Mutagenetix > Incidental Mutation

Incidental Mutation 'R4207:Vmn2r92'

318997

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r92

Ensembl Gene

ENSMUSG00000091350

Gene Name

vomeronasal 2, receptor 92

Synonyms

EG627111

MMRRC Submission

041036-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.073) question?

Stock #

R4207 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

18151887-18188886 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 18184261 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Valine to Methionine at position 556 (V556M)

Ref Sequence

ENSEMBL: ENSMUSP00000128685 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000169686]

AlphaFold

L7N2A4

Predicted Effect

possibly damaging
Transcript: ENSMUST00000169686
AA Change: V556M

PolyPhen 2 Score 0.622 (Sensitivity: 0.87; Specificity: 0.91)

SMART Domains

Protein: ENSMUSP00000128685
Gene: ENSMUSG00000091350
AA Change: V556M

Domain	Start	End	E-Value	Type
signal peptide	1	20	N/A	INTRINSIC
Pfam:ANF_receptor	83	463	4.7e-38	PFAM
Pfam:NCD3G	510	564	2.5e-19	PFAM
Pfam:7tm_3	597	832	1.1e-52	PFAM
low complexity region	843	855	N/A	INTRINSIC

Meta Mutation Damage Score

0.1795

Coding Region Coverage

1x: 99.2%
3x: 98.6%
10x: 97.3%
20x: 95.5%

Validation Efficiency

100% (60/60)

Allele List at MGI

Other mutations in this stock

Total: 54 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca8b	G	A	11: 109,981,725	Q17*	probably null	Het
Acap2	T	A	16: 31,119,427	N293I	probably damaging	Het
Adgrg4	G	A	X: 56,918,749	V1893I	possibly damaging	Het
Aff1	T	C	5: 103,818,988		probably null	Het
Ap1b1	A	G	11: 5,031,637	D515G	probably damaging	Het
Brk1	T	C	6: 113,615,844	Y63H	possibly damaging	Het
Cand1	T	C	10: 119,211,845	D580G	probably damaging	Het
Casp4	A	G	9: 5,328,451	D311G	probably benign	Het
Crygs	C	T	16: 22,805,551	G102D	possibly damaging	Het
Ctnnd2	G	T	15: 30,972,827	V1033F	probably damaging	Het
Dhx29	G	T	13: 112,927,949	A53S	probably benign	Het
Dis3	T	G	14: 99,095,316	I227L	probably benign	Het
Efhc2	T	C	X: 17,230,550	N186S	possibly damaging	Het
Efl1	T	C	7: 82,750,816	V592A	probably damaging	Het
Elovl7	A	T	13: 108,282,506	Q224L	possibly damaging	Het
Fcgr3	T	A	1: 171,054,075	K160N	probably benign	Het
Flg	A	G	3: 93,279,862	Y207C	probably benign	Het
Fmn2	A	G	1: 174,581,955	T585A	unknown	Het
Gm7135	T	C	1: 97,469,895		noncoding transcript	Het
Gm8104	G	T	14: 43,101,634	D94Y	probably damaging	Het
Hjurp	G	C	1: 88,277,215		probably benign	Het
Ino80b	G	C	6: 83,122,333	P178R	probably damaging	Het
Kbtbd4	T	C	2: 90,909,755	F495L	probably damaging	Het
Lingo2	T	C	4: 35,709,810	I57V	probably benign	Het
Me2	T	C	18: 73,791,085	K352R	probably benign	Het
Mthfsd	A	G	8: 121,105,626	V133A	probably damaging	Het
Nav2	T	A	7: 49,572,298		probably null	Het
Nav2	T	A	7: 49,597,231	I2168N	probably damaging	Het
Nlrp10	T	A	7: 108,924,341	D644V	possibly damaging	Het
Olfr1472	T	C	19: 13,454,471	I15M	probably benign	Het
Olfr148	A	G	9: 39,613,957	Y130C	possibly damaging	Het
Olfr15	T	C	16: 3,839,570	L199P	probably damaging	Het
Oplah	C	T	15: 76,302,710	R635H	probably damaging	Het
Peli1	A	G	11: 21,147,115		probably null	Het
Pfkfb1	A	T	X: 150,622,188	D208V	possibly damaging	Het
Pld5	T	G	1: 175,993,875	T242P	probably damaging	Het
Rbm5	A	G	9: 107,750,483	S420P	probably benign	Het
Rhag	A	T	17: 40,831,653	I250F	probably damaging	Het
Rnase4	A	G	14: 51,105,005	K62R	probably benign	Het
Scaf4	C	T	16: 90,260,215	V83I	unknown	Het
Slc24a2	A	G	4: 87,227,205	V204A	probably damaging	Het
Slc5a8	G	T	10: 88,911,413	L409F	probably damaging	Het
Spns3	A	T	11: 72,538,361	V199E	probably damaging	Het
Sspo	A	G	6: 48,478,293	T3030A	probably benign	Het
Sstr2	A	C	11: 113,624,656	T134P	probably damaging	Het
Stk39	G	T	2: 68,220,920	T527K	probably benign	Het
Sult2a1	T	A	7: 13,801,547	T194S	probably benign	Het
Tamm41	AGGG	AGG	6: 115,012,359		probably benign	Het
Trav7-3	A	G	14: 53,443,746	T82A	probably benign	Het
Umodl1	G	A	17: 30,959,367	V106I	probably damaging	Het
Vmn2r85	A	C	10: 130,418,705	C703W	probably damaging	Het
Zfp292	T	C	4: 34,806,079	I2322V	probably benign	Het
Zfp644	T	C	5: 106,618,276	E93G	probably damaging	Het
Zfp81	C	T	17: 33,334,916	C308Y	probably damaging	Het

Other mutations in Vmn2r92

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01591:Vmn2r92	APN	17	18185161	missense	unknown
IGL01758:Vmn2r92	APN	17	18152013	nonsense	probably null
IGL02614:Vmn2r92	APN	17	18167241	splice site	probably benign
IGL03095:Vmn2r92	APN	17	18166710	missense	possibly damaging	0.55
IGL03403:Vmn2r92	APN	17	18166852	missense	probably damaging	0.98
R0133:Vmn2r92	UTSW	17	18167957	missense	probably damaging	1.00
R0225:Vmn2r92	UTSW	17	18167957	missense	probably damaging	1.00
R0227:Vmn2r92	UTSW	17	18167957	missense	probably damaging	1.00
R0265:Vmn2r92	UTSW	17	18167957	missense	probably damaging	1.00
R0266:Vmn2r92	UTSW	17	18167957	missense	probably damaging	1.00
R0267:Vmn2r92	UTSW	17	18167957	missense	probably damaging	1.00
R0420:Vmn2r92	UTSW	17	18168921	missense	probably benign	0.01
R0426:Vmn2r92	UTSW	17	18167957	missense	probably damaging	1.00
R0494:Vmn2r92	UTSW	17	18167957	missense	probably damaging	1.00
R1253:Vmn2r92	UTSW	17	18166766	missense	probably benign	0.08
R1497:Vmn2r92	UTSW	17	18167363	missense	probably benign	0.02
R1571:Vmn2r92	UTSW	17	18152090	missense	probably damaging	0.96
R1656:Vmn2r92	UTSW	17	18151936	missense	probably benign
R1816:Vmn2r92	UTSW	17	18166677	missense	probably damaging	0.98
R2229:Vmn2r92	UTSW	17	18167392	missense	probably benign	0.01
R2909:Vmn2r92	UTSW	17	18185115	missense	possibly damaging	0.89
R3694:Vmn2r92	UTSW	17	18151943	nonsense	probably null
R4548:Vmn2r92	UTSW	17	18171316	missense	probably benign
R4612:Vmn2r92	UTSW	17	18166870	missense	probably benign	0.25
R4742:Vmn2r92	UTSW	17	18166857	missense	probably benign	0.06
R4824:Vmn2r92	UTSW	17	18151921	utr 5 prime	probably benign
R4865:Vmn2r92	UTSW	17	18167372	missense	probably benign	0.16
R4900:Vmn2r92	UTSW	17	18184343	missense	probably benign	0.27
R5084:Vmn2r92	UTSW	17	18185177	makesense	probably null
R5140:Vmn2r92	UTSW	17	18152050	missense	probably benign	0.07
R5995:Vmn2r92	UTSW	17	18168951	critical splice donor site	probably null
R6045:Vmn2r92	UTSW	17	18168043	critical splice donor site	probably null
R6269:Vmn2r92	UTSW	17	18166774	missense	probably benign	0.01
R6877:Vmn2r92	UTSW	17	18168822	missense	probably damaging	1.00
R7151:Vmn2r92	UTSW	17	18166743	missense	probably benign	0.01
R7260:Vmn2r92	UTSW	17	18166876	missense	probably damaging	1.00
R7344:Vmn2r92	UTSW	17	18167251	missense	probably benign	0.01
R7514:Vmn2r92	UTSW	17	18171271	missense	probably damaging	1.00
R7576:Vmn2r92	UTSW	17	18167359	missense	probably benign	0.01
R7584:Vmn2r92	UTSW	17	18166766	missense	probably benign	0.08
R7912:Vmn2r92	UTSW	17	18184708	missense	possibly damaging	0.91
R7941:Vmn2r92	UTSW	17	18184837	missense	possibly damaging	0.89
R8178:Vmn2r92	UTSW	17	18166726	missense	possibly damaging	0.69
R8238:Vmn2r92	UTSW	17	18185016	missense	probably benign	0.00
R8239:Vmn2r92	UTSW	17	18185016	missense	probably benign	0.00
R8252:Vmn2r92	UTSW	17	18166872	missense	probably damaging	1.00
R8322:Vmn2r92	UTSW	17	18166624	missense	probably damaging	0.99
R8355:Vmn2r92	UTSW	17	18184799	missense	probably damaging	0.99
R9399:Vmn2r92	UTSW	17	18168875	missense	probably benign	0.29
R9639:Vmn2r92	UTSW	17	18152090	missense	probably damaging	0.96
R9747:Vmn2r92	UTSW	17	18184939	missense	possibly damaging	0.66
R9773:Vmn2r92	UTSW	17	18166687	missense	probably damaging	1.00
X0066:Vmn2r92	UTSW	17	18184895	missense	probably damaging	1.00
Z1177:Vmn2r92	UTSW	17	18184533	missense	probably damaging	0.96

Predicted Primers

PCR Primer
(F):5'- TGTAGAATTTTGCATACCAGTGTTC -3'
(R):5'- GCAAAGGTGGTCTGCTGAAG -3'

Sequencing Primer
(F):5'- AGTGCCATGACTTCTGAG -3'
(R):5'- CTCGATTATTGGCCTTGACAATAGG -3'

Posted On

2015-06-10