Mutagenetix > Incidental Mutation

Incidental Mutation 'R4206:Tex2'

318929

Institutional Source

Beutler Lab

Gene Symbol

Tex2

Ensembl Gene

ENSMUSG00000040548

Gene Name

testis expressed gene 2

Synonyms

Def-5, Taz4, 4930568E07Rik

MMRRC Submission

041035-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R4206 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

106502147-106613423 bp(-) (GRCm38)

Type of Mutation

unclassified

DNA Base Change (assembly)

A to G at 106567572 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Gene Model

predicted gene model for transcript(s): [ENSMUST00000042780] [ENSMUST00000103070] [ENSMUST00000128933] [ENSMUST00000153870]

AlphaFold

Q6ZPJ0

Predicted Effect

unknown
Transcript: ENSMUST00000042780
AA Change: I344T

SMART Domains

Protein: ENSMUSP00000041985
Gene: ENSMUSG00000040548
AA Change: I344T

Domain	Start	End	E-Value	Type
low complexity region	119	186	N/A	INTRINSIC
low complexity region	319	341	N/A	INTRINSIC
low complexity region	346	360	N/A	INTRINSIC
transmembrane domain	473	492	N/A	INTRINSIC
transmembrane domain	494	516	N/A	INTRINSIC
PH	543	712	5.05e-1	SMART
low complexity region	732	752	N/A	INTRINSIC
low complexity region	811	823	N/A	INTRINSIC
low complexity region	946	965	N/A	INTRINSIC
low complexity region	1003	1016	N/A	INTRINSIC

Predicted Effect

unknown
Transcript: ENSMUST00000103070
AA Change: I344T

SMART Domains

Protein: ENSMUSP00000099359
Gene: ENSMUSG00000040548
AA Change: I344T

Domain	Start	End	E-Value	Type
low complexity region	119	186	N/A	INTRINSIC
low complexity region	319	341	N/A	INTRINSIC
low complexity region	346	360	N/A	INTRINSIC
transmembrane domain	473	492	N/A	INTRINSIC
transmembrane domain	494	516	N/A	INTRINSIC
PH	543	712	5.05e-1	SMART
low complexity region	732	752	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000128933

SMART Domains

Protein: ENSMUSP00000120781
Gene: ENSMUSG00000040548

Domain	Start	End	E-Value	Type
low complexity region	119	168	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000153870

Predicted Effect

probably benign
Transcript: ENSMUST00000207249

Coding Region Coverage

1x: 99.2%
3x: 98.6%
10x: 97.3%
20x: 95.5%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 49 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4921509C19Rik	T	C	2: 151,473,515	K81R	probably benign	Het
Acacb	T	C	5: 114,213,651	F1150L	probably benign	Het
Acat3	A	G	17: 12,927,386	Y237H	possibly damaging	Het
Arfgap3	T	C	15: 83,322,668	T240A	probably benign	Het
Arl6ip1	AAAATAAATAAATAAATAAATAAATA	AAAATAAATAAATAAATAAATAAATAAATA	7: 118,121,899		probably benign	Het
Cabin1	T	C	10: 75,754,841	S23G	possibly damaging	Het
Clasp1	A	G	1: 118,578,906	N949S	probably damaging	Het
Csrp1	T	G	1: 135,745,327	C61G	probably damaging	Het
Dgka	A	T	10: 128,721,195	L637Q	probably damaging	Het
Dst	G	A	1: 34,212,247	R1801H	probably damaging	Het
Edil3	T	C	13: 89,180,278	S284P	probably damaging	Het
Eif2d	A	G	1: 131,154,363	Y64C	probably damaging	Het
Ell2	A	G	13: 75,761,948	D139G	probably damaging	Het
Fam187a	A	G	11: 102,886,212	R281G	probably damaging	Het
Gin1	A	G	1: 97,792,420	D380G	possibly damaging	Het
Gpr149	T	G	3: 62,604,503	D25A	possibly damaging	Het
Gyg	A	G	3: 20,152,737	S90P	probably benign	Het
Hpx	C	T	7: 105,595,147	M190I	probably null	Het
Irf2bpl	C	T	12: 86,883,036	V288I	probably benign	Het
Lyst	A	G	13: 13,635,989	H748R	probably benign	Het
Mmrn1	G	A	6: 60,958,180	G220D	probably damaging	Het
Mpdz	A	T	4: 81,381,762	M333K	probably benign	Het
Muc5ac	C	T	7: 141,817,110	S2556F	possibly damaging	Het
Nfix	CAAAAA	CAAAA	8: 84,716,247		probably null	Het
Ntsr1	A	G	2: 180,500,752	D112G	probably damaging	Het
Olfr1410	A	C	1: 92,608,595	T253P	possibly damaging	Het
Olfr657	T	A	7: 104,636,149	N158K	possibly damaging	Het
Olfr8	T	C	10: 78,955,283	F26S	probably benign	Het
Parg	A	G	14: 32,254,536	K178R	probably benign	Het
Pde8b	C	A	13: 95,222,545	C90F	probably benign	Het
Pld1	G	A	3: 28,120,783	V857I	probably benign	Het
Rad54l2	A	C	9: 106,717,795	V321G	probably damaging	Het
Rcn2	A	G	9: 56,045,207	Y112C	possibly damaging	Het
Rnf123	A	T	9: 108,063,963	D639E	probably benign	Het
Rufy2	C	T	10: 63,004,772	Q441*	probably null	Het
Scgb2b12	T	C	7: 32,326,638	Y43C	probably damaging	Het
Scrn3	T	A	2: 73,319,501		probably null	Het
Shroom3	G	T	5: 92,943,086	V1151F	probably damaging	Het
Slc22a8	T	C	19: 8,608,233	S321P	probably benign	Het
Tex11	C	A	X: 100,933,415	A487S	possibly damaging	Het
Tmem2	G	T	19: 21,842,115	R1090L	probably damaging	Het
Trip13	A	G	13: 73,932,890	I119T	probably benign	Het
Tsku	C	T	7: 98,352,998	R42H	probably damaging	Het
Ttn	A	G	2: 76,772,567	I16691T	possibly damaging	Het
Tyr	A	G	7: 87,429,068	L528P	possibly damaging	Het
Ubxn2b	T	C	4: 6,204,565	V142A	probably damaging	Het
Uggt2	C	T	14: 119,049,262	D221N	probably damaging	Het
Wnt4	A	G	4: 137,296,343	K207R	possibly damaging	Het
Zfp608	T	C	18: 54,988,195	R107G	probably damaging	Het

Other mutations in Tex2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00090:Tex2	APN	11	106568535	missense	probably damaging	1.00
IGL01380:Tex2	APN	11	106544315	nonsense	probably null
IGL02607:Tex2	APN	11	106546747	missense	unknown
IGL02680:Tex2	APN	11	106568232	unclassified	probably benign
IGL02699:Tex2	APN	11	106568433	missense	possibly damaging	0.53
IGL03187:Tex2	APN	11	106568077	unclassified	probably benign
IGL03398:Tex2	APN	11	106568272	missense	probably damaging	1.00
R0242:Tex2	UTSW	11	106519955	nonsense	probably null
R0242:Tex2	UTSW	11	106519955	nonsense	probably null
R1085:Tex2	UTSW	11	106568487	missense	probably damaging	0.98
R1491:Tex2	UTSW	11	106503640	missense	possibly damaging	0.72
R1664:Tex2	UTSW	11	106567782	unclassified	probably benign
R1794:Tex2	UTSW	11	106567902	unclassified	probably benign
R1855:Tex2	UTSW	11	106546876	missense	possibly damaging	0.87
R2077:Tex2	UTSW	11	106506864	splice site	probably null
R2151:Tex2	UTSW	11	106567335	unclassified	probably benign
R2175:Tex2	UTSW	11	106503687	missense	unknown
R2984:Tex2	UTSW	11	106546663	critical splice donor site	probably null
R3156:Tex2	UTSW	11	106533869	critical splice donor site	probably null
R3722:Tex2	UTSW	11	106546740	nonsense	probably null
R3724:Tex2	UTSW	11	106529330	missense	unknown
R3770:Tex2	UTSW	11	106544252	missense	unknown
R3771:Tex2	UTSW	11	106546894	missense	unknown
R3813:Tex2	UTSW	11	106511944	missense	unknown
R3947:Tex2	UTSW	11	106520003	missense	unknown
R4342:Tex2	UTSW	11	106567006	unclassified	probably benign
R4554:Tex2	UTSW	11	106544386	missense	unknown
R4896:Tex2	UTSW	11	106568404	missense	probably damaging	1.00
R5207:Tex2	UTSW	11	106546840	missense	unknown
R5249:Tex2	UTSW	11	106546789	missense	unknown
R5257:Tex2	UTSW	11	106567759	unclassified	probably benign
R5258:Tex2	UTSW	11	106567759	unclassified	probably benign
R5278:Tex2	UTSW	11	106567813	missense	probably benign	0.34
R5702:Tex2	UTSW	11	106544395	missense	possibly damaging	0.58
R5835:Tex2	UTSW	11	106519913	missense	unknown
R6150:Tex2	UTSW	11	106567080	missense	probably benign	0.34
R6785:Tex2	UTSW	11	106533950	missense	probably damaging	1.00
R6879:Tex2	UTSW	11	106534010	missense	unknown
R7038:Tex2	UTSW	11	106511900	critical splice donor site	probably null
R7117:Tex2	UTSW	11	106544245	missense	unknown
R7336:Tex2	UTSW	11	106548859	missense	unknown
R7568:Tex2	UTSW	11	106548736	missense	unknown
R7622:Tex2	UTSW	11	106546895	missense	unknown
R8228:Tex2	UTSW	11	106567171	missense	probably benign	0.34
R8407:Tex2	UTSW	11	106568395	missense	probably damaging	1.00
R8807:Tex2	UTSW	11	106544368	missense	unknown
R8807:Tex2	UTSW	11	106567588	missense	unknown
R8882:Tex2	UTSW	11	106544236	missense	unknown
R8926:Tex2	UTSW	11	106568404	missense
R8936:Tex2	UTSW	11	106567318	nonsense	probably null
R8988:Tex2	UTSW	11	106511905	missense	unknown
R9165:Tex2	UTSW	11	106567269	missense	unknown
R9294:Tex2	UTSW	11	106568535	missense	probably damaging	1.00
R9314:Tex2	UTSW	11	106544249	missense	unknown
R9405:Tex2	UTSW	11	106544388	missense	unknown
R9419:Tex2	UTSW	11	106567009	nonsense	probably null
R9477:Tex2	UTSW	11	106519880	critical splice donor site	probably null
R9626:Tex2	UTSW	11	106546753	missense	unknown
R9634:Tex2	UTSW	11	106568152	missense	unknown
T0970:Tex2	UTSW	11	106546946	missense	unknown
Z1177:Tex2	UTSW	11	106534008	missense	unknown

Predicted Primers

PCR Primer
(F):5'- CTCCGTGTACAGTTCACAGAAC -3'
(R):5'- ACTAAGCGACGCCTTTCTG -3'

Sequencing Primer
(F):5'- TGCTCACTAAAGCAGACAGAG -3'
(R):5'- GAAGTTATCTATGAGCCCTTCCAG -3'

Posted On

2015-06-10