Incidental Mutation 'R4206:Gpr149'
ID |
318906 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Gpr149
|
Ensembl Gene |
ENSMUSG00000043441 |
Gene Name |
G protein-coupled receptor 149 |
Synonyms |
PGR10, 9630018L10Rik, R35, Ieda |
MMRRC Submission |
041035-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.074)
|
Stock # |
R4206 (G1)
|
Quality Score |
225 |
Status
|
Not validated
|
Chromosome |
3 |
Chromosomal Location |
62436851-62512861 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
T to G
at 62511924 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Aspartic acid to Alanine
at position 25
(D25A)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000060893
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000058535]
|
AlphaFold |
Q3UVY1 |
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000058535
AA Change: D25A
PolyPhen 2
Score 0.923 (Sensitivity: 0.81; Specificity: 0.94)
|
SMART Domains |
Protein: ENSMUSP00000060893 Gene: ENSMUSG00000043441 AA Change: D25A
Domain | Start | End | E-Value | Type |
Pfam:7tm_1
|
52 |
363 |
7.2e-7 |
PFAM |
coiled coil region
|
694 |
730 |
N/A |
INTRINSIC |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000149007
|
Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.3%
- 20x: 95.5%
|
Validation Efficiency |
|
MGI Phenotype |
PHENOTYPE: Female mice homozygous for a knock-out allele exhibit increased fertility with increased litter size and frequency. [provided by MGI curators]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 49 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
4921509C19Rik |
T |
C |
2: 151,315,435 (GRCm39) |
K81R |
probably benign |
Het |
Acacb |
T |
C |
5: 114,351,712 (GRCm39) |
F1150L |
probably benign |
Het |
Acat3 |
A |
G |
17: 13,146,273 (GRCm39) |
Y237H |
possibly damaging |
Het |
Arfgap3 |
T |
C |
15: 83,206,869 (GRCm39) |
T240A |
probably benign |
Het |
Arl6ip1 |
AAAATAAATAAATAAATAAATAAATA |
AAAATAAATAAATAAATAAATAAATAAATA |
7: 117,721,122 (GRCm39) |
|
probably benign |
Het |
Cabin1 |
T |
C |
10: 75,590,675 (GRCm39) |
S23G |
possibly damaging |
Het |
Cemip2 |
G |
T |
19: 21,819,479 (GRCm39) |
R1090L |
probably damaging |
Het |
Clasp1 |
A |
G |
1: 118,506,636 (GRCm39) |
N949S |
probably damaging |
Het |
Csrp1 |
T |
G |
1: 135,673,065 (GRCm39) |
C61G |
probably damaging |
Het |
Dgka |
A |
T |
10: 128,557,064 (GRCm39) |
L637Q |
probably damaging |
Het |
Dst |
G |
A |
1: 34,251,328 (GRCm39) |
R1801H |
probably damaging |
Het |
Edil3 |
T |
C |
13: 89,328,397 (GRCm39) |
S284P |
probably damaging |
Het |
Eif2d |
A |
G |
1: 131,082,100 (GRCm39) |
Y64C |
probably damaging |
Het |
Ell2 |
A |
G |
13: 75,910,067 (GRCm39) |
D139G |
probably damaging |
Het |
Fam187a |
A |
G |
11: 102,777,038 (GRCm39) |
R281G |
probably damaging |
Het |
Gin1 |
A |
G |
1: 97,720,145 (GRCm39) |
D380G |
possibly damaging |
Het |
Gyg1 |
A |
G |
3: 20,206,901 (GRCm39) |
S90P |
probably benign |
Het |
Hpx |
C |
T |
7: 105,244,354 (GRCm39) |
M190I |
probably null |
Het |
Irf2bpl |
C |
T |
12: 86,929,810 (GRCm39) |
V288I |
probably benign |
Het |
Lyst |
A |
G |
13: 13,810,574 (GRCm39) |
H748R |
probably benign |
Het |
Mmrn1 |
G |
A |
6: 60,935,164 (GRCm39) |
G220D |
probably damaging |
Het |
Mpdz |
A |
T |
4: 81,299,999 (GRCm39) |
M333K |
probably benign |
Het |
Muc5ac |
C |
T |
7: 141,370,847 (GRCm39) |
S2556F |
possibly damaging |
Het |
Nfix |
CAAAAA |
CAAAA |
8: 85,442,876 (GRCm39) |
|
probably null |
Het |
Ntsr1 |
A |
G |
2: 180,142,545 (GRCm39) |
D112G |
probably damaging |
Het |
Or56b1 |
T |
A |
7: 104,285,356 (GRCm39) |
N158K |
possibly damaging |
Het |
Or7a42 |
T |
C |
10: 78,791,117 (GRCm39) |
F26S |
probably benign |
Het |
Or9s14 |
A |
C |
1: 92,536,317 (GRCm39) |
T253P |
possibly damaging |
Het |
Parg |
A |
G |
14: 31,976,493 (GRCm39) |
K178R |
probably benign |
Het |
Pde8b |
C |
A |
13: 95,359,053 (GRCm39) |
C90F |
probably benign |
Het |
Pld1 |
G |
A |
3: 28,174,932 (GRCm39) |
V857I |
probably benign |
Het |
Rad54l2 |
A |
C |
9: 106,594,994 (GRCm39) |
V321G |
probably damaging |
Het |
Rcn2 |
A |
G |
9: 55,952,491 (GRCm39) |
Y112C |
possibly damaging |
Het |
Rnf123 |
A |
T |
9: 107,941,162 (GRCm39) |
D639E |
probably benign |
Het |
Rufy2 |
C |
T |
10: 62,840,551 (GRCm39) |
Q441* |
probably null |
Het |
Scgb2b12 |
T |
C |
7: 32,026,063 (GRCm39) |
Y43C |
probably damaging |
Het |
Scrn3 |
T |
A |
2: 73,149,845 (GRCm39) |
|
probably null |
Het |
Shroom3 |
G |
T |
5: 93,090,945 (GRCm39) |
V1151F |
probably damaging |
Het |
Slc22a8 |
T |
C |
19: 8,585,597 (GRCm39) |
S321P |
probably benign |
Het |
Tex11 |
C |
A |
X: 99,977,021 (GRCm39) |
A487S |
possibly damaging |
Het |
Tex2 |
A |
G |
11: 106,458,398 (GRCm39) |
|
probably benign |
Het |
Trip13 |
A |
G |
13: 74,081,009 (GRCm39) |
I119T |
probably benign |
Het |
Tsku |
C |
T |
7: 98,002,205 (GRCm39) |
R42H |
probably damaging |
Het |
Ttn |
A |
G |
2: 76,602,911 (GRCm39) |
I16691T |
possibly damaging |
Het |
Tyr |
A |
G |
7: 87,078,276 (GRCm39) |
L528P |
possibly damaging |
Het |
Ubxn2b |
T |
C |
4: 6,204,565 (GRCm39) |
V142A |
probably damaging |
Het |
Uggt2 |
C |
T |
14: 119,286,674 (GRCm39) |
D221N |
probably damaging |
Het |
Wnt4 |
A |
G |
4: 137,023,654 (GRCm39) |
K207R |
possibly damaging |
Het |
Zfp608 |
T |
C |
18: 55,121,267 (GRCm39) |
R107G |
probably damaging |
Het |
|
Other mutations in Gpr149 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00330:Gpr149
|
APN |
3 |
62,438,094 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01339:Gpr149
|
APN |
3 |
62,511,718 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01399:Gpr149
|
APN |
3 |
62,511,852 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01954:Gpr149
|
APN |
3 |
62,438,348 (GRCm39) |
missense |
probably benign |
0.36 |
IGL02115:Gpr149
|
APN |
3 |
62,502,336 (GRCm39) |
missense |
probably benign |
0.02 |
IGL02218:Gpr149
|
APN |
3 |
62,437,952 (GRCm39) |
utr 3 prime |
probably benign |
|
IGL02592:Gpr149
|
APN |
3 |
62,511,231 (GRCm39) |
missense |
possibly damaging |
0.75 |
IGL03393:Gpr149
|
APN |
3 |
62,511,366 (GRCm39) |
missense |
probably benign |
0.15 |
R0578:Gpr149
|
UTSW |
3 |
62,510,110 (GRCm39) |
missense |
possibly damaging |
0.81 |
R1173:Gpr149
|
UTSW |
3 |
62,511,888 (GRCm39) |
missense |
probably damaging |
1.00 |
R1174:Gpr149
|
UTSW |
3 |
62,511,888 (GRCm39) |
missense |
probably damaging |
1.00 |
R1175:Gpr149
|
UTSW |
3 |
62,511,888 (GRCm39) |
missense |
probably damaging |
1.00 |
R1432:Gpr149
|
UTSW |
3 |
62,438,439 (GRCm39) |
missense |
probably damaging |
1.00 |
R1484:Gpr149
|
UTSW |
3 |
62,502,592 (GRCm39) |
missense |
probably benign |
0.00 |
R1972:Gpr149
|
UTSW |
3 |
62,438,216 (GRCm39) |
missense |
probably benign |
0.39 |
R1973:Gpr149
|
UTSW |
3 |
62,438,216 (GRCm39) |
missense |
probably benign |
0.39 |
R2180:Gpr149
|
UTSW |
3 |
62,511,489 (GRCm39) |
missense |
probably damaging |
1.00 |
R2241:Gpr149
|
UTSW |
3 |
62,511,474 (GRCm39) |
missense |
probably benign |
0.00 |
R3118:Gpr149
|
UTSW |
3 |
62,502,443 (GRCm39) |
missense |
probably benign |
0.00 |
R3547:Gpr149
|
UTSW |
3 |
62,502,549 (GRCm39) |
missense |
probably benign |
0.01 |
R3548:Gpr149
|
UTSW |
3 |
62,502,549 (GRCm39) |
missense |
probably benign |
0.01 |
R4332:Gpr149
|
UTSW |
3 |
62,511,794 (GRCm39) |
missense |
possibly damaging |
0.93 |
R4531:Gpr149
|
UTSW |
3 |
62,510,099 (GRCm39) |
missense |
probably benign |
0.00 |
R4557:Gpr149
|
UTSW |
3 |
62,511,918 (GRCm39) |
missense |
probably benign |
0.02 |
R4557:Gpr149
|
UTSW |
3 |
62,438,291 (GRCm39) |
missense |
probably damaging |
1.00 |
R4593:Gpr149
|
UTSW |
3 |
62,510,151 (GRCm39) |
intron |
probably benign |
|
R5397:Gpr149
|
UTSW |
3 |
62,438,226 (GRCm39) |
missense |
probably damaging |
1.00 |
R6592:Gpr149
|
UTSW |
3 |
62,437,961 (GRCm39) |
missense |
probably benign |
0.02 |
R6642:Gpr149
|
UTSW |
3 |
62,437,995 (GRCm39) |
missense |
probably damaging |
1.00 |
R6845:Gpr149
|
UTSW |
3 |
62,511,942 (GRCm39) |
missense |
possibly damaging |
0.58 |
R7303:Gpr149
|
UTSW |
3 |
62,502,491 (GRCm39) |
missense |
possibly damaging |
0.59 |
R7659:Gpr149
|
UTSW |
3 |
62,511,256 (GRCm39) |
missense |
probably benign |
0.01 |
R7682:Gpr149
|
UTSW |
3 |
62,438,160 (GRCm39) |
missense |
probably damaging |
1.00 |
R7803:Gpr149
|
UTSW |
3 |
62,438,136 (GRCm39) |
missense |
probably damaging |
1.00 |
R7904:Gpr149
|
UTSW |
3 |
62,502,356 (GRCm39) |
missense |
probably benign |
0.00 |
R7943:Gpr149
|
UTSW |
3 |
62,438,132 (GRCm39) |
missense |
probably damaging |
1.00 |
R8844:Gpr149
|
UTSW |
3 |
62,502,572 (GRCm39) |
missense |
probably benign |
0.05 |
R8919:Gpr149
|
UTSW |
3 |
62,438,478 (GRCm39) |
missense |
probably damaging |
1.00 |
R9043:Gpr149
|
UTSW |
3 |
62,511,360 (GRCm39) |
missense |
probably damaging |
1.00 |
R9209:Gpr149
|
UTSW |
3 |
62,511,093 (GRCm39) |
missense |
probably benign |
0.40 |
Z1177:Gpr149
|
UTSW |
3 |
62,511,380 (GRCm39) |
frame shift |
probably null |
|
Z1190:Gpr149
|
UTSW |
3 |
62,511,972 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
Predicted Primers |
PCR Primer
(F):5'- TTGGCCACTGTAAAACCATGAAG -3'
(R):5'- GGAGACATGTCTGGACCAAC -3'
Sequencing Primer
(F):5'- CCATGAAGATGGCCACGGAC -3'
(R):5'- GAGACATGTCTGGACCAACACATG -3'
|
Posted On |
2015-06-10 |