Incidental Mutation 'R4198:Cdca5'
Institutional Source Beutler Lab
Gene Symbol Cdca5
Ensembl Gene ENSMUSG00000024791
Gene Namecell division cycle associated 5
Synonymssororin p35, 2610036L13Rik
MMRRC Submission 041640-MU
Accession Numbers
Is this an essential gene? Essential (E-score: 1.000) question?
Stock #R4198 (G1)
Quality Score225
Status Not validated
Chromosomal Location6084983-6091777 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 6090352 bp
Amino Acid Change Valine to Alanine at position 181 (V181A)
Ref Sequence ENSEMBL: ENSMUSP00000025704 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000025704]
Predicted Effect possibly damaging
Transcript: ENSMUST00000025704
AA Change: V181A

PolyPhen 2 Score 0.454 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000025704
Gene: ENSMUSG00000024791
AA Change: V181A

low complexity region 17 34 N/A INTRINSIC
Pfam:Sororin 88 228 4.1e-31 PFAM
low complexity region 251 264 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000152528
Predicted Effect noncoding transcript
Transcript: ENSMUST00000156961
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 95.4%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aox1 G A 1: 58,085,607 M1002I probably benign Het
Ap2b1 C A 11: 83,342,603 Q481K probably damaging Het
Arhgap31 G A 16: 38,623,913 A194V probably damaging Het
Atp10a A G 7: 58,813,686 D989G probably damaging Het
Ccny G A 18: 9,332,928 T201I probably damaging Het
Ces1g A G 8: 93,305,868 I488T probably benign Het
Csmd2 A G 4: 128,510,924 T2368A probably benign Het
Cux1 T A 5: 136,286,848 I1113F probably damaging Het
Dnah3 C T 7: 119,922,838 G4033D probably damaging Het
Fam122c G A X: 53,293,499 R94H possibly damaging Het
Foxg1 T A 12: 49,385,299 S272T possibly damaging Het
Fyco1 T C 9: 123,826,634 N1020D probably benign Het
Gprc5c T G 11: 114,863,860 L121R probably damaging Het
Hyou1 G A 9: 44,388,859 R815H probably damaging Het
Kera T C 10: 97,612,973 *352Q probably null Het
Kirrel C T 3: 87,089,151 M380I probably null Het
Lnpk T C 2: 74,569,109 E30G probably damaging Het
Map2 C T 1: 66,425,298 R128C probably damaging Het
Olfr1357 A T 10: 78,612,067 D191E possibly damaging Het
Olfr1381 G A 11: 49,552,634 V296M possibly damaging Het
Olfr573-ps1 A G 7: 102,941,797 F260S probably damaging Het
Olfr97 T A 17: 37,232,134 M79L probably benign Het
Ror2 A G 13: 53,110,644 M792T probably benign Het
Serpinb9d A G 13: 33,202,674 probably null Het
Serpinb9d A G 13: 33,202,965 I339V probably benign Het
Slc1a1 A G 19: 28,901,452 K197R probably benign Het
Snx20 A G 8: 88,627,598 V168A possibly damaging Het
Sowaha T C 11: 53,478,568 E447G possibly damaging Het
Stx19 G T 16: 62,822,676 C285F possibly damaging Het
Syp A G X: 7,639,927 probably null Het
Tbkbp1 C T 11: 97,149,068 probably null Het
Trim29 G T 9: 43,311,380 E169* probably null Het
Ttll12 T C 15: 83,577,013 N602D probably damaging Het
Zfp26 T C 9: 20,436,716 T851A probably benign Het
Zfp316 T C 5: 143,254,471 M598V probably benign Het
Zhx2 A G 15: 57,821,729 I165V probably benign Het
Other mutations in Cdca5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01377:Cdca5 APN 19 6090282 missense probably damaging 0.97
R0277:Cdca5 UTSW 19 6090712 missense unknown
R0480:Cdca5 UTSW 19 6090298 missense probably damaging 0.97
R1859:Cdca5 UTSW 19 6090094 missense possibly damaging 0.51
R4897:Cdca5 UTSW 19 6090397 nonsense probably null
R5000:Cdca5 UTSW 19 6085433 missense possibly damaging 0.73
R5840:Cdca5 UTSW 19 6090369 missense possibly damaging 0.95
Predicted Primers PCR Primer

Sequencing Primer
Posted On2015-06-10