Incidental Mutation 'R4213:Or5d16'
ID 319288
Institutional Source Beutler Lab
Gene Symbol Or5d16
Ensembl Gene ENSMUSG00000075145
Gene Name olfactory receptor family 5 subfamily D member 16
Synonyms Olfr1155, GA_x6K02T2Q125-49426894-49425950, MOR174-10
MMRRC Submission 041040-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.100) question?
Stock # R4213 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 87773026-87773970 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 87773465 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Cysteine at position 169 (Y169C)
Ref Sequence ENSEMBL: ENSMUSP00000149428 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099843] [ENSMUST00000214641] [ENSMUST00000215903] [ENSMUST00000216191] [ENSMUST00000216726]
AlphaFold Q8VFR3
Predicted Effect probably benign
Transcript: ENSMUST00000099843
AA Change: Y169C

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000097431
Gene: ENSMUSG00000075145
AA Change: Y169C

DomainStartEndE-ValueType
Pfam:7tm_4 33 310 2.7e-44 PFAM
Pfam:7tm_1 43 292 5.3e-16 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000214641
AA Change: Y169C

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Predicted Effect probably benign
Transcript: ENSMUST00000215903
AA Change: Y169C

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Predicted Effect probably benign
Transcript: ENSMUST00000216191
Predicted Effect probably benign
Transcript: ENSMUST00000216726
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.6%
Validation Efficiency 97% (38/39)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ankrd11 A C 8: 123,617,765 (GRCm39) V2029G probably benign Het
Arhgap28 A T 17: 68,178,988 (GRCm39) V291E probably benign Het
Cad G A 5: 31,229,688 (GRCm39) V1390I probably benign Het
Cadps2 A T 6: 23,599,462 (GRCm39) D281E probably damaging Het
Celsr1 G A 15: 85,916,008 (GRCm39) T655I probably damaging Het
Cep350 C G 1: 155,811,707 (GRCm39) G411A probably damaging Het
Chml A T 1: 175,514,261 (GRCm39) F210L probably damaging Het
Col4a4 A T 1: 82,430,865 (GRCm39) M1679K unknown Het
Ct45a C T X: 55,590,568 (GRCm39) V78I probably benign Het
Depdc1b T G 13: 108,525,225 (GRCm39) F527V probably damaging Het
Dipk1b C T 2: 26,525,960 (GRCm39) T298I probably benign Het
Dsg2 T C 18: 20,731,571 (GRCm39) L731P probably benign Het
Fbxo25 A G 8: 13,989,581 (GRCm39) T343A probably damaging Het
Gk5 T C 9: 96,011,106 (GRCm39) L72P probably damaging Het
Gpr137c G A 14: 45,483,965 (GRCm39) E231K probably damaging Het
Hdc C T 2: 126,439,786 (GRCm39) probably null Het
Hydin A G 8: 111,183,139 (GRCm39) N1112S possibly damaging Het
Itgae A G 11: 73,010,178 (GRCm39) H556R probably benign Het
Kcnh8 GAGACCAACGAGCAGCTGATGCTTCAGA GAGA 17: 53,032,934 (GRCm39) 74 probably benign Het
Kplce G A 3: 92,776,434 (GRCm39) P83L probably benign Het
Krtap17-1 A G 11: 99,884,740 (GRCm39) L9P unknown Het
Nmur1 T G 1: 86,315,506 (GRCm39) T87P probably damaging Het
Pira13 C A 7: 3,824,553 (GRCm39) A510S probably damaging Het
Ppp2r5e A G 12: 75,516,325 (GRCm39) I244T probably damaging Het
Robo3 C T 9: 37,333,194 (GRCm39) G781D probably damaging Het
Siglec1 C T 2: 130,916,038 (GRCm39) E1275K probably damaging Het
Slc2a12 A T 10: 22,577,993 (GRCm39) K596N probably benign Het
Sorcs1 G A 19: 50,213,613 (GRCm39) R705C probably damaging Het
Sqor G T 2: 122,629,418 (GRCm39) G92V probably damaging Het
Tlr4 T A 4: 66,758,563 (GRCm39) I452N probably damaging Het
Tob1 A G 11: 94,105,018 (GRCm39) T185A probably damaging Het
Yjefn3 G T 8: 70,343,540 (GRCm39) H50Q probably benign Het
Zswim1 T C 2: 164,667,705 (GRCm39) V319A probably benign Het
Other mutations in Or5d16
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02507:Or5d16 APN 2 87,773,262 (GRCm39) nonsense probably null
IGL03245:Or5d16 APN 2 87,773,086 (GRCm39) missense possibly damaging 0.75
B5639:Or5d16 UTSW 2 87,773,942 (GRCm39) missense probably benign 0.03
PIT4531001:Or5d16 UTSW 2 87,773,571 (GRCm39) missense probably damaging 1.00
R0212:Or5d16 UTSW 2 87,773,435 (GRCm39) missense probably damaging 1.00
R0393:Or5d16 UTSW 2 87,773,909 (GRCm39) missense possibly damaging 0.62
R1178:Or5d16 UTSW 2 87,773,490 (GRCm39) missense probably benign 0.02
R1180:Or5d16 UTSW 2 87,773,490 (GRCm39) missense probably benign 0.02
R1181:Or5d16 UTSW 2 87,773,490 (GRCm39) missense probably benign 0.02
R1266:Or5d16 UTSW 2 87,773,877 (GRCm39) missense probably benign 0.01
R1847:Or5d16 UTSW 2 87,773,065 (GRCm39) splice site probably null
R1998:Or5d16 UTSW 2 87,773,490 (GRCm39) missense probably benign 0.02
R2000:Or5d16 UTSW 2 87,773,490 (GRCm39) missense probably benign 0.02
R4119:Or5d16 UTSW 2 87,773,787 (GRCm39) missense probably damaging 1.00
R5157:Or5d16 UTSW 2 87,773,232 (GRCm39) missense probably benign
R5688:Or5d16 UTSW 2 87,773,552 (GRCm39) missense probably benign 0.02
R5731:Or5d16 UTSW 2 87,773,771 (GRCm39) missense possibly damaging 0.89
R6064:Or5d16 UTSW 2 87,773,828 (GRCm39) missense probably benign 0.00
R6372:Or5d16 UTSW 2 87,773,319 (GRCm39) missense probably benign 0.00
R6505:Or5d16 UTSW 2 87,773,518 (GRCm39) nonsense probably null
R6555:Or5d16 UTSW 2 87,773,632 (GRCm39) missense probably damaging 1.00
R6909:Or5d16 UTSW 2 87,773,034 (GRCm39) missense probably benign 0.27
R7257:Or5d16 UTSW 2 87,773,915 (GRCm39) missense probably damaging 1.00
R8037:Or5d16 UTSW 2 87,773,319 (GRCm39) missense probably benign 0.00
R8367:Or5d16 UTSW 2 87,773,441 (GRCm39) missense possibly damaging 0.75
R9301:Or5d16 UTSW 2 87,773,297 (GRCm39) missense probably benign 0.00
Z1088:Or5d16 UTSW 2 87,773,792 (GRCm39) missense probably damaging 1.00
Z1176:Or5d16 UTSW 2 87,773,811 (GRCm39) missense probably damaging 1.00
Z1176:Or5d16 UTSW 2 87,773,553 (GRCm39) missense possibly damaging 0.57
Predicted Primers PCR Primer
(F):5'- TCAGGGCAGTGACAACAATG -3'
(R):5'- TCCCAAGATGCTGGTGAACC -3'

Sequencing Primer
(F):5'- GCAGTGACAACAATGAACAAATACG -3'
(R):5'- ACCTTGTTGTAGAAGATAGGACC -3'
Posted On 2015-06-10