Incidental Mutation 'R4198:Or2y11'
ID 318641
Institutional Source Beutler Lab
Gene Symbol Or2y11
Ensembl Gene ENSMUSG00000095187
Gene Name olfactory receptor family 2 subfamily Y member 11
Synonyms MOR256-26, Olfr1381, GA_x6K02T2QP88-5884501-5883566
MMRRC Submission 041640-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.062) question?
Stock # R4198 (G1)
Quality Score 225
Status Not validated
Chromosome 11
Chromosomal Location 49442576-49443511 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 49443461 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Methionine at position 296 (V296M)
Ref Sequence ENSEMBL: ENSMUSP00000149881 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000167248] [ENSMUST00000213256] [ENSMUST00000215360]
AlphaFold Q7TQT4
Predicted Effect possibly damaging
Transcript: ENSMUST00000167248
AA Change: V296M

PolyPhen 2 Score 0.610 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000126003
Gene: ENSMUSG00000095187
AA Change: V296M

DomainStartEndE-ValueType
Pfam:7tm_4 31 306 5.9e-48 PFAM
Pfam:7TM_GPCR_Srsx 35 219 2.4e-5 PFAM
Pfam:7tm_1 41 289 1.2e-20 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000213256
AA Change: V296M

PolyPhen 2 Score 0.610 (Sensitivity: 0.87; Specificity: 0.91)
Predicted Effect probably benign
Transcript: ENSMUST00000215360
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 95.4%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aox1 G A 1: 58,124,766 (GRCm39) M1002I probably benign Het
Ap2b1 C A 11: 83,233,429 (GRCm39) Q481K probably damaging Het
Arhgap31 G A 16: 38,444,275 (GRCm39) A194V probably damaging Het
Atp10a A G 7: 58,463,434 (GRCm39) D989G probably damaging Het
Ccny G A 18: 9,332,928 (GRCm39) T201I probably damaging Het
Cdca5 T C 19: 6,140,382 (GRCm39) V181A possibly damaging Het
Ces1g A G 8: 94,032,496 (GRCm39) I488T probably benign Het
Csmd2 A G 4: 128,404,717 (GRCm39) T2368A probably benign Het
Cux1 T A 5: 136,315,702 (GRCm39) I1113F probably damaging Het
Dnah3 C T 7: 119,522,061 (GRCm39) G4033D probably damaging Het
Foxg1 T A 12: 49,432,082 (GRCm39) S272T possibly damaging Het
Fyco1 T C 9: 123,655,699 (GRCm39) N1020D probably benign Het
Gprc5c T G 11: 114,754,686 (GRCm39) L121R probably damaging Het
Hyou1 G A 9: 44,300,156 (GRCm39) R815H probably damaging Het
Kera T C 10: 97,448,835 (GRCm39) *352Q probably null Het
Kirrel1 C T 3: 86,996,458 (GRCm39) M380I probably null Het
Lnpk T C 2: 74,399,453 (GRCm39) E30G probably damaging Het
Map2 C T 1: 66,464,457 (GRCm39) R128C probably damaging Het
Or1i2 A T 10: 78,447,901 (GRCm39) D191E possibly damaging Het
Or1o2 T A 17: 37,543,025 (GRCm39) M79L probably benign Het
Or51h7 A G 7: 102,591,004 (GRCm39) F260S probably damaging Het
Pabir3 G A X: 52,382,376 (GRCm39) R94H possibly damaging Het
Ror2 A G 13: 53,264,680 (GRCm39) M792T probably benign Het
Serpinb9d A G 13: 33,386,948 (GRCm39) I339V probably benign Het
Serpinb9d A G 13: 33,386,657 (GRCm39) probably null Het
Slc1a1 A G 19: 28,878,852 (GRCm39) K197R probably benign Het
Snx20 A G 8: 89,354,226 (GRCm39) V168A possibly damaging Het
Sowaha T C 11: 53,369,395 (GRCm39) E447G possibly damaging Het
Stard8 AGAGGAGGAGGAGGAGGAGGA AGAGGAGGAGGAGGAGGA X: 98,110,114 (GRCm39) probably benign Het
Stx19 G T 16: 62,643,039 (GRCm39) C285F possibly damaging Het
Syp A G X: 7,506,166 (GRCm39) probably null Het
Tbkbp1 C T 11: 97,039,894 (GRCm39) probably null Het
Trim29 G T 9: 43,222,677 (GRCm39) E169* probably null Het
Ttll12 T C 15: 83,461,214 (GRCm39) N602D probably damaging Het
Zfp26 T C 9: 20,348,012 (GRCm39) T851A probably benign Het
Zfp316 T C 5: 143,240,226 (GRCm39) M598V probably benign Het
Zhx2 A G 15: 57,685,125 (GRCm39) I165V probably benign Het
Other mutations in Or2y11
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01621:Or2y11 APN 11 49,442,964 (GRCm39) missense probably damaging 1.00
IGL02166:Or2y11 APN 11 49,442,757 (GRCm39) missense probably damaging 1.00
IGL02723:Or2y11 APN 11 49,443,506 (GRCm39) missense probably benign 0.28
R0518:Or2y11 UTSW 11 49,443,291 (GRCm39) missense probably damaging 1.00
R0521:Or2y11 UTSW 11 49,443,291 (GRCm39) missense probably damaging 1.00
R2109:Or2y11 UTSW 11 49,443,260 (GRCm39) missense probably damaging 1.00
R6155:Or2y11 UTSW 11 49,443,411 (GRCm39) missense possibly damaging 0.93
R6181:Or2y11 UTSW 11 49,443,120 (GRCm39) missense probably damaging 0.97
R6250:Or2y11 UTSW 11 49,442,711 (GRCm39) missense probably damaging 1.00
R6372:Or2y11 UTSW 11 49,442,757 (GRCm39) missense probably damaging 1.00
R6616:Or2y11 UTSW 11 49,442,868 (GRCm39) missense probably damaging 0.97
R7391:Or2y11 UTSW 11 49,443,371 (GRCm39) missense probably damaging 1.00
R9030:Or2y11 UTSW 11 49,442,808 (GRCm39) missense probably damaging 1.00
R9566:Or2y11 UTSW 11 49,443,162 (GRCm39) missense probably benign
Z1177:Or2y11 UTSW 11 49,443,111 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GTGCATCTCATCTCATTGTGG -3'
(R):5'- AAGTAGTGTCTTGGCCACCTAG -3'

Sequencing Primer
(F):5'- CATCTCATTGTGGTTGCCATG -3'
(R):5'- GGTGACCCTATCTGGCACATAC -3'
Posted On 2015-06-10