Incidental Mutation 'R4202:Gucy2g'
ID 318808
Institutional Source Beutler Lab
Gene Symbol Gucy2g
Ensembl Gene ENSMUSG00000055523
Gene Name guanylate cyclase 2g
Synonyms 2410077I05Rik, GC-G
MMRRC Submission 041032-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R4202 (G1)
Quality Score 225
Status Validated
Chromosome 19
Chromosomal Location 55186531-55229668 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 55218201 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 416 (S416P)
Ref Sequence ENSEMBL: ENSMUSP00000068253 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000069183]
AlphaFold Q6TL19
Predicted Effect possibly damaging
Transcript: ENSMUST00000069183
AA Change: S416P

PolyPhen 2 Score 0.956 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000068253
Gene: ENSMUSG00000055523
AA Change: S416P

DomainStartEndE-ValueType
low complexity region 27 38 N/A INTRINSIC
Pfam:ANF_receptor 65 416 5.2e-36 PFAM
low complexity region 471 487 N/A INTRINSIC
Pfam:Pkinase 574 826 2e-26 PFAM
Pfam:Pkinase_Tyr 577 826 6e-35 PFAM
CYCc 865 1059 6.42e-96 SMART
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.5%
Validation Efficiency 92% (33/36)
MGI Phenotype PHENOTYPE: Mice homozygous for a null mutation are viable and fertile with no gross abnormalities and are protected against acute ischemia induced renal injury. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 30 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adsl C T 15: 80,836,417 (GRCm39) T58I probably damaging Het
Ano7 A G 1: 93,308,200 (GRCm39) D77G probably benign Het
Ap2b1 T A 11: 83,226,430 (GRCm39) probably null Het
Bclaf3 T A X: 158,336,829 (GRCm39) S419T probably damaging Het
Bysl A G 17: 47,915,251 (GRCm39) S166P probably benign Het
Cd101 A C 3: 100,926,001 (GRCm39) D239E probably damaging Het
Cdc42bpb G A 12: 111,260,573 (GRCm39) P1702S probably benign Het
Cfap65 G T 1: 74,959,701 (GRCm39) F816L probably damaging Het
Cnot6 T C 11: 49,593,463 (GRCm39) Y6C probably damaging Het
Csrp1 T G 1: 135,673,065 (GRCm39) C61G probably damaging Het
Gmeb2 A G 2: 180,895,766 (GRCm39) V468A possibly damaging Het
Hormad1 G A 3: 95,492,509 (GRCm39) R362H probably benign Het
Lancl2 T A 6: 57,689,977 (GRCm39) V61D probably benign Het
Lta4h A G 10: 93,306,669 (GRCm39) D287G probably damaging Het
Maml1 A T 11: 50,148,740 (GRCm39) L1000Q probably damaging Het
Or6c206 T C 10: 129,097,646 (GRCm39) V272A probably benign Het
Or7a42 T C 10: 78,791,129 (GRCm39) V30A probably benign Het
Osbpl9 G T 4: 109,029,437 (GRCm39) probably benign Het
Oser1 T C 2: 163,253,375 (GRCm39) T45A probably benign Het
Pip4p1 A G 14: 51,168,112 (GRCm39) S41P probably damaging Het
Ppfibp1 C A 6: 146,931,079 (GRCm39) S878R probably damaging Het
Prss43 T A 9: 110,656,529 (GRCm39) V72D probably benign Het
Sdhb T A 4: 140,706,379 (GRCm39) M272K possibly damaging Het
Shroom3 G T 5: 93,090,945 (GRCm39) V1151F probably damaging Het
Stx17 T A 4: 48,158,870 (GRCm39) D83E probably damaging Het
Tas2r138 T C 6: 40,589,410 (GRCm39) M279V possibly damaging Het
Tsku C T 7: 98,002,205 (GRCm39) R42H probably damaging Het
Tyr A G 7: 87,078,276 (GRCm39) L528P possibly damaging Het
Vmn2r87 T C 10: 130,308,448 (GRCm39) I597V probably benign Het
Wnt5b T C 6: 119,417,272 (GRCm39) N198D probably damaging Het
Other mutations in Gucy2g
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00801:Gucy2g APN 19 55,221,535 (GRCm39) missense probably benign 0.01
IGL01954:Gucy2g APN 19 55,187,123 (GRCm39) missense probably benign 0.01
IGL01969:Gucy2g APN 19 55,215,870 (GRCm39) missense probably benign 0.00
IGL02164:Gucy2g APN 19 55,226,455 (GRCm39) missense probably benign
IGL02534:Gucy2g APN 19 55,229,500 (GRCm39) missense probably damaging 1.00
IGL02667:Gucy2g APN 19 55,194,609 (GRCm39) missense possibly damaging 0.64
IGL02755:Gucy2g APN 19 55,198,786 (GRCm39) missense probably benign 0.10
IGL03187:Gucy2g APN 19 55,219,484 (GRCm39) missense possibly damaging 0.91
IGL03354:Gucy2g APN 19 55,221,512 (GRCm39) missense possibly damaging 0.95
PIT4366001:Gucy2g UTSW 19 55,226,214 (GRCm39) missense probably null 0.51
R0040:Gucy2g UTSW 19 55,205,734 (GRCm39) missense possibly damaging 0.73
R0126:Gucy2g UTSW 19 55,229,598 (GRCm39) missense probably benign
R0318:Gucy2g UTSW 19 55,226,230 (GRCm39) missense probably benign 0.00
R0576:Gucy2g UTSW 19 55,187,202 (GRCm39) missense probably damaging 1.00
R0604:Gucy2g UTSW 19 55,191,519 (GRCm39) missense probably benign 0.00
R0962:Gucy2g UTSW 19 55,198,716 (GRCm39) nonsense probably null
R1348:Gucy2g UTSW 19 55,211,338 (GRCm39) missense possibly damaging 0.68
R1458:Gucy2g UTSW 19 55,203,468 (GRCm39) splice site probably benign
R1693:Gucy2g UTSW 19 55,211,358 (GRCm39) missense probably damaging 1.00
R1795:Gucy2g UTSW 19 55,187,973 (GRCm39) missense probably damaging 1.00
R1804:Gucy2g UTSW 19 55,198,741 (GRCm39) missense probably benign 0.34
R1830:Gucy2g UTSW 19 55,211,362 (GRCm39) missense possibly damaging 0.94
R1902:Gucy2g UTSW 19 55,198,669 (GRCm39) missense probably benign 0.20
R1927:Gucy2g UTSW 19 55,226,191 (GRCm39) missense probably benign 0.02
R1969:Gucy2g UTSW 19 55,221,485 (GRCm39) missense probably benign 0.42
R1969:Gucy2g UTSW 19 55,211,328 (GRCm39) missense possibly damaging 0.90
R2071:Gucy2g UTSW 19 55,210,772 (GRCm39) missense possibly damaging 0.72
R2842:Gucy2g UTSW 19 55,229,379 (GRCm39) missense probably damaging 1.00
R2971:Gucy2g UTSW 19 55,198,708 (GRCm39) missense probably damaging 1.00
R4405:Gucy2g UTSW 19 55,226,269 (GRCm39) missense probably benign 0.08
R4407:Gucy2g UTSW 19 55,226,269 (GRCm39) missense probably benign 0.08
R4614:Gucy2g UTSW 19 55,190,579 (GRCm39) nonsense probably null
R4671:Gucy2g UTSW 19 55,226,500 (GRCm39) missense probably damaging 1.00
R4684:Gucy2g UTSW 19 55,194,688 (GRCm39) missense probably damaging 1.00
R4837:Gucy2g UTSW 19 55,214,485 (GRCm39) missense probably benign
R4969:Gucy2g UTSW 19 55,214,445 (GRCm39) missense probably benign
R5050:Gucy2g UTSW 19 55,229,367 (GRCm39) missense probably benign 0.05
R5059:Gucy2g UTSW 19 55,214,503 (GRCm39) missense probably benign 0.00
R5070:Gucy2g UTSW 19 55,218,219 (GRCm39) missense probably damaging 0.98
R5288:Gucy2g UTSW 19 55,203,548 (GRCm39) missense probably damaging 1.00
R5384:Gucy2g UTSW 19 55,203,548 (GRCm39) missense probably damaging 1.00
R5386:Gucy2g UTSW 19 55,203,548 (GRCm39) missense probably damaging 1.00
R5497:Gucy2g UTSW 19 55,187,133 (GRCm39) missense probably benign 0.00
R5531:Gucy2g UTSW 19 55,229,572 (GRCm39) missense probably benign 0.24
R5536:Gucy2g UTSW 19 55,226,359 (GRCm39) missense probably benign 0.05
R5679:Gucy2g UTSW 19 55,219,511 (GRCm39) missense possibly damaging 0.87
R5715:Gucy2g UTSW 19 55,221,587 (GRCm39) missense possibly damaging 0.93
R5941:Gucy2g UTSW 19 55,203,563 (GRCm39) missense probably damaging 1.00
R6250:Gucy2g UTSW 19 55,205,856 (GRCm39) missense probably damaging 0.99
R6288:Gucy2g UTSW 19 55,215,945 (GRCm39) missense probably benign 0.01
R6378:Gucy2g UTSW 19 55,229,377 (GRCm39) missense probably benign 0.00
R6605:Gucy2g UTSW 19 55,229,460 (GRCm39) missense probably damaging 1.00
R7020:Gucy2g UTSW 19 55,221,482 (GRCm39) missense probably damaging 0.98
R7064:Gucy2g UTSW 19 55,198,764 (GRCm39) missense probably benign 0.01
R7078:Gucy2g UTSW 19 55,229,583 (GRCm39) missense probably damaging 1.00
R7402:Gucy2g UTSW 19 55,194,725 (GRCm39) missense probably damaging 1.00
R7539:Gucy2g UTSW 19 55,191,586 (GRCm39) missense probably damaging 0.99
R7561:Gucy2g UTSW 19 55,194,772 (GRCm39) missense probably benign 0.38
R7583:Gucy2g UTSW 19 55,224,047 (GRCm39) missense probably damaging 1.00
R7804:Gucy2g UTSW 19 55,216,584 (GRCm39) missense probably benign 0.02
R7880:Gucy2g UTSW 19 55,194,712 (GRCm39) missense probably damaging 1.00
R8442:Gucy2g UTSW 19 55,205,833 (GRCm39) missense probably benign 0.00
R8559:Gucy2g UTSW 19 55,198,786 (GRCm39) missense probably benign 0.10
R8970:Gucy2g UTSW 19 55,191,478 (GRCm39) missense possibly damaging 0.56
R8972:Gucy2g UTSW 19 55,226,406 (GRCm39) missense probably benign 0.17
R9085:Gucy2g UTSW 19 55,221,597 (GRCm39) nonsense probably null
R9390:Gucy2g UTSW 19 55,190,607 (GRCm39) missense probably null 1.00
R9462:Gucy2g UTSW 19 55,221,469 (GRCm39) critical splice donor site probably null
R9502:Gucy2g UTSW 19 55,198,816 (GRCm39) missense probably damaging 1.00
R9610:Gucy2g UTSW 19 55,194,605 (GRCm39) missense probably damaging 1.00
R9611:Gucy2g UTSW 19 55,194,605 (GRCm39) missense probably damaging 1.00
R9644:Gucy2g UTSW 19 55,219,537 (GRCm39) missense probably benign 0.05
Z1177:Gucy2g UTSW 19 55,198,809 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- TGACCTTTGTGAGTTCAGAAGG -3'
(R):5'- AGGTTCTGTGAAATGGCAAAGC -3'

Sequencing Primer
(F):5'- CAGGCTTCACGTGAGTTTACAAG -3'
(R):5'- AGCTGTGAGAGCCACATT -3'
Posted On 2015-06-10