Incidental Mutation 'R0395:Nav1'
| ID |
31910 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Nav1
|
| Ensembl Gene |
ENSMUSG00000009418 |
| Gene Name |
neuron navigator 1 |
| Synonyms |
9930003A20Rik, unc53H1, steerin-1, POMFIL3, C230080M11Rik |
| MMRRC Submission |
038601-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.934)
|
| Stock # |
R0395 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
1 |
| Chromosomal Location |
135362318-135615843 bp(-) (GRCm39) |
| Type of Mutation |
nonsense |
| DNA Base Change (assembly) |
G to T
at 135460359 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Tyrosine to Stop codon
at position 321
(Y321*)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000140322
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000040599]
[ENSMUST00000067414]
[ENSMUST00000190298]
|
| AlphaFold |
Q8CH77 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000040599
AA Change: Y321*
|
| SMART Domains |
Protein: ENSMUSP00000043803
Gene: ENSMUSG00000009418
AA Change: Y321*
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
16 |
33 |
N/A |
INTRINSIC |
|
low complexity region
|
48 |
65 |
N/A |
INTRINSIC |
|
low complexity region
|
119 |
132 |
N/A |
INTRINSIC |
|
low complexity region
|
303 |
318 |
N/A |
INTRINSIC |
|
low complexity region
|
414 |
428 |
N/A |
INTRINSIC |
|
low complexity region
|
436 |
456 |
N/A |
INTRINSIC |
|
low complexity region
|
739 |
749 |
N/A |
INTRINSIC |
|
low complexity region
|
807 |
818 |
N/A |
INTRINSIC |
|
low complexity region
|
892 |
913 |
N/A |
INTRINSIC |
|
low complexity region
|
975 |
989 |
N/A |
INTRINSIC |
|
coiled coil region
|
1070 |
1105 |
N/A |
INTRINSIC |
|
low complexity region
|
1179 |
1210 |
N/A |
INTRINSIC |
|
low complexity region
|
1260 |
1281 |
N/A |
INTRINSIC |
|
low complexity region
|
1296 |
1304 |
N/A |
INTRINSIC |
|
coiled coil region
|
1328 |
1360 |
N/A |
INTRINSIC |
|
AAA
|
1548 |
1702 |
3.16e-5 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000067414
AA Change: Y321*
|
| SMART Domains |
Protein: ENSMUSP00000067241
Gene: ENSMUSG00000009418
AA Change: Y321*
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
16 |
33 |
N/A |
INTRINSIC |
|
low complexity region
|
48 |
65 |
N/A |
INTRINSIC |
|
low complexity region
|
119 |
132 |
N/A |
INTRINSIC |
|
low complexity region
|
303 |
318 |
N/A |
INTRINSIC |
|
low complexity region
|
414 |
428 |
N/A |
INTRINSIC |
|
low complexity region
|
436 |
456 |
N/A |
INTRINSIC |
|
low complexity region
|
739 |
749 |
N/A |
INTRINSIC |
|
low complexity region
|
807 |
818 |
N/A |
INTRINSIC |
|
low complexity region
|
892 |
913 |
N/A |
INTRINSIC |
|
low complexity region
|
975 |
989 |
N/A |
INTRINSIC |
|
coiled coil region
|
1070 |
1105 |
N/A |
INTRINSIC |
|
low complexity region
|
1179 |
1210 |
N/A |
INTRINSIC |
|
low complexity region
|
1260 |
1281 |
N/A |
INTRINSIC |
|
low complexity region
|
1296 |
1304 |
N/A |
INTRINSIC |
|
coiled coil region
|
1328 |
1360 |
N/A |
INTRINSIC |
|
AAA
|
1548 |
1702 |
3.16e-5 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000190298
AA Change: Y321*
|
| SMART Domains |
Protein: ENSMUSP00000140322
Gene: ENSMUSG00000009418
AA Change: Y321*
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
16 |
33 |
N/A |
INTRINSIC |
|
low complexity region
|
48 |
65 |
N/A |
INTRINSIC |
|
low complexity region
|
119 |
132 |
N/A |
INTRINSIC |
|
low complexity region
|
303 |
318 |
N/A |
INTRINSIC |
|
low complexity region
|
414 |
428 |
N/A |
INTRINSIC |
|
low complexity region
|
436 |
456 |
N/A |
INTRINSIC |
|
low complexity region
|
739 |
749 |
N/A |
INTRINSIC |
|
low complexity region
|
807 |
818 |
N/A |
INTRINSIC |
|
low complexity region
|
892 |
913 |
N/A |
INTRINSIC |
|
low complexity region
|
975 |
989 |
N/A |
INTRINSIC |
|
coiled coil region
|
1013 |
1048 |
N/A |
INTRINSIC |
|
low complexity region
|
1122 |
1153 |
N/A |
INTRINSIC |
|
low complexity region
|
1200 |
1221 |
N/A |
INTRINSIC |
|
low complexity region
|
1236 |
1244 |
N/A |
INTRINSIC |
|
coiled coil region
|
1268 |
1300 |
N/A |
INTRINSIC |
|
AAA
|
1488 |
1642 |
3.16e-5 |
SMART |
|
| Meta Mutation Damage Score |
0.9755 |
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.1%
- 10x: 95.9%
- 20x: 91.4%
|
| Validation Efficiency |
98% (103/105) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene belongs to the neuron navigator family and is expressed predominantly in the nervous system. The encoded protein contains coiled-coil domains and a conserved AAA domain characteristic for ATPases associated with a variety of cellular activities. This gene is similar to unc-53, a Caenorhabditis elegans gene involved in axon guidance. The exact function of this gene is not known, but it is thought to play a role in in neuronal development and regeneration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 102 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4921517D22Rik |
T |
C |
13: 59,837,470 (GRCm39) |
K205R |
possibly damaging |
Het |
| 9630041A04Rik |
A |
T |
9: 101,819,934 (GRCm39) |
N118I |
probably damaging |
Het |
| AAdacl4fm3 |
A |
G |
4: 144,429,765 (GRCm39) |
V408A |
probably benign |
Het |
| Acsm2 |
G |
A |
7: 119,174,969 (GRCm39) |
D245N |
probably damaging |
Het |
| Adgrv1 |
A |
T |
13: 81,534,072 (GRCm39) |
H5836Q |
probably benign |
Het |
| Ahcyl2 |
T |
C |
6: 29,886,167 (GRCm39) |
V391A |
probably damaging |
Het |
| Alcam |
A |
T |
16: 52,130,227 (GRCm39) |
M41K |
probably benign |
Het |
| Aldh3b3 |
A |
C |
19: 4,016,472 (GRCm39) |
E363D |
probably benign |
Het |
| Alk |
A |
G |
17: 72,910,526 (GRCm39) |
V60A |
probably damaging |
Het |
| Als2cl |
G |
A |
9: 110,727,152 (GRCm39) |
R906H |
probably damaging |
Het |
| Ap5z1 |
T |
C |
5: 142,456,317 (GRCm39) |
|
probably benign |
Het |
| Apba2 |
T |
A |
7: 64,393,156 (GRCm39) |
I547N |
probably benign |
Het |
| Apol10b |
A |
T |
15: 77,469,840 (GRCm39) |
D112E |
probably damaging |
Het |
| Ash1l |
C |
A |
3: 88,965,896 (GRCm39) |
R2433S |
probably damaging |
Het |
| Cachd1 |
T |
C |
4: 100,810,402 (GRCm39) |
F335L |
probably damaging |
Het |
| Cbfa2t3 |
G |
T |
8: 123,365,690 (GRCm39) |
Q181K |
probably benign |
Het |
| Cct6b |
A |
G |
11: 82,630,506 (GRCm39) |
M265T |
probably benign |
Het |
| Cd151 |
G |
A |
7: 141,050,304 (GRCm39) |
V180I |
probably damaging |
Het |
| Ces1h |
T |
A |
8: 94,083,706 (GRCm39) |
N412I |
unknown |
Het |
| Chmp7 |
T |
C |
14: 69,969,905 (GRCm39) |
T12A |
probably benign |
Het |
| Clasp1 |
A |
G |
1: 118,467,061 (GRCm39) |
T534A |
possibly damaging |
Het |
| Cldn15 |
T |
A |
5: 136,997,052 (GRCm39) |
V31E |
possibly damaging |
Het |
| Col16a1 |
G |
A |
4: 129,966,902 (GRCm39) |
G583D |
probably damaging |
Het |
| Csmd1 |
T |
C |
8: 16,396,652 (GRCm39) |
N426S |
probably damaging |
Het |
| Dapp1 |
C |
T |
3: 137,641,398 (GRCm39) |
C199Y |
possibly damaging |
Het |
| Dchs1 |
A |
G |
7: 105,407,745 (GRCm39) |
L2029P |
probably damaging |
Het |
| Dmc1 |
A |
G |
15: 79,472,973 (GRCm39) |
F158S |
probably damaging |
Het |
| Dst |
C |
T |
1: 34,228,200 (GRCm39) |
P1606L |
probably damaging |
Het |
| Dthd1 |
T |
A |
5: 62,971,676 (GRCm39) |
N166K |
possibly damaging |
Het |
| Enam |
A |
T |
5: 88,649,367 (GRCm39) |
Y292F |
probably damaging |
Het |
| Esrrg |
A |
T |
1: 187,930,832 (GRCm39) |
I285F |
probably damaging |
Het |
| Fam50b |
A |
G |
13: 34,931,220 (GRCm39) |
D232G |
probably damaging |
Het |
| Fam91a1 |
T |
A |
15: 58,326,641 (GRCm39) |
S792T |
probably benign |
Het |
| Fbxw22 |
A |
C |
9: 109,210,753 (GRCm39) |
C419W |
probably damaging |
Het |
| Flt4 |
G |
A |
11: 49,521,170 (GRCm39) |
S393N |
probably benign |
Het |
| Fras1 |
A |
T |
5: 96,917,512 (GRCm39) |
T3511S |
possibly damaging |
Het |
| Frat2 |
A |
C |
19: 41,836,263 (GRCm39) |
S30A |
probably damaging |
Het |
| Glp1r |
T |
A |
17: 31,155,312 (GRCm39) |
M433K |
probably benign |
Het |
| Gm10300 |
G |
A |
4: 131,802,299 (GRCm39) |
|
probably benign |
Het |
| Gpatch4 |
A |
G |
3: 87,961,661 (GRCm39) |
|
probably benign |
Het |
| Gpr22 |
A |
T |
12: 31,759,461 (GRCm39) |
S220R |
possibly damaging |
Het |
| Grn |
T |
C |
11: 102,327,049 (GRCm39) |
V549A |
probably benign |
Het |
| Gtf3c5 |
T |
C |
2: 28,467,930 (GRCm39) |
D177G |
probably damaging |
Het |
| Htr1b |
A |
T |
9: 81,513,704 (GRCm39) |
M301K |
probably benign |
Het |
| Ifi207 |
A |
T |
1: 173,557,431 (GRCm39) |
S436T |
possibly damaging |
Het |
| Ifnb1 |
A |
T |
4: 88,440,766 (GRCm39) |
N82K |
possibly damaging |
Het |
| Ina |
T |
G |
19: 47,010,358 (GRCm39) |
N384K |
probably damaging |
Het |
| Kirrel2 |
T |
C |
7: 30,149,883 (GRCm39) |
N541D |
possibly damaging |
Het |
| Lrp2 |
A |
T |
2: 69,263,421 (GRCm39) |
I4377N |
possibly damaging |
Het |
| Lrrc37a |
A |
G |
11: 103,355,221 (GRCm39) |
V2532A |
unknown |
Het |
| Mast4 |
T |
C |
13: 102,871,781 (GRCm39) |
E2529G |
probably damaging |
Het |
| Myh6 |
T |
C |
14: 55,183,777 (GRCm39) |
H1719R |
possibly damaging |
Het |
| Myo5a |
A |
T |
9: 75,101,259 (GRCm39) |
H150L |
probably benign |
Het |
| Naglu |
C |
T |
11: 100,964,933 (GRCm39) |
|
probably benign |
Het |
| Nags |
G |
A |
11: 102,036,530 (GRCm39) |
A40T |
unknown |
Het |
| Neu3 |
C |
T |
7: 99,462,985 (GRCm39) |
S246N |
probably benign |
Het |
| Npy5r |
C |
T |
8: 67,134,625 (GRCm39) |
G56D |
probably benign |
Het |
| Nrxn1 |
A |
G |
17: 91,395,742 (GRCm39) |
V138A |
possibly damaging |
Het |
| Nuggc |
C |
T |
14: 65,850,921 (GRCm39) |
Q264* |
probably null |
Het |
| Ogfod1 |
G |
A |
8: 94,790,156 (GRCm39) |
|
probably null |
Het |
| Or1o11 |
T |
A |
17: 37,756,757 (GRCm39) |
F115Y |
probably damaging |
Het |
| Or2t45 |
A |
T |
11: 58,669,195 (GRCm39) |
M81L |
probably benign |
Het |
| Or5b101 |
A |
G |
19: 13,005,663 (GRCm39) |
F10S |
probably damaging |
Het |
| Or5p66 |
A |
G |
7: 107,885,478 (GRCm39) |
V285A |
probably benign |
Het |
| Per1 |
T |
A |
11: 68,993,103 (GRCm39) |
I340N |
probably damaging |
Het |
| Pkhd1 |
C |
T |
1: 20,451,771 (GRCm39) |
A2175T |
probably benign |
Het |
| Pogk |
A |
G |
1: 166,231,171 (GRCm39) |
V52A |
probably damaging |
Het |
| Pou2af3 |
C |
T |
9: 51,191,834 (GRCm39) |
|
probably benign |
Het |
| Ppib |
A |
T |
9: 65,973,601 (GRCm39) |
T185S |
possibly damaging |
Het |
| Ptar1 |
G |
T |
19: 23,697,563 (GRCm39) |
M358I |
probably damaging |
Het |
| Qser1 |
A |
C |
2: 104,593,226 (GRCm39) |
I1597S |
probably damaging |
Het |
| Ranbp17 |
T |
C |
11: 33,424,896 (GRCm39) |
I487V |
probably benign |
Het |
| Repin1 |
C |
A |
6: 48,574,459 (GRCm39) |
R460S |
probably damaging |
Het |
| Sfmbt1 |
T |
C |
14: 30,509,574 (GRCm39) |
|
probably benign |
Het |
| Sh3rf1 |
C |
T |
8: 61,846,696 (GRCm39) |
|
probably benign |
Het |
| Shroom3 |
C |
T |
5: 92,928,762 (GRCm39) |
R106C |
probably damaging |
Het |
| Siglecf |
T |
A |
7: 43,005,399 (GRCm39) |
V453D |
probably damaging |
Het |
| Slc2a9 |
A |
G |
5: 38,610,512 (GRCm39) |
S96P |
probably damaging |
Het |
| Slc5a2 |
A |
G |
7: 127,866,654 (GRCm39) |
Y124C |
probably damaging |
Het |
| Slf1 |
A |
G |
13: 77,254,088 (GRCm39) |
|
probably benign |
Het |
| Smad1 |
T |
G |
8: 80,076,411 (GRCm39) |
K269T |
probably benign |
Het |
| Srp54b |
G |
A |
12: 55,296,884 (GRCm39) |
R194H |
probably damaging |
Het |
| St8sia6 |
T |
A |
2: 13,670,247 (GRCm39) |
S238C |
probably damaging |
Het |
| Stat3 |
A |
T |
11: 100,780,763 (GRCm39) |
|
probably benign |
Het |
| Tafa2 |
A |
T |
10: 123,429,497 (GRCm39) |
H37L |
probably benign |
Het |
| Tas1r2 |
T |
A |
4: 139,382,665 (GRCm39) |
M101K |
possibly damaging |
Het |
| Tesc |
A |
G |
5: 118,191,647 (GRCm39) |
|
probably null |
Het |
| Tle3 |
T |
A |
9: 61,317,353 (GRCm39) |
M334K |
probably damaging |
Het |
| Tmem151a |
A |
T |
19: 5,132,261 (GRCm39) |
V315E |
probably damaging |
Het |
| Tmprss2 |
T |
C |
16: 97,368,245 (GRCm39) |
D480G |
probably damaging |
Het |
| Trmt1 |
C |
A |
8: 85,423,741 (GRCm39) |
|
probably null |
Het |
| Tsr3 |
T |
C |
17: 25,461,198 (GRCm39) |
|
probably null |
Het |
| Ube2u |
A |
G |
4: 100,338,845 (GRCm39) |
K37E |
probably benign |
Het |
| Usp16 |
T |
A |
16: 87,272,334 (GRCm39) |
D382E |
probably damaging |
Het |
| Usp9y |
A |
T |
Y: 1,340,053 (GRCm39) |
F1442Y |
probably damaging |
Het |
| Utp20 |
A |
T |
10: 88,654,457 (GRCm39) |
M210K |
probably damaging |
Het |
| Utp25 |
T |
C |
1: 192,805,984 (GRCm39) |
E187G |
possibly damaging |
Het |
| V1ra8 |
C |
T |
6: 90,179,991 (GRCm39) |
L65F |
possibly damaging |
Het |
| Vmn2r10 |
T |
C |
5: 109,149,859 (GRCm39) |
N395S |
probably damaging |
Het |
| Vmn2r100 |
C |
A |
17: 19,742,382 (GRCm39) |
P252Q |
possibly damaging |
Het |
| Zfp217 |
C |
T |
2: 169,957,382 (GRCm39) |
A539T |
probably benign |
Het |
| Zfp330 |
G |
A |
8: 83,491,511 (GRCm39) |
Q221* |
probably null |
Het |
|
| Other mutations in Nav1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01061:Nav1
|
APN |
1 |
135,378,368 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01455:Nav1
|
APN |
1 |
135,397,373 (GRCm39) |
missense |
probably benign |
0.44 |
|
IGL01650:Nav1
|
APN |
1 |
135,382,498 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01872:Nav1
|
APN |
1 |
135,381,814 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01967:Nav1
|
APN |
1 |
135,464,983 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02167:Nav1
|
APN |
1 |
135,398,699 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02278:Nav1
|
APN |
1 |
135,391,452 (GRCm39) |
splice site |
probably benign |
|
|
IGL02343:Nav1
|
APN |
1 |
135,382,490 (GRCm39) |
nonsense |
probably null |
|
|
IGL02378:Nav1
|
APN |
1 |
135,397,716 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL02554:Nav1
|
APN |
1 |
135,512,651 (GRCm39) |
synonymous |
silent |
|
|
IGL03148:Nav1
|
APN |
1 |
135,397,762 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL03286:Nav1
|
APN |
1 |
135,382,274 (GRCm39) |
missense |
probably benign |
|
|
IGL03372:Nav1
|
APN |
1 |
135,378,641 (GRCm39) |
missense |
probably damaging |
0.99 |
|
PIT4802001:Nav1
|
UTSW |
1 |
135,380,671 (GRCm39) |
missense |
unknown |
|
|
R0388:Nav1
|
UTSW |
1 |
135,376,655 (GRCm39) |
splice site |
probably benign |
|
|
R0390:Nav1
|
UTSW |
1 |
135,377,704 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R0395:Nav1
|
UTSW |
1 |
135,460,361 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R0416:Nav1
|
UTSW |
1 |
135,398,864 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R0463:Nav1
|
UTSW |
1 |
135,379,945 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R0538:Nav1
|
UTSW |
1 |
135,392,430 (GRCm39) |
splice site |
probably benign |
|
|
R0594:Nav1
|
UTSW |
1 |
135,395,381 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R0696:Nav1
|
UTSW |
1 |
135,460,352 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0699:Nav1
|
UTSW |
1 |
135,380,687 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0759:Nav1
|
UTSW |
1 |
135,382,998 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R1164:Nav1
|
UTSW |
1 |
135,400,148 (GRCm39) |
missense |
probably benign |
|
|
R1169:Nav1
|
UTSW |
1 |
135,382,943 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1401:Nav1
|
UTSW |
1 |
135,388,163 (GRCm39) |
missense |
probably benign |
0.20 |
|
R1421:Nav1
|
UTSW |
1 |
135,512,748 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1642:Nav1
|
UTSW |
1 |
135,380,010 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1705:Nav1
|
UTSW |
1 |
135,512,337 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1713:Nav1
|
UTSW |
1 |
135,522,972 (GRCm39) |
intron |
probably benign |
|
|
R1728:Nav1
|
UTSW |
1 |
135,512,465 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R1729:Nav1
|
UTSW |
1 |
135,512,465 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R1730:Nav1
|
UTSW |
1 |
135,512,465 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R1739:Nav1
|
UTSW |
1 |
135,512,465 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R1740:Nav1
|
UTSW |
1 |
135,386,127 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1762:Nav1
|
UTSW |
1 |
135,512,465 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R1783:Nav1
|
UTSW |
1 |
135,512,465 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R1784:Nav1
|
UTSW |
1 |
135,512,465 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R1785:Nav1
|
UTSW |
1 |
135,512,465 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R1895:Nav1
|
UTSW |
1 |
135,386,396 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1896:Nav1
|
UTSW |
1 |
135,388,475 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1901:Nav1
|
UTSW |
1 |
135,400,148 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1902:Nav1
|
UTSW |
1 |
135,400,148 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1925:Nav1
|
UTSW |
1 |
135,534,967 (GRCm39) |
utr 5 prime |
probably benign |
|
|
R1939:Nav1
|
UTSW |
1 |
135,393,636 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1971:Nav1
|
UTSW |
1 |
135,460,091 (GRCm39) |
missense |
probably benign |
0.06 |
|
R2063:Nav1
|
UTSW |
1 |
135,376,742 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2066:Nav1
|
UTSW |
1 |
135,376,742 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2084:Nav1
|
UTSW |
1 |
135,535,158 (GRCm39) |
unclassified |
probably benign |
|
|
R2090:Nav1
|
UTSW |
1 |
135,534,903 (GRCm39) |
utr 5 prime |
probably benign |
|
|
R2107:Nav1
|
UTSW |
1 |
135,376,742 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2110:Nav1
|
UTSW |
1 |
135,376,742 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2111:Nav1
|
UTSW |
1 |
135,376,742 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2112:Nav1
|
UTSW |
1 |
135,376,742 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2136:Nav1
|
UTSW |
1 |
135,382,174 (GRCm39) |
missense |
probably null |
0.18 |
|
R2268:Nav1
|
UTSW |
1 |
135,399,974 (GRCm39) |
nonsense |
probably null |
|
|
R2269:Nav1
|
UTSW |
1 |
135,399,974 (GRCm39) |
nonsense |
probably null |
|
|
R2847:Nav1
|
UTSW |
1 |
135,378,382 (GRCm39) |
splice site |
probably null |
|
|
R2869:Nav1
|
UTSW |
1 |
135,388,495 (GRCm39) |
synonymous |
silent |
|
|
R2871:Nav1
|
UTSW |
1 |
135,388,495 (GRCm39) |
synonymous |
silent |
|
|
R2872:Nav1
|
UTSW |
1 |
135,388,495 (GRCm39) |
synonymous |
silent |
|
|
R2904:Nav1
|
UTSW |
1 |
135,512,976 (GRCm39) |
missense |
probably benign |
|
|
R3690:Nav1
|
UTSW |
1 |
135,395,382 (GRCm39) |
missense |
probably benign |
0.11 |
|
R3716:Nav1
|
UTSW |
1 |
135,378,368 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3717:Nav1
|
UTSW |
1 |
135,378,368 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3718:Nav1
|
UTSW |
1 |
135,378,368 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3815:Nav1
|
UTSW |
1 |
135,398,862 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R4282:Nav1
|
UTSW |
1 |
135,385,651 (GRCm39) |
intron |
probably benign |
|
|
R4361:Nav1
|
UTSW |
1 |
135,535,175 (GRCm39) |
unclassified |
probably benign |
|
|
R4610:Nav1
|
UTSW |
1 |
135,520,186 (GRCm39) |
intron |
probably benign |
|
|
R4730:Nav1
|
UTSW |
1 |
135,535,049 (GRCm39) |
unclassified |
probably benign |
|
|
R4784:Nav1
|
UTSW |
1 |
135,386,477 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4788:Nav1
|
UTSW |
1 |
135,397,461 (GRCm39) |
missense |
probably benign |
|
|
R4808:Nav1
|
UTSW |
1 |
135,382,942 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4996:Nav1
|
UTSW |
1 |
135,393,709 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5284:Nav1
|
UTSW |
1 |
135,377,701 (GRCm39) |
nonsense |
probably null |
|
|
R5514:Nav1
|
UTSW |
1 |
135,398,299 (GRCm39) |
missense |
probably benign |
0.04 |
|
R5769:Nav1
|
UTSW |
1 |
135,379,995 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5834:Nav1
|
UTSW |
1 |
135,460,144 (GRCm39) |
missense |
probably benign |
0.07 |
|
R5898:Nav1
|
UTSW |
1 |
135,512,884 (GRCm39) |
missense |
probably benign |
|
|
R6081:Nav1
|
UTSW |
1 |
135,398,560 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6344:Nav1
|
UTSW |
1 |
135,378,534 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6378:Nav1
|
UTSW |
1 |
135,382,433 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7001:Nav1
|
UTSW |
1 |
135,382,349 (GRCm39) |
splice site |
probably null |
|
|
R7185:Nav1
|
UTSW |
1 |
135,398,746 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R7291:Nav1
|
UTSW |
1 |
135,393,597 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7361:Nav1
|
UTSW |
1 |
135,380,591 (GRCm39) |
missense |
unknown |
|
|
R7390:Nav1
|
UTSW |
1 |
135,512,656 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7464:Nav1
|
UTSW |
1 |
135,512,647 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7502:Nav1
|
UTSW |
1 |
135,397,404 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7601:Nav1
|
UTSW |
1 |
135,388,176 (GRCm39) |
missense |
unknown |
|
|
R7625:Nav1
|
UTSW |
1 |
135,395,483 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7639:Nav1
|
UTSW |
1 |
135,398,860 (GRCm39) |
missense |
probably benign |
0.09 |
|
R7786:Nav1
|
UTSW |
1 |
135,397,733 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7808:Nav1
|
UTSW |
1 |
135,379,986 (GRCm39) |
missense |
unknown |
|
|
R7815:Nav1
|
UTSW |
1 |
135,512,377 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R7825:Nav1
|
UTSW |
1 |
135,377,782 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8030:Nav1
|
UTSW |
1 |
135,464,977 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8370:Nav1
|
UTSW |
1 |
135,398,882 (GRCm39) |
nonsense |
probably null |
|
|
R8405:Nav1
|
UTSW |
1 |
135,382,508 (GRCm39) |
missense |
unknown |
|
|
R8720:Nav1
|
UTSW |
1 |
135,388,464 (GRCm39) |
missense |
unknown |
|
|
R8868:Nav1
|
UTSW |
1 |
135,512,943 (GRCm39) |
missense |
probably benign |
0.05 |
|
R8973:Nav1
|
UTSW |
1 |
135,512,463 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9039:Nav1
|
UTSW |
1 |
135,371,487 (GRCm39) |
missense |
unknown |
|
|
R9261:Nav1
|
UTSW |
1 |
135,388,095 (GRCm39) |
missense |
unknown |
|
|
R9523:Nav1
|
UTSW |
1 |
135,379,929 (GRCm39) |
missense |
unknown |
|
|
Z1088:Nav1
|
UTSW |
1 |
135,398,462 (GRCm39) |
missense |
probably benign |
0.01 |
|
Z1176:Nav1
|
UTSW |
1 |
135,400,158 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Nav1
|
UTSW |
1 |
135,380,624 (GRCm39) |
missense |
unknown |
|
|
Z1177:Nav1
|
UTSW |
1 |
135,397,469 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
| Predicted Primers |
PCR Primer
(F):5'- AGGTCACTGTCACTCATGTAGCCG -3'
(R):5'- TAGCCACACTCACAGGATAGGCTC -3'
Sequencing Primer
(F):5'- GATTTGAGGTCCACCTCGTCAG -3'
(R):5'- TTGACAGCCTGAGATACCCTG -3'
|
| Posted On |
2013-04-24 |
Incidental Mutation