Incidental Mutation 'R4177:Selenoo'
ID 319570
Institutional Source Beutler Lab
Gene Symbol Selenoo
Ensembl Gene ENSMUSG00000035757
Gene Name selenoprotein O
Synonyms Selo, 1300018J18Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.101) question?
Stock # R4177 (G1)
Quality Score 225
Status Validated
Chromosome 15
Chromosomal Location 88973287-88984543 bp(+) (GRCm39)
Type of Mutation unclassified
DNA Base Change (assembly) C to T at 88983662 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Gene Model predicted gene model for transcript(s): [ENSMUST00000041656] [ENSMUST00000082439] [ENSMUST00000109353] [ENSMUST00000130700] [ENSMUST00000166480]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000041656
SMART Domains Protein: ENSMUSP00000040132
Gene: ENSMUSG00000051786

DomainStartEndE-ValueType
Pfam:Spc97_Spc98 355 1667 3.3e-119 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000082439
SMART Domains Protein: ENSMUSP00000081020
Gene: ENSMUSG00000035757

DomainStartEndE-ValueType
low complexity region 24 38 N/A INTRINSIC
Pfam:UPF0061 79 625 8.3e-131 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000109353
SMART Domains Protein: ENSMUSP00000104977
Gene: ENSMUSG00000051786

DomainStartEndE-ValueType
Pfam:Spc97_Spc98 355 1675 2.8e-94 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000130700
SMART Domains Protein: ENSMUSP00000138382
Gene: ENSMUSG00000035757

DomainStartEndE-ValueType
low complexity region 24 38 N/A INTRINSIC
Pfam:UPF0061 80 241 1.5e-39 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000163290
SMART Domains Protein: ENSMUSP00000131359
Gene: ENSMUSG00000051786

DomainStartEndE-ValueType
Pfam:Spc97_Spc98 91 288 2.9e-37 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000164717
Predicted Effect noncoding transcript
Transcript: ENSMUST00000166994
Predicted Effect noncoding transcript
Transcript: ENSMUST00000169208
Predicted Effect noncoding transcript
Transcript: ENSMUST00000168256
Predicted Effect probably benign
Transcript: ENSMUST00000169069
SMART Domains Protein: ENSMUSP00000132786
Gene: ENSMUSG00000051786

DomainStartEndE-ValueType
coiled coil region 77 107 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000166480
SMART Domains Protein: ENSMUSP00000132108
Gene: ENSMUSG00000051786

DomainStartEndE-ValueType
Pfam:Spc97_Spc98 2 123 5e-18 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000170877
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.2%
Validation Efficiency 100% (46/46)
MGI Phenotype FUNCTION: This gene encodes a selenoprotein that is localized to the mitochondria. It is the largest mammalian selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. The exact function of this selenoprotein is not known, but it is thought to have redox activity. [provided by RefSeq, Jan 2017]
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aicda A T 6: 122,538,043 (GRCm39) D67V probably benign Het
Arhgap32 A G 9: 32,158,510 (GRCm39) R182G probably null Het
Bbx T C 16: 50,045,221 (GRCm39) K447E probably damaging Het
Bscl2 A G 19: 8,817,120 (GRCm39) D16G possibly damaging Het
Celsr2 A G 3: 108,321,294 (GRCm39) V506A probably damaging Het
Cenpf T A 1: 189,400,816 (GRCm39) Q441L possibly damaging Het
Crebbp A T 16: 3,937,663 (GRCm39) M700K possibly damaging Het
Dhcr7 A G 7: 143,394,910 (GRCm39) Y142C probably damaging Het
Dnajc2 A G 5: 21,962,394 (GRCm39) M602T probably benign Het
Dysf C T 6: 84,044,013 (GRCm39) R254* probably null Het
Ednra A C 8: 78,401,677 (GRCm39) I204M possibly damaging Het
Fabp2 A G 3: 122,690,547 (GRCm39) T77A possibly damaging Het
Gm10322 C A 10: 59,452,052 (GRCm39) N56K probably benign Het
Gnb1 T C 4: 155,625,113 (GRCm39) probably benign Het
Gpc2 T C 5: 138,275,621 (GRCm39) probably benign Het
Kmt2a T C 9: 44,732,280 (GRCm39) probably benign Het
Lypla2 T C 4: 135,696,403 (GRCm39) probably benign Het
Maf A T 8: 116,433,210 (GRCm39) Y131* probably null Het
Mfsd4a T A 1: 131,968,295 (GRCm39) H335L probably damaging Het
Mrgpra9 A G 7: 46,885,302 (GRCm39) Y122H probably damaging Het
Myo10 A T 15: 25,734,137 (GRCm39) Q342L possibly damaging Het
N4bp2 A G 5: 65,955,513 (GRCm39) probably null Het
Or5t15 A T 2: 86,681,745 (GRCm39) M99K possibly damaging Het
Pomt1 A G 2: 32,138,689 (GRCm39) N435S probably damaging Het
Pram1 A G 17: 33,860,203 (GRCm39) I257V probably benign Het
Rab9 G T X: 165,241,296 (GRCm39) S5* probably null Het
Ralgapa2 A T 2: 146,327,083 (GRCm39) Y59N probably damaging Het
Rasgrf2 C T 13: 92,038,717 (GRCm39) G1043D probably damaging Het
Rps6kc1 G A 1: 190,532,616 (GRCm39) T462M possibly damaging Het
Sptb G C 12: 76,659,953 (GRCm39) D982E probably benign Het
Tab2 A G 10: 7,795,123 (GRCm39) V453A probably damaging Het
Ubald1 A G 16: 4,693,745 (GRCm39) probably benign Het
Ube2d1 T C 10: 71,094,033 (GRCm39) K101R probably damaging Het
Unc5cl A G 17: 48,769,298 (GRCm39) T261A probably benign Het
Zcwpw1 G T 5: 137,798,395 (GRCm39) K197N probably damaging Het
Zfp268 T C 4: 145,347,225 (GRCm39) L43S probably damaging Het
Zfyve19 A G 2: 119,046,693 (GRCm39) T296A possibly damaging Het
Other mutations in Selenoo
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00496:Selenoo APN 15 88,979,875 (GRCm39) missense probably damaging 1.00
IGL01922:Selenoo APN 15 88,983,852 (GRCm39) missense probably benign 0.06
IGL02103:Selenoo APN 15 88,984,173 (GRCm39) missense probably damaging 1.00
R0655:Selenoo UTSW 15 88,979,858 (GRCm39) missense probably damaging 1.00
R0960:Selenoo UTSW 15 88,980,957 (GRCm39) missense probably benign 0.08
R1610:Selenoo UTSW 15 88,984,119 (GRCm39) missense probably benign
R2152:Selenoo UTSW 15 88,983,485 (GRCm39) missense probably benign 0.01
R4588:Selenoo UTSW 15 88,980,921 (GRCm39) missense probably benign 0.01
R4622:Selenoo UTSW 15 88,979,910 (GRCm39) nonsense probably null
R4731:Selenoo UTSW 15 88,983,531 (GRCm39) missense probably benign 0.00
R4926:Selenoo UTSW 15 88,983,881 (GRCm39) missense probably damaging 0.98
R4934:Selenoo UTSW 15 88,982,970 (GRCm39) missense probably damaging 0.98
R4999:Selenoo UTSW 15 88,978,387 (GRCm39) missense probably damaging 1.00
R5000:Selenoo UTSW 15 88,978,387 (GRCm39) missense probably damaging 1.00
R5033:Selenoo UTSW 15 88,976,969 (GRCm39) missense probably damaging 1.00
R5120:Selenoo UTSW 15 88,978,508 (GRCm39) missense possibly damaging 0.79
R6034:Selenoo UTSW 15 88,983,546 (GRCm39) missense probably benign 0.00
R6034:Selenoo UTSW 15 88,983,546 (GRCm39) missense probably benign 0.00
R7238:Selenoo UTSW 15 88,973,427 (GRCm39) missense probably benign 0.15
R7287:Selenoo UTSW 15 88,982,903 (GRCm39) missense probably benign 0.01
R7378:Selenoo UTSW 15 88,973,681 (GRCm39) missense probably benign 0.07
R7818:Selenoo UTSW 15 88,981,019 (GRCm39) missense probably damaging 1.00
R8058:Selenoo UTSW 15 88,976,942 (GRCm39) missense possibly damaging 0.95
R9233:Selenoo UTSW 15 88,984,044 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GTCGAACCCACAGCTCTTTG -3'
(R):5'- GTTCCTCAGGACGTACTTGG -3'

Sequencing Primer
(F):5'- GCACTCATTGGTACTCAAGCCAATG -3'
(R):5'- TTGTTGGCACGCATGACAC -3'
Posted On 2015-06-10