (GRCm39) missense probably benign 0.01
R6972:Trim29 UTSW 9 43,238,409 (GRCm39) missense probably benign 0.01
R7191:Trim29 UTSW 9 43,222,906 (GRCm39) missense probably damaging 1.00
R7434:Trim29 UTSW 9 43,246,428 (GRCm39) missense probably damaging 1.00
R7588:Trim29 UTSW 9 43,246,425 (GRCm39) missense probably damaging 1.00
R7590:Trim29 UTSW 9 43,222,788 (GRCm39) missense probably damaging 1.00
R8781:Trim29 UTSW 9 43,222,615 (GRCm39) missense probably benign 0.27
R8866:Trim29 UTSW 9 43,222,945 (GRCm39) missense probably damaging 1.00
R8922:Trim29 UTSW 9 43,233,636 (GRCm39) missense possibly damaging 0.80
R9336:Trim29 UTSW 9 43,238,350 (GRCm39) missense possibly damaging 0.59
R9709:Trim29 UTSW 9 43,231,797 (GRCm39) missense probably benign 0.12
X0065:Trim29 UTSW 9 43,233,621 (GRCm39) missense probably benign 0.06
Predicted Primers PCR Primer
(F):5'- GGCTTCCAAGAAACCTCCTG -3'
(R):5'- GATAACAGATGCAGGTCTGGTC -3'

Sequencing Primer
(F):5'- AAGAAACCTCCTGTGACCTTTG -3'
(R):5'- CTGACAGAAGAGCTCCATAGTCTTG -3'
Posted On 2015-06-10